Digital Commons Network^™

Fluorescence Angiography With Dual Fluorescence For The Early Detection And Longitudinal Quantitation Of Vascular Leakage In Retinopathy, Benjamin Pomeroy, Alexander W Venanzi, Wei Li, Abigail S Hackam, Midhat H Abdulreda

Faculty, Staff and Students Publications

BACKGROUND: Diabetic retinopathy (DR) afflicts more than 93 million people worldwide and is a leading cause of vision loss in working adults. While DR therapies are available, early DR development may go undetected without treatment due to the lack of sufficiently sensitive tools. Therefore, early detection is critically important to enable efficient treatment before progression to vision-threatening complications. A major clinical manifestation of early DR is retinal vascular leakage that may progress from diffuse to more localized focal leakage, leading to increased retinal thickness and diabetic macular edema (DME). In preclinical research, a hallmark of DR in mouse models is …

Svhound: Detection Of Regions That Harbor Yet Undetected Structural Variation, Luis F Paulin, Muthuswamy Raveendran, R Alan Harris, Jeffrey Rogers, Arndt Von Haeseler, Fritz J Sedlazeck

Faculty, Staff and Students Publications

BACKGROUND: Recent population studies are ever growing in number of samples to investigate the diversity of a population or species. These studies reveal new polymorphism that lead to important insights into the mechanisms of evolution, but are also important for the interpretation of these variations. Nevertheless, while the full catalog of variations across entire species remains unknown, we can predict which regions harbor additional not yet detected variations and investigate their properties, thereby enhancing the analysis for potentially missed variants.

RESULTS: To achieve this we developed SVhound ( https://github.com/lfpaulin/SVhound ), which based on a population level SVs dataset can predict …

Assessing The Effectiveness Of Integrated Multi-Trophic Aquaculture For Growing West Coast Venus Clams, Avery Wallace

Theses

With demand for sustainable sources of seafood on the rise, California is looking to expand aquaculture with a focus on innovative culturing methods and use of native or resident species. Therefore, this study examined the potential for culturing native North American west coast venus clams (Chione californiensis and Chione undatella) using integrated multi-trophic aquaculture (IMTA). An ITMA approach was chosen because it is a culture method that uses species from different but functionally complementary trophic levels that have been found to reduce the potential negative effects of traditional monoculture. California sea cucumber (Parastichopus californicus) and the seaweeds red ogo (Gracilaria …

Strategic Thinking On China’S Food System Transition From Perspective Of Sustainable Development Goals, Xiaojie Liu, Siqi He, Weiqiang Chen, Dan Yan, Litao Liu, Gangqiang Ding, Zhongjie Zhang, Gang Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Food system is the foundation of human society, thus the sustainable transition of food system is one of the key topics towards global sustainability. Facing the global climate crisis, regional conflict, and pandemic that unseen in a century, it becomes critical to build a sustainable food system in line with the Chinese context for ensuring its grain and food security, national nutrition and health, social justice, ecological balance, market effectiveness, and system resilience. To address these focuses, this study analyzed the main issues and challenges faced by China's current food system, and decoded the relationship between food system and sustainable …

2022 Research Fronts: Development Trends And Key Research Questions In 11 Broad Research Areas, Jiaofeng Pan, Haixia Wang, Fuhai Leng, Feng Zhang, Fan Yang, Jianxia Yuan, Ying Xing, Weiwei Fan, Qiuju Zhou, Wenyue Bian, Chaoxing Zhang, Longguang Huang, Haiming Wang, Lin Han, Ruimin Pei

Bulletin of Chinese Academy of Sciences (Chinese Version)

In 2022, Institutes of Science and Development, Chinese Academy of Sciences (CASISD), the National Science Library, CAS, and Clarivate Analytics released their joint report Research Fronts 2022. The report utilized the Essential Science Indicators (ESI) database to do co-citation analysis. The 2022 report started from 12 610 research fronts in ESI and identified a total of 165 research fronts, including hot and emerging specialties spanning 11 broad research areas in sciences and social sciences. With the 165 research fronts and the related core papers and citing papers as the basis for analysis, this study summarized 8 development trends in science …

Personalized Therapeutics For Katp-Dependent Pathologies, Colin G Nichols

2020-Current year OA Pubs

Ubiquitously expressed throughout the body, ATP-sensitive potassium (K

A Pleiotropic Chemoreceptor Facilitates The Production And Perception Of Mating Pheromones, Cassondra L Vernier, Nicole Leitner, Kathleen M Zelle, Merrin Foltz, Sophia Dutton, Xitong Liang, Sean Halloran, Jocelyn G Millar, Yehuda Ben-Shahar

2020-Current year OA Pubs

Optimal mating decisions depend on the robust coupling of signal production and perception because independent changes in either could carry a fitness cost. However, since the perception and production of mating signals are often mediated by different tissues and cell types, the mechanisms that drive and maintain their coupling remain unknown for most animal species. Here, we show that in

Synthetic Biology Design As A Paradigm Shift Toward Manufacturing Affordable Adeno-Associated Virus Gene Therapies, Logan Thrasher Collins, Selvarangan Ponnazhagan, David T Curiel

2020-Current year OA Pubs

Gene therapy has demonstrated enormous potential for changing how we combat disease. By directly engineering the genetic composition of cells, it provides a broad range of options for improving human health. Adeno-associated viruses (AAVs) represent a leading gene therapy vector and are expected to address a wide range of conditions in the coming decade. Three AAV therapies have already been approved by the FDA to treat Leber's congenital amaurosis, spinal muscular atrophy, and hemophilia B. Yet these therapies cost around $850,000, $2,100,000, and $3,500,000, respectively. Such prices limit the broad applicability of AAV gene therapy and make it inaccessible to …

Utilizing Drones To Streamline Wildlife Hazard Management Efforts By Airport Operators, Flavio A. C. Mendonca Ph.D., Ryan Wallace, Jose Cabrera, Cole Mcnall

National Training Aircraft Symposium (NTAS)

Airports operating under the Code of Federal Regulations Part 139 should conduct a wildlife hazard assessment (WHA) when some wildlife-strike events have occurred at or near the airport. The WHA must be conducted by a Qualified Airport Wildlife Biologist (QAWB). The required elements in a WHA include the identification of the wildlife species observed and their numbers, and the location of features on and near the airport that could attract wildlife. Service learning and research projects enable undergraduate students to develop transferable skills that are highly valued by the aviation industry, including critical thinking, self-confidence, the ability to integrate theory …

Improved Feedback Mechanisms Of The Hydraulics Sandbox Simulator, Karen J. Johnson, Martin Hebel

National Training Aircraft Symposium (NTAS)

The proposed presentation will include the following project and results from implementation in an aircraft hydraulic systems course.

In 2020 we developed a digital hydraulics system schematic sandbox for use in an FAA Part 147 airframe maintenance technician training program (See Figure 1). The sandbox allows students to drag-drop-connect components used in systems such as those found in aircraft. It allows them to ‘test-connect’ the components to get feedback on correct and incorrect ‘construction’. As shown in Figure 1, light green ‘hoses’ are correct supply connections, dark green are correct return connections and red are incorrect connections per established rules …

556 U.S. 662

Civil Matter Files

No abstract provided.

Ashcroft V. Iqbal

Civil Matter Files

No abstract provided.

The Adaptive Capacity To Implement Climate Migration Policy In Response To Sea-Level Rise In The Maldives, Kelsey Garrett

Capstone Collection

This exploratory study is centered on the increasing harmful impacts of climate change and its connection to human life. The effects are exacerbating the current drivers of migration like livelihoods, security, and politics. People are losing their homes and livelihoods because of drought, rising seas, or increasing natural disasters. Millions of people are. Displaced by climate events every year, the number is expected to increase. Due to this, there is value in studying climate change and migration. Amongst the most vulnerable are those living in Small Island Developing States (SIDS). This exploratory study examined the Maldives to understand their adaptive …

Static And Dynamic Analysis Of A Bistable Frequency Up-Converter Piezoelectric Energy Harvester, Mohammad Atmeh, Alwathiqbellah Ibrahim, Abdallah Ramini

Mechanical Engineering Faculty Publications and Presentations

Using energy harvesting to convert ambient vibrations efficiently to electrical energy has become a worthy concept in recent years. Nevertheless, the low frequencies of the ambient vibrations cannot be effectively converted to power using traditional harvesters. Therefore, a frequency up-conversion harvester is presented to convert the low-frequency vibrations to high-frequency vibrations utilizing magnetic coupling. The presented harvester consists of a low-frequency beam (LFB) and a high-frequency beam (HFB) with identical tip magnets facing each other at the same polarity. The HFB, fully covered by a piezoelectric strip, is utilized for voltage generation. The dynamic behavior of the system and the …

Issue 410: January 19-February 2, 2023, The Local Voice

The Local Voice

Townies Favorites 2023

Trisomy 21 Induces Pericentrosomal Crowding Delaying Primary Ciliogenesis And Mouse Cerebellar Development., Cayla E Jewett, Bailey L Mccurdy, Eileen T O'Toole, Alexander J Stemm-Wolf, Katherine S Given, Carrie H Lin, Valerie Olsen, Whitney Martin, Laura G Reinholdt, Joaquín M Espinosa, Kelly D Sullivan, Wendy B Macklin, Rytis Prekeris, Chad G Pearson

Faculty Research 2023

Trisomy 21, the genetic cause of Down syndrome, disrupts primary cilia formation and function, in part through elevated Pericentrin, a centrosome protein encoded on chromosome 21. Yet how trisomy 21 and elevated Pericentrin disrupt cilia-related molecules and pathways, and the in vivo phenotypic relevance remain unclear. Utilizing ciliogenesis time course experiments combined with light microscopy and electron tomography, we reveal that chromosome 21 polyploidy elevates Pericentrin and microtubules away from the centrosome that corral MyosinVA and EHD1, delaying ciliary membrane delivery and mother centriole uncapping essential for ciliogenesis. If given enough time, trisomy 21 cells eventually ciliate, but these ciliated …

The Indiana Statesman, January 19, 2023, Indiana State University

Student Newspaper

New section debuts for the Statesman; Bingo begins again; ISU celebrates MLK day with service; Child molester pleads guilty; Founders Day celebration set for end of January

Usage Statistics: Project Counter R5 Dr_D1 Report Fy2022 - Database Search And Item Usage, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report DR_D1 for the University of Rhode Island for the period from July 1, 2021 - June 30, 2022. The DR_D1 report is defined as "Database Search and Item Usage." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Searches Automated - 316,771

Searches Federated - 52,533

Searches Regular - 768,218

Total Item Investigations - 930,171

Total Item Requests - 251,936

Researchers Find That Chromatically Simulated Myopic Blur May Be Useful As A Myopia Control Therapy, Anna Jones

Browse All News

No abstract provided.

The Association Between Civic Engagement Via Participatory Art And Adolescents’ Self-Esteem And Self-Efficacy, Michaela Ann Hayes

Theses and Dissertations

Civic engagement refers to actions taken by individuals to address issues of public concern, which can come in many forms including engagement in art. Participation in these activities can have positive impacts on the individual, including improved mental and physical health, as well as on the community through increased appreciation for differences and acquisition of values such as tolerance. The Bioecological Model suggests that an individual's participation in civic activities is influenced by the various levels of their environment. These experiences may be particularly impactful for adolescents. Indeed, adolescents who participated in civic engagement activities have been found to have …

The Inbio Barcoding Initiative Database: Dna Barcodes Of Iberian Trichoptera, Documenting Biodiversity For Freshwater Biomonitoring In A Mediterranean Hotspot, Joana Pauperio, Luis Martin Gonzalez, Jesus Martinez, Marcos A. González, Filipa Ms Martins, Joana Veríssimo, Pamela Puppo, Joana Pinto, Cátia Chaves, Catarina J. Pinho, José Manuel Grosso-Silva, Lorenzo Quaglietta, Teresa Luísa L. Silva, Pedro Sousa, Paulo Celio Alves, Nuno Fonseca, Pedro Beja, Sónia Ferreira

Biological Sciences Faculty Research

Background

The Trichoptera are an important component of freshwater ecosystems. In the Iberian Peninsula, 380 taxa of caddisflies are known, with nearly 1/3 of the total species being endemic in the region. A reference collection of morphologically identified Trichoptera specimens, representing 142 Iberian taxa, was constructed. The InBIO Barcoding Initiative (IBI) Trichoptera 01 dataset contains records of 438 sequenced specimens. The species of this dataset correspond to about 37% of Iberian Trichoptera species diversity. Specimens were collected between 1975 and 2018 and are deposited in the IBI collection at the CIBIO (Research Center in Biodiversity and Genetic Resources, Portugal) or …

Rogue Entrepreneurship, Russ Mcbride, Mark D. Packard, Brent B. Clark

Marketing & Entrepreneurship Faculty Publications

We suggest a new category of “rogue entrepreneurship,” that describes entrepreneurial activity where the core business idea violates established or expert consensus, to be contrasted with “conforming entrepreneurship,” where it does not. There are large entrepreneurial rents hidden behind a bulwark of expert consensus that predicts doom for a venture based upon a rogue and unlikely claim. The “rogue” cases, where the predominant assessment context is different from the entrepreneur’s, result in broad skepticism against the entrepreneurial claim. We explain what rogue entrepreneurship is and how it works.

“What important truth do very few people agree with you on? A …

Investigating Stigma During The Early Stages Of A Pandemic Through The Lens Of Covid-19, Zach Thornton, Bethany Hodge, Sheridan Langford

The University of Louisville Journal of Respiratory Infections

Background: Individuals face stigma associated with numerous health conditions. Stigma can arise rapidly during the early spread of a new disease, adding to the burden felt by those affected. COVID-19 can be used as an example to study stigma during the early phases of a pandemic. This narrative review is a descriptive analysis that tracks the ways in which COVID-19 stigma was discussed in the scholarly literature during the first year of the pandemic to understand how stigma was viewed in the context of a rapidly spreading pandemic.

Methods: PubMed was used as a non-exhaustive sample of the literature. Searches …

Usage Statistics: Project Counter R5 Tr_J1 Report Fy2022 - Journal Requests (Excluding Oa_Gold) By Title, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report TR_J1 for the University of Rhode Island for the period from July 1, 2021 - June 30, 2022. The TR_J1 report is defined as "Journal Requests (Excluding OA_Gold)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Total Item Requests - 771,947

Unique Item Requests - 578,437

Development Of Food-Based Recommendation And Nutrient-Dense Meal For Female Shift Workers In West Java, Indonesia, Shanti Puji Lestari, Nuri Purwito Adi, Umi Fahmida, Dian Kusuma Dewi, Muchtaruddin Mansyur

Occupational and Environmental Medicine Journal of Indonesia

Introduction. Some manufacturing industries employ not only male workers but also female workers, who are required to undergo shift work. Given the altered eating habits as well as metabolic and endocrine profiles of shift workers, this will affect their nutritional needs. Considering that anemia that occurs in female workers is primarily nutritional anemia, this becomes a challenge in the field of occupational nutrition, especially in terms of preparing food for female workers in accordance with their nutritional needs. The aim of the study is to develop a set of FBR for female shift workers using the Linear Programming (LP) approach. …

Usage Statistics: Project Counter R5 Tr_B1 Report Fy2022 - Book Requests (Excluding Oa_Gold) By Title, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report TR_B1 for the University of Rhode Island for the period from July 1, 2021 - June 30, 2022. The TR_B1 report is defined as "Book Requests (Excluding OA_Gold)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Total Item Requests - 92,619

Unique Title Requests - 43,012

Usage Statistics: Project Counter R5 Ir_M1 Report Fy2022 - Multimedia Item Requests, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report IR_M1 for the University of Rhode Island for the period from July 1, 2021 - June 30, 2022. The IR_M1 report is defined as "Multimedia Item Requests." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Total Item Requests - 4,309

Integrated Mrna Sequence Optimization Using Deep Learning, Haoran Gong, Jianguo Wen, Ruihan Luo, Yuzhou Feng, Jingjing Guo, Hongguang Fu, Xiaobo Zhou

Faculty, Staff and Student Publications

The coronavirus disease of 2019 pandemic has catalyzed the rapid development of mRNA vaccines, whereas, how to optimize the mRNA sequence of exogenous gene such as severe acute respiratory syndrome coronavirus 2 spike to fit human cells remains a critical challenge. A new algorithm, iDRO (integrated deep-learning-based mRNA optimization), is developed to optimize multiple components of mRNA sequences based on given amino acid sequences of target protein. Considering the biological constraints, we divided iDRO into two steps: open reading frame (ORF) optimization and 5' untranslated region (UTR) and 3'UTR generation. In ORF optimization, BiLSTM-CRF (bidirectional long-short-term memory with conditional random …

Board Of Mgrs. Of The Charleston Condominium V. Oppenheim

All Decisions

No abstract provided.

2023 January 19 - From My Notepads Newsletter, Office Of The President, East Tennessee State University, Brian Noland

From My Notepads: A Newsletter from President Brian Noland

No abstract provided.