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Recreating Pastoralist Futures, T. J. P. Lynam

IGC Proceedings (1977-2023)

Research experience in southern Africa is used to reflect on key determinants of pastoral futures and how they might need to be addressed. The paper begins with a brief review of what we mean by marginality. A set of observations on key issues defining the option sets for pastoralism in the future is then presented. The first of these is that only a small number of structures or processes actually control the behaviour of social-ecological systems such as pastoralist systems. A second observation is that the future is so uncertain that there is a need to learn to design for …

Challenges And Opportunities For Sustainable Rangeland Pastoral Systems In The Edwards Plateau Of Texas, J. W. Walker, J. L. Johnson, C. A. Taylor Jr.

IGC Proceedings (1977-2023)

This paper focuses on pastoral systems in an area of west-central Texas known as the Edwards Plateau. These rangelands have a combination of grass, forb and browse species and are used primarily for combinations of grazing by cattle, sheep, goats and wildlife. A major ecological challenge is woody plant encroachment. Stocking rate is the major factor affecting sustainability and historically this area was heavily grazed. Today the stocking rate is half or less of its historical peak. Species of livestock has shifted from predominantly small ruminant to cattle. About 70 % of pastoralists use some sort of rotational grazing system. …

Working Within Constraints: Managing African Savannas For Animal Production And Biodiversity, J. T. Du Toit

IGC Proceedings (1977-2023)

The mean density of livestock biomass on African rangelands now greatly exceeds that of indigenous large herbivores, although livestock cannot fully substitute for wildlife with respect to co-evolved ecosystem processes involving herbivory. The dominance of livestock in semi-arid rangelands is largely due to water provision, which uncouples livestock population dynamics from the rainfall-driven trajectories followed by indigenous ungulate species in wildlife areas. Ecological sustainability cannot be achieved with a few exotic species maintained at unprecedented biomass densities in savanna ecosystems, which are evolutionarily adapted for species-rich communities of ungulates of a wise range of sizes. Integrating wildlife and livestock in …

Diversity And Variation In Nutritive Value Of Plants Growing On 2 Saline Sites In Southwestern Australia, H. C. Norman, R. A. Dynes, D. G. Masters

IGC Proceedings (1977-2023)

In south-western Australia 10% or 1.8 million ha of the farmed area is affected by dryland salinity and a further 6 million ha are at risk of salinity (NLWRA, 2001). Animal production from saltbush (Atriplex spp.)-based pasture systems represents the most likely large-scale opportunity for productive use of saline land in the short to medium term. Feeding saltbush-based pastures as a maintenance feed during the prolonged autumn feed gap typical in Mediterranean-type climates maximises their economic value. The aim of this study was to explore the diversity and nutritive value of plants that typically persist in saltbush-based saltland pastures.

The Long Road To Developing Native Herbaceous Summer Forage Legume Ecotypes, J. P. Muir, T. J. Butler, W. R. Ocumpaugh

IGC Proceedings (1977-2023)

Only a handful of well-adapted herbaceous summer forage legumes are currently marketed for drier regions of North America and even fewer are true natives. There is a growing demand for native germplasm in the region as a new generation of landowner attempts to return grasslands to a semblance of their original species and diversity. The objective of this paper is to describe preliminary research results of a grasslands team collecting, studying and promulgating native leguminous germplasm in Texas.

Grazing Animal Production Systems And Grazing Land Characteristics In A Semi-Arid Region Of Greece, I. Hadjigeorgiou, G. Economou, D. Lolis, N. Moustakas, G. Zervas

IGC Proceedings (1977-2023)

Rough grazing in Greece cover about 40% of the total land area, is publicly owned and managed extensively (Hadjigeorgiou et al., 2002). The Prefecture of Larisa is in the centre of Greece, and has 212,000 ha of rough grazing land, with a variable topography ranging from sea level up to 3,000 m a.s.l. This area is utilized by a total population of 135,000 LU (mainly sheep, goats and some suckler cows), which consumes annually an appreciable fraction of their total nutrient requirements from rough grazing.

Grass And Forage Plant Improvement In The Tropics And Sub-Tropics, Liana Jank, C. B. Do Valle, Rosangela M. S. Resende

IGC Proceedings (1977-2023)

1. The majority of tropical and subtropical forage grass genera and/or species have not yet been collected, or need further collection to be representative of their natural distribution.
2. New biotechnological techniques will only result in the release of superior forage cultivars if supported by strong breeding programs.
3. More funding and investment in the formation of strong public research teams in forage conservation and improvement are needed to guarantee the sustainability of tropical and subtropical pasture-based livestock systems in the future.
4. The creation of a permanent international working group on tropical and subtropical forages is essential to assist the International Plant Genetic …

Artificial Intelligence, Basic Skills, And Quantitative Literacy, Gizem Karaali

Numeracy

The introduction in November 2022 of ChatGPT, a freely available language-based artificial intelligence, has led to concerns among some educators about the feasibility and benefits of teaching basic writing and critical thinking skills to students in the context of easily accessed, AI-based cheating mechanisms. As of now, ChatGPT can write pretty convincing student-level prose, but it is still not very good at answering quantitatively rich questions. Therefore, for the time being, the preceding concerns may not be shared by a large portion of the numeracy education community. However, as Google and WolframAlpha are definitely capable of answering standard and some …

The Beacon, January 20, 2023, Beacon Staff

The Beacon, 2022-2023

Unsung Heroes: Dr. Bob Hubbard; How MLK changed America forever; SZA makes killer return with newest album; Long-awaited sequel introduces new faces; Visiting professor impacts Music Department; Make some noise for Northwestern percussion; Students experienced extreme weather; Campus celebrates Martin Luther King, Jr.; 20 Students experience Urbana Mission Conference; An honored theatre professor; AI won't break the Internet (But It Will Try); The Overrated City of Paris, France; Raiders win NAIA National Championship; Junior Schany Starts Semester off Strong; NWC Raiders Demolish Hastings in Weekend Sweep; Exploring questions about identity; Twelve Japanese students welcomed to campus;

The Bison, January 20, 2023

The Bison Newspapers

No abstract provided.

Faculty Senate Meeting Minutes Jan 20, 2023, A-State Faculty Senate

Faculty Senate Minutes

Meeting minutes for the Faculty Senate held on January 20, 2023.

Fast Blue And Cholera Toxin-B Survival Guide For Alpha-Motoneurons Labeling: Less Is Better In Young B6sjl Mice, But More Is Better In Aged C57bl/J Mice, Hasan Farid, Weston B. Gleford, Lori L. Goss, Teresa L. Garrett, Sherif M. Elbasiouny

Neuroscience, Cell Biology & Physiology Faculty Publications

Fast Blue (FB) and Cholera Toxin-B (CTB) are two retrograde tracers extensively used to label alpha-motoneurons (α-MNs). The overall goals of the present study were to (1) assess the effectiveness of different FB and CTB protocols in labeling α-MNs, (2) compare the labeling quality of these tracers at standard concentrations reported in the literature (FB 2% and CTB 0.1%) versus lower concentrations to overcome tracer leakage, and (3) determine an optimal protocol for labeling α-MNs in young B6SJL and aged C57Bl/J mice (when axonal transport is disrupted by aging). Hindlimb muscles of young B6SJL and aged C57Bl/J mice were intramuscularly …

"Women Are Again Unsafe": Preventing Violence And Poor Maternal Outcomes During Current Floods In Pakistan, Sarmad Muhammad Soomar, Abir Arefin, Salman Muhammad Soomar

School of Nursing & Midwifery

No abstract provided.

Depletion Of Hiv Reservoir By Activation Of Isr Signaling In Resting Cd4+T Cells, Dajiang Li, Lilly M. Wong, Yuyang Tang, Brigitte Allard, Katherine S. James, George R. Thompson, Satya Dandekar, Edward P. Browne, Qingsheng Li, Jeremy M. Simon, Nancie M. Archin, David M. Margolis, Guochun Jiang

School of Biological Sciences: Faculty Publications

HIV reservoirs are extremely stable and pose a tremendous challenge to clear HIV infection. Here, we demonstrate that activation of ISR/ATF4 signaling reverses HIV latency, which also selectively eliminates HIV+ cells in primary CD4⁺T cell model of latency without effect on HIV-negative CD⁴⁺T cells. The reduction of HIV+ cells is associated with apoptosis enhancement, but surprisingly is largely seen in HIV-infected cells in which gag-pol RNA transcripts are detected in HIV RNA-induced ATF4/IFIT signaling. In resting CD4⁺ (rCD4⁺) T cells isolated from people living with HIV on antiretroviral therapy, induction of ISR/ATF4 signaling …

Synthesize Heterogeneous Biological Knowledge Via Representation Learning For Alzheimer’S Disease Drug Repurposing, Kang-Lin Hsieh, German Plascencia-Villa, Ko-Hong Lin, George Perry, Xiaoqian Jiang, Yejin Kim

Faculty, Staff and Student Publications

Developing drugs for treating Alzheimer's disease has been extremely challenging and costly due to limited knowledge of underlying mechanisms and therapeutic targets. To address the challenge in AD drug development, we developed a multi-task deep learning pipeline that learns biological interactions and AD risk genes, then utilizes multi-level evidence on drug efficacy to identify repurposable drug candidates. Using the embedding derived from the model, we ranked drug candidates based on evidence from post-treatment transcriptomic patterns, efficacy in preclinical models, population-based treatment effects, and clinical trials. We mechanistically validated the top-ranked candidates in neuronal cells, identifying drug combinations with efficacy in …

Dietary Strawberries Improve Serum Metabolites Of Cardiometabolic Risks In Adults With Features Of The Metabolic Syndrome In A Randomized Controlled Crossover Trial, Arpita Basu, Kenneth Izuora, Andrew Hooyman, Hal R. Scofield, Jeffrey L. Ebersole

Physical Therapy Faculty Articles and Research

Dietary strawberries have been shown to improve cardiometabolic risks in multiple clinical trials. However, no studies have reported effects on serum metabolomic profiles that may identify the target pathways affected by strawberries as underlying mechanisms. We conducted a 14-week randomized, controlled crossover study in which participants with features of metabolic syndrome were assigned to one of the three arms for four weeks separated by a one-week washout period: control powder, 1 serving (low dose: 13 g strawberry powder/day), or 2.5 servings (high dose: 32 g strawberry powder/day). Blood samples, anthropometric measures, blood pressure, and dietary and physical activity data were …

Co-Culture Models Of Endothelial Cells, Macrophages, And Vascular Smooth Muscle Cells For The Study Of The Natural History Of Atherosclerosis, Martin Liu, Saurabhi Samant, Charu Hasini Vasa, Ryan M. Pedrigi, Usama Oguz, Sangjin Ryu, Timothy Wei, Daniel R. Anderson, Devandra K. Agrawal, Yiannis Chatzizisis

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Background

This work aims to present a fast, affordable, and reproducible three-cell co-culture system that could represent the different cellular mechanisms of atherosclerosis, extending from atherogenesis to pathological intimal thickening.

Methods and results

We built four culture models: (i) Culture model #1 (representing normal arterial intima), where human coronary artery endothelial cells were added on top of Matrigel-coated collagen type I matrix, (ii) Culture model #2 (representing atherogenesis), which demonstrated the subendothelial accumulation and oxidative modification of low-density lipoproteins (LDL), (iii) Culture model #3 (representing intimal xanthomas), which demonstrated the monocyte adhesion to the endothelial cell monolayer, transmigration into the …

Forgotten "People": Reviving Textualism In The Fourth Amendment, Peter C. Douglas

San Diego Law Review

For more than a century, the Supreme Court has struggled to develop a coherent and sustainable theory of the Fourth Amendment. Before the ink is dry on a new Fourth Amendment opinion, it is cabined, abrogated, or outright overruled. As one scholar has commented, the “evolution of Fourth Amendment doctrine over the past century bears a striking resemblance to Hamlet’s descent into insanity.” While the Court vacillates between “theories” of the Fourth Amendment that might bring clarity to a difficult body of constitutional law, the rights it bespeaks lie vulnerable and unprotected. This Article argues that the problem flows from …

2023-01-20 Institutional Animal Care And Use Committee Meeting Minutes, Morehead State University. Faculty Senate., Institutional Animal Care And Use Committee.

Faculty Senate Records

Institutional Animal Care and Use Committee meeting minutes of January 20, 2023.

Examining The Release Of Synthetic Microfibres To The Environment Via Two Major Pathways: Atmospheric Deposition And Treated Wastewater Effluent, I. E. Napper, F. N.F. Parker-Jurd, S. L. Wright, R. C. Thompson

School of Biological and Marine Sciences

Research on the discharge of synthetic microfibres to aquatic environments has typically focused on laundering, where fibres can be discharged via wastewater effluent. However emerging research suggests that microfibres generated during the wear of textiles in normal use could present a major, additional, pathway for microfibre pollution to the environment. This study aimed to quantify and compare the quantities of microfibre entering the marine environment via both these pathways; wastewater discharge and atmospheric deposition. Areas of high and low population density were also evaluated. Samples were collected in and around two British cities (Bristol and Plymouth) both of which are …

Fluorescence Angiography With Dual Fluorescence For The Early Detection And Longitudinal Quantitation Of Vascular Leakage In Retinopathy, Benjamin Pomeroy, Alexander W Venanzi, Wei Li, Abigail S Hackam, Midhat H Abdulreda

Faculty, Staff and Students Publications

BACKGROUND: Diabetic retinopathy (DR) afflicts more than 93 million people worldwide and is a leading cause of vision loss in working adults. While DR therapies are available, early DR development may go undetected without treatment due to the lack of sufficiently sensitive tools. Therefore, early detection is critically important to enable efficient treatment before progression to vision-threatening complications. A major clinical manifestation of early DR is retinal vascular leakage that may progress from diffuse to more localized focal leakage, leading to increased retinal thickness and diabetic macular edema (DME). In preclinical research, a hallmark of DR in mouse models is …

Svhound: Detection Of Regions That Harbor Yet Undetected Structural Variation, Luis F Paulin, Muthuswamy Raveendran, R Alan Harris, Jeffrey Rogers, Arndt Von Haeseler, Fritz J Sedlazeck

Faculty, Staff and Students Publications

BACKGROUND: Recent population studies are ever growing in number of samples to investigate the diversity of a population or species. These studies reveal new polymorphism that lead to important insights into the mechanisms of evolution, but are also important for the interpretation of these variations. Nevertheless, while the full catalog of variations across entire species remains unknown, we can predict which regions harbor additional not yet detected variations and investigate their properties, thereby enhancing the analysis for potentially missed variants.

RESULTS: To achieve this we developed SVhound ( https://github.com/lfpaulin/SVhound ), which based on a population level SVs dataset can predict …

Assessing The Effectiveness Of Integrated Multi-Trophic Aquaculture For Growing West Coast Venus Clams, Avery Wallace

Theses

With demand for sustainable sources of seafood on the rise, California is looking to expand aquaculture with a focus on innovative culturing methods and use of native or resident species. Therefore, this study examined the potential for culturing native North American west coast venus clams (Chione californiensis and Chione undatella) using integrated multi-trophic aquaculture (IMTA). An ITMA approach was chosen because it is a culture method that uses species from different but functionally complementary trophic levels that have been found to reduce the potential negative effects of traditional monoculture. California sea cucumber (Parastichopus californicus) and the seaweeds red ogo (Gracilaria …

Strategic Thinking On China’S Food System Transition From Perspective Of Sustainable Development Goals, Xiaojie Liu, Siqi He, Weiqiang Chen, Dan Yan, Litao Liu, Gangqiang Ding, Zhongjie Zhang, Gang Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Food system is the foundation of human society, thus the sustainable transition of food system is one of the key topics towards global sustainability. Facing the global climate crisis, regional conflict, and pandemic that unseen in a century, it becomes critical to build a sustainable food system in line with the Chinese context for ensuring its grain and food security, national nutrition and health, social justice, ecological balance, market effectiveness, and system resilience. To address these focuses, this study analyzed the main issues and challenges faced by China's current food system, and decoded the relationship between food system and sustainable …

2022 Research Fronts: Development Trends And Key Research Questions In 11 Broad Research Areas, Jiaofeng Pan, Haixia Wang, Fuhai Leng, Feng Zhang, Fan Yang, Jianxia Yuan, Ying Xing, Weiwei Fan, Qiuju Zhou, Wenyue Bian, Chaoxing Zhang, Longguang Huang, Haiming Wang, Lin Han, Ruimin Pei

Bulletin of Chinese Academy of Sciences (Chinese Version)

In 2022, Institutes of Science and Development, Chinese Academy of Sciences (CASISD), the National Science Library, CAS, and Clarivate Analytics released their joint report Research Fronts 2022. The report utilized the Essential Science Indicators (ESI) database to do co-citation analysis. The 2022 report started from 12 610 research fronts in ESI and identified a total of 165 research fronts, including hot and emerging specialties spanning 11 broad research areas in sciences and social sciences. With the 165 research fronts and the related core papers and citing papers as the basis for analysis, this study summarized 8 development trends in science …

Personalized Therapeutics For Katp-Dependent Pathologies, Colin G Nichols

2020-Current year OA Pubs

Ubiquitously expressed throughout the body, ATP-sensitive potassium (K

A Pleiotropic Chemoreceptor Facilitates The Production And Perception Of Mating Pheromones, Cassondra L Vernier, Nicole Leitner, Kathleen M Zelle, Merrin Foltz, Sophia Dutton, Xitong Liang, Sean Halloran, Jocelyn G Millar, Yehuda Ben-Shahar

2020-Current year OA Pubs

Optimal mating decisions depend on the robust coupling of signal production and perception because independent changes in either could carry a fitness cost. However, since the perception and production of mating signals are often mediated by different tissues and cell types, the mechanisms that drive and maintain their coupling remain unknown for most animal species. Here, we show that in

Synthetic Biology Design As A Paradigm Shift Toward Manufacturing Affordable Adeno-Associated Virus Gene Therapies, Logan Thrasher Collins, Selvarangan Ponnazhagan, David T Curiel

2020-Current year OA Pubs

Gene therapy has demonstrated enormous potential for changing how we combat disease. By directly engineering the genetic composition of cells, it provides a broad range of options for improving human health. Adeno-associated viruses (AAVs) represent a leading gene therapy vector and are expected to address a wide range of conditions in the coming decade. Three AAV therapies have already been approved by the FDA to treat Leber's congenital amaurosis, spinal muscular atrophy, and hemophilia B. Yet these therapies cost around $850,000, $2,100,000, and $3,500,000, respectively. Such prices limit the broad applicability of AAV gene therapy and make it inaccessible to …

Utilizing Drones To Streamline Wildlife Hazard Management Efforts By Airport Operators, Flavio A. C. Mendonca Ph.D., Ryan Wallace, Jose Cabrera, Cole Mcnall

National Training Aircraft Symposium (NTAS)

Airports operating under the Code of Federal Regulations Part 139 should conduct a wildlife hazard assessment (WHA) when some wildlife-strike events have occurred at or near the airport. The WHA must be conducted by a Qualified Airport Wildlife Biologist (QAWB). The required elements in a WHA include the identification of the wildlife species observed and their numbers, and the location of features on and near the airport that could attract wildlife. Service learning and research projects enable undergraduate students to develop transferable skills that are highly valued by the aviation industry, including critical thinking, self-confidence, the ability to integrate theory …

Improved Feedback Mechanisms Of The Hydraulics Sandbox Simulator, Karen J. Johnson, Martin Hebel

National Training Aircraft Symposium (NTAS)

The proposed presentation will include the following project and results from implementation in an aircraft hydraulic systems course.

In 2020 we developed a digital hydraulics system schematic sandbox for use in an FAA Part 147 airframe maintenance technician training program (See Figure 1). The sandbox allows students to drag-drop-connect components used in systems such as those found in aircraft. It allows them to ‘test-connect’ the components to get feedback on correct and incorrect ‘construction’. As shown in Figure 1, light green ‘hoses’ are correct supply connections, dark green are correct return connections and red are incorrect connections per established rules …