Digital Commons Network^™

Constituent Loads And Trends In The Upper Illinois River Watershed: A Nonpoint Source Management Program Priority Watershed, Erin M. Grantz, Brian E. Haggard

Arkansas Water Resources Center Technical Reports

The Arkansas Department of Agriculture - Natural Resources Division (ANRD) has identified the Upper Illinois River Watershed (UIRW; 11110103), a hydrologic unit code (HUC) 8 watershed, located in Northwest Arkansas for prioritization by the Nonpoint Source (NPS) Management Program. URIW encompasses the Illinois River from its headwaters to the state line with Oklahoma and has been the subject of interstate disputes over water quality for decades. Nonpoint source pollution concerns in UIRW are excess nutrients from agriculture and sediment from changes in land use/land cover (LULC).

Local, state, and national groups, including the NPS Source Management Program, have invested in …

Hepatoprotective And Anti-Inflammatory Effects Of Entecavir Or Probiotics On Oxaliplatin-Induced Liver Injury In The Rats, Asem Anwar Askandar, Ansam Naji Alhassani

Polytechnic Journal

Oxaliplatin (OXA), a current cancer chemotherapeutic, has low efficacy and is linked to serious adverse effects, including liver damage. We anticipated that probiotics and entecavir would help reduce OXA-induced liver damage because the pathophysiology of drug-induced liver damage is thought to be related to the disordered gut microbiota. Twenty-four rats were used in this study and divided into 4 groups: control group (n=6), OXA group (n=6), entecavir (ENT) group (n=6), and probiotics (PRO) group (n=6). After 3 weeks, all rats were sacrificed, and blood samples were analyzed for alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), interleukin 6 …

Cc Magazine, Winter 2023, Connecticut College

Alumni News/Connecticut College Magazine

No abstract provided.

Stop Trashing The Planet: Addressing Global Warming And Climate Change From The Perspective Of Food Waste Reduction, Dorothy Chen

North Carolina Journal of International Law

No abstract provided.

Love And Information, Caryl Churchill

Theatre and Performance Studies Programs

In a world that is increasingly virtual, how do we traverse the devastating gap between our longing for love and our addictive need for information? In this fascinating kaleidoscope of 57 short plays, more than 100 characters try to find true human connection and make sense of what they know--and don't know. A mesmerizing and unpredictable play by one of the world's most groundbreaking playwrights, Caryl Churchill. Directed by Emily Kitchens.

Canine As A Comparative And Translational Model For Human Mammary Tumor., Jee Young Kwon, Nicholas Moskwa, Wonyoung Kang, Timothy M Fan, Charles Lee

Faculty Research 2023

Despite the advances in research and treatment of human breast cancer, its incidence rate continues to increase by 0.5% per year, and the discovery of novel therapeutic strategies for specific subtypes of human breast cancer remains challenging. Traditional laboratory mouse models have contributed tremendously to human breast cancer research. However, mice do not develop tumors spontaneously; consequently, genetically engineered mouse models or patient-derived xenograft models are often relied upon for more sophisticated human breast cancer studies. Since human breast cancer develops spontaneously, there is a need for alternative, yet complementary, models that can better recapitulate the features of human breast …

An Integrative Approach For Exploring The Nature Of Fibroepithelial Neoplasms., Jihui Yun, Woohang Heo, Eun-Shin Lee, Deukchae Na, Wonyoung Kang, Jinjoo Kang, Jeesoo Chae, Dakyung Lee, Woochan Lee, Jinha Hwang, Tae-Kyung Yoo, Bok Sil Hong, Hye-Youn Son, Dong-Young Noh, Charles Lee, Hyeong-Gon Moon, Jong-Il Kim

Faculty Research 2023

BACKGROUND: Malignant phyllodes tumour (MPT) is a rare breast malignancy with epithelial and mesenchymal features. Currently, there are no appropriate research models or effective targeted therapeutic approaches for MPT.

METHODS: We collected fresh frozen tissues from nine patients with MPT and performed whole-exome and RNA sequencing. Additionally, we established patient-derived xenograft (PDX) models from patients with MPT and tested the efficacy of targeting dysregulated pathways in MPT using the PDX model from one MPT.

RESULTS: MPT has unique molecular characteristics when compared to breast cancers of epithelial origin and can be classified into two groups. The PDX model derived from …

Bmp10 Functions Independently From Bmp9 For The Development Of A Proper Arteriovenous Network., Hyunwoo Choi, Bo-Gyeong Kim, Yong Hwan Kim, Se-Jin Lee, Young Jae Lee, S Paul Oh

Faculty Research 2023

Hereditary hemorrhagic telangiectasia (HHT) is a genetic vascular disorder characterized by the presence of arteriovenous malformation (AVM) in multiple organs. HHT is caused by mutations in genes encoding major constituents for transforming growth factor-β (TGF-β) family signaling: endoglin (ENG), activin receptor-like kinase 1 (ALK1), and SMAD4. The identity of physiological ligands for this ENG-ALK1 signaling pertinent to AVM formation has yet to be clearly determined. To investigate whether bone morphogenetic protein 9 (BMP9), BMP10, or both are physiological ligands of ENG-ALK1 signaling involved in arteriovenous network formation, we generated a novel Bmp10 conditional knockout mouse strain. We examined whether global …

Comment: The United Nations And Robot Rights, Heather Alexander

Canadian Journal of Law and Technology

This comment predicts that robot rights under the law are likely to become a reality in the next fifty years, possibly in multiple countries, as governments pass laws granting rights to robots, including civil rights like voting. This comment calls on the United Nations (‘‘UN”) to be pro-active in guiding the emergence of robot rights by convening a working group on robot rights to better guide member states through what will be a time of momentous change.

Why are robots likely to soon gain rights in some UN member states? There have been huge advances in AI that can pass …

Kentucky Warbler (Vol. 99, No. 1), Department Of Library Special Collections

The Kentucky Warbler

No abstract provided.

Sanctified; A Formational Hermeneutic Of The Sanctuary In Seven Reflections, Miguel Mendez

Doctor of Ministry

The initial impetus for the project was to produce a hermeneutical approach that would privilege diversity within the Adventist church. The NPO as initially envisioned was directed to church leadership; the foci however shifted toward a local congregation as it dealt with denominational pressure and internal conflict. The notion of a heavenly Sanctuary that serves as a replica of the Earthly tabernacle looms large in Adventism, it remains foundational to the denomination’s understanding of eschatology, ecclesiology, and missiology. Adventism espouses the belief that Jesus has been ministering in this heavenly Sanctuary since October 22, 1844. This unique understanding of Christ’s …

Novel Signposts On The Road From Natural Sources To Pharmaceutical Applications: A Combinative Approach Between Lc-Dad-Ms And Offline Lc-Nmr For The Biochemical Characterization Of Two Hypericum Species (H. Montbretii And H. Origanifolium), Stefania Sut, Stefano Dall'acqua, Gokhan Zengin, Ismail Senkardes, Abdullahi Ibrahim Uba, Abdelhakim Bouyahya, Abdurrahman Aktumsek

College of Science & Mathematics Departmental Research

The members of the genus Hypericum have great potential to develop functional uses in nutraceutical and pharmaceutical applications. With this in mind, we aimed to determine the chemical profiling and biological properties of different extracts (ethyl acetate, methanol and water) from two Hypericum species (H. montbretii and H. origanifolium). We combined two approaches (LC-DAD-MS and LC-NMR) to identify and quantify chemical compounds of the extracts. Antioxidant properties (free radical quenching, reducing power and metal chelating) and enzyme inhibitory effects (cholinesterase, tyrosinase, amylase and glucosidase) were determined as biological properties. The tested extracts were rich in caffeic acid derivatives and flavonoids, …

Animal Welfare - Environment - Sustainable Development Nexus: Scoping Study, Janice H. Cox

Nexus – UNEP – Animal Welfare, Environment, Sustainable Development

A detailed report on the links between animal welfare, environmental health and global sustainability. Issues discussed include climate change, biodiversity, pollution and waste management, one health, sustainable development and just transitions.

Loss Of Circsry Reduces Γh2ax Level In Germ Cells And Impairs Mouse Spermatogenesis., Yanze Song, Min Chen, Yingfan Zhang, Jiayi Li, Bowen Liu, Na Li, Min Chen, Miaomiao Qiao, Nan Wang, Yuanwei Cao, Shan Lu, Jian Chen, Wen Sun, Fei Gao, Haoyi Wang

Faculty Research 2023

Sry on the Y chromosome is the master switch of sex determination in mammals. It has been well established that Sry encodes a transcription factor that is transiently expressed in somatic cells of the male gonad, leading to the formation of testes. In the testis of adult mice, Sry is expressed as a circular RNA (circRNA) transcript. However, the physiological function of Sry circRNA (circSRY) remains unknown since its discovery in 1993. Here we show that circSRY is mainly expressed in the spermatocytes, but not in mature sperm or somatic cells of the testis. Loss of circSRY led to germ …

Neurobehavioral Deficits Of Mice Expressing A Low Level Of G127v Mutant Frataxin., Daniel Fil, Robbie L Conley, Aamir Zuberi, Cathleen Lutz, Terry Gemelli, Marek Napierala, Jill S Napierala

Faculty Research 2023

Friedreich’s ataxia (FRDA) is a neurodegenerative disease caused by reduced expression of the mitochondrial protein frataxin (FXN). Most FRDA patients are homozygous for large expansions of GAA repeats in intron 1 of FXN, while some are compound heterozygotes with an expanded GAA tract in one allele and a missense or nonsense mutation in the other. A missense mutation, changing a glycine to valine at position 130 (G130V), is prevalent among the clinical variants. We and others have demonstrated that levels of mature FXN protein in FRDA G130V samples are reduced below those detected in samples harboring homozygous repeat expansions. Little …

The Case For Standardizing Gene Nomenclature In Vertebrates., Fiona M Mccarthy, Tamsin E M Jones, Anne E Kwitek, Cynthia Smith, Peter D Vize, Monte Westerfield, Elspeth A Bruford

Faculty Research 2023

No abstract provided.

Bringing Back Former Vegans And Vegetarians: An Obstacle Analysis, Jo Anderson, Coni Arévalo

Diet

People have a variety of motivations for switching to plant-based diets, yet not all people who begin the transition to a vegan or vegetarian (collectively called veg*n) diet maintain it long-term. In fact, Faunalytics’ study of current and former veg*ns (2014) found that the number of lapsed (former) vegans and vegetarians in the United States far surpasses the number of current veg*ns, and most who lapse do so within a year. Are these people the low-hanging fruit for diet advocates? They could be—there are many of them and they’re clearly at least somewhat willing to go veg*n, so maybe more …

Dissociating Statistically Determined Normal Cognitive Abilities And Mild Cognitive Impairment Subtypes With Dctclock., Emily F. Matusz, Catherine C. Price, Melissa Lamar, Rod Swenson, Rhoda Au, Sheina Emrani, Victor Wasserman, David J Libon, Louisa I. Thompson

Rowan-Virtua School of Osteopathic Medicine Departmental Research

OBJECTIVE: To determine whether the DCTclock can detect differences across groups of patients seen in the memory clinic for suspected dementia.

METHOD: Patients (n = 123) were classified into the following groups: cognitively normal (CN), subtle cognitive impairment (SbCI), amnestic cognitive impairment (aMCI), and mixed/dysexecutive cognitive impairment (mx/dysMCI). Nine outcome variables included a combined command/copy total score and four command and four copy indices measuring drawing efficiency, simple/complex motor operations, information processing speed, and spatial reasoning.

RESULTS: Total combined command/copy score distinguished between groups in all comparisons with medium to large effects. The mx/dysMCI group had the lowest total …

Racial Injustice In Astrid Lindgren’S Kati In America, Irina I. Holden

University Libraries Faculty Scholarship

This article addresses Astrid Lindgren’s Kati in America, which was written in 1950 and translated into English in 1964. The novel reflects Lindgren’s impressions of the United States, where she traveled in 1948 on assignment for the publishing house Åhland and Åkerlund. By chance, the author of this article discovered that there is a fifteenth chapter of the book in the Russian, Polish, French, Spanish, and German translations, but which is missing in the English. This missing chapter describes the racism Lindgren’s protagonist witnesses during her visit to New Orleans. Astrid Lindgren’s depiction of racial injustice in the South …

Commonwealth Times 2023-02-01

Commonwealth Times, 1969-

No abstract provided.

42nd Street, Lynn University

Drama Programs

Elaine's Annual Musical Treat

Exclusive production sponsor Elaine J. Wold invites you to 42nd Street, a performance directed by Lynn University Assistant Professor Danielle Jolie Dale-Hancock and featuring Lynn’s B.F.A. in drama program students.

Based on the novel by Bradford Ropes and the motion picture owned by Turner Entertainment Co. and distributed by Warner Bros., 42nd Street follows the rehearsal process for a Broadway show during the height of the Great Depression. The musical, written by Michael Stewart and Mark Bramble, follows small-town Peggy Sawyer as she lands her first chorus job in the ensemble of a glitzy new …

Comparative Evaluation Of Biased Agonists Sarcosine , D-Alanine -Angiotensin (Ang) Ii (Sd Ang Ii) And Sarcosine , Isoleucine -Ang Ii (Si Ang Ii) And Their Radioiodinated Congeners Binding To Rat Liver Membrane At Receptors, Natalia M. Noto, Yazmin M. Restrepo, Hong W. Pang, Filipe Stoyell-Conti, Crystal A. West, Robert C. Speth, Nova Southeastern University

HPD Articles

Angiotensin II analogue and β-arrestin biased agonist TRV027 (Sarcosine , d-Alanine -Angiotensin (Ang) II; SD Ang II), developed by Trevena, Inc. in the early 2010s, brought hopes of a novel treatment for cardiovascular diseases, due to its ability to simultaneously cause signaling through the β-arrestin signaling pathway, while antagonizing the pathophysiological effects of Ang II mediated by the AT receptor G protein signaling cascades. However, a phase II clinical trial of this agent revealed no significant benefit compared to placebo treatment. Using I-Sarcosine , Isoleucine -Ang II ( I-SI Ang II) radioligand receptor competition binding assays, we assessed the relative …

Children’S Trust In Robots, Rachel L. Severson

University Grant Program Reports

The UGP Small Grant (2019-20 AY) was awarded to support research investigating whether children trust a smart speaker (Amazon Alexa) when learning factual information and making moral decisions. The project was amended and extended due to the pandemic. Data collection is on-going and is projected to be completed in April 2023.

From The Organismal To Biosphere Levels: Environmental Impacts On The Amphibian Microbiota, Obed Hernandez-Gomez, Jessica Hua

Natural Sciences and Mathematics | Faculty Scholarship

This review summarizes the role of environmental factors on amphibian microbiotas at the organismal, population, community, ecosystem, and biosphere levels. At the organismal-level, tissue source, disease status, and experimental manipulations were the strongest predictors of variation in amphibian microbiotas. At the population-level, habitat quality, disease status, and ancestry were commonly documented as drivers of microbiota turnover. At the community-level, studies focused on how species’ niche influence microbiota structure and function. At the ecosystem-level, abiotic and biotic reservoirs were important contributors to microbiota structure. At the biosphere-level, databases, sample banks, and semi-natural experiments were commonly used to describe microbiota assembly mechanisms …

Lifestyle Modifications And Nutritional And Therapeutic Interventions In Delaying The Progression Of Chronic Kidney Disease: A Review, Lean Alkhatib, Lorena A. Velez Diaz, Samyukta Varma, Arsh Chowdhary, Prachi Bapat, Hai Pan, Geetika Kukreja, Prasannalaxmi Palabindela, Sri Abirami Selvam, Kartik Kalra

Hematology/Oncology Articles

Chronic kidney disease (CKD) is a debilitating progressive illness that affects more than 10% of the world's population. In this literature review, we discussed the roles of nutritional interventions, lifestyle modifications, hypertension (HTN) and diabetes mellitus (DM) control, and medications in delaying the progression of CKD. Walking, weight loss, low-protein diet (LPD), adherence to the alternate Mediterranean (aMed) diet, and Alternative Healthy Eating Index (AHEI)-2010 slow the progression of CKD. However, smoking and binge alcohol drinking increase the risk of CKD progression. In addition, hyperglycemia, altered lipid metabolism, low-grade inflammation, over-activation of the renin-angiotensin-aldosterone system (RAAS), and overhydration (OH) increase …

The Latest Interface: Using Data Privacy As A Sword And Shield In Antitrust Litigation, Sammi Chen

UC Law Journal

The new and growing intersection between data privacy and antitrust uses data privacy as both a sword and shield against antitrust liability. On one hand, large technology firms have begun using privacy as a business justification for alleged antitrust misconduct. On the other hand, private and government plaintiffs have raised privacy concerns in antitrust litigation. Although antitrust law and data privacy law are two distinct bodies of legal doctrines, there is literature suggesting their consolidation in certain contexts. The Hipster Antitrust movement and integrationist theory purport that data privacy should be included in an antitrust review when privacy is a …

February 2023, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

Oria Stage Ii Expansion: Keep River Post-Development Aquatic Fauna And Targeted Sawfish Survey - 2022, Indopacific Environmental, Department Of Primary Industries And Regional Development, Western Australia

Irrigated Agricultural Development in the North

This report presents the results of the 2022 Keep River Aquatic Fauna and Targeted Sawfish Survey which represents the final post-development survey required as per the project conditions of the Goomig Irrigation Development. Unlike the 2021 survey, which was affected by pandemic related travel restrictions that prohibited some sites from being surveyed, all regular monitoring sites were able to be sampled in 2022. Field work was undertaken September 2022 and sampling and analyses undertaken during the current study aligned with standardised methodologies set forth in the Ord River Irrigation Area – Weaber Plain Development Project Aquatic Fauna Management Plan.

Evaluation Of Topical Microbicides For Their Acute Toxicities And Ability To Induce Proinflammatory Cytokines Tnf-A, Il-1b, Il-6 And Il-8 In Peripheral Blood Mononuclear Cells And Macrophages, Aladin A. Siddig, Olivier M. Tchimou, Mohammad N. Uddin, Kwame Yeboah

Faculty Research ​and Publications

Purpose: Topical Microbicides have been used as vaginal microbicides in clinical trials as anti-HIV-1 products. The objectives of this project were to evaluate selected popular topical microbicide drug products for their acute toxicities to colorectal epithelial cells and primary immune cells such as Peripheral Blood Mononuclear Cells (PBMC) and Macrophages and to further determine if these microbicide products could induce genital tract inflammation via extra production of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6 and IL-8.

Methodology: Toxicities of Nonoxynol-9, KY jelly, CAP, PRO2000 (4%), PRO2000 (0.5%), UC781(1%), UC781(0.1%) and VenaGelTM microbicides were determined by cellular viability of colorectal adenocarcinoma …

Higher Concentrations Of Microplastics In Runoff From Biosolid-Amended Croplands Than Manure-Amended Croplands, Nasrin Naderi Beni, Shahab Karimifard, John Gilley, Tiffany L. Messer, Amy Schmidt, Shannon Bartelt-Hunt

UK CARES Faculty Publications

Land-applied municipal biosolids, produced from municipal wastewater treatment sludge, contributes to microplastics contamination in agroecosystems. The impacts of biosolids on microplastic concentrations in agricultural soil have been previously investigated, however, the potential for microplastics transport from biosolid-amended croplands has not been previously quantified. In this study, manure and biosolids were applied to field plots, runoff was collected following natural precipitation events and the potential of bacterial biofilm to grow on different microplastic morphologies was investigated. Higher concentrations of microplastics were detected in runoff from plots with land-applied biosolid in comparison with manure-amended and control plots. Fibers and fragments were the …