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2023 February 17 - Board Of Trustees Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

Efficacy Of A Combined Food-Response Inhibition And Attention Training For Weight Loss, Eric Stice, Sonja Yokum, Timothy D. Nelson, Elliot Berkman, Harm Veling, Natalia Lawrence

Department of Psychology: Faculty Publications

This Current Opinion in Behavioral Sciences article reviews trials that evaluated an obesity treatment that combines response-inhibition training with high-calorie foods and training designed to reduce attention for high-calorie foods. Two randomized controlled trials suggest that food-response inhibition and attention training produced significant body-fat loss, along with a reduction in valuation of, and reward-region response to, high-calorie foods. However, these effects did not emerge in a third trial, potentially because this trial used more heterogeneous food images, which reduced inhibition learning and attentional learning. Collectively, results suggest that food-response inhibition and attention training can devalue high-calorie foods and result in …

Price Analysis Of Aquafeed Containing Microalgae (Dunaliella Salina (Dunal) Teodoresco 1905 Meal For Color Enhancement In Shrimp, Wa Iba, Sumarno, Ruslaini, Agus Kurnia, Irdam Riani

Fisheries, Animal and Veterinary Sciences Faculty Publications

The price of aqua feed containing Dunaliella salina meal was calculated. Also, the formulated feed’s protein, lipid, and total carotenoid content were examined. The price of shrimp feed containing D. salina meal was higher than commercial feed with better protein and carotenoid content in the feed. This indicated that the inclusion of microalgae meal may increase coloration and growth in shrimp. We recommend using these formulated fish in shrimp aquaculture with necessary investment in microalgae meal and aqua feed production.

Alternative Polyadenylation Alters Protein Dosage By Switching Between Intronic And 3’Utr Sites, Nicola De Prisco, Caitlin Ford, Nathan D Elrod, Winston Lee, Lauren C Tang, Kai-Lieh Huang, Ai Lin, Ping Ji, Venkata S Jonnakuti, Lia Boyle, Maximilian Cabaj, Salvatore Botta, Katrin Õunap, Karit Reinson, Monica H Wojcik, Jill A Rosenfeld, Weimin Bi, Kristian Tveten, Trine Prescott, Thorsten Gerstner, Audrey Schroeder, Chin-To Fong, Jaya K George-Abraham, Catherine A Buchanan, Andrea Hanson-Khan, Jonathan A Bernstein, Aikaterini A Nella, Wendy K Chung, Vicky Brandt, Marko Jovanovic, Kimara L Targoff, Hari Krishna Yalamanchili, Eric J Wagner, Vincenzo A Gennarino

Faculty, Staff and Students Publications

Alternative polyadenylation (APA) creates distinct transcripts from the same gene by cleaving the pre-mRNA at poly(A) sites that can lie within the 3' untranslated region (3'UTR), introns, or exons. Most studies focus on APA within the 3'UTR; however, here, we show that CPSF6 insufficiency alters protein levels and causes a developmental syndrome by deregulating APA throughout the transcript. In neonatal humans and zebrafish larvae, CPSF6 insufficiency shifts poly(A) site usage between the 3'UTR and internal sites in a pathway-specific manner. Genes associated with neuronal function undergo mostly intronic APA, reducing their expression, while genes associated with heart and skeletal function …

Antiangiogenic Drugs In Combination With Seaweed Fucoidan: A Mechanistic In Vitro And In Vivo Study Exploring The Vegf Receptor And Its Downstream Signaling Molecules In Hepatic Cancer, Maha R.A. Abdollah, Aya A. Ali, Hassnaa Hamed Elgohary, M. M. Elmazar

Pharmacy

Hepatocellular carcinoma (HCC) is one of the most common cancers reported worldwide with poor morbidity and high mortality rates. HCC is a very vascular solid tumour as angiogenesis is not only a key driver for tumour progression but also an exciting therapeutic target. Our research investigated the use of fucoidan, a sulfated polysaccharide readily abundant in edible seaweeds commonly consumed in Asian diet due to their extensive health benefits. Fucoidan was reported to possess a strong anti-cancer activity, but its anti-angiogenic potential is still to be fully unraveled. Our research investigated fucoidan in combination with sorafenib (an anti-VEGFR tyrosine kinase …

What’S Effective Altruism? A Philosopher Explains, Jacob Bauer

Materials from the University of Dayton Magazine Website

Effective altruism, a term coined in 2011, refers to people who seek to use their money and time to make as much progress as possible toward solving the world’s most pressing problems. Jacob Bauer, University of Dayton lecturer of philosophy, explains.

Cd5 Expression By Dendritic Cells Directs T Cell Immunity And Sustains Immunotherapy Responses, Mingyu He, Kate Roussak, Feiyang Ma, Nicholas Borcherding, Vince Garin, Mike White, Charles Schutt, Trine I Jensen, Yun Zhao, Courtney A Iberg, Kairav Shah, Himanshi Bhatia, Daniel Korenfeld, Sabrina Dinkel, Judah Gray, Alina Ulezko Antonova, Stephen Ferris, David Donermeyer, Cecilia Lindestam Arlehamn, Matthew M Gubin, Jingqin Luo, Laurent Gorvel, Matteo Pellegrini, Alessandro Sette, Thomas Tung, Rasmus Bak, Robert L Modlin, Ryan C Fields, Robert D Schreiber, Paul M Allen, Eynav Klechevsky

Faculty, Staff and Student Publications

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c+CD5+ DCs are reduced in melanoma-affected lymph nodes, with CD5 expression on DCs correlating with patient survival. Activating CD5 on DCs enhanced T cell priming and improved survival after ICB therapy. CD5+ DC numbers increased during ICB therapy, and low interleukin-6 (IL-6) concentrations promoted their de novo differentiation. Mechanistically, CD5 expression by DCs was required to generate optimally protective CD5hi T helper and CD8+ T cells; further, deletion of CD5 from T …

Developing Methods For Measuring In Vivo Lipid Metabolism, Russell L. Denton

Theses and Dissertations

Lipid metabolism is critically important to the normal function of individual cells and for signaling between tissues of the human body. There is a great need to quantify changes in lipid metabolism because of its implications in both normal healthy conditions and during disease development. In our first study, we developed a liquid chromatography mass spectrometry based workflow to assess in vivo metabolism of murine brain lipids. This involved sample preparation, data acquisition, and analysis software development and improvements. Regarding sample preparation, we maintained the mice at 5% body water for the duration of the experiment. As mouse metabolism proceeds, …

An Older Diabetes-Induced Mice Model For Studying Skin Wound Healing, Carlos Poblete Jara, Guilherme Nogueira, Joseane Morari, Thaís Paulino Do Prado, Renan De Medeiros Bezerra, Lício A. Velloso, William Velander, Eliana Pereira De Araújo

Department of Chemical and Biomolecular Engineering: Faculty Publications

Advances in wound treatment depend on the availability of animal models that reflect key aspects of human wound healing physiology. To this date, the accepted mouse models do not reflect defects in the healing process for chronic wounds that are associated with type two diabetic skin ulcers. The long term, systemic physiologic stress that occurs in middle aged or older Type 2 diabetes patients is difficult to simulate in preclinical animal model. We have strived to incorporate the essential elements of this stress in a manageable mouse model: long term metabolic stress from obesity to include the effects of middle …

Exploiting Prmt5 As A Target For Combination Therapy In Mantle Cell Lymphoma Characterized By Frequent Atm And Tp53 Mutations, Yuxuan Che, Yang Liu, Yixin Yao, Holly A Hill, Yijing Li, Qingsong Cai, Fangfang Yan, Preetesh Jain, Wei Wang, Lixin Rui, Michael Wang

Faculty, Staff and Student Publications

Constant challenges for the treatment of mantle cell lymphoma (MCL) remain to be recurrent relapses and therapy resistance, especially in patients harboring somatic mutations in the tumor suppressors ATM and TP53, which are accumulated as therapy resistance emerges and the disease progresses, consistent with our OncoPrint results that ATM and TP53 alterations were most frequent in relapsed/refractory (R/R) MCL. We demonstrated that protein arginine methyltransferase-5 (PRMT5) was upregulated in R/R MCL, which predicted a poor prognosis. PRMT5 inhibitors displayed profound antitumor effects in the mouse models of MCL with mutated ATM and/or TP53, or refractory to CD19-targeted CAR T-cell therapy. …

Drug-Like Small Molecules That Inhibit Expression Of The Oncogenic Microrna-21, Matthew D Shortridge, Bhawna Chaubey, Huanyu J Zhang, Thomas Pavelitz, Venkata Vidadala, Changyan Tang, Gregory L Olsen, George A Calin, Gabriele Varani

Faculty, Staff and Student Publications

We report the discovery of drug-like small molecules that bind specifically to the precursor of the oncogenic and pro-inflammatory microRNA-21 with mid-nanomolar affinity. The small molecules target a local structure at the Dicer cleavage site and induce distinctive structural changes in the RNA, which correlate with specific inhibition of miRNA processing. Structurally conservative single nucleotide substitutions eliminate the conformational change induced by the small molecules, which is also not observed in other miRNA precursors. The most potent of these compounds reduces cellular proliferation and miR-21 levels in cancer cell lines without inhibiting kinases or classical receptors, while closely related compounds …

Exploiting Metabolic Vulnerabilities After Anti-Vegf Antibody Therapy In Ovarian Cancer, Deanna Glassman, Mark S Kim, Meredith Spradlin, Sunil Badal, Mana Taki, Pratip Bhattacharya, Prasanta Dutta, Charles V Kingsley, Katherine I Foster, Olamide Animasahun, Jin Heon Jeon, Abhinav Achreja, Anusha Jayaraman, Praveen Kumar, Minal Nenwani, Fulei Wuchu, Emine Bayraktar, Yutuan Wu, Elaine Stur, Lingegowda Mangala, Sanghoon Lee, Timothy A Yap, Shannon N Westin, Livia S Eberlin, Deepak Nagrath, Anil K Sood

Faculty, Staff and Student Publications

Despite modest clinical improvement with anti-vascular endothelial growth factor antibody (AVA) therapy in ovarian cancer, adaptive resistance is ubiquitous and additional options are limited. A dependence on glutamine metabolism, via the enzyme glutaminase (GLS), is a known mechanism of adaptive resistance and we aimed to investigate the utility of a GLS inhibitor (GLSi). Our in vitro findings demonstrated increased glutamine abundance and a significant cytotoxic effect in AVA-resistant tumors when GLSi was administered in combination with bevacizumab. In vivo, GLSi led to a reduction in tumor growth as monotherapy and when combined with AVA. Furthermore, GLSi initiated after the emergence …

Batf2 Promotes Hsc Myeloid Differentiation By Amplifying Ifn Response Mediators During Chronic Infection, Duy T Le, Marcus A Florez, Pawel Kus, Brandon T Tran, Bailee Kain, Yingmin Zhu, Kurt Christensen, Antrix Jain, Anna Malovannaya, Katherine Y King

Faculty, Staff and Students Publications

Basic leucine zipper ATF-like transcription factor 2 (BATF2), an interferon-activated immune response regulator, is a key factor responsible for myeloid differentiation and depletion of HSC during chronic infection. To delineate the mechanism of BATF2 function in HSCs, we assessed Batf2 KO mice during chronic infection and found that they produced less pro-inflammatory cytokines, less immune cell recruitment to the spleen, and impaired myeloid differentiation with better preservation of HSC capacity compared to WT. Co-IP analysis revealed that BATF2 forms a complex with JUN to amplify pro-inflammatory signaling pathways including CCL5 during infection. Blockade of CCL5 receptors phenocopied Batf2 KO differentiation …

The Use Of Characteristics And Indicators Of Body Construction As Predictors In The Identification Of The Angle Values Of The Physiological Curves Of The Spine In Sequential Objective Testing - Mathematical Models, Jacek Tuz, Adam Maszczyk, Anna Zwierzchowska

Baltic Journal of Health and Physical Activity

Introduction: The physiological curvatures of the spine in the sagittal plane are constantly evolving along with changes in the structure and proportions of the body and physical activity. The aim of this study is to identify and assess the strength of the influence of body features and indices on the values of lumbar lordosis and thoracic kyphosis angles with the use of a mathematical model. In the years 2006–2016, 1,314 female students aged ( ± SD 19.7 ± 0.4) (min.–max. 18.1–22.5) were examined.

Materials and Methods. The following measurements were made: body mass (BM), body height (BH), waist circumference (WC), …

Ensiling Of Tannin-Containing Sorghum Grain, E. M. Ott, Y. Acosta Aragón, M. Gabel

IGC Proceedings (1977-2023)

Sorghum is known as important feed-stuff in tropical regions where rainfall is insufficient for the cultivation of maize. Furthermore, those sorghum cultivars rich in tannins are naturally protected to a certain extent against bird damage, insect pests and moulds. Nevertheless, tannins impair the feed quality. Thus, the objectives of this study were to investigate whether ensiling could be a suitable preservation method for sorghum grain originally rich in tannins and if it is possible to reduce tannin content during fermentation.

Astaxanthin Reduces Heart Rate And Carbohydrate Oxidation Rates During Exercise In Overweight Individuals, Alissa Wika, Kyle W. Reason, Matt Green, Lauren Killen, Matthew J. Mcallister, Hunter Waldman

International Journal of Exercise Science

International Journal of Exercise Science 16(2): 252-266, 2023. Astaxanthin (AX) is an antioxidant which may spare endogenous carbohydrates and improve fat oxidation rates, thus improving metabolic flexibility. To date, no studies have attempted to examine the impact of AX in an overweight cohort, whom often suffer from metabolic inflexibility. Nineteen subjects (mean ± SD: age: 27.5 ± 6.3 years; height: 169.7 ± 9.0 cm; body mass: 96.4 ± 17.9 kg; BF%: 37.9 ± 7.0%; BMI: 33.4 ± 5.6 kg/m²; VO_2peak: 25.9 ± 6.7 ml·kg⁻¹·min⁻¹) were recruited and supplemented with either 12 mg …

Editorial: Magical Vessels: Size In Children’S Literature, Nicholas E. Husbye

First Opinions, Second Reactions

No abstract provided.

Sustained Aerobic Stability Of By-Products Silage Stored As A Total Mixed Ration, N. Nishino, H. Hattori, H. Wada

IGC Proceedings (1977-2023)

Ensiling a total mixed ration (TMR) has been practiced in Japan when high-moisture by-products are used as ruminant feed. Wet brewers grains (BG) are a common feed resource and approximately one million t are produced annually. Nishino et al. (2003; 2004) reported that, although silage would easily deteriorate in the presence of air when wet BG were ensiled alone, the spoilage could be avoided when stored as a TMR. Interestingly, the resistance to deterioration was consistently found whether high (> 106 cfu/g) or no (/g) yeasts were detected at unloading. In this study, changes during ensilage and after exposure …

Ndf Digestion In Dairy Cows Fed Grass Or Red Clover Silages Cut At Two Stages Of Growth, K. Kuoppala, S. Ahvenjärvi, M. Rinne, A. Vanhatalo

IGC Proceedings (1977-2023)

Increasing demand for organic dairy products has encouraged research on red clover, as it is an important plant species in organic farming systems. The objective of this experiment was to investigate the effects of plant species and growth stage on NDF digestion in dairy cows.

Effect Of Stage Of Maturity On The Nutrient Content Of Alfalfa, Y. Tyrolova, A. Vyborna

IGC Proceedings (1977-2023)

Alfalfa (Medicago sativa), one of the major agricultural crops in the Czech Republic, is grown on 15.8% of the arable land. Alfalfa silage forms a substantial part of diets for farm animals. It is very important to choose a suitable term of harvesting for ensilage from the view of optimal nutrient content. The stage of maturity at cutting has large effects on each component, except crude protein (Yu et al., 2004). Alfalfa can be difficult to ensile due to a high buffering capacity and a low WSC content.

Justice For Dogs, Alexander J. Lindvall

Arkansas Law Review

This Essay summarizes the Fourth Amendment’s protection of dogs. The Fourth Amendment protects people from unreasonable seizures. And nearly every circuit has held that it is unreasonable (and therefore unconstitutional) for an officer to shoot (seize) a dog without a very good reason. Killing a nonthreatening family pet is one of the most egregious forms of police misconduct. The courts rightfully recognize that the unjustified harming of a dog violates the Fourth Amendment.

Issue 412: February 16-March 2, 2023, The Local Voice

The Local Voice

No abstract provided.

Spartan Daily, February 16, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 160, Issue 10

The Indiana Statesman, February 16, 2023, Indiana State University

Student Newspaper

Dreiser Hall to be rededicated; SPO spreads campus cheer to Sycamores; MSU students protest gun laws; Sturgeon resigns as Scotland’s first minister

Where The Wild Moose Are, Nicholas Gosling

UNH Today Archive

No abstract provided.

Certifiably Employable?: The Effects Of Occupational Regulation On Unemployment Duration, Ilya Kukaev, Edward Timmons

Economics Faculty Working Papers Series

Occupational regulation is a labor market institution that has received a growing amount of attention by researchers. Existing research has explored the effects of occupational regulation on wages and employment. To the best of our knowledge, no existing study has estimated the effect of occupational credentials on unemployment duration in the US. We derive a random search model to explain differences in individual unemployment duration resulting from heterogeneous effects from licenses and certificates. Our model predicts that an occupational credential with a stronger signaling or human capital effect results in a shorter individual unemployment duration. To estimate the effect of …

Journal Of Dairy Science® 2022 Editorial Report, Paul J. Kononoff

Department of Animal Science: Faculty Publications

In 2022, the 105th volume of the Journal of Dairy Science was published. As we review the journal’s last year, it may be useful to reflect on the purpose of scientific publishing. This can be simply stated as the dissemination of results that extends knowledge to open the door for new concepts or advances in the field (Chan, 2018). Similar to other journals, in addition to original research articles, Journal of Dairy Science also publishes invited reviews and other paper types to pursue this purpose. The journal also has other valuable roles. For example, scientific journals actively support authors in …

Language Classification In Western Amazonia: Advances In Favor Of The Pano-Takana Hypothesis, Pilar M. Valenzuela, Roberto Zariquiey

World Languages and Cultures Faculty Articles and Research

The languages of the Pano and Takana families exhibit a considerable number of lexical and structural affinities that cannot be ascribed to mere chance and are not readily detectable instances of borrowing. After the comparative studies by Key (1968) and Girard (1971) the proposal of a genetic relationship between these two families was generally accepted (e.g. Loos 1973, 2005; Suárez 1973; Kaufman 1990; Campbell 1997). Without solid argumentation, however, this classification was later put into question (Fabre 1998; Loos 1999; Fleck 2013) and, even today, there is no full consensus as to whether the observed similarities are due to genetic …

Michael Uslan To Address The Class Of 2023, James Owsley Boyd

Keep Up With the Latest News from the Law School (blog)

Film producer, teacher, and writer Michael Uslan ’76 will serve as the Indiana University Maurer School of Law’s graduation speaker this May, the school announced today (Feb. 16). Holder of three degrees from Indiana University, Uslan is credited with helping to make the Batman franchise one of the most successful film projects of all time. He has served as executive producer on each one of the films, ranging from 1989’s Batman to the conclusion of Christopher Nolan’s trilogy. He served as executive producer on the award-winning Joker in 2019 and his latest project, Joker: Folie à Deux, is currently in …

Virtuous Dialogues: A Study On Wisdom And Quiet Ego In Church Settings, Jeffrey A. Dunkerley Ii

Doctor of Psychology (PsyD)

An individual’s ability to balance the identity of self with the identity of the other, Quiet Ego, consider situations from various perspectives (Reflective Wisdom) and reflect on emotional reactivity (Affective Wisdom) are influential components to engaging in dialogue. The context for dialogue within the United States is increasingly impacted by the backdrop of polarization and defensiveness, impacting one’s ability to develop and maintain the characteristics above. The Christian Church in the United States is not immune to the shifts in dialogue and are experiencing similar difficulties with dialogue seen in the broader society. Virtuous Dialogues is a training curriculum that …