Digital Commons Network^™

An Open Label Randomized Controlled Trial Of Ivermectin Plus Favipiravir-Based Standard Of Care Versus Favipiravir-Based Standard Of Care For Treatment Of Moderate Covid-19 In Thailand, Phahol Sarojvisut, Anucha Apisarnthanarak, Kittiya Jantarathaneewat, Ornnicha Sathitakorn, Thanus Pienthong, Chatchai Mingmalairak, David K. Warren, David J. Weber

2020-Current year OA Pubs

BACKGROUND: The role of ivermectin in the treatment of moderate coronavirus disease 2019 (COVID-19) is controversial. We performed an open label randomized controlled trial to evaluate the role of ivermectin plus favipiravir-based standard of care versus favipiravir-based standard of care for the treatment of moderate COVID-19 infection.

MATERIALS AND METHODS: An open-label randomized control trial was performed at Thammasat Field Hospital and Thammasat University Hospital from October 1st, 2021 to May 31st, 2022. Patients with moderate COVID-19 infections were randomized to the intervention (ivermectin plus favipiravir-based standard of care) or control group (favipiravir-based standard of care alone). Patients were followed …

Associations Between The Human Immune System And Gut Microbiome With Neurodevelopment In The First 5 Years Of Life: A Systematic Scoping Review, Vincent O. Mancini, Juliet Brook, Christian Hernandez, Deborah Strickland, Claus T. Christophersen, Nina D'Vaz, Desiree Silva, Susan Prescott, Bridget Callaghan, Jenny Downs, Amy Finlay-Jones

Research outputs 2022 to 2026

The aim of this review was to map the literature assessing associations between maternal or infant immune or gut microbiome biomarkers and child neurodevelopmental outcomes within the first 5 years of life. We conducted a PRISMA-ScR compliant review of peer-reviewed, English-language journal articles. Studies reporting gut microbiome or immune system biomarkers and child neurodevelopmental outcomes prior to 5 years were eligible. Sixty-nine of 23,495 retrieved studies were included. Of these, 18 reported on the maternal immune system, 40 on the infant immune system, and 13 on the infant gut microbiome. No studies examined the maternal microbiome, and only one study …

Molecular Characterization Of Germination Of Date Palm Seeds Maintained At Microgravity In Outer Pace (International Space Station), Wesam Izzeldeen Khader

Theses

Over the past decade, the UAE has experienced unprecedented innovations in the space sector. Collaborating closely with universities and space agencies around the world, the country's efforts have advanced steadily but quietly under the public radar. The proposed research focuses on basic research to complement the UAE initiative to send date palms to Mars for future space missions. Plant growth analysis of date palm seeds was performed after maintaining at zero gravity in outer space in the International Space Station (ISS) and simultaneously under normal gravity at ground level. In this context, this work was carried out to analyze the …

Safeguarding Sandalwood: A Review Of Current And Emerging Tools To Support Sustainable And Legal Forestry, Ellyse Bunney, Francesca A. Mcinerney, Eleanor Dormontt, Arif Malik, Nina Welti, David Wilkins, Malcolm Plant, Dhanushka S. Hettiarachchi, Darren Thomas, Ashley Dowell, Tresa Hamalton, Andrew J. Lowe

Research outputs 2022 to 2026

Societal Impact Statement: Sandalwood and other high value tree species are under significant threat from illegal harvest. Illegal logging is an increasing problem contributing to deforestation, biodiversity loss, human rights abuses and funding transnational crime. Successful prosecution of illegal logging is hindered by a lack of methods to provide evidence of the origin of timber. New analytical techniques have been developed to trace timber back to its source. These methods, together with the establishment of sustainable sources of forest resources, can help protect vulnerable species by providing evidence to prosecute illegal harvest and ensure that commercially available forest products come …

Association Of Healthful Plant-Based Diet Adherence With Risk Of Mortality And Major Chronic Diseases Among Adults In The Uk, Alysha S. Thompson, Anna Tresserra-Rimbau, Nena Karavasiloglou, Amy Jennings, Marie Cantwell, Claire Hill, Aurora Perez-Cornago, Nicola P. Bondonno, Neil Murphy, Sabine Rohrmann, Aedín Cassidy, Tilman Kühn

Research outputs 2022 to 2026

Importance: Plant-based diets have gained popularity for both environmental and health reasons, but a comprehensive assessment of their quality in relation to risk of mortality and major chronic diseases is lacking. Objective: To examine whether healthful vs unhealthful plant-based dietary patterns are associated with mortality and major chronic diseases among UK adults. Design, Setting, and Participants: This prospective cohort study used data from adults in the UK Biobank, a large-scale population-based study. Participants were recruited between 2006 and 2010 and followed up using record linkage data until 2021; follow-up for different outcomes ranged between 10.6 and 12.2 years. Data analysis …

Biomarkers Of Oxidative Stress And Its Nexus With Haemoglobin Variants And Adverse Foeto-Maternal Outcome Among Women With Preeclampsia In A Ghanaian Population: A Multi-Centre Prospective Study, Ganiwu Abdul, William Osei-Wusu, Gordon Akuffo Asare, Samira Daud, Stephen Opoku, Valentine Christian Kodzo Tsatsu Tamakloe, Joseph Frimpong, Benedict Sackey, Wina Ivy Ofori Boadu, Vivian Paintsil, Max Efui Annani-Akollor, Yaw Amo Wiafe, Enoch Odame Anto, Otchere Addai-Mensah

Research outputs 2022 to 2026

Introduction Haemoglobin variants and preeclampsia (PE) are associated with adverse fatal events of which oxidative stress may be an underlying factor. Oxidative stress (OS) among preeclamptic women with haemoglobin variants has been well established. It is, however, unclear whether haemoglobin variants induce OS to aggravate the risk of adverse foeto-maternal outcomes in pregnant women with preeclampsia. We measured the levels of OS biomarkers and determined the association between haemoglobin variants, and adverse foeto-maternal outcomes among pregnant women with PE. Methods This multi-centre prospective study recruited 150 PE women from three major health facilities in both Bono and Bono east regions …

Going, Going, Gone The Diminishing Capacity Of Museum Specimen Collections To Address Global Change Research: A Case Study On Urban Reptiles, Yanlin Li, Anna J. M. Hopkins, Robert A. Davis

Research outputs 2022 to 2026

It has been increasingly popular to use natural history specimens to examine environmental changes. As the current functionality of museum specimens has extended beyond their traditional taxonomic role, there has been a renewed focus on the completeness of biological collections to provide data for current and future research. We used the collections of the Western Australian Museum to answer questions about the change in occurrence of five common reptile species due to the rapid urbanization of Perth. We recorded a significant decline in collection effort from the year 2000 onwards (F = 7.65, p < 0.01) compared to the period 1990–1999. Spatial analysis revealed that only 0.5% of our study region was well sampled, 8.5% were moderately sampled and the majority of the regions (91%) were poorly sampled. By analysing the trend of specimen acquisition from 1950 to 2010, we discovered a significant inconsistency in specimen sampling effort for 13 common reptile species across time and space. A large proportion of past specimens lacked information including the place and time of collection. An increase in investment to museums and an increase in geographically and temporally systematic collecting is advocated to ensure that collections can answer questions about environmental change.

Relationships Between Farmer Psychological Profiles And Farm Business Performance Amongst Smallholder Beef And Poultry Farmers In South Africa, Renato A. Villano, Isaac Koomson, Nkhanedzeni B. Nengovhela, Livhuwani Mudau, Heather M. Burrow, Navjot Bhullar

Research outputs 2022 to 2026

Beef cattle and poultry are critically important livestock for improving household food security and alleviating poverty amongst smallholder farmers in South Africa. In this paper, our goal is to examine the relationships between farmer psychological profiles and farm business performance of commercially oriented beef cattle and poultry smallholder farmers in South Africa. We employ a multipronged interdisciplinary approach to test the theory of planned behaviour and its relationship to farm business performance. First, a behavioural science-informed survey instrument was employed to collect data from randomly selected farmer participants in two major beef and poultry projects undertaken by the authors. Second, …

Tweak/Fn14 Signalling Regulates The Tissue Microenvironment In Chronic Pancreatitis, N. Dianah B. Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Köhn-Gaone, Vincent Williams, Marco Falasca, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker

Research outputs 2022 to 2026

Chronic pancreatitis increases the risk of developing pancreatic cancer through the upregulation of pathways favouring proliferation, fibrosis, and sustained inflammation. We established in previous studies that the ligand tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) signals through its cognate receptor fibroblast growth factor-inducible 14 (Fn14) to regulate these underlying cellular processes in the chronic liver injury niche. However, the role of the TWEAK/Fn14 signalling pathway in pancreatic disease is entirely unknown. An analysis of publicly available datasets demonstrated that the TWEAK receptor Fn14 is upregulated in pancreatitis and pancreatic adenocarcinoma, with single cell RNA sequencing revealing pancreatic ductal …

Tennessee Farm Bureau News - March 2023, Tennessee Farm Bureau Federation

Tennessee Farm Bureau News

No abstract provided.

Profiling Disease-Selective Drug Targets: From Proteomics To Ligandomics, Prabuddha Waduge, Hong Tian, Keith A Webster, Wei Li

Faculty, Staff and Students Publications

Despite advancements in omics technologies, including proteomics and transcriptomics, identification of therapeutic targets remains challenging. Ligandomics recently emerged as a unique technology of functional proteomics for global profiling of cell-binding protein ligands. When applied to diseased versus healthy vasculatures, comparative ligandomics systematically maps novel disease-restricted ligands that allow selective targeting of pathological but not physiological pathways, providing high efficacy with intrinsic safety. In this review, we discuss the potential of cellular ligands as therapeutic targets and summarize the development of ligandomics. We further compare the advantages and limitations of different omics technologies for drug target discovery and discuss target selection …

Tubular-Specific Expression Of Hiv Protein Vpr Leads To Severe Tubulointerstitial Damage Accompanied By Progressive Fibrosis And Cystic Development, Yuqiang Chen, Ya Chen, Jia Fu, Zeguo Sun, Huilin Li, Wenzhen Xiao, Jing E, Benjamin Y Lo, Niansong Wang, Weijia Zhang, Mary E Klotman, Paul E Klotman, Jeffrey B Kopp, Vivette D D'Agati, John Cijiang He, Kyung Lee

Faculty, Staff and Students Publications

Chronic kidney disease (CKD) is a common cause of morbidity in human immunodeficiency virus (HIV)-positive individuals. HIV infection leads to a wide spectrum of kidney cell damage, including tubular epithelial cell (TEC) injury. Among the HIV-1 proteins, the pathologic effects of viral protein R (Vpr) are well established and include DNA damage response, cell cycle arrest, and cell death. Several in vitro studies have unraveled the molecular pathways driving the cytopathic effects of Vpr in tubular epithelial cells. However, the in vivo effects of Vpr on tubular injury and CKD pathogenesis have not been thoroughly investigated. Here, we use a …

The Development Of The Protocol For Advancing Inclusive Teaching Efforts (Paite), Tracie M. Addy, Hamna Younas, Pelin Cetin, Fatimata Cham, Monica Rizk, Chidiebere Nwankpa, Manuela Borzone

Journal of Educational Research and Practice

Inclusive teaching is instruction that fosters a sense of belonging, is equitable for a diverse student body, and shows students that they matter. Inclusivity is associated with positive student outcomes and is critical at institutions of higher education given the diversity of student populations. While there are a number of recommended practices for inclusive teaching, valid and reliable classroom observation tools that provide instructors with formative feedback on their instructional efforts are lacking. This article describes the development of the Protocol for Advancing Inclusive Teaching Efforts (PAITE). The PAITE was developed for formative purposes to provide higher education instructors with …

Badging Information Literacy Skills, Nicole Mountjoy, Veronica Wells

Pacific's Annual Assessment Conference

No abstract provided.

Factors Influencing Political Participation In Lebanon: The Mediating Role Of Perceived Congruence, Mahmoud A. El Homssi, Alaaeldin A. Ali, Amal Kurdi

BAU Journal - Society, Culture and Human Behavior

Abstract

This study analyzes the factors that influence political participation. These factors include: political information efficacy, political interest, community engagement, political party affiliation and perceived congruence. Moreover, this study addresses the mediating role of perceived congruence on the relationship between political interest, community engagement and political participation. A quantitative survey method was used and structured questionnaire was administered to a convenience sample of 412 respondents. The findings of this study revealed that political interest, community engagement, and political party affiliation have a positive effect on political participation. In addition, the results indicated that perceived congruence has no direct or mediate …

Your Customers Are Demanding That Your Business Be Sustainable, Mark Field

Turning The Dial conference

At Turning the Dial, Mark Field discussed your customers are demanding that your business be sustainable. Mark is the founder and CEO of Prof Consulting Group, an award-winning international consulting group specialising across the food and grocery supply chains. Prof supports their clients through growth consulting through innovation, new market access and strategic procurement, in addition to running a dedicated ESG team specialising in human rights, animal welfare, sustainable packaging, and environmental operations. The ability to bring ESG and Growth into the same conversation or strategy helps deliver profitable long-term outcomes. Mark is a former Group Technical Director for UK …

Complementary Of Blacklight Trap And Flight Interception Trap In A Multi-Year Study Of Flying Coleoptera Near A Farm Pond In Southern Québec (Canada), Claire Levesque, Gilles-Yvon Levesque

The Great Lakes Entomologist

Abstract

A blacklight trap (LT) and a flight interception trap (FIT) were installed throughout the May-September period during four years (2014-2017), near a farm pond within an orchard at Compton, in southern Québec (Canada). We collected by LT 162,001 adults representing 560 beetle species and morphospecies belonging to 49 families, and using a FIT 10,159 individuals for 468 Coleoptera species belonging to 48 families. We observed a similarity of 9.8% between these two assemblages including 214 common species (26.3% of total of 814 caught taxa). We caught mainly nocturnal Carabidae, Hydrophilidae, Staphylinidae and Dryopidae in the LT, and primarily diurnal …

Insect Floral Visitors Of Red Maple And Tree-Of-Heaven At Potential Risk Of Neonicotinoid Residue Exposure From Spotted Lanternfly Control, Jonathan Elmquist, Kelli Hoover, David Biddinger

The Great Lakes Entomologist

To manage spotted lanternfly (Lycorma delicatula (White)), an invasive planthopper recently introduced to the United States, governmental agencies, homeowners, and landscape professionals may treat its host plants with systemic neonicotinoid insecticides. Neonicotinoids can be harmful to non-target insect floral visitors collecting pollen or nectar. The insect floral visitors of red maple (Acer rubrum L.) or tree-of-heaven (Ailanthus altissima (Mill.), which are two of the preferred hosts of L. delicatula in Pennsylvania, are often targeted with neonicotinoid applications for control of this pest. To identify the floral visitors of these tree species, we conducted observations and collections of …

Full Issue For Tgle Vol. 55 Nos. 3&4

The Great Lakes Entomologist

Full Issue for TGLE Vol. 55 Nos. 3&4

The Road Ahead: Clearance Toward Sustainability In Bosnia And Herzegovina, Sean Sutton

The Journal of Conventional Weapons Destruction

Accessible pdf attached.

The 1992-1995 Yugoslav wars resulted in landmines and explosive remnants of war that continue to contaminate the Balkans. In 2021—over 25 years after the end of the wars—the Landmine & Cluster Munition Monitor considered Bosnia and Herzegovina to be the most explosive ordnance-contaminated country in Europe, and characterized the landmine contamination alone as "massive." As of March 2022, The Landmine Monitor reported that Bosnia and Herzegovina had more than 945 km2 of suspected hazardous areas (SHA) and more than 20 km2 of confirmed hazardous areas.

The Indiana Statesman, February 28, 2023, Indiana State University

Student Newspaper

SLC to host Sycamores Got Talent; Trump holds large lead over DeSantis; SoM students in Lyric Theater Workshop; 4 killed, 4 injured in vehicle crash in St. Louis

Know Before You Go: A Community-Derived Approach To Planning For And Preventing Sexual Harassment At Oceanographic Field Sites, Abby Ackerman, Kristen Yarincik, Stephanie Murphy, Ivona Cetinić, Allison Fundis, Allison Miller, Emily Shroyer, Aly Busse, Qu’Derrick Covington, Annette Desilva, Alison Haupt, Leah Johnson, Craig Lee, Laura Lorenzoni, Brandi Murphy, Jennifer Ramarui, Brad Rosenheim, Deborah Steinberg

Marine Science Faculty Publications and Presentations

Sexual harassment is a pervasive problem on oceanographic research vessels and while conducting fieldwork in general. A variety of factors contribute to inadequate protection against sexual harassment, such as poor training in prevention, support, and response; remoteness of field sites; academic hierarchies that reinforce uneven power dynamics that extend to fieldwork; and multi-institutional teams with distinct policies or reporting structures that can lead to confusion in reporting and responding to incidents in the field. In compromising individuals’ physical and mental health, sexual harassment can negatively affect research expeditions. For example, harassed individuals may decide to refrain from working on complicated …

Inspiring The Next Generation Of Humanitarian Mine Action Researchers, Madison Tuohy, Eva Greenspan, Sofia Fasullo, Jasper Baur, Gabriel Steinberg, Linda Zheng, Alex Nikulin Phd, Garrett M. Clayton Phd, Timothy De Smet Phd

The Journal of Conventional Weapons Destruction

Accessible pdf attached.

Humanitarian mine action (HMA) is a critically under-researched field when compared to other hazards fields of similar societal impact. A potential solution to this problem is early exposure to and engagement in the HMA field in undergraduate education. Early undergraduate education emphasizing technical and social aspects of HMA can help protect lives by building a robust pipeline of passionate researchers who will find new solutions to the global explosive ordnance (EO) crisis. Early engagement of the next generation of HMA researchers and policy makers can occur through various classroom experiences, undergraduate research projects, and public outreach events. …

When A Safety Measure Becomes A Risk Accelerant: Removing The Option To Blast-In-Place When Clearing Explosive Remnants Of War, Lieutenant Colonel Geir P. Novik

The Journal of Conventional Weapons Destruction

Accessible pdf attached.

The legacy of unexploded ordnance (UXO) and abandoned ammunition following armed conflict will, in many cases, have a severe impact on society and daily life, even for years or decades after hostilities end. These explosive remnants of war (ERW) represent a grave threat in many aspects, and the human, societal, and environmental impact can be severe. These explosive objects must therefore be located and disposed of—a job in itself that involves serious risks. Therefore, various safety measures are implemented to mitigate these risks. Some safety measures, however, could prove to have less than the desired effect, and …

The Application Of Natural Dyes From Rambutan Skin For Eco-Printing On Tanned Leather, Ra. Ataswarin Oetopo, Ririn Despriliani, Fariz Al Hazmi

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

The use of natural materials is a creative and innovative process to increase the potential of the surrounding environment, such as the use of natural dyes. As rambutan skin has been rarely used and reported as a natural dye, this study explores its usage on leather. In this study, we applied rambutan skin as a natural dye to tanned leather from goat crust skin using the creative eco-printing method. We used an experimental method with a pre-experiment one-shot case study design. Each sample was dyed at different times using distinct solutions during the mordant process. The solution was made from …

Augmented Reality (Ar) Media-Aided Literature Learning Tool For Elementary School Students, Seni Apriliya, Weni Nuraeni, Yeyen Nurjanah, Muhammad Feri

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

Learning devices need to be designed according to the characteristics of the material and be innovative. The results of the field study show that learning the subject of Indonesian fairy tale messages in elementary schools has not been fully implemented using such media, teaching materials, and assessment tools. Referring to this, this study aims to develop a literary learning device assisted by Augmented Reality (AR) media. This development research refers to the design-based research (DBR) development model from Amiel and Reeves (2008). The subjects of this development research trial were twenty students and a third-grade elementary school teacher. Data collection …

Understanding The Roles Of Images And Intermodal Relationships For Optimized Use Of Visual And Verbal Resources In Vietnam’S Textbooks For Lower Secondary Levels, Yusnita Febrianti, Thao Vu

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

The study investigates the roles of images and intermodal relationships of both language and images in two English textbooks used in Vietnamese lower secondary schools, namely Tieng Anh and Solutions textbooks to gain insights on the ways to optimise the use of both language and images as resources in teaching and learning activities. Kress and Van Leeuwen’s (1996, 2006) framework on the grammar of visual design is used to analyse the images, looking at the types of image representations and the compositional meanings. The language-image relationships in the books, on the other hand, are analysed using the framework of Intermodal …

Exploring Batik Semarangan As A Medium To Develop Intercultural Communication Awareness And Global Competence, Ekawati Marhaenny Dukut

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

People doing work from home are mostly depending on what the internet has to offer for communication. Because people want to make good use of the Internet for communication, such information is available in English as a global language. One of the advantages of having ready information in English is that local cultural products can now have better chances to compete globally with products from other cultures. One of those products is Indonesia’s Batik Semarangan, which is produced in Semarang, the capital city of Central Java. Through studying the motifs found in Batik Semarangan, an intercultural communication awareness of rich …

Reimagining Singapore In Verse: A Critical Discourse Analysis Of Contemporary Poetry And Its Role In Emerging National Identity, Benjamin Baguio Mangila

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This paper critically examines how contemporary Singaporean writers use language in verse, that is poetry, to make vivid representations of Singapore as a nation and discursively construct the social notion of the country's national identity. Utilizing Wodak's (2001) Discourse-Historical framework, this paper reveals how the two authors use some common discursive strategies, mainly representational and predicational, in making explicit representations of Singapore and creating a strong sense of national identity. In their poetry, authors frequently utilize referential linguistic devices such as first personal pronouns to attach specific human traits that help personify Singapore and express an in-group identity that functions …

Lexical Semantic Fields On Textbook For Reading Course In Universitas Negeri Malang, Nurhidayati Nurhidayati, Kholisin Kholisin, Irhamni Irhamni, Mohd Azidan Bin Abdul Jabar, Dzulfikri Dzulfikri

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

This study aims to describe the lexical semantic fields of reading textbooks in Universitas Negeri Malang, specifically in categories being, cosmic, energetic, substantial, terrestrial, objective, living, animate, and human. It used a descriptive qualitative method with a semantic analysis approach. The semantic approach was selected since we intended to comprehend the semantic phenomenon from the lexical-semantic field aspect of a specific textbook course. In detail, we started the research by describing the lexical-semantic field in the textbook and classified the words and phrases. Further, we identified the rational understanding of those words and phrases as a complete understanding of a …