Digital Commons Network^™

Perivascular Cells Induce Microglial Phagocytic States And Synaptic Engulfment Via Spp1 In Mouse Models Of Alzheimer's Disease., Sebastiaan De Schepper, Judy Z Ge, Gerard Crowley, Laís S S Ferreira, Dylan Garceau, Christina E Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong

Faculty Research 2023

Alzheimer's disease (AD) is characterized by synaptic loss, which can result from dysfunctional microglial phagocytosis and complement activation. However, what signals drive aberrant microglia-mediated engulfment of synapses in AD is unclear. Here we report that secreted phosphoprotein 1 (SPP1/osteopontin) is upregulated predominantly by perivascular macrophages and, to a lesser extent, by perivascular fibroblasts. Perivascular SPP1 is required for microglia to engulf synapses and upregulate phagocytic markers including C1qa, Grn and Ctsb in presence of amyloid-β oligomers. Absence of Spp1 expression in AD mouse models results in prevention of synaptic loss. Furthermore, single-cell RNA sequencing and putative cell-cell interaction analyses reveal …

Specific Performance: On Freedom And Commitment In Contract Law, Hanoch Dagan, Michael Heller

Notre Dame Law Review

When should specific performance be available for breach of contract? This question—at the core of contract—divides common-law and civil-law jurisdictions and it has bedeviled generations of comparativists, along with legal economists, historians, and philosophers. Yet none of these disciplines has provided a persuasive answer. This Article provides a normatively attractive and conceptually coherent account, one grounded in respect for the autonomy of the promisor’s future self. Properly understood, autonomy explains why expectation damages should be the ordinary remedy for contract breach. This same normative commitment justifies the “uniqueness exception,” where specific performance is typically awarded, and the personal services exclusion, …

Rotunda - Vol 103, No 5 - Feb 29, 2024, Longwood University

Rotunda

No abstract provided.

The Scope Of Compelling Government Interests, R. George Wright

Notre Dame Law Review Reflection

In constitutional cases, any relevant government interest may be said to vary in its breadth or scope. Government interests can be characterized narrowly or broadly. The narrowness or breadth of how courts choose to formulate a government interest may well affect that interest’s overall weight or legal significance. For example, a public interest in safety and security, broadly conceived, may seem compelling. But the public interest in merely some modest upgrading of a safety and security regulation may seem less than compelling. A court might adopt either description. A court’s choice to characterize the government interest at stake as either …

Addressing Plastic Pollution Through Green Consumption: Predicting Intentions To Use Menstrual Cups In The Philippines, Alvin Patrick M. Valentin, Ma. Regina Hechanova-Alampay

Quantitative Methods and Information Technology Faculty Publications

Plastic pollution is a global environmental crisis that poses a huge threat to the health of people and marine ecosystems worldwide. A significant source of plastic pollution is menstrual hygiene management, and an approach that can help address this crisis is the usage of washable and reusable menstrual cups. Using an extended theory of planned behavior model that includes self-identity and perceived quality, the study predicted intentions to use menstrual cups in the Philippines. Structural equation modeling results showed that perceived quality predicted attitudes towards menstrual cup usage. Moreover, attitudes, perceived behavioral control, and self-identity predicted intentions to use menstrual …

Why Gliding Symmetry Used To Be Prevalent In Biology But Practically Disappeared, Julio C. Urenda, Vladik Kreinovich

Departmental Technical Reports (CS)

At present, many living creatures have symmetries; in particular, the left-right symmetry is ubiquitous. Interestingly, 600 million years ago, very fee living creatures had the left-right symmetry: most of them had a gliding symmetry, symmetry with respect to shift along a line followed by reflection in this line. This symmetry is really seen in living creatures today. In this paper, we provide a physical-based geometric explanation for this symmetry change: we explain both why gliding symmetry was ubiquitous, and why at present, it is rarely observed, while the left-right symmetry is prevalent.

College Of Natural Sciences Newsletter, February 2023, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volume 4, Issue 1

Page 1 Dean's Message
Page 2 Awards and Recognition
Page 3-4 Nobel Recipient Visits Campus
Page 4 Adopting the Pantry
Page 5 Growing a Recruitment Mindset
Page 6 February Outreach Events
Page 7 Media Coverage of CNS
Page 8 Open PRAIRIE Data
Page 9 54th Geography Convention, and Tom Loveland EROS Geography Scholarship
Page 10 Photos of Dr. Carolyn Bertozzi's Visit

C. Monteiro Aged 539 Project, Craig Monteiro

Agricultural Education: Graduate Internship Reports

This report includes validation documents required in meeting the quality criteria for secondary-level programs of instruction in agriculture in the State of California. The supporting material includes information to receive state and local funding, and provides an overview of the the goals and objectives of the program of instruction in agriculture at El Diamante High School in Visalia, CA.

Aged 539 Internship Program, Danielle Hyatt

Agricultural Education: Graduate Internship Reports

This internship and project report is a computation of documents required in meeting the quality criteria for secondary-level programs of instruction in agriculture for Ripon High School.

The Dwell Bible Listening App As An Effective Tool To Habituate Daily Bible Engagement In The Local Congregation, Daniel Russell Prugh

Doctor of Ministry Major Applied Project

Prugh, Daniel R. “The Dwell Bible Listening App as an Effective Tool to Habituate Daily Bible Engagement in the Local Congregation.” Doctor of Ministry. Major Applied Project, Concordia Seminary, 2023. "115" pp.

Congregational members desire to engage the Bible daily. However, oftentimes there are barriers to this goal. One of the most important barriers is that people do not regularly read. This is problematic if the church desires for people to read the Bible daily. In addition, people encounter a tsunami of information every day, that makes it hard to prioritize regular engagement with the Bible. However, the church can …

All Pain, Whose Gain? A Fifty-State Analysis Of The Independent State Legislature Doctrine For Redistricting

The University of New Hampshire Law Review

The “Independent State Legislature” (ISL) doctrine has recently been offered as a reinterpretation of legislative control over federal elections and may upend decades of election law precedent. Based on Article I of the U.S. Constitution, the ISL doctrine holds that such authority of state legislatures potentially overrides state constitutions, as well as state courts, citizen initiatives, and even the governor. The original political goals of the ISL doctrine were the 2000 and 2016 Presidential elections. The doctrine has recently come before the Supreme Court in Moore v. Harper, a case concerning redistricting, and could open the door to increased gerrymandering …

Advances In Cartilage Tissue Engineering Using Bioinks With Decellularized Cartilage And Three-Dimensional Printing, Roxanne N. Stone, Jonathon C. Reeck, Julia Thom Oxford

Biology Faculty Publications and Presentations

Osteoarthritis, a chronic, debilitating, and painful disease, is one of the leading causes of disability and socioeconomic burden, with an estimated 250 million people affected worldwide. Currently, there is no cure for osteoarthritis and treatments for joint disease require improvements. To address the challenge of improving cartilage repair and regeneration, three-dimensional (3D) printing for tissue engineering purposes has been developed. In this review, emerging technologies are presented with an overview of bioprinting, cartilage structure, current treatment options, decellularization, bioinks, and recent progress in the field of decellularized extracellular matrix (dECM)–bioink composites is discussed. The optimization of tissue engineering approaches using …

Creche Herald Vol. 27, No. 1, Rita B. Bocher

Creche Herald

The Spring 2023 publication features nativity sets and personal reflections from members in the organization; information about nativities and nativity exhibits; and information about the Friends of the Creche annual meeting.

Twitch Trivia Battle Royale: Interactive Entertainment Engineering Game, Noah Tyler Ravetch

Computer Science and Software Engineering

As the world of digital media evolves, so too does the way producers and consumers of entertainment content interact with each other. Live streaming is one such evolution. In this format, one person broadcasts their camera and/or their computer screen to a large audience of viewers in real time. People tuning in can communicate with other viewers and the streamer using the chat feature built-in to the streaming platform.

A new type of entertainment has recently entered the marketplace: interactive entertainment. Concerts are being held virtually in games like Fortnite (Epic Games 2021). TV Shows on Netflix are beginning to …

Ipulse: March 2023, Lynn University

Student Newspapers

Issues:

• March 2023 [Spring Week #5]: Finding a Job as an International Student; Needing Help is Ok; The Art of Pseudocide; Viva LatinoAmerica!; Travel to the Max; Covered in Crystals; Mascara Gate: The Latest Beauty Controversy
• March 2023 [Spring Week #6]: Strut Your Stuff; Working Through the Gloom; Making the Most Out of Your Money; To Read or Not to Read?; Local vs. Global; Queen Bey is Back and Better Than Ever; Delray's Take on Latin Flavor; Fighting for Inclusivity in Fashion; Career Fair Week is Around the Corner
• March 2023 [Spring Week #7]: It's Great to Debate!l The Issue …

"The Veneer Of Civilization Washed Off": Anti-Black Posse-Lynchings In The Twentieth-Century Rural Midwest, Brent M. S. Campney

History Faculty Publications

This study seeks to identify anti-Black posse-lynchings in the Midwest between 1910 and 1930, and to examine the ways in which they were framed by the media for their readers. It posits that these lynchings emerged as the foremost type of anti-Black lynching by the second decade of the twentieth century, casting doubt thereby on the prevailing scholarly assumption that the number of lynchings declined precipitously in these years. Because most of these incidents received little attention at the time and few received significant attention outside of the locality in which they occurred, this essay uses as its primary documentation …

French Tort Law Reform: A Rapprochement To Other Legal Systems?, Dimitra Tsiaklagkanou

Journal of International Business and Law

The revision of French tort law is proving to be a long process, starting with a first draft by the working group directed by Pierre Catala and Geneviève Viney in 2005, and only reaching a proposed new law tabled by Senators in 2020. The need for revision arose due to the silence of the current French Civil Code on tortious liability, which was mainly developed over the last two centuries by the jurisprudence, while only five such articles can be found. The intended revision of French tort law looks beyond the codification of jurisprudential solutions and towards legal innovations. This …

A Single-Cell Gene Expression Atlas Of Human Follicular Aspirates: Identification Of Leukocyte Subpopulations And Their Paracrine Factors, Yohan Choi, Hayce Jeon, Mats Brännström, James W. Akin, Thomas E. Curry, Misung Jo

UK CARES Faculty Publications

Leukocytes are in situ regulators critical for ovarian function. However, little is known about leukocyte subpopulations and their interaction with follicular cells in ovulatory follicles, especially in humans. Single-cell RNA sequencing (scRNA- seq) was performed using follicular aspirates obtained from four IVF patients and identified 13 cell groups: one granulosa cell group, one thecal cell group, 10 subsets of leukocytes, and one group of RBC/platelet. RNA velocity analyses on five granulosa cell populations predicted developmental dynamics denoting two projections of differentiation states. The cell type-specific transcriptomic profiling analyses revealed the presence of a diverse array of leukocyte-derived factors that can …

The Duty To Teach And Restore Bodily Autonomy: Reflections From The Classroom, Cynthia Richards

Intersections

No abstract provided.

When Hay Was King: Energy History And Economic Nationalism In The Nineteenth-Century United States, Ariel Ron

History Faculty Publications

Hay was a linchpin of the early industrial energy regime. It was the primary fodder for working horses, who became more rather than less important over the 1800s. Though largely ignored by historians, hay was of comparable value to cotton and wheat in the nineteenth-century United States. The crop’s historiographical invisibility is partly due to its relatively informal and decidedly subglobal production and exchange patterns. Whereas cotton and wheat exports passed through customhouses and institutionalized exchanges that carefully recorded trade volumes, hay was almost never exported and often underwent no market transaction at all, instead being used as an intermediate …

2023 Genz Story Expression Projects: Laszlo Selly, Sindee Kerker

GenZ Story Expression Projects eBooks

On February 13, 2023, Lynn University held its 12th GenZ Story Expression Workshop, and features Holocaust survivor Laszlo Selly.

There were approximately 152 students from 12 different classes with 11 facilitators who participated in this event. The workshop was conducted on Zoom with the technical assistance of Dr. Sanne Unger. Dr. Unger moderated the Q&A after the Holocaust survivor, Mr. Selly, shared his story.

First Amendment Speech Protections In A Post-Dobbs World: Providing Instruction On Instructional Speech, Samantha Mitchell

Fordham Law Review

In its June 2022 opinion, Dobbs v. Jackson Women’s Health Organization, the U.S. Supreme Court overruled Roe v. Wade and Planned Parenthood of Southeastern Pennsylvania v. Casey, thus revoking the constitutional right to abortion. As states continue to pass laws outlawing abortion to varying degrees, not only has Dobbs led to uncertainty for medical professionals and those who might want to seek an abortion, but it has also prompted questions for internet users across the world. May an organization or an individual post instructions on the internet regarding how to obtain an abortion if a resident of a …

Gibbon Surgical Review, Volume 6, Issue 1, 2023

Gibbon Surgical Review

Table of Contents

6 - Dr. Thomas Mütter’s Legacy: The Mütter Museum

8 - The History and Progression of Laparoscopic Surgery

10 - An Interview with Dr. Andrew Morgan

12 - A Surgical Perspective of the Effects of the COVID-19 Pandemic on Healthcare

14 - An Interview with Dr. Deviney Rattigan

16 - The Importance of Mentorship in Improving the Outlook and Perception of General Surgery Among Medical Students

18 - Surgical Fellow Spotlight: An Interview with Dr. Steve Gurien

20 - Point of Care Ultrasound in General Surgery Training

22 - Surgical Resident Spotlight: An Interview with Hamza Rshaidat …

Word Analysis: Contemplating The Word La Madre To Develop An Approach For The Instruction Of Cultural Perspectives, Gregory De La Piedra

Dimensions

Word Analysis is an approach to teach second language (L2) students about cultural perspectives which are understood collectively as the ideas, values, beliefs, and experiences many native speakers have regarding cultural domains within their own cultures. Word Analysis is anchored on the relationships between language and communication, and language and culture. The present study researches the history behind the dual value of the term “la madre” [mother] in Mexican Spanish to deliver a practical method that language instructors easily could easily incorporate within their materials to teach L2 culture, or that publishers could integrate within their textbooks. The primary purpose …

The Use Of Open Data Kit (Odk) In Characterizing The Cacao Industry Sites In Panay Island, Rhea J. Subong-Espina, Reynold D. Tan, Christine Mae D. Hernando

The Philippine Agricultural Scientist

Cacao is one of the world's most valuable export commodities and cash crops. Western Visayas, along with the other regions in the Philippines, has committed to participate in national efforts to strengthen the production capacity of the cacao industry and address prospects and opportunities for the industry growth and development. This paper presents the results of a region-wide study that mapped out and assessed key cacao-producing areas in Western Visayas, specifically Aklan, Antique, Capiz, and Iloilo. The study sought their current production levels, important agricultural properties of farming areas, production densities, and growth potentials. Geospatial data was generated, analyzed, and …

High Sucrose Consumption Decouples Intrinsic And Synaptic Excitability Of Agrp Neurons Without Altering Body Weight., Austin C Korgan, Klausen Oliveira-Abreu, Wei Wei, Sophie L A Martin, Zoey J D Bridges, José Henrique Leal-Cardoso, Catherine Kaczorowski, Kristen M S O'Connell

Faculty Research 2023

BACKGROUND/OBJECTIVE: As the obesity epidemic continues, the understanding of macronutrient influence on central nervous system function is critical for understanding diet-induced obesity and potential therapeutics, particularly in light of the increased sugar content in processed foods. Previous research showed mixed effects of sucrose feeding on body weight gain but has yet to reveal insight into the impact of sucrose on hypothalamic functioning. Here, we explore the impact of liquid sucrose feeding for 12 weeks on body weight, body composition, caloric intake, and hypothalamic AgRP neuronal function and synaptic plasticity.

METHODS: Patch-clamp electrophysiology of hypothalamic AgRP neurons, metabolic phenotyping and food …

Genetic Mapping Of Microbial And Host Traits Reveals Production Of Immunomodulatory Lipids By Akkermansia Muciniphila In The Murine Gut., Qijun Zhang, Vanessa Linke, Katherine A Overmyer, Lindsay L Traeger, Kazuyuki Kasahara, Ian J Miller, Daniel E Manson, Thomas J Polaske, Robert L Kerby, Julia H Kemis, Edna A Trujillo, Thiru R Reddy, Jason D Russell, Kathryn L Schueler, Donald S Stapleton, Mary E Rabaglia, Marcus Seldin, Daniel M Gatti, Gregory R Keele, Duy T Pham, Joseph P Gerdt, Eugenio I Vivas, Aldons J Lusis, Mark P Keller, Gary Churchill, Helen E Blackwell, Karl W Broman, Alan D Attie, Joshua J Coon, Federico E Rey

Faculty Research 2023

The molecular bases of how host genetic variation impacts the gut microbiome remain largely unknown. Here we used a genetically diverse mouse population and applied systems genetics strategies to identify interactions between host and microbe phenotypes including microbial functions, using faecal metagenomics, small intestinal transcripts and caecal lipids that influence microbe-host dynamics. Quantitative trait locus (QTL) mapping identified murine genomic regions associated with variations in bacterial taxa; bacterial functions including motility, sporulation and lipopolysaccharide production and levels of bacterial- and host-derived lipids. We found overlapping QTL for the abundance of Akkermansia muciniphila and caecal levels of ornithine lipids. Follow-up in …

An Analysis Of College Students’ Stories About How Their Religious Backgrounds Impacted Their Sexual Attitudes, Brookelyn Bochenek

Communication Studies

The goal of this paper was to examine the impact of college students’ religious background on their sexual attitudes. Grounded in the Narrative Paradigm (Fisher, 1984), qualitative interviews were conducted to allow participants to share their experiences. Thematic analysis of the data (Braun & Clarke, 2006) was conducted to uncover the themes that animated their narratives. The themes that emerged were a) conceptualization of sex, b) exploration of sexuality and dating, and c) negotiation of religious identity and beliefs. Findings were consistent with and corroborated past research regarding sexual socialization and religious dualities. Study limitations and directions for further research …

The Legacy Of Trayvon Martin—Neighborhood Watches, Vigilantes, Race, And Our Law Of Self-Defense, Mark S. Brodin

Marquette Law Review

Reflecting back a decade later, what is the enduring significance of the Trayvon Martin case—a Black teenager whose life is violently cut short, and a legal system that accepted his death without consequence? The poet Elizabeth Alexander speaks of “The Trayvon Generation” of Black youth who have grown up in the haunting shadow of his killing, and the anguished parents who cannot protect their children from such a fate. America’s first Black president spoke for them: “When I think about this boy, I think about my own kids. If I had a son, he’d look like Trayvon,” Barack Obama told …

Warren/Burger Courts Exalted “Free” Expression Over Other American Values, Louis W. Hensler Iii

Marquette Law Review

Anglo-American defamation law started with a simple condemnation of the sin of evil speaking. Eventually, this value condemning harmful speech was accommodated to the value of speaking the truth, even hurtful truth. A third value of fostering responsible self-government was injected into American defamation law at and around the time of the American Revolution. This value makes it especially important for citizens to freely speak even hurtful truth about their government.