Digital Commons Network^™

The Role Of O-Glcnac Transferase In Ventromedial Hypothalamic Control Of Energy Balance, Qi Wang

Yale Graduate School of Arts and Sciences Dissertations

The central nervous system plays a vital role in the homeostatic control of body weight and metabolism. Among brain nuclei, the ventromedial hypothalamus (VMH) is an important hypothalamic nucleus known to regulate body weight, energy balance, and counterregulatory response. However, the pathways for VMH neurons to regulate lipid metabolism and the mechanisms by which VMH neurons sense nutrients and hormones remain obscure. O-linked β-D-N-acetylglucosamine modification (O-GlcNAcylation), catalyzed by O-GlcNAc transferase (OGT), is considered a cellular sensor of stress, nutrients, and hormones, regulating a variety of cellular activities. Here we report that mice with VMH neuron-specific OGT deletion exhibit rapid development …

The Taste Of Love: Detection Of Pheromones By The Taste System, Yichen Luo

Yale Graduate School of Arts and Sciences Dissertations

Courtship is a critical and fascinating behavior. To propagate, animals must find suitable mating partners in a complex environment, and dedicate significant amounts of time and energy towards the pursuit of a mate. Multiple sensory cues play crucial roles in guiding this process, as evidenced by the elaborate song of a male zebra finch, the complex dance of a bird of paradise, and the exceptional pheromone-sensing ability of a moth. These behaviors rely on different sensory systems. Given its remarkable diversity and its importance in evolution and neuroethology, the neural basis of courtship behavior has long been a subject of …

Discovery And Synthesis Of N-Heterocyclic Drug-Like Compounds By Leveraging Novel Rh(I)-Catalyzed C-H Activation Methods, Oh Sang Kweon

Yale Graduate School of Arts and Sciences Dissertations

Nitrogen heterocycles are present in almost two-thirds of U.S. FDA approved pharmaceuticals, as well as biologically active natural products. The first two chapters discuss the application of C-H activation methodology to explore novel, nitrogen heterocycle containing molecules as potent and selective ligands towards different protein targets. The third chapter depicts the design of new N-heterocyclic covalent molecular probes that uniquely labels a serine hydrolase protein in a chemoproteomics screen. Chapter 1 details an investigation using structure-based docking with a virtual library of tetrahydropyridines (THPs) to identify unique agonists for the serotonin 5-HT2A receptor (5-HT2AR). Based around combinations of three inputs, …

Specificity And Regulation Of Sodium Channel Trafficking: Exploring A Novel Therapeutic Strategy For Pain, Grant Philip Higerd-Rusli

Yale Graduate School of Arts and Sciences Dissertations

The burden of pain is significant and current pain treatments are often ineffective. Opiate use has led to an epidemic, requiring alternative pain medications that are more effective and non-addictive. Voltage-gated sodium channel NaV1.7 is preferentially expressed in pain-sensing neurons. Mutations in NaV1.7 can cause disorders ranging from intense pain to complete painlessness in humans, suggesting that its inhibition could provide analgesia without CNS side-effects or addictive potential. Indeed, existing non-selective NaV channels blockers prevent pain, but their utility is limited due to serious side-effects caused by inhibition of NaV isoforms expressed in the heart and brain. Selective inhibition of …

The Evolutionary Origins Of Social Evaluation, Zachary A. Silver

Yale Graduate School of Arts and Sciences Dissertations

Social evaluation refers to the process of using observed social behavior to determine who will be a suitable social partner. While this phenomenon is well-documented in this human species, less is known regarding how we acquired the cognitive abilities needed to make this assessment of with whom we should affiliate. To better understand the evolutionary origins of social evaluation abilities in the human species, researchers have explored nonhuman animals’ capacities for social evaluation. In this dissertation, I present three experiments designed to explore whether domestic dogs, a species who evolved alongside humans and who share our social environment demonstrate human-like …

H. Cole Aged 539 Project, Hannah M. Cole

Agricultural Education: Graduate Internship Reports

This project report includes documentation required in meeting the quality criteria for secondary-level programs of instruction in agriculture. the documents are concurrently used for the Ag Incentive Grant review process at Johansen High School conducted by staff of the California Department of Education. The supporting documents include information to receive state and local funding and they outline the goals and objectives of the program. This document also provides an overview of operations of the Johansen High School Agriculture Department.

Helen Dupré Moseley: Artist, Author, Roller-Coaster Fan, And Air Stewardess On Flying Saucers, Lizzie Richards

Gender Studies Student Scholarship

Helen Dupré Moseley (1887-1984) was a prominent woman from Spartanburg, South Carolina who deserves to be recognized for transcending gender norms through her education, professional career, and overall artistic prowess and pioneering artistic style. She was born into a family that clearly placed high value on personal achievement and general notoriety, playing a big factor into how Moseley viewed herself. Previous research about her remains local to Spartanburg and needed to be expanded upon to further understand Moseley and her importance to the city. Most importantly, Moseley will be highlighted as an artist creating both brushwork pieces and later oil …

Masthead

UC Law SF Journal on Gender and Justice

No abstract provided.

The Influence Of Nature On Well-Being During The Covid-19 Pandemic: Views From New England Island Residents, Nicole Kras

Publications and Research

Researchers are beginning to explore the impact of the COVID-19 pandemic on island populations, but little is known about the experiences of the residents of Nantucket and Martha’s Vineyard in the Northeast region of the United States. In this study, islanders (N=41) provide insight into how spending time in nature influenced their well-being, especially their mental well-being, during this unprecedented time. For the majority of participants, the influence of nature on their well-being increased during the pandemic. Additionally, participants shared benefits of island living such as isolation from the mainland, as well as challenges such as food and supply shortages. …

Dairy Digest 2023 : Live Like Someone Left The Gate Open, South Dakota State University Dairy Club

Dairy Digest

This is the 2023 Dairy Digest. The Diary Digest is published annually by the South Dakota State University Dairy Club. The Digest contains information and news about the activities and members of the SDSU Dairy Club for the academic year 2022 - 2023.

Giving Voice To The Body: Slam Poetry In The Poet X, Stefanny Leung Yu

Student Theses

When the world silences her, can slam poetry become her voice? Elizabeth Acevedo, an author and poet, uses her beautiful piece of slam poetry to explore how language can empower marginalized voices, speaking on behalf of those who are usually silenced. The Poet X is a verse novel that narrates the powerful story of a young Afro-Latina girl, Xiomara Batista, who navigates the intersecting pressures of school bullies, family issues, religious conservatism, patriarchal rules, and racialized body politics in her Harlem community. This research engages with Acevedo’s work to focus on how slam poetry serves as a powerful outlet and …

April 2023, Robert Kelly

Robert Kelly Manuscripts

No abstract provided.

The Lantern, 2022-2023, Kate Isabel Foley, Jenna Lozzi, Emily Gurganus, Elliot Cetinski, Juliana Valerio, Morgan Grabowski, Laura Bradley, Elliott Hannam, Catherine Stump, Tyler Ways, Alessandra Armour, Emily Bradigan, Erin Corcoran, Leo Cox, Olivia Cross, Connor Donovan, Tatiana Kent, Andrew Kmett, Olivia Negro, Miles D. Noecker, Leo Quinn, Emilia Reed, Ryan Savage, Ze'ev Shaheen, Amy Smith, Vanessa Worley, Aurora Mckee, Evan Chartock, Matilda Dumaine, Sharon Gearhart, Yemu Huang, Sophie K. Louis, Mairead Mcdermott, Jordan Ulsh, Mattie Young, Emilio De Sousa, Sarah Fales, Owen Fazzini, Georgia Gardner, Christopher Gerrow, Jonny Gherman, Keegan Mcgowan, David Mccauley, Madeline O'Connor, Hannah Conley

The Lantern Literary Magazines, 1933 to Present

The Genie and the Scotsman • Taxi Driver Savior Complex • Midnight Waltz • Eulogy of Caution • Don't cry over spilled milk!! • I am the spider • The Lamb • The Witch and the Shepherd • Nostalgia • In the Summer I Want Light • I Am (Not) • Thanatophobia • We're not children anymore • Hamlet's Fool • Lemon • the last two people in the world • Amongst Chaos (what captivated me) • How About Now, Billy Joel • Bug Trap • Spring, Musser Hall, Room 219 • Time's Denial • A Song of History • …

Clinician Heal Thyself: Turning The Mirror Inward To Dismantle The Barriers Of Psychotherapy, Lynne-Marie Shea

Graduate Theses and Dissertations

The practice of psychotherapy developed in the United States within and in response to its sociopolitical context. As such it has always been unable to live up to its stated value of being accessible and effective for all people who are willing to seek and accept help. We explore the practice of psychotherapy within the larger field of Psychology and its ongoing commitment to capitalism and the social hierarchy at its center. We consider how Psychology’s intentional avoidance of class identity in the therapy space has allowed the field to justify and maintain this hierarchy while simultaneously ignoring its existence. …

Achieving The Achievable: Realistic Labor Law Reform, Rafael Gely

Faculty Publications

A common reprise among labor activists and scholars has been that for the fortunes of labor to change, the law must change. Prompted perhaps by a seeming surge in labor movement activity over the past few years, including headline-grabbing strikes and recent union victories at several U.S. Starbucks locations, various labor law activists and scholars have called to seize the moment and proposed the enactment of comprehensive labor law reform. We argue in this Article that broad-scale labor law reform is unlikely to be enacted by the current U.S. Congress or even have all its provisions pass muster when potentially …

Code^Shift Newsletter Spring 2023, Srividya Ramasubramanian, Chelsea Brown

CODE^SHIFT Research

No abstract provided.

The Geography Of Altithermal Subsistence Adaptations On The North American Great Plains, Ryan Breslawski

Anthropology Theses and Dissertations

On the Great Plains, the Middle Holocene (8200–5000 yr BP) was a warm period where foraging peoples expanded into new food resources and developed new food processing technologies. It is unclear precisely what drove these cultural changes, and environmental explanations tend to assume that climatically mediated causes occurred along latitudinal gradients, with the southern Plains experiencing severe water shortages and declining abundances of important resources relative to the northern Plains. A decline in one such resource, bison, has been repeatedly proposed as the mechanism that drove the adoption of new resources and technologies, with the most pronounced consequences at southern …

Conceptions Of Zero A Review Of Amir D. Aczel’S Finding Zero: A Mathematician's Odyssey To Uncover The Origins Of Numbers, Sean Chorney

The Mathematics Enthusiast

In the 2003 Pixar animation Finding Nemo, a clownfish named Marlin is an overprotective father, and for good reason: he has recently gone through the trauma of losing both his wife and all their fertilized eggs save one. Nemo is his only remaining offspring, a son. On Nemo’s first day of school, he gets caught in a fishing net and is taken far away. Marlin spends the rest of the movie looking for Nemo. He gets to know a variety characters in his search, some providing comic relief, some providing leads. But in each interaction Marlin learns a more …

A Randomized Waitlist-Controlled Pilot Trial Of Online-Delivered Comprehensive Behavioral Intervention For Tics-Enhanced, Jordan Stiede

Dissertations (1934 -)

Although studies demonstrate that comprehensive behavioral intervention for tics (CBIT) is more effective than nonspecific supportive therapy in reducing tics and related impairment, there is room for improvement, as up to 47% of treatment seeking youth do not show adequate response to treatment. Accordingly, the current randomized, waitlist-controlled pilot trial examined the preliminary efficacy, acceptability, and durability of online-delivered CBIT-Enhanced (CBIT-E), which included the standard CBIT protocol, plus specific and targeted instrumental conditioning procedures focused on directly reinforcing the use of inhibitory competing responses. The present study also explored differences in tic severity outcomes between CBIT-E participants and waitlist control …

Feasibility Of Sewer Overflow Treatment Using Chemical Oxidation After Rapid Solids Removal, Paige Peters

Dissertations (1934 -)

Sewer overflows discharge 850 billion gallons of untreated sewage into U.S. lakes and rivers every year during high-intensity precipitation events. Common approaches include storage tanks or rapid solids removal followed by chlorine disinfection. These approaches can be capital intensive and only achieve partial treatment. A decentralized, end-of-pipe sewer overflow treatment system would eliminate detrimental overflow effects while handling highly variable flow and pollutant loading. Specifically, the rapid reaction rate of chemical oxidation can achieve soluble organics removal and disinfection of chlorine-resistant pathogens in a small footprint. To address the overflow issue, an advanced high-rate treatment system (AH-RTS) was developed and …

2023 Commencement Program - Spring, Morehead State University. Registrar's Office.

Morehead State Commencement Programs

2023 Spring Commencement program for Morehead State University.

Kenyon Alumni Magazine - Spring 2023

Kenyon College Alumni Bulletin

No abstract provided.

Beyond “Psychic Income”: An Exploration Of Interventions To Address Work-Life Imbalances, Burnout, And Precarity In Contemporary Nonprofit Work, Robbie W. Robichau, Billie Sandberg, Andrew Russo

Public Administration Faculty Publications and Presentations

Nonprofit scholars and practitioners alike adhere to a long-held assumption that nonprofit work is, and will remain, inherently meaningful work. The long-term marketization of the nonprofit sector coupled with the influence of the COVID-19 pandemic has undercut this narrative. Our research on meaningful nonprofit work indicates that while many nonprofit workers do find their work meaningful, pay, flexibility, and work/life balance are increasingly important to them. This commentary suggests that nonprofit leaders can no longer presume that workers motivated by prosocial values will seek out and stay with nonprofit work, satisfied with the “psychic income” that comes from doing good …

Pestfacts Wa Issue 01 - April 2023, Cindy L. Webster, Svetlana Micic, Janette Pratt, Jean Galloway, Adam H. Sparks

PestFacts WA

PestFacts WA newsletter contents:

• Now is the time bait snails
• Black Portugue Millipedes
• Green bridge surveillance findings
• 2023 autumn winter insecticide spray guide is now available
• Pre-season climate and insect webinars are available online
• Canola blackleg risk forecasts
• Managing Ascochyta blight chickpea at seeding

Humanity's Fate: An Analysis Of Speculative Human Evolution In Literary Fiction, Celeste T. Johnson

Senior Theses

Speculative human evolution is a literature subgenre of science fiction that explores the potential future of humanity and descendant species. Little academic research has been done to evaluate the scientific accuracy of works of this genre or assess the relationship between the themes presented in the works and our current world. Future human species and their evolutionary journeys were assessed for scientific possibility through comparison with current research in fields such as anthropology, evolutionary biology, and sociology. It was found that the species depicted in works of speculative human evolution were largely based in scientific accuracy and could possibly exist …

Using Podcasts To Bring National Estuarine Research Reserves Into The Classroom For Grades 6-12, Kaitlyn M. Dirr

Senior Theses

In a typical classroom setting, there are significant challenges to exposing students to concepts related to earth sciences and the environment. These challenges are exacerbated when conveying lessons about geographic areas with limited access, such as oceans and coastlines (Louv, 2010). It is now more important than ever for environmental education to improve and adapt to our changing world. Educators may have the opportunity to bring these subjects to life by using media content such as podcasts to introduce students to new places and the scientists, managers and educators that work in those spaces. In the United States, there exists …

Recognizing Menstrual Equity As A Dimension Of Equal Educational Opportunity Student Note, Reilly H. Lerner

The Journal of Law and Education

No abstract provided.

Transcriptional Activation Of Jun And Fos Members Of The Ap-1 Complex Is A Conserved Signature Of Immune Aging That Contributes To Inflammaging., Emin Onur Karakaslar, Neerja Katiyar, Muneer G. Hasham, Ahrim Youn, Siddhartha Sharma, Cheng-Han Chung, Radu Marches, Ron Korstanje, Jacques Banchereau, Duygu Ucar

Faculty Research 2023

Diverse mouse strains have different health and life spans, mimicking the diversity among humans. To capture conserved aging signatures, we studied long-lived C57BL/6J and short-lived NZO/HILtJ mouse strains by profiling transcriptomes and epigenomes of immune cells from peripheral blood and the spleen from young and old mice. Transcriptional activation of the AP-1 transcription factor complex, particularly Fos, Junb, and Jun genes, was the most significant and conserved aging signature across tissues and strains. ATAC-seq data analyses showed that the chromatin around these genes was more accessible with age and there were significantly more binding sites for these TFs with age …

A System Out Of Balance: A Critical Analysis Of Philosophical Justifications For Copyright Law Through The Lenz Of Users' Rights, Mitchell Longan

University of Michigan Journal of Law Reform

Ultimately, this Article has three goals. The first is to offer an analysis of users’ rights under copyright law from four commonly used theoretical perspectives. These are labor, personality, economic and utilitarian theories. In doing so, this Article will demonstrate that the philosophies that underpin modern copyright law support a broad and liberal set of rights for derivative creativity. It will argue that current treatment of derivative works is unnecessarily conservative from a theoretical perspective. Second, this Article will demonstrate how, in spite of theory that supports a healthy community of derivative creativity, those who practice it have been further …

Nft For Eternity, Hadar Y. Jabotinsky, Michal Lavi

University of Michigan Journal of Law Reform

Non-fungible tokens (NFTs) are unique tokens stored on a digital ledger – the blockchain. They are meant to represent unique, non-interchangeable digital assets, as there is only one token with that exact data. Moreover, the information attached to the token cannot be altered as on a regular database. While copies of these digital items are available to all, NFTs are tracked on blockchains to provide the owner with proof of ownership. This possibility of buying and owning digital assets can be attractive to many individuals.

NFTs are presently at the stage of early adoption and their uses are expanding. In …