Digital Commons Network^™

Swapping Classrooms For Cow Barns, Nicholas Gosling

UNH Today Archive

No abstract provided.

Animation Of 3u Cubesat Trajectory Upon P-Pod Ejection, Ian Tyler Gray

Honors Capstone Projects and Theses

No abstract provided.

Mmu: 04/03/23–04/09/23, Student Bar Association

Monday Morning Update

This Week @ NDLS

Mass Times

Commons Daily Menu

General Announcements

NDLS Faculty & Staff Spotlights: Ann Kiley

1L of the Week: Sage Yang

Ask a 3L: Morgan Cleary

Sport Report by Stephen Nugent

Tim's Corner

Inhibition Of Stat6 With Antisense Oligonucleotides Enhances The Systemic Antitumor Effects Of Radiotherapy And Anti-Pd-1 In Metastatic Non-Small Cell Lung Cancer, Kewen He, Hampartsoum B Barsoumian, Nahum Puebla-Osorio, Yun Hu, Duygu Sezen, Mark D Wasley, Genevieve Bertolet, Jie Zhang, Carola Leuschner, Liangpeng Yang, Claudia S Kettlun Leyton, Natalie Wall Fowlkes, Morgan Maureen Green, Lisa Hettrick, Dawei Chen, Fatemeh Masrorpour, Meidi Gu, Hadi Maazi, Alexey S Revenko, Maria Angelica Cortez, James W Welsh

Faculty, Staff and Student Publications

Diverse factors contribute to the limited clinical response to radiotherapy (RT) and immunotherapy in metastatic non-small cell lung cancer (NSCLC), among which is the ability of these tumors to recruit a retinue of suppressive immune cells-such as M2 tumor-associated macrophages (TAM)-thereby establishing an immunosuppressive tumor microenvironment that contributes to tumor progression and radio resistance. M2 TAMs are activated by the STAT6 signaling pathway. Therefore, we targeted STAT6 using an antisense oligonucleotide (ASO) along with hypofractionated RT (hRT; 3 fractions of 12 Gy each) to primary tumors in three bilateral murine NSCLC models (Lewis lung carcinoma, 344SQ-parental, and anti-PD-1-resistant 344SQ lung …

Dysregulation And Epigenetic Reprogramming Of Nrf2 Signaling Axis Promote Acquisition Of Cisplatin Resistance And Metastasis In Head And Neck Squamous Cell Carcinoma, Abdullah A Osman, Emre Arslan, Mason Bartels, Chieko Michikawa, Antje Lindemann, Katarzyna Tomczak, Wangjie Yu, Vlad Sandulache, Wencai Ma, Li Shen, Jing Wang, Anand K Singh, Mitchell J Frederick, Nakia D Spencer, Jeffery Kovacs, Timothy Heffernan, William F Symmans, Kunal Rai, Jeffrey N Myers

Faculty, Staff and Student Publications

PURPOSE: Cisplatin (CDDP)-based chemotherapy is a first-line treatment for patients with advanced head and neck squamous cell carcinomas (HNSCC), despite a high rate of treatment failures, acquired resistance, and subsequent aggressive behavior. The purpose of this study was to study the mechanism of CDDP resistance and metastasis in HNSCC. We investigated the role of NRF2 pathway activation as a driven event for tumor progression and metastasis of HNSCC.

EXPERIMENTAL DESIGN: Human HNSCC cell lines that are highly resistant to CDDP were generated. Clonogenic survival assays and a mouse model of oral cancer were used to examine the impact of NRF2 …

Emt-Activated Secretory And Endocytic Vesicular Trafficking Programs Underlie A Vulnerability To Pi4k2a Antagonism In Lung Cancer, Xiaochao Tan, Guan-Yu Xiao, Shike Wang, Lei Shi, Yanbin Zhao, Xin Liu, Jiang Yu, William K Russell, Chad J Creighton, Jonathan M Kurie

Faculty, Staff and Students Publications

Hypersecretory malignant cells underlie therapeutic resistance, metastasis, and poor clinical outcomes. However, the molecular basis for malignant hypersecretion remains obscure. Here, we showed that epithelial-mesenchymal transition (EMT) initiates exocytic and endocytic vesicular trafficking programs in lung cancer. The EMT-activating transcription factor zinc finger E-box-binding homeobox 1 (ZEB1) executed a PI4KIIIβ-to-PI4KIIα (PI4K2A) dependency switch that drove PI4P synthesis in the Golgi and endosomes. EMT enhanced the vulnerability of lung cancer cells to PI4K2A small-molecule antagonists. PI4K2A formed a MYOIIA-containing protein complex that facilitated secretory vesicle biogenesis in the Golgi, thereby establishing a hypersecretory state involving osteopontin (SPP1) and other prometastatic ligands. …

Editorial: Preterm Birth And Placental Pathology, Sam Schoenmakers, Kjersti Aagaard, Liron Borenstein-Levin, Kondwani Kawaza, Der Meeren Le Van, Ben Willem Mol, Nathasha Raygaan Rhoda, Jill Shawe, Karel Allegaert

School of Nursing and Midwifery

No abstract provided.

Monocyte Depletion Enhances Neutrophil Influx And Proneural To Mesenchymal Transition In Glioblastoma, Zhihong Chen, David H Gutmann, Et Al.

2020-Current year OA Pubs

Myeloid cells comprise the majority of immune cells in tumors, contributing to tumor growth and therapeutic resistance. Incomplete understanding of myeloid cells response to tumor driver mutation and therapeutic intervention impedes effective therapeutic design. Here, by leveraging CRISPR/Cas9-based genome editing, we generate a mouse model that is deficient of all monocyte chemoattractant proteins. Using this strain, we effectively abolish monocyte infiltration in genetically engineered murine models of de novo glioblastoma (GBM) and hepatocellular carcinoma (HCC), which show differential enrichment patterns for monocytes and neutrophils. Eliminating monocyte chemoattraction in monocyte enriched PDGFB-driven GBM invokes a compensatory neutrophil influx, while having no …

The Association Between Caffeine Intake And The Colonic Mucosa-Associated Gut Microbiota In Humans-A Preliminary Investigation, Annie Dai, Kristi Hoffman, Anthony A Xu, Shawn Gurwara, Donna L White, Fasiha Kanwal, Albert Jang, Hashem B El-Serag, Joseph F Petrosino, Li Jiao

Faculty, Staff and Students Publications

We examined the association between caffeine and coffee intake and the community composition and structure of colonic microbiota. A total of 34 polyp-free adults donated 97 colonic biopsies. Microbial DNA was sequenced for the 16S rRNA gene V4 region. The amplicon sequence variant was assigned using DADA2 and SILVA. Food consumption was ascertained using a food frequency questionnaire. We compared the relative abundance of taxonomies by low (<82.9 mg) vs. high (≥82.9 mg) caffeine intake and by never or <2 cups vs. 2 cups vs. ≥3 cups coffee intake. False discovery rate-adjusted p values (q values) <0.05 indicated statistical significance. Multivariable negative binomial regression models were used to estimate the incidence rate ratio and its 95% confidence interval of having a non-zero count of certain bacteria by intake level. Higher caffeine and coffee intake was related to higher alpha diversity (Shannon index p < 0.001), higher relative abundance of Faecalibacterium and Alistipes, and lower relative abundance of Erysipelatoclostridium (q values < 0.05). After adjustment of vitamin B2 in multivariate analysis, the significant inverse association between Erysipelatoclostridium count and caffeine intake remained statistically significant. Our preliminary study could not …

Anti-Cancer Effect Of Cissus Quadrangularis On Human Glioblastoma Cells, Benxu Cheng, Yunlin Wei, Lili Guerra, Rozena Shirvani-Arani, Santiago Balderas, Laura Valdez, Andrew Tsin, Xiaoqian Fang

School of Medicine Publications

Objectives

Glioblastoma multiforme (GBM) is a common and fatal brain tumour in the central nervous system with a poor survival rate and a median survival time of 15 months only. The standard treatment is aggressive surgical resection followed by radiotherapy and chemotherapy. However, effective drugs available in chemotherapy are limited. This study was designed to evaluate, for the first time, the potential therapeutic effect of Cissus quadrangularis (CQ) in human glioblastoma cells and to investigate its possible mechanisms of action. Methods

In this study, we examined the anticancer activity of CQ in human glioblastoma U87 MG cells by cell viability …

Antagonism Between Prdm16 And Smad4 Specifies The Trajectory And Progression Of Pancreatic Cancer, Eric Hurwitz, Parash Parajuli, Seval Ozkan, Celine Prunier, Thien Ly Nguyen, Deanna Campbell, Creighton Friend, Allan Austin Bryan, Ting-Xuan Lu, Mohammed S. Razzaque

School of Medicine Publications

The transcription factor Prdm16 functions as a potent suppressor of transforming growth factor-beta (TGF-β) signaling, whose inactivation is deemed essential to the progression of pancreatic ductal adenocarcinoma (PDAC). Using the KrasG12D-based mouse model of human PDAC, we surprisingly found that ablating Prdm16 did not block but instead accelerated PDAC formation and progression, suggesting that Prdm16 might function as a tumor suppressor in this malignancy. Subsequent genetic experiments showed that ablating Prdm16 along with Smad4 resulted in a shift from a well-differentiated and confined neoplasm to a highly aggressive and metastatic disease, which was associated with a striking deviation in the …

Method For The Enrichment Of Sensor-Detected Driving Events, Axel Unger

Defensive Publications Series

No abstract provided.

Phonic Faces As A Method For Improving Decoding For Children With Persistent Decoding Deficits, Chantal H Farag Hanna

LSU Master's Theses

Background: Decoding is a foundational skill for reading, contributing to both reading fluency and comprehension (Lyon et al., 2003). Visual enhancements of alphabetic letters such as shaping letters to resemble words beginning with that sound (e.g., “f” drawn as a flower) (Handler & Fierson, 2011) and associating photographs of lips producing the sounds (Lindamood & Lindamood, 1998) have been shown to improve decoding skills. This study investigated whether a more direct pictured association using faces with alphabet letters placed in the mouth to cue speech sounds, termed Phonic Faces (Norris,2001), would enable students with persistent decoding impairment to acquire orthographic …

Independent Reproduction Of The Flash Effect On The Gastrointestinal Tract: A Multi-Institutional Comparative Study, Anet Valdés Zayas, Neeraj Kumari, Kevin Liu, Denae Neill, Abagail Delahoussaye, Patrik Gonçalves Jorge, Reiner Geyer, Steven H Lin, Claude Bailat, François Bochud, Raphael Moeckli, Albert C Koong, Jean Bourhis, Cullen M Taniguchi, Fernanda G Herrera, Emil Schüler

Faculty, Staff and Student Publications

FLASH radiation therapy (RT) is a promising new paradigm in radiation oncology. However, a major question that remains is the robustness and reproducibility of the FLASH effect when different irradiators are used on animals or patients with different genetic backgrounds, diets, and microbiomes, all of which can influence the effects of radiation on normal tissues. To address questions of rigor and reproducibility across different centers, we analyzed independent data sets from The University of Texas MD Anderson Cancer Center and from Lausanne University (CHUV). Both centers investigated acute effects after total abdominal irradiation to C57BL/6 animals delivered by the FLASH …

The Clash Between Luxury Brands And The Environment, Antoinette Harkness

Honors College Theses

ABSTRACT

Luxury brands are known for their high end material, craftsmanship, quality, materials, exclusive designs and high cost. Luxury attracts the eye of all consumers, especially young consumers that desire to be a true luxury consumer. As luxury companies try to appeal to the masses, with plenty of inventory but at what cost? Luxury brands are polluting our environment, as the textile and apparel industry is currently the second leading polluter in the world. Sustainable fashion is an all inclusive term describing products, processes, activities and actors aiming to achieve a carbon-neutral fashion industry, built on equality, social justice, animal …

Abstract Book (Pdf), School Of Public Health

School of Public Health Delta Omega Honors Day Poster Sessions

The collection of abstracts for the 20XX Delta Omega Honors Day Poster Session.

Cell-Penetrating Peptides For Use In Development Of Transgenic Plants, Betty Revon Liu, Chi Wei Chen, Yue-Wern Huang, Han Jung Lee

Biological Sciences Faculty Research & Creative Works

Genetically Modified Plants and Crops Can Contribute to Remarkable Increase in Global Food Supply, with Improved Yield and Resistance to Plant Diseases or Insect Pests. the Development of Biotechnology Introducing Exogenous Nucleic Acids in Transgenic Plants is Important for Plant Health Management. Different Genetic Engineering Methods for DNA Delivery, Such as Biolistic Methods, Agrobacterium Tumefaciens-Mediated Transformation, and Other Physicochemical Methods Have Been Developed to Improve Translocation Across the Plasma Membrane and Cell Wall in Plants. Recently, the Peptide-Based Gene Delivery System, Mediated by Cell-Penetrating Peptides (CPPs), Has Been Regarded as a Promising Non-Viral Tool for Efficient and Stable Gene Transfection …

Comparative Study Of Calcium Phosphate Versus Formocresol In Pulp Treatment Of Primary Teeth, Taghrid Mohammed, Mervat Fawzy, Mohamad Mostafa

Al-Azhar Journal of Dentistry

ABSTRACT:Purpose: Clinical and radiographic evaluation of the postoperative success of Calcium Phosphate and formocreosl (FC) materials in pulpotomy treatment of primary teeth. Materials and Method: 75 Primary molars in 25 patients were chosen according to specific criteria. Teeth were devided depending on the pulpotomy material into 3 groups: Group I (Calcium phosphate with physiologic saline cleansing group), Group II (Calcium phosphate with Sodium hypochlorite) and GroupIII (formcresol group). This was followed by clinical follow up after 1, 6 months and a year. In addition, Periapical radiographs were collected post-operatively, 6 and 12 months visits. Results: Despite decreasing with time, the …

Evaluation Of Anti-Carcinogenic Effect Of Selenium Nanoparticles On Induced Oral Squamous Cell Carcinoma, Aya Yehia, Amany Taha, Eman Abo Hager

Al-Azhar Journal of Dentistry

Purpose: Current study proposed to estimate the anticarcinogenic influence of Selenium Nanoparticles (SeNps) on induced squamous cell carcinoma utilizing caspase3 as an apoptotic marker. Material and Methods: Thirty hamsters were used, divided into four groups. Group I: 2 hamsters were left untreated, Group II: 8 hamsters received SeNPs orally for 14 weeks at dosage of 0.5 mg/kg on alternative day along the experimental period. Group III: 10 hamsters received Dimethylbenz [a]anthracene (DMBA) (0.5%) painted by brush on the buccal pouch 3 times per week for 8 weeks, then received DMBA with 5-Fluorouracil (5-FU) for another 6 weeks twice a week …

Effect Of Polycaprolactone Nanofiber Membrane Versus Concentrated Growth Factor On Periodontal Ligament Model Defect, Ola Dewedar, Heba Adawy, Mai Attia, Mena Abdullah

Al-Azhar Journal of Dentistry

Purpose: This study was carried out to evaluate the effect of two different regenerative materials on periodontal Ligament Model Defect through histological examination of rabbit’s mandible. Material and Methods: Thirty-six (36) adult male New Zealand rabbits (weight 3 to 3.5 kg) were used and then divided randomly into 3 groups according to material received (n=12).Group I (GI) control group that did not receive any treatment, Group II (GII) that received polycarolactone nanofiber membrane (PCL), Group III (GIII) that received concentrated growth factor membrane (CGF), surgical procedures were done to create a bony defect of 5x5mm size in the right side …

Collapse: The History Of How We Fail, And What We Can Do To Save Ourselves, David Ace, Grace Funke, Aj Abdel-Rahman, Nate Floccare, Kristen Russell, Madison Ingram, Douglas Mock

2023 Celebration of Student Scholarship - Poster Presentations

Using Diamond's Five point framework for how societies have collapsed in the past allow us in the present to recognize these signs in modern societies. We have the gift of hindsight in which we now know that factors such as climate change, impact on the environment, decline on friendly contact, increase in hostile contact, and a conservative outlook have all contributed to past societies' collapse. We now recognize these issues in modern societies such as China, Australia, Rwanda, and Haiti. This allows these societies to reevaluate their current environmental standards on whether they are compatible with their survival or collapse. …

High School Students' Response To Writing Mentor Feedback Of "Mirrors, Windows, Doors Literature Circle", Lee Mcconnell, Christopher Logan, Alison Hruby, Andrea Olinger, James Chisholm

2023 Celebration of Student Scholarship - Poster Presentations

How do high school writers feel about feedback on their writing drafts from pre-service English teachers, when those drafts are written during a Mirrors, Windows, Doors Literature Circles unit?

Relationships Among Maternal Characteristics In Hair Sheep, Rebekah Mills, Audrey Burton, Annika Weaver, Flint Harrelson, Patricia Harrelson

2023 Celebration of Student Scholarship - Poster Presentations

Since the spring of 2022, the MSU sheep flock has been an Innovation Flock for the Sheep GEMS project, managed by the University of Nebraska-Lincoln. The GEMS project is a multi-breed, national project evaluating longevity of ewes within flocks. Our part as a participant in the project involves collecting and sending raw data which is compiled into 1 very large data set. The research discussed here uses our preliminary data from the 2022 and 2023 lambing seasons collected from our Katahdin ewes (n =38; 1-4.5 years of age). Collected data included fecal egg count (FEC), body condition scoring (BCS), FAMACHA …

Applying Hallgren’S Algorithm For Solving Pell’S Equation To Finding The Irrational Slope Of The Launch Of A Billiard Ball, Sangheon Choi

Mathematical Sciences Technical Reports (MSTR)

This thesis is an exploration of Quantum Computing applied to Pell’s equation in an attempt to find solutions to the Billiard Ball Problem. Pell’s equation is a Diophantine equation in the form of x² − ny² = 1, where n is a given positive nonsquare integer, and integer solutions are sought for x and y. We will be applying Hallgren’s algorithm for finding irrational periods in functions, in the context of billiard balls and their movement on a friction-less unit square billiard table. Our central research question has been the following: Given the cutting sequence of the billiard …

Keynoter, April/May 2023, Boise State University Association Of Office Professionals

Boise State University Association of Office Professionals - Keynoter

President's Message

Professional Development Day

PDD Schedule

PDD Presenter Bios

NAEOP Conference

Brown Bag Learning

New website information

Calendar of Events

PSP Standards

Membership

Honors Oracle, April 2023, Marshall University Honors College

Honors Oracle

Marshall University’s Honors College newsletter.

Theological Foundations Of Nonviolent Communication In The Christian Lived Experience, Edward Khoa Ngô

Jesuit School of Theology Dissertations

In places globally and locally, people will likely find some sense of division, and/or violence in the world they live. There might be conflict in their homes, workplaces, schools, and places of worship but not limited to those areas. In the 1960’s, psychologist Marshall Rosenberg first developed Nonviolent Communication (NVC) amid the United States of America, starting the work with youth and then spreading to include school integration. NVC has found success in places with histories of violence – among families, prisons, warring tribes, and ethnic/racial groups. As NVC has been witnessed bring greater peace, understanding, and reconciliation to these …

Reading (In) A Quadriform Cosmos:Gospel Books In The Early Christian Bibliographic Imagination, Jeremiah Coogan

Jesuit School of Theology

Early Christian thinkers developed the widespread linguistic cosmology of the Roman Mediterranean in a novel way in order to advance a specific bibliographic project: aligning the emergent fourfold Gospel with the structure of the physical cosmos. Employing interlocking concepts from the disciplines of meteorology, geography, music, mathematics, and astronomy, a number of figures—including Irenaeus, Origen, Ephrem, Eusebius, Fortunatianus, Augustine, and Maximus—imagined a Gospel corpus consisting of precisely four texts. Number provided a way to articulate the coherence of the fourfold Gospel—both with itself and with the rest of the world. By situating both familiar and neglected evidence in the context …

Faculty Achievements, April 2023, Otterbein University

Faculty Achievement Reports

No abstract provided.

Profile: Beyond The Classroom, Communications And Marketing

Profile (1996-)

In this issue: Her Campus, Her Cause, Helen Jane Morrison: 1921-2022; Gift of Rare Maps; Scholarships Foster Study Abroad and Experiential Learning; Burks Appointed to National Transportation Study Committee; Education Building Renamed in Honor of Bill and Ida Stewart; UMN Morris Included in HHMI Grant; Sloan Foundation Grant to Increase STEM Opportunities for Native American Students; Spotlight on MAX Fund; Environmental Studies Internship Leads to Job; International Student Brings New Perspective to Music Research; Renewable Energy Trail Leads Student to a New Experience in a New Setting; UMN Morris Archives Offers Online Trip Back in Time; Randy Koopman '78, UMMAA …