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Marijuana Use During Pregnancy: Outcomes For The Pregnant Person, The Fetus, And Provider Recommendations, Anna E. Sump

Honors Thesis

Background

Marijuana is the most commonly used federally illicit substance in the United States, with the Centers for Disease Control and Prevention (CDC, 2022) reporting it was used by an estimated 48.2 million people in 2019. The legalization of marijuana for medical and recreational use, as well as its decriminalization over the past 20 years, has created a new challenge for healthcare providers and researchers. As of December 2022, 18 states and the District of Columbia have legalized recreational use, while the remaining 32 do not offer legalized recreational use (U.S. Department of Health and Human Services, 2022). Regardless of …

Arabian Partridge Abundance And Limiting Factors At The Northern Boundary Of Its Range, Alaaeldin Soultan, Moayyed Sher Shah, Ahmed Mohammed Almalki, Stephen Browne, Nico Arcilla

Center for Great Plains Studies: Staff and Fellows Publications

The Arabian Partridge (Alectoris melanocephala), is an endemic bird species of the Arabian Desert that lives in groups and inhabits rocky hillsides with patchy vegetation. Throughout their range, Arabian Partridges contend with hunting and habitat destruction, factors that may limit their distribution and abundance. Although the abundance of this species has been assumed to be stable, no actual estimate of its population size has been undertaken. We assessed the distribution and estimated the abundance of the Arabian Partridge at the northern boundary of its range in Saudi Arabia. The estimated density and abundance of the Arabian Partridge in …

Infrasound Detection Of Approaching Lahars, J. B. Johnson, J. F. Anderson, J. Mock, A. Bosa

Geosciences Faculty Publications and Presentations

Infrasound may be used to detect the approach of hazardous volcanic mudflows, known as lahars, tens of minutes before their flow fronts arrive. We have analyzed signals from more than 20 secondary lahars caused by precipitation events at Fuego Volcano during Guatemala’s rainy season in May through October of 2022. We are able to quantify the capabilities of infrasound monitoring through comparison with seismic data, time lapse camera imagery, and high-resolution video of a well-recorded event on August 17. We determine that infrasound sensors, deployed adjacent to the lahar path and in small-aperture (10 s of meters) arrays, are particularly …

Philosophical Counseling And Psychological Counseling In Relation To Moral Injury: A Thought Experiment, Leah Richardson

Longwood Senior Theses

This thesis investigates the similarities and differences between Acceptance and Commitment Therapy (ACT), a psychological therapy model, and Logic-Based Therapy (LBT), a philosophical therapy model, on moral injury. ACT emphasizes the importance of language in context in addition to a framework that addresses individuals as a whole. This approach contrasts with a variety of other psychological models designed to treat specific symptoms or diagnoses. LBT helps clients recognize and overcome irrationalities in thinking and subconscious rule-following behaviors to reach a point of equilibrium and tranquility. Moral injury is the observation of or participation in the violation of one's own moral …

Naphtha Characterization (Piona, Density, Distillation Curve And Sulfur Content): An Origin Comparison, Aline Pioli Silva, Juliana Otavia Bahú, Renato Soccol Jr., Leonardo Rodriguez-Urrego, William Stive Fajardo-Moreno, Hiram Moya, Jeffrey Leon-Pulido, Víktor Oswaldo Cárdenas Concha

Manufacturing & Industrial Engineering Faculty Publications

Naphtha is an important distillation product of crude oil, and is used as a raw material for first-generation products such as ethylene, propylene, gasoline, xylene (BTX), and others. However, due to the different sources of crude oil, differences in naphtha composition impact the quality of conversion processes. Parameters such as pressure, charge flow, and temperature need to be adjusted for conversion efficiency. This work aims to compare naphtha samples from different origins, through the analysis of distillation curve (ASTM D86), density (ASTM D4052), total sulfur (ASTM D4294), and n-paraffins, iso-paraffins, olefins, naphthene, and aromatics (PIONA, ASTM D5134). Among these parameters …

Art Therapy And Internal Family Systems For Adolescents At A Therapeutic School: A Qualitative, Arts-Based Study, Emma Pici-D'Ottavio

Expressive Therapies Capstone Theses

Adolescence is an important developmental period marked by a search for identity and an increase in impulsive behaviors and intense emotions. The current study explored how a combined art therapy and Internal Family Systems (IFS) model is beneficial and appropriate for adolescents in a school setting. A brief art therapy group was facilitated with students at a therapeutic high school. The intervention integrated IFS approaches, including externalization and guided visualizations, with the goal of understanding parts and increasing self-compassion. Three main themes emerged based on observations of the sessions: 1) the concept of parts encouraged self-understanding and reduced shame; 2) …

Responses To Many Anti-Aging Interventions Are Sexually Dimorphic., Andrzej Bartke, Erin Hascup, Kevin Hascup

Articles

There is increasing appreciation that sex differences are not limited to reproductive organs or traits related to reproduction and that sex is an important biological variable in most characteristics of a living organism. The biological process of aging and aging-related traits are no exception and exhibit numerous, often major, sex differences. This article explores one aspect of these differences, namely sex differences in the responses to anti-aging interventions. Aging can be slowed down and/or postponed by a variety of environmental ("lifestyle"), genetic or pharmacological interventions. Although many, particularly older studies utilized only one sex of experimental animals, there is considerable …

Responses To Many Anti-Aging Interventions Are Sexually Dimorphic., Andrzej Bartke, Erin Hascup, Kevin Hascup

Articles

There is increasing appreciation that sex differences are not limited to reproductive organs or traits related to reproduction and that sex is an important biological variable in most characteristics of a living organism. The biological process of aging and aging-related traits are no exception and exhibit numerous, often major, sex differences. This article explores one aspect of these differences, namely sex differences in the responses to anti-aging interventions. Aging can be slowed down and/or postponed by a variety of environmental ("lifestyle"), genetic or pharmacological interventions. Although many, particularly older studies utilized only one sex of experimental animals, there is considerable …

A Critical Review Of Animal And Fetus Rights In Utilitarianism Or “How Come When It’S Us, It’S An Abortion, And When It’S A Chicken, It’S An Omelette?”, Katharine Mcdaid

Departmental Honors & Graduate Capstone Projects

In this paper, I will be considering the moral standing of animals and fetuses within utilitarianism—by discussing the Time Relative Interest Account and Harm-Based Account—and how the question of moral standing relates to discussions of abortion. The Time Relative Interest Account provides a more effective framework for considering the rights of both animals and fetuses in utilitarianism, and a lack of access to abortion poses a significant challenge to the utilitarian viewpoint often espoused by anti-abortion advocates because they fail to consider the lack of access implications within their utilitarian approach. Therefore, the utilitarianism that is animal rights-based arguments used …

Computational Design And Molecular Modeling Of Morphine Derivatives For Preferential Binding In Inflamed Tissue, Makena Augenstein, Nayiri Alexander, Matthew Gartner

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

The opioid epidemic has impacted over 10 million Americans in 2019. Opioids, like morphine, bind non-selectively in both peripheral tissue, leading to effective pain relief, and central tissue, resulting in dangerous side effects and addiction. The inflamed conditions of injured tissues have a lower pH (pH = 6–6.5) environment than healthy tissue (pH = 7.4). We aim to design a morphine derivative that binds selectively within inflamed tissue using molecular extension and dissection techniques. Morphine binds to the μ-opioid receptor (MOR) when the biochemically active amine group is protonated. Fluorination of a β-carbon from the tertiary amine group led to …

Perfusion Pressure-Flow Relationships In Synthetic Poroelastic Vocal Fold Models, Cooper B. Thacker

Theses and Dissertations

The purpose of this research was to study perfusion pressure-flow relationships in self-oscillating synthetic poroelastic vocal fold (VF) models before, during, and after vibration. This was accomplished by developing a custom ultra-soft poroelastic material, incorporating the poroelastic material as the cover layer in a synthetic VF model, and studying the model vibratory response and the flow rate of fluid perfused through the cover layer while undergoing flow-induced vibration. The custom ultra-soft poroelastic material was developed using the method of direct templating with sucrose spheres as the sacrificial template and silicone as the infiltration medium. The average modulus of elasticity of …

Cats Of Unl: An Investigation Into The Human-Feral Cat Relationships On A University Campus In Nebraska, Jacey Skoda

Honors Program: Senior Projects (Public)

At the University of Nebraska-Lincoln (UNL), there exists a population of feral cats that is monitored and cared for by a group known as Husker Cats. As the cats wander the sidewalks and gardens of the university, they may appear non-threatening and pleasant to have around. However, a feral cat presence could have detrimental impacts on the surrounding ecosystem, property, and community. The first component of this project, a survey of individuals on UNL campus, ultimately seeks to understand what those in the UNL community know about the feral cats, how they feel about the feral cats, and how they …

Car-Neutrophil Mediated Delivery Of Tumor-Microenvironment Responsive Nanodrugs For Glioblastoma Chemo-Immunotherapy, Yun Chang, Xuechao Cai, Ramizah Syahirah, Yuxing Yao, Yang Xu, Gyuhyung Jin, Vijesh J. Bhute, Sandra Torregrosa-Allen, Bennett D. Elzey, You-Yeon Won, Qing Deng, Xiaojun Lance Lian, Xiaoguang Wang, Omolola Eniola-Adefeso, Xiaoping Bao

Purdue University Libraries Open Access Publishing Fund

Glioblastoma (GBM) is one of the most aggressive and lethal solid tumors in human. While efficacious therapeutics, such as emerging chimeric antigen receptor (CAR)-T cells and chemotherapeutics, have been developed to treat various cancers, their effectiveness in GBM treatment has been hindered largely by the blood-brain barrier and blood-brain-tumor barriers. Human neutrophils effectively cross physiological barriers and display effector immunity against pathogens but the short lifespan and resistance to genome editing of primary neutrophils have limited their broad application in immunotherapy. Here we genetically engineer human pluripotent stem cells with CRISPR/Cas9-mediated gene knock-in to express various anti-GBM CAR constructs with …

First- Versus Third-Generation Egfr Tyrosine Kinase Inhibitors In Egfr-Mutated Non-Small Cell Lung Cancer Patients With Brain Metastases, Ahmad Ozair, Atulya Khosla, Shreya Saxena, Manmeet Ahluwalia

All Publications

Introduction: Up to 50% of non-small cell lung cancer (NSCLC) harbor EGFR alterations, the most common etiology behind brain metastases (BMs). First-generation EGFR-directed tyrosine kinase inhibitors (EGFR-TKI) are limited by blood-brain barrier penetration and T790M tumor mutations, wherein third-generation EGFR-TKIs, like Osimertinib, have shown greater activity. However, their efficacy has not been well-studied in later therapy lines in NSCLC patients with BMs (NSCLC-BM). We sought to compare outcomes of NSCLC-BM treated with either first- or third-generation EGFR-TKIs in first-line and 2nd-to-5th-line settings. Methods: A retrospective review of NSCLC-BM patients diagnosed during 2010–2019 at Cleveland Clinic, Ohio, US, a quaternary-care center, …

Corneal Injury Is Associated With Stromal And Vascular Alterations Within Cranial Dura Mater, Olga V. Glinskii, Vladislav V. Glinsky, Leike Xie, Filiz Bunyak, Vladimir V. Glinskii, Sunilima Sinha, Suneel Gupta, Renato V. Iozzo, Rajiv R. Mohan

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The cornea and cranial dura mater share sensory innervation. This link raises the possibility that pathological impulses mediated by corneal injury may be transmitted to the cranial dura, trigger dural perivascular/connective tissue nociceptor responses, and induce vascular and stromal alterations affecting dura mater blood and lymphatic vessel functionality. In this study, using a mouse model, we demonstrate for the first time that two weeks after the initial insult, alkaline injury to the cornea leads to remote pathological changes within the coronal suture area of the dura mater. Specifically, we detected significant pro-fibrotic changes in the dural stroma, as well as …

Psychological Influences On Problem-Solving Following Lab-Induced Learned Helplessness, Aqdas Khan

Honors Theses

The purpose of the present study was to examine psychological influences on problem-solving following lab-induced learned helplessness. There are several related psychological constructs in the literature that appear relevant. These have been typically examined in isolation in various sub-fields within psychology. Determining which is most influential, and their unique and overlapping contributions, could provide important conceptual clarity and point to ways to streamline and guide targets of psychological intervention. The constructs of interest were: need for cognition, psychological flexibility, grit, learned helplessness (LH) attributional style, cognitive fusion, and the Big 5 personality trait of neuroticism. A within-subjects correlational research group …

Ivermectin: Covid-19 "Miracle Cure?": A Case Study On Public Health Communication To Combat Disinformation, Ashley Dittmar

Honors Theses

Communicating accurate health information to the public has always been a vital role of public health professionals. This role became especially prominent in light of the COVID-19 pandemic, when public health professionals had the challenge of sharing up-to-date information about a novel coronavirus while other messages about the virus - both true and false - were being spread by other entities. This paper focuses on one case of intentionally incorrect information (disinformation) that was spread during the COVID-19 pandemic, purporting anti-parasitic drug ivermectin as a “miracle cure” for COVID-19. This case study is analyzed through the lens of the Media …

The Public Trust Doctrine: Roman Law Roots And Future In Environmental Litigation, Phoebe Liccardo

Honors Theses

The public trust is an ancient and enduring legal doctrine. With roots in Roman law, the public trust persists through English law, and into the United States. Scholars and jurists in the field of Roman and environmental law do not all agree on the history and continuity of the public trust doctrine (PTD). There are those who argue the Roman law introducing a public trust did not assert the same protections present in the doctrine today. Conversely, there are those who believe the Roman law did enshrine similar protections, and further, that it calls for an expansion of PTD in …

В Поисках Снарка, Victor Fet

Open Access Books

Фет, В. В поисках Снарка. Библиотека Университета Маршалла, Хантингтон. 2023. 434 с.

Этот том содержит статьи и рецензии Виктора Фета (1955 г.р.), написанные и опубликованные в 1995-2022 гг на различные темы, от истории науки до рецензий на театральные спектакли. Автор, биолог по профессии, который провёл первую половину жизни (1955-1988) в СССР, соединяет глубоко личный опыт, воспоминания и наблюдения, преследуя одну основную тему: уникальность творчества во всех аспектах гуманитарных и естественных наук. Интересы автора прежде всего фокусиртуются на двух очень разных, но не независимых фигурах Льюиса Кэрролла и Владимира Набокова. В наши дни, при быстром распаде и трансформации русской культуры, …

Database Of Video Games And Their Therapeutic Properties, Tyler Brinkman

Student Capstone Papers

There are reported to be 2.96 billion video game players in the world as of 2021 and this number is expected to grow to 3.32 billion by the year 2024. Of that total, 215.5 million video game players live in the United States with a reported average age of 33 years old. Thousands of commercial video games are released every year. There is evidence to support video game technology use as therapeutic media however it predominately utilizes outdated technology or technology designed for a specific purpose also called “serious games.” The problem is that OT practitioners are unaware of the …

The Cowl - V. 87 N. 16 - April 20, 2023

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 16 - April 20, 2023. 24 pages.

The Role Of Interleukin-15 In The Development And Treatment Of Hematological Malignancies, Paola Sindaco, Hritisha Pandey, Colleen Isabelle, Nitin Chakravarti, Jonathan Edward Brammer, Pierluigi Porcu, Anjali Mishra

Kimmel Cancer Center Faculty Papers

Cytokines are a vital component of the immune system that controls the activation and growth of blood cells. However, chronic overexpression of cytokines can trigger cellular events leading to malignant transformation. The cytokine interleukin-15 (IL-15) is of particular interest, which has been shown to contribute to the development and progression of various hematological malignancies. This review will provide an overview of the impact of the immunopathogenic function of IL-15 by studying its role in cell survival, proliferation, inflammation, and treatment resistance. We will also review therapeutic approaches for inhibiting IL-15 in blood cancers.

Effects Of Cannabichromene On Pain And Neuroinflammation In Hiv-1 Tat Transgenic Mice, Sydney Wheeler

Honors Theses

HIV-1 TransActivator of Transcription (Tat) is a vital regulatory protein involved in HIV replication and implicated in development of HIV-associated pain and neurocognitive deficits. Tat is thought to contribute to these pathologies through proinflammatory pathways. Developing mechanisms to curb Tat-mediated inflammation is a key step in improving the quality of life of those living with HIV. Both recreational and medicinal cannabis use is prevalent among many people living with HIV; given this prevalence and the perceived anti-inflammatory benefits of cannabis use, it is important to investigate how chemical constituents of cannabis may impact HIV. In the present study, the effects …

Implementation Of Seasonal Diets Through Seasonal Diet Surveys In Sloth Bears (Melursus Ursinus): A Case Study At Idaho Falls Zoo, Noah Clever

Undergraduate Honors Thesis Projects

Wild sloth bears (Melursus ursinus) display seasonal diet preferences for insects and fruit during the dry and monsoon season respectively. To potentially utilize as a method for reducing abnormal behaviors and improving animal welfare, the purpose of the study is to survey zoos with captive sloth bears and determine if zoo-housed individuals display seasonal diet preferences. From May 18th, 2022 to March 2nd, 2023 data was collected on Priya, a sloth bear from Idaho Falls Zoo, and her preference for fruit and insects. Temperature, season, fruit choice based on sugar levels, and insect choice based on texture of …

Sustainable Diets: Improving Planetary And Population Health (Evidence Summary For Policymakers), C Pettinger

School of Health Professions

No abstract provided.

Research On Risk Identification Framework Of Future Technology—Based On Perspective Of Techno-Economic Security, Jie Chen, Zhongqi Wu, Tao Dai

Bulletin of Chinese Academy of Sciences (Chinese Version)

Under the background of a new round of scientific and technological revolution and industrial transformation, the future technology represented by disruptive technology and emerging technology has become the focus of attention and game among countries. The future technology is not only related to taking the lead in future development, enhancing national strength and competitiveness, but also related to whether the economy and national security can be maintained. Based on the perspective of techno-economic security, this study analyzes the connotation and characteristics of future technology, puts forward the ‘three stages and three levels’ economic security influential mechanism of future technology, and …

Industrialization Of Tall Wheatgrass For Construction Of “Coastal Grass Belt”, Hongwei Li, Qi Zheng, Jianlin Wang, Hongyong Sun, Kexin Zhang, Hongman Fang, Xuerong Xing, Weicai Yang, Xiaofeng Cao, Xiaojing Liu, Haichun Jing, Kang Chong, Zhensheng Li

Bulletin of Chinese Academy of Sciences (Chinese Version)

Tall wheatgrass (Elytrigia elongata) is a perennial cool-season bunchgrass with high productivity and tolerance to salt and alkali, waterlogging, and drought. Since first introduced into China in 1950s, tall wheatgrass has long been used as a wild parent for distant hybridization with wheat (Triticum aestivum). During 1980s─1990s, a few tall wheatgrass varieties were introduced to China as forage grass, nonetheless, currently they are still not widely cultivated and no variety was certificated. In 2020, Zhensheng Li put forward a proposal to construct “Coastal Grass Belt” on saline and alkaline soils in the Circum-Bohai sea region, which provides an opportunity for …

An Altered Extracellular Matrix-Integrin Interface Contributes To Huntington’S Disease-Associated Cns Dysfunction In Glial And Vascular Cells, Sarah J Hernandez, Ryan G Lim, Tarik Onur, Mark A Dane, Rebecca Smith, Keona Wang, Grace En-Hway Jean, Andrea Reyes-Ortiz, Kaylyn Devlin, Ricardo Miramontes, Jie Wu, Malcolm Casale, David Kilburn, Laura M Heiser, James E Korkola, David Van Vactor, Juan Botas, Katherine L Thompson-Peer, Leslie M Thompson

Faculty, Staff and Students Publications

Astrocytes and brain endothelial cells are components of the neurovascular unit that comprises the blood-brain barrier (BBB) and their dysfunction contributes to pathogenesis in Huntington's disease (HD). Defining the contribution of these cells to disease can inform cell-type-specific effects and uncover new disease-modifying therapeutic targets. These cells express integrin (ITG) adhesion receptors that anchor the cells to the extracellular matrix (ECM) to maintain the integrity of the BBB. We used HD patient-derived induced pluripotent stem cell (iPSC) modeling to study the ECM-ITG interface in astrocytes and brain microvascular endothelial cells and found ECM-ITG dysregulation in human iPSC-derived cells that may …

Mutational Analysis Of Anesthetic Binding Sites And Their Effects On Gabaa Receptor Activation And Modulation By Positive Allosteric Modulators Of The Α7 Nicotinic Receptor, Spencer R Pierce, Allison L Germann, Sophia Q Xu, Saumith L Menon, Marcelo O Ortells, Hugo R Arias, Gustav Akk

2020-Current year OA Pubs

The positive allosteric modulators (PAMs) of the α7 nicotinic receptor

Analysis The Role Of The Internet Of Things And Industry 4.0 In Healthcare Supply Chain Using Neutrosophic Sets, Ahmed M. Abdelmouty, Ahmed Abdel-Monem, Samah Ibrahim Abdel Aal, Mahmoud M. Ismail

Neutrosophic Systems with Applications

In today's global economy, the Healthcare supply chain (HCSC) must be aware of a market that is both complicated and ever-changing. The HCSC in Industry 4.0 aims to give patients the medicine they need as quickly and cheaply as possible. The HCSC can improve operations by automating routine tasks and reducing human error by using new technologies like the "Internet of Things" (IoT); so, there is a need to analyze the role of IoT and Industry 4.0 in the Healthcare Supply Chain. This paper aims to analyze the role of IoT and Industry 4.0 in HCSC. Also, this paper proposes …