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Sleep Problems In Old Age: Metabotropic Glutamate Receptor To The Rescue, Sho Inami, Dinis J.S. Afonso, Kyunghee Koh

Farber Institute for Neuroscience Faculty Papers

No abstract provided.

Fighting Heat And Rain: New York City’S Climatic Problems And The Effect On The City’S Urbanism, Moises D. Lopez

Student Theses 2015-Present

Severe weather events have come about as a result of the changing global climate, which have drastically changed local and global environments. These events have destroyed many homes, land areas, and, unfortunately, lives. Therefore, it is important for cities that are highly populated to be aware of the great damage a severe weather event can bring. New York City (NYC) has been hit with many severe weather conditions, and with over 8 million habitants, it is important that this city should be prepared for any future weather events that may occur. This paper analyzes the effects of heat waves and …

Du Undergraduate Showcase: Research, Scholarship, And Creative Works, Caitlyn Aldersea, Justin Bravo, Sam Allen, Anna Block, Connor Block, Emma Buechler, Maria De Los Angeles Bustillos, Arianna Carlson, William Christensen, Olivia Kachulis, Noah Craver, Kate Dillon, Muskan Fatima, Angel Fernandes, Emma Finch, Colleen Cassidy, Amy Fishman, Andrea Francis, Stacia Fritz, Simran Gill, Emma Gries, Rylie Hansen, Shannon Powers, Jacqueline Martinez, Zachary Harker, Ashley Hasty, Mykaela Tanino-Springsteen, Kathleen Hopps, Adelaide Kerenick, Colin Kleckner, Ci Koehring, Elijah Kruger, Braden Krumholz, Maddie Leake, Lyneé Alves, Seraphina Loukas, Yatzari Lozano Vazquez, Haley Maki, Emily Martinez, Sierra Mckinney, Audrey Mitchell, Kipling Newman, Audrey Ng, Megan Lucyshyn, Andrew Nguyen, Stevie Ostman, Casandra Pearson, Alexandra Penney, Julia Gielczynski, Tyler Ball, Anna Rini, Christina Rorres, Simon Ruland, Helayna Schafer, Emma Sellers, Sarah Schuller, Claire Shaver, Kevin Summers, Isabella Shaw, Madison Sinar, Claudia Pena, Apshara Siwakoti, Carter Sorensen, Madi Sousa, Anna Sparling, Alexandra Revier, Brandon Thierry, Dylan Tyree, Maggie Williams, Lauren Wols

DU Undergraduate Research Journal Archive

DU Undergraduate Showcase: Research, Scholarship, and Creative Works

The Exile's War, Stephen Edwards Arnold

Master of Arts in Professional Writing Capstones

In Gaelwyn, the village of a thousand stories, Katchan receives a powerful ruby and an ancient technique called writing hidden by his grandmother, Maggaline. Jealous of the power Katchan has, the village Elder seeks to destroy him. After escaping the Elder, Katchan must leave his home and traverse a dangerous and mysterious wasteland that will lead him directly into an ancient conflict that lost a powerful empire to the sands of time.

Combating The Climate Crisis: Anishinaabe Philosophy And Environmental Justice, Margaret Hunt

Student Theses 2015-Present

The climate crisis is considered one of humans' most detrimental issues today. Although there is a struggle to find solutions, many have been and continue to be at the forefront of the environmental movement, specifically Indigenous communities. The Anishinaabe people, in particular, have philosophies centered around environmental care. They view the environment as something deserving of honor and respect. Although these ideas have allowed them to have a respectful relationship with their local ecosystems, the United States government has ignored these ideas from the early stages of the environmental movement. With this, there is also an extensive history of harmful …

State Run Dry: How California Manages Inevitable Drought Due To Climate Change, Rachelle Yang

Student Theses 2015-Present

This thesis paper addresses the severe drought brought on by climate change that California is currently experiencing and examines methods to counter the drought in order to minimize water usage and increase water levels. Historically, California has experienced several periods of drought which are increasingly becoming more detrimental to the environment. It is crucial to mitigate the drought as California has already been feeling its major effects from it. As temperatures rise and the atmosphere becomes drier, the water supply in California could be diminished by 10% by 2040. Chapter 1 uses several studies and reports on the California drought …

Influences Of Post-Fledging Protein Supplementation On Growth And Reactive Stress Response In Zebra Finches (Taeniopygia Castanotis), Gabrielle Morris, Mary Lindley Tharp

Honors Theses

Protein needs of non-poultry birds, like Zebra Finches (ZF) are understudied. ZFs consume proteinaceous half-ripe seeds during breeding and chicken eggs are recommended supplements for captive ZFs; but developmental needs are unclear. Eggs contain essential amino acids that impact the “stress” hormone, corticosterone (CORT). Diet and corticosterone influence avian growth and stress management. Juvenile egg-fed ZFs outgrow seed-fed birds. Juvenile egg-supplementation boosts adult male attractiveness due to cheek patch augmentation compared to seed-only birds. Across studies, timing of diet (nestling Vs. fledgling) varies, both sexes have not been included, and simultaneous measures of growth and corticosterone are lacking. We are …

Examining The Influence Of Training On An Event-Based Prospective Memory Task In 3-Year-Olds, Emeri Rose Nosal

Honors Theses

Given the significance of prospective memory (PM) throughout an individual’s lifespan, PM has gained great momentum as a topic of research. Surprisingly, less studies have examined PM in children than adults despite the fact that cognitive abilities are developing during this time. Performance in event-based PM tasks has been shown to be poor in preschoolers and particularly weak in 3-year-olds. Previous studies of event-based PM tasks have included manipulations such as cues and incentives to aid in performance. In this study, I examined another potential manipulation to aid in PM performance not previously examined in literature: training. To assess whether …

The Effects Of Acute Exercise On Memory: Considerations Of The Testing Effect, Philip Christian

Honors Theses

This study had three main objectives. The first objective was to determine whether or not there was evidence of a testing effect being present when a short-term memory assessment is included along with a long-term memory assessment. The second objective was to determine whether acute exercise can improve long-term memory recall over a control condition. The third objective was to determine if the potential effects of acute exercise on long-term memory are confounded by the inclusion of a short-term memory assessment. Participants were 54 undergraduate students at the University of Mississippi, with an age range of 18-22 years old. Participants …

Functional And Location Context Effects On Reading Sentences In Healthy Young Adults: Evidence From Eye Tracking Methods, Elizabeth Baird

Honors Theses

Spreading activation theory proves the way our brains are semantically wired to accept outside information and understand it. Previous studies have demonstrated the effects of spreading activation theory in different settings and activities. These effects are important to understand because they can be used in therapy and assessment for communication disorders. This study explores how the context of sentences affects reading time on noun targets in healthy young adults using an eye tracking method. Specifically, we compared functional and location context types and manipulated the context to be incongruent or congruent to the targets. Our research questions were (1) whether …

Identification Of Novel Anti-Amoebic Pharmacophores From Kinase Inhibitor Chemotypes, Lori Ferrins, Melissa J. Buskes, Madison M. Kapteyn, Hannah N. Engels, Suzanne E. Enos, Chenyang Lu, Dana M. Klug, Baljinder Singh, Antonio Quotadamo, Kelly Bachovchin, Westley F. Tear, Andrew E. Spaulding, Katherine C. Forbes, Seema Bag, Mitch Rivers, Catherine Leblanc, Erin Burchfield, Jeremy R. Armand, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Raquel Garcia-Hernandez, Guiomar Perez-Moreno, Cristina Bosch-Navarrete, Claudia Gomez-Linan, Luis Miguel Ruiz-Perez, Francisco Gamarro, Dolores Gonzalez-Pacanowska, Miguel Navarro, Kojo Mensa-Wilmot, Michael P. Pollastri, Dennis E. Kyle, Christopher A. Rice

Purdue University Libraries Open Access Publishing Fund

Acanthamoeba species, Naegleria fowleri, and Balamuthia mandrillaris are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic free-living amoebae (pFLA) are commonly misdiagnosed and have sub-optimal treatment regimens which contribute to the extremely high mortality rates (>90%) when they infect the central nervous system. To address the unmet medical need for effective therapeutics, we screened kinase inhibitor chemotypes against three pFLA using phenotypic drug assays involving CellTiter-Glo 2.0. Herein, we report the activity of the compounds against the trophozoite stage of each of the three amoebae, ranging from …

Losing And Finding Braj: Commodification And Entrepreneurship In The Sacred Land Of Krishna, Leena Taneja

All Works

Braj is a sacred place revered by Bengali Vaishnavas, followers of the bhakti sect of Vaishnavism, one of four branches of Hindu devotion. Followers of the sect worship the God Krishna, who it is believed manifested in Braj and carried out many divine feats and activities that are imprinted onto the land. Braj today is dotted with thousands of holy shrines, temples and natural places connected to Krishna. Devotees connect to Krishna through the landscape of Braj; it is where the transcendental and the physical realms meet. Braj has been transformed in a multitude of ways with the influx of …

Perception Of Threat And Intent To Harm From Vocal And Facial Cues, James Tompkinson, Mila Mileva, Dominic Watt, Burton A Mike

School of Psychology

What constitutes a “threatening tone of voice”? There is currently little research exploring how listeners infer threat, or the intention to cause harm, from speakers’ voices. Here, we investigated the influence of key linguistic variables on these evaluations (Study 1). Results showed a trend for voices perceived to be lower in pitch, particularly those of male speakers, to be evaluated as sounding more threatening and conveying greater intent to harm. We next investigated the evaluation of multimodal stimuli comprising voices and faces varying in perceived dominance (Study 2). Visual information about the speaker’s face had a significant effect on threat …

My Kinship With The Trees, C. Daniela Shapiro

MFA in Illustration & Visual Culture

This paper explores facets of patriarchy affecting women and the natural world. The paper suggests a cultivation of allyship and relationality between women and nature due to a shared experience of objectification within patriarchy. The separation of women from nature through origin stories, science, religion, language, and advertisement will be discussed. Examples from the graphic memoir Running without Moving are employed to emphasize this philosophy, including first person accounts.

The Dark House And Its Inhabitants, Emily Bielski

MFA in Illustration & Visual Culture

From the inception of the genre, Gothic horror has been fixated on the domestic space in distress. This essay explores domestic archetypes and roles of the Gothic novel, serving as a “tour of the house”, analyzing the iconography of the dark castle, and how it externalizes and exacerbates the fears and behaviors of its inhabitants. The power dynamic of the household is starkly divided by the expectations and authority of masculine and feminine figures. In turn the “house” becomes a vehicle for the anxieties of the inhabitants—both experienced and inflicted—regarding gender, sexuality, isolation, and abuse. Exploration of the visual and …

Monster Planet Bounty Hunter, Arthur Santoro

MFA in Illustration & Visual Culture

In this paper I will be discussing my personal interest in games and art as well as my experience and process working on my original board game: Monster Planet Bounty Hunter. I will also discuss my visual influences, how I approach making games and why I think games are an important form of art.

Shambles & Crowley: Autobiographical Fiction In Four Panels, Shumyle Haider

MFA in Illustration & Visual Culture

This paper explores the development of Shambles & Crowley, a collection of autobiographical fiction comic strips featuring Shambles, a burnt-out boy, Crowley, a loudmouthed crow, Franz Kafka, a silent companion, Saadat Manto, a prankster, and God, an overbearing authority figure. Drawing inspiration from comic strips such as Peanuts by Charles Schulz, Calvin & Hobbes by Will Waterson, and shows such as Louie by Louis C.K, and Mr. Robot by Sam Esmail, the stories explore the inner conflicts of Shambles, which are induced by struggles with love, loneliness, depression, and faith.

Ambivalent Images, Beloved Objects: Building Bridges Between Picture Books And The Tangible World, Danielle Ridolfi

MFA in Illustration & Visual Culture

"Ambivalent Images, Beloved Objects" examines how pedagogical theories prioritizing objects and direct sensory experiences in early childhood can be applied to the creation of picture book illustrations. In doing so, it positions picture books as educational tools, and advocates for the importance of using them not to recreate nature, but to connect readers with the tangible world of natural and human-made objects that our digital-driven culture eclipses. It strives towards a unifying pedagogical and aesthetic philosophy that accomplishes what illustrator Eric Carle characterizes as a bridge between the tactile world of objects and the world represented in illustrations.

This exploration …

Helminth Parasites Of The Giant Toad, Rhinella Horribilis (Wiegmann, 1833) (Anura: Bufonidae) From Central Mexico, Jorge Falcón-Ordaz, Cristian Raúl Olvera-Olvera, Marisol Moreno-Chávez, Griselda Pulido-Flores, Scott Monks, Luis García-Prieto

MANTER: Journal of Parasite Biodiversity

As part of an ongoing project to inventory the helminth parasites of amphibians from the state of Hidalgo, Central Mexico, specimens of Rhinella horribilis were collected from three municipalities: Eloxochitlán, Huehuetla, and San Felipe Orizatlán. A total of eight taxa of helminths were found: three digeneans (Haematoloechus sp., Langeronia macrocirra, and Mesocoelium danforthi) and five nematodes (Cosmocerca sp., Cruzia morleyi, Ochoterenella chiapensis, Oswaldocruzia subauricularis, and Rhabdias sp.). The highest species richness was recorded in Huehuetla. All reports of these species of helminths represent new locality records for Mexico.

Exploring The Antikythera Mechanism Through Augmented Reality., Tiffany Hatzidimitriu

Honors College Theses

The Antikythera mechanism is the oldest known analogue computer. Discovered off the coast of the Greek island of Antikythera, the Antikythera mechanism predicts and displays the position of astronomical bodies as well as astronomical phenomena. Due to its complexity, visualization of the gears movement can be very difficult. For my project I created an interactive Augmented Reality (AR) model of the Antikythera mechanism using Unity game engine. I hope this AR application exposes people to the Antikythera mechanism and its inner workings.

Para Todes: ¿Sí O No? The Use Of Inclusive-Language Alternatives In The Spanish Language In Montevideo, Uruguay, Gabrielle Goulet

Honors Theses

This thesis investigates the attitudes towards the possible implementation of gender-neutral language, through the use of the -e, on official documents and schools in Montevideo, Uruguay, and how the attitudes of Spanish speakers in Uruguay align with the country’s history of inclusivity. In this context, Uruguay is considered an inclusive country because there is evidence of legal changes that promote gender equality, thus creating an gender-inclusive environment. This thesis utilizes a mixed-methods approach which includes both qualitative and quantitative research. The findings show that many people will use inclusive language when asked of them. They also believe that this usage …

Effects Of Group Ii Metal Binding On The Stability Of Dna I-Motif Structures, Charlotte Powers

Honors Theses

B-form DNA can adopt alternative structures while in superhelical duress. Alternative DNA structures are favored when there is an asymmetric distribution on complementary DNA strands. Cytosine rich strands may utilize cytosine-cytosine base pairing to form a four-stranded structure known as the i-motif (iM). The stability of iMs is affected by several factors such as DNA sequence, temperature, pH, ionic strength of the solution, and crowded conditions. While the effects of temperature, pH, and crowding conditions on iM stability have been well documented, the effects of ion presence in a solution has been less studied. Hence, those studies are the basis …

Anticoagulant And Anti-Sars-Cov-2 Effects Of Botryocladia Occidentalis Sulfated Glycans, Reena Thara

Honors Theses

Marine algal species are composed of various macromolecules endowed with potential biological actions, such as carbohydrates. Sugars are complex in nature with a multitude of monosaccharides constructed into polymers. We call complex carbohydrate polysaccharides those of great structural variation. The sulfation pattern adds to their complexity, creating scientific interest in the aquatic organisms from which these molecules can be extracted. Sulfated polysaccharides are now increasingly studied for their potential biological properties as anticoagulants and as antivirals. Heparin is a naturally occurring sugar in the human body that is necessary for proper anticoagulation. Many people today suffer from a dysfunctional coagulation …

Financial Accounting Case Studies, Winn Sams

Honors Theses

This thesis is an assembly of eleven accounting case studies completed during the 2021-2022 academic year, while enrolled in the ACCY 420 course instructed by Dr. Victoria Dickinson. The case studies included in this thesis cover a broad range of topics within the field of accounting. These topics include the impact of the September 11, 2001, terrorist attacks on businesses, the financial effects of COVID-19 on Pfizer Inc., examining cities of future residence for accounting careers, an interview with a business owner, and an Excel verification course. Cases 6 through 11 are dedicated to the analysis of ExxonMobil and its …

The Adventures Of A Right-Handed Debitor, James Aubrey Christian

Honors Theses

The Accounting Capstone is designed to force accounting students to think through problems in the accounting industry. This will be accomplished by working through a series of case studies dealing with several areas of financial reporting. After selecting the group’s focus area, my group and I presented a case study regarding tax recommendations for Goldman Sachs.

Human-Wildlife Conflict In Tanzania: A Mixed-Methods Exploration Of A Collaborative, Community-Engaged Approach To Conservation Challenges, Kylie Page

Honors Theses

This paper describes the development, implementation and outcomes of a conservation education program designed to empower youth and adults to address the problem of human-wildlife conflict in rural Tanzania. The participatory approach included a three day workshop at Mikumi National Park (MNP) and community-based fieldwork that employed techniques for active engagement, such as games, role plays, field trips, and the photovoice method, which combines photography and storytelling with solution finding. Focusing on the problem of human-lion conflict, adults and youth from two villages came together with lion experts, park wardens, and educators for training at Mikumi National Park in which …

The Relationship Between Coping Behaviors And Misophonia Symptom Severity And Impairment, Ruth Emmon Tyson

Honors Theses

Misophonia is a complex disorder that is characterized by an extreme disliking of sounds. Individuals with misophonia may engage in anxiety-driven coping behaviors that constitute avoidance and safety behaviors. Current literature shows that while coping behavior may offer temporary relief of anxiety and distress, they can lead to persisting anxiety and avoidance of experiences. Given preliminary evidence demonstrating a link between coping behaviors and maintained or worsening symptoms, additional research is warranted to further understand the role of coping behaviors in misophonia. However, few studies have investigated the relationship between coping behaviors and maintenance or worsening of misophonia symptom severity …

A Stability Indicating Lc-Ms/Ms Method For Quantification Of A Nox Inhibitor R14 In Its Bisulfite Adduct Form For Pharmacokinetic Studies, Yang Wang, Jing Ma, Shiaw-Yih Lin, Huan Xie, Dong Liang

Faculty, Staff and Student Publications

R14, also known as NOX Inhibitor VII, is a potent inhibitor of NADPH oxidases (NOX) which has recently been identified as a novel agent targeting to triple-negative breast cancer. It is also rapidly degraded in collected pharmacokinetic plasma and blood samples even stored under - 70 °C. The purpose of this study was to develop a stability indicating LC-MS/MS assay that would be suitable for quantification of R14 in plasma and blood. In the presence of sodium sulfite under acidic pH, R14, an aryl lactam compound which is not a typically reactive compound for bisulfite addition, readily and completely converted …

Integrated Agriculture-Aquaculture As An Alternative To Improving Small-Scale Fish Production In Zambia, Oliver J. Hasimuna, Sahya Maulu, Kundananji Nawanzi, Benjamin Lundu, Joseph Mphande, Chisomo J. Phiri, Edwin Kikamba, Enock Siankwilimba, Sillah Siavwapa, Moses Chibesa

School of Biological and Marine Sciences

Aquaculture is a significant industry in food production, and its contribution to food and nutrition security is well acknowledged. Zambia’s aquaculture production has continued to increase significantly, thus playing a key role in supplying animal protein sources for human consumption. However, recent estimates show that 75% of the national aquaculture production comes from large-scale commercial producers despite being by far the minority while the majority of small-scale producers contribute the remaining 25% of the total annual production. This low production by small-scale producers is attributed to insufficient financial resources, poor management and utilization of farm resources, lack of access to …

This Is A Present From A Small, Distant World, Samantha Slone

MFA in Visual Art

I make toxic pastoral paintings in the style of the Dutch and Old Masters, and media installations which depict natural landscapes as distanced, deconstructed forms. What I explore most in my practice is our damaged relationship with land and nature, and our capitalist and media ecologies as artificial landscapes which suspend us from the natural. In a dissection of the dualisms of man and nature, and progress and sustainability, I create microcosms of our detached condition.