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Toxicokinetics And Bioaccumulation Of Silver Sulfide Nanoparticles In Benthic Invertebrates In An Indoor Stream Mesocosm, Pv Silva, Arr Silva, Nathaniel J. Clark, Joanne Vassallo, Marta Baccaro, Neja Medvešček, Magdalena Grgić, Abel Ferreira, Martí Busquets-Fité, Kerstin Jurkschat, Anastasios G. Papadiamantis, Victor Puntes, Iseult Lynch, Claus Svendsen, Den Brink Nw Van, Richard D. Handy, Gestel Cam Van, Susana Loureiro May 2023

Toxicokinetics And Bioaccumulation Of Silver Sulfide Nanoparticles In Benthic Invertebrates In An Indoor Stream Mesocosm, Pv Silva, Arr Silva, Nathaniel J. Clark, Joanne Vassallo, Marta Baccaro, Neja Medvešček, Magdalena Grgić, Abel Ferreira, Martí Busquets-Fité, Kerstin Jurkschat, Anastasios G. Papadiamantis, Victor Puntes, Iseult Lynch, Claus Svendsen, Den Brink Nw Van, Richard D. Handy, Gestel Cam Van, Susana Loureiro

School of Health Professions

Mesocosms allow the simulation of environmentally relevant conditions and can be used to establish more realistic scenarios of organism exposure to nanoparticles. An indoor mesocosm experiment simulating an aquatic stream ecosystem was conducted to assess the toxicokinetics and bioaccumulation of silver sulfide nanoparticles (Ag2S NPs) and AgNO3 in the freshwater invertebrates Girardia tigrina, Physa acuta and Chironomus riparius, and determine if previous single-species tests can predict bioaccumulation in the mesocosm. Water was daily spiked at 10 μg Ag L−1. Ag concentrations in water and sediment reached values of 13.4 μg Ag L−1 and 0.30 μg Ag g−1 in the Ag2S …

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Prevalence, Sociocultural Risks And Protective Factors Of Suicidal Behaviors: A Cross Sectional Study Of Middle School Students In The Greater Accra Region Of Ghana, Enoch Kordjo Azasu May 2023

Prevalence, Sociocultural Risks And Protective Factors Of Suicidal Behaviors: A Cross Sectional Study Of Middle School Students In The Greater Accra Region Of Ghana, Enoch Kordjo Azasu

Brown School Graduate Student Theses and Dissertations

Suicide is a serious public health issue with more deaths worldwide than malaria, and HIV/AIDS in 2019, according to the World Health Organization. Almost nine out of 10 adolescents who died by suicide in 2019 were from low- and middle-income countries. In Ghana non-fatal suicide rates are higher among middle school and high school students yet the data we have is about a decade old. Using a sample of 800 middle school students in the Greater Accra Region and applying a theoretical-driven analytic approach, this dissertation seeks to understand the prevalence, sociocultural correlates, risk, and protective factors of adolescent suicidal …

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Global Disruption Of Coral Broadcast Spawning Associated With Artificial Light At Night, Thomas W. Davies, Svenja Tidau, Laura F.B. Marangoni, Joerg Wiedenmann, Oren Levy, Cecilia D'Angelo, Tim Smyth May 2023

Global Disruption Of Coral Broadcast Spawning Associated With Artificial Light At Night, Thomas W. Davies, Svenja Tidau, Laura F.B. Marangoni, Joerg Wiedenmann, Oren Levy, Cecilia D'Angelo, Tim Smyth

School of Biological and Marine Sciences

Coral broadcast spawning events - in which gametes are released on certain nights predictably in relation to lunar cycles - are critical to the maintenance and recovery of coral reefs following mass mortality. Artificial light at night (ALAN) from coastal and offshore developments threatens coral reef health by masking natural light:dark cycles that synchronize broadcast spawning. Using a recently published atlas of underwater light pollution, we analyze a global dataset of 2135 spawning observations from the 21st century. For the majority of genera, corals exposed to light pollution are spawning between one and three days closer to the full moon …

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Protocol For A Systematic Review Of Long-Term Physical Sequelae And Financial Burden Of Multidrug-Resistant And Extensively Drug-Resistant Tuberculosis, Ty Akalu, Aca Clements, Ag Baraki, Ka Alene May 2023

Protocol For A Systematic Review Of Long-Term Physical Sequelae And Financial Burden Of Multidrug-Resistant And Extensively Drug-Resistant Tuberculosis, Ty Akalu, Aca Clements, Ag Baraki, Ka Alene

Peninsula Medical School

Introduction Multidrug resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are major public health threats that are significant causes of physical sequelae and financial consequences for infected people. Treatment for MDR- and XDR-TB are more toxic and take longer duration than for drug-susceptible-TB. As a result, the long-term sequelae are thought to be more common among patients with MDR- and XDR-TB than drug-susceptible-TB, but this is yet to be quantified. Hence, the aim of this systematic review and meta-analysis is to quantify the global burden and types of long-term physical sequelae and financial burden associated with both MDR- and XDR-TB. …

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Mapping, Modifying, And Stimulating Skeletal Nerves To Explore Their Regulatory Role In Bone Metabolism, Alec Thomas Beeve May 2023

Mapping, Modifying, And Stimulating Skeletal Nerves To Explore Their Regulatory Role In Bone Metabolism, Alec Thomas Beeve

McKelvey School of Engineering Graduate Student Theses & Dissertations

The skeleton is innervated by sensory and sympathetic nerves, which are known facilitators of pain and vasoregulation. Recent studies suggest that nerves in bone play an additional direct role in regulating bone metabolism through local release of neuropeptides near bone cells; however, this remains controversial. The overall hypothesis of this thesis is that skeletal nerves are therapeutic targets for increasing bone mass and enhancing bone health. To address the feasibility of nerve-targeted skeletal therapeutics, the work in this thesis explores mapping, modification, and stimulation of nerves in bone and the subsequent effects on bone formation and metabolism.Bone is innervated by …

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An Investigation Of Peripheral Nerve Imaging Methods And Therapeutic Electrical Stimulation Parameters, Nathan Kennedy Birenbaum May 2023

An Investigation Of Peripheral Nerve Imaging Methods And Therapeutic Electrical Stimulation Parameters, Nathan Kennedy Birenbaum

McKelvey School of Engineering Graduate Student Theses & Dissertations

Treatment of peripheral nerve injuries depends on an accurate diagnosis of their severity to inform treatment options. Current clinical practice often necessitates delayed electrodiagnostics or surgical exploration of the injury site to determine whether surgical repair is necessary. This delays patient treatment, increases the time that muscle is denervated, and may impose an unnecessary surgery if surgical repair is not ultimately required. While imaging techniques such as diffusion tensor imaging enable visualization of healthy nerve tissue, the inflammation and axonal loss present in injured nerve obfuscates diffusion signals and confounds quantification of injury severity. Diffusion basis spectrum imaging uses multiple …

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The Role Of Trpv4 In The Intervertebral Disc Response To Mechanical Loading, Garrett Easson May 2023

The Role Of Trpv4 In The Intervertebral Disc Response To Mechanical Loading, Garrett Easson

McKelvey School of Engineering Graduate Student Theses & Dissertations

Low back pain (LBP) is one of the most common and debilitating musculoskeletal disorders in the world, with a lifetime prevalence above 80%. The cause of LBP is multifactorial, with intervertebral disc (IVD) degeneration being one of the most prominent contributors to its development. IVD degeneration occurs due to aging, aberrant mechanical loading, and injury. The IVD responds to these stimuli and experiences inflammation, catabolism, neovascularization, and innervation. While the degenerative cascade is well characterized, how the IVD transduces mechanical loading and injury stimuli into a degenerative response is still poorly understood. Mechanosensitive ion channels are one mechanism that musculoskeletal …

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Injective Mapping Under Constraints, Xingyi Du May 2023

Injective Mapping Under Constraints, Xingyi Du

McKelvey School of Engineering Graduate Student Theses & Dissertations

Injective mapping of meshes is a fundamental yet long-standing problem in computer graphics. The problem is particularly challenging in the presence of constraints, as an injective initial map is often not available. In this dissertation, we propose methods for computing injective maps that satisfy constraints without the need for an injective initial map. Our key contribution is a family of novel energies that are smoothly defined for arbitrary maps (injective or non-injective) and that promote injectivity when minimized. We first introduce the Total Lifted Content (TLC) energy for mapping 2D and 3D meshes into target domains with constrained boundaries. Next, …

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Chronic Prestress Regulation Of Cardiomyocyte Electrophysiology, Daniel Simmons May 2023

Chronic Prestress Regulation Of Cardiomyocyte Electrophysiology, Daniel Simmons

McKelvey School of Engineering Graduate Student Theses & Dissertations

Mechanical loading plays critical roles in regulating heart and cardiomyocyte physiology, with volume overload playing an important role in healthy cardiac development from the fetus to adulthood. Inhibition of mechanical loading during fetal development leads to weak and dysfunctional heart chambers, hypertension, organ failure, and even fetal death in severe cases. Increased loading on the heart has also been clinically shown to increase arrhythmia risk in athletes, including those with no genetic predisposition.Clinical observations studying the effects of cardiac genetic disorders may reveal the mechanisms in which mechanical loading influences cardiomyocyte development. Genetic mutations affecting plakophilin-2 (PKP2), a protein in …

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Nalcn-Encoded Sodium Leak Currents In The Regulation Of Daily Rhythms In The Excitability Of Neurons In The Suprachiasmatic Nucleus, Nien-Du Yang May 2023

Nalcn-Encoded Sodium Leak Currents In The Regulation Of Daily Rhythms In The Excitability Of Neurons In The Suprachiasmatic Nucleus, Nien-Du Yang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Circadian rhythms have evolved to enable organisms to adapt to daily (24 hour) changes in the environment. In mammals, including humans, the suprachiasmatic nucleus (SCN), located in the hypothalamus, is the master circadian pacemaker that governs daily rhythms in physiology and behavior. It is known that neurons in the SCN generate circadian changes in spontaneous repetitive firing rates (higher during the day than at night) that regulate and synchronize daily physiological and behavioral rhythms, although the critical ionic conductances driving these rhythms remain elusive. Considerable evidence suggests that the daily rhythms in the repetitive firing rates of SCN neurons are …

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Ultrasound Guided Diffuse Optical Tomography: Better Image Quality Enables Better Classification, Menghao Zhang May 2023

Ultrasound Guided Diffuse Optical Tomography: Better Image Quality Enables Better Classification, Menghao Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

According to the American Cancer Society, breast cancer incidence rates have risen in the past four decades, and breast cancer has become the second most diagnosed cancer in the US women. Ultrasound (US)-guided diffuse optical tomography (DOT), a promising non-invasive functional imaging technique for diagnosing breast cancer and monitoring breast cancer treatment response, has been applied in clinical studies over the past two decades. By utilizing multiple wavelengths in the near-infrared range (NIR), USDOT can provide quantitative estimations of functional information related to tumor angiogenesis, including oxygenated and deoxygenated hemoglobin, and total hemoglobin concentration. However, due to the extensive scattering …

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Development Of Intravital Microscopy For Brain Imaging With Improved Spatiotemporal Coverage And Contrast, Yifeng Zhou May 2023

Development Of Intravital Microscopy For Brain Imaging With Improved Spatiotemporal Coverage And Contrast, Yifeng Zhou

McKelvey School of Engineering Graduate Student Theses & Dissertations

Capitalizing on the Brownian motion of red blood cells, the distinct optical absorption spectra of oxy-hemoglobin and deoxy-hemoglobin, and the blood flow-induced signal decorrelation, multi-parametric photoacoustic microscopy (PAM) is capable of quantifying concentration of hemoglobin (CHb), blood oxygen saturation (sO2), and hemodynamics at the microscopic level via statistical, spectroscopic, and correlation analyses. Multi-parametric PAM has found broad biomedical applications. In fact, there are still much room to further improve the performance and imaging capability of multi-parametric PAM to meet the ever-increasing demanding requirements of biomedical research. To date, there are two main obstacles that prevent multi-parametric PAM from being more …

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Pet/Mr Imaging Biomarkers For Cerebral Small Vascular Diseases: Tissue Oxygenation Stress And Neuroinflammation, Chunwei Ying May 2023

Pet/Mr Imaging Biomarkers For Cerebral Small Vascular Diseases: Tissue Oxygenation Stress And Neuroinflammation, Chunwei Ying

McKelvey School of Engineering Graduate Student Theses & Dissertations

Fifty million people are affected by dementia worldwide. Cerebral small vessel disease (CSVD) often leads to vascular contributions to cognitive impairment and dementia (VCID), the second leading cause of dementia after Alzheimer’s disease (AD), accounting for up to 45% of dementia. White matter hyperintensities (WMH) on fluid-attenuated inversion recovery (FLAIR) imaging and disrupted white matter microstructure on diffusion tensor imaging (DTI) have been widely used as biomarkers to evaluate CSVD.The pathogenesis underlying CSVD is not well understood. It has been postulated that exposure to risk factors, including hypertension, diabetes, and smoking over years injures small arterioles, impairs autoregulation and leads …

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A High-Efficiency Gene Silencing In Plants Using Two-Hit Asymmetrical Artificial Micrornas, Sachin Teotia, Xiaoran Wang, Na Zhou, Mengmeng Wang, Haiping Liu, Jun Qin, Dianwei Han, Chingwen Li, Christine E. Li, Shangjin Pan, Haifeng Tang, Wenjun Kang, Zhanhui Zhang, Xiaoqing Tang, Ting Peng, Guiliang Tang May 2023

A High-Efficiency Gene Silencing In Plants Using Two-Hit Asymmetrical Artificial Micrornas, Sachin Teotia, Xiaoran Wang, Na Zhou, Mengmeng Wang, Haiping Liu, Jun Qin, Dianwei Han, Chingwen Li, Christine E. Li, Shangjin Pan, Haifeng Tang, Wenjun Kang, Zhanhui Zhang, Xiaoqing Tang, Ting Peng, Guiliang Tang

Michigan Tech Publications, Part 1

MicroRNAs (miRNAs) are small non-coding RNA molecules that play a crucial role in gene regulation. They are produced through an enzyme-guided process called dicing and have an asymmetrical structure with two nucleotide overhangs at the 3′ ends. Artificial microRNAs (amiRNAs or amiRs) are designed to mimic the structure of miRNAs and can be used to silence specific genes of interest. Traditionally, amiRNAs are designed based on an endogenous miRNA precursor with certain mismatches at specific positions to increase their efficiency. In this study, the authors modified the highly expressed miR168a in Arabidopsis thaliana by replacing the single miR168 stem-loop/duplex with …

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Biomechanical Models And Mechanisms Of Cellular Morphogenesis And Cerebral Cortical Expansion And Folding, David C Van Essen May 2023

Biomechanical Models And Mechanisms Of Cellular Morphogenesis And Cerebral Cortical Expansion And Folding, David C Van Essen

2020-Current year OA Pubs

Morphogenesis of the nervous system involves a highly complex spatio-temporal pattern of physical forces (mainly tension and pressure) acting on cells and tissues that are pliable but have an intricately organized cytoskeletal infrastructure. This review begins by covering basic principles of biomechanics and the core cytoskeletal toolkit used to regulate the shapes of cells and tissues during embryogenesis and neural development. It illustrates how the principle of 'tensegrity' provides a useful conceptual framework for understanding how cells dynamically respond to forces that are generated internally or applied externally. The latter part of the review builds on this foundation in considering …

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The Effect Of Demographic Imbalance On Crime, Maher Bhadri May 2023

The Effect Of Demographic Imbalance On Crime, Maher Bhadri

Theses

This study investigates demographic imbalance on crimes in the UAE by analyzing a record of crimes from 2020 to 2022 using descriptive and inferential statistics. The findings reveal gender, marital status, and age imbalance among crime offenders in the UAE. Males, married individuals, and individuals in their 30s are more prevalent in committing crimes. Certain countries, accused individuals, and certain types of crimes are also more frequent in the UAE. Policymakers and law enforcement agencies can use these insights to develop targeted interventions to reduce crime rates in the country. Future studies should investigate the underlying causes of these imbalances …

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Single-Nucleus Multi-Omics Of Human Stem Cell-Derived Islets Identifies Deficiencies In Lineage Specification, Punn Augsornworawat, Nathaniel J Hogrebe, Matthew Ishahak, Mason D Schmidt, Erica Marquez, Marlie M Maestas, Daniel A Veronese-Paniagua, Sarah E Gale, Julia R Miller, Leonardo Velazco-Cruz, Jeffrey R Millman May 2023

Single-Nucleus Multi-Omics Of Human Stem Cell-Derived Islets Identifies Deficiencies In Lineage Specification, Punn Augsornworawat, Nathaniel J Hogrebe, Matthew Ishahak, Mason D Schmidt, Erica Marquez, Marlie M Maestas, Daniel A Veronese-Paniagua, Sarah E Gale, Julia R Miller, Leonardo Velazco-Cruz, Jeffrey R Millman

2020-Current year OA Pubs

Insulin-producing β cells created from human pluripotent stem cells have potential as a therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC-islets) still differ from their in vivo counterparts. To better understand the state of cell types within SC-islets and identify lineage specification deficiencies, we used single-nucleus multi-omic sequencing to analyse chromatin accessibility and transcriptional profiles of SC-islets and primary human islets. Here we provide an analysis that enabled the derivation of gene lists and activity for identifying each SC-islet cell type compared with primary islets. Within SC-islets, we found that the difference between β cells and awry …

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Glutamatergic Cerebellar Neurons Differentially Contribute To The Acquisition Of Motor And Social Behaviors, Meike E Van Der Heijden, Alejandro G Rey Hipolito, Linda H Kim, Dominic J Kizek, Ross M Perez, Tao Lin, Roy V Sillitoe May 2023

Glutamatergic Cerebellar Neurons Differentially Contribute To The Acquisition Of Motor And Social Behaviors, Meike E Van Der Heijden, Alejandro G Rey Hipolito, Linda H Kim, Dominic J Kizek, Ross M Perez, Tao Lin, Roy V Sillitoe

Duncan NRI Faculty and Staff Publications

Insults to the developing cerebellum can cause motor, language, and social deficits. Here, we investigate whether developmental insults to different cerebellar neurons constrain the ability to acquire cerebellar-dependent behaviors. We perturb cerebellar cortical or nuclei neuron function by eliminating glutamatergic neurotransmission during development, and then we measure motor and social behaviors in early postnatal and adult mice. Altering cortical and nuclei neurons impacts postnatal motor control and social vocalizations. Normalizing neurotransmission in cortical neurons but not nuclei neurons restores social behaviors while the motor deficits remain impaired in adults. In contrast, manipulating only a subset of nuclei neurons leaves social …

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Cardiac Pericytes Mediate The Remodeling Response To Myocardial Infarction, Pearl Quijada, Shuin Park, Peng Zhao, Kamal Ss Kolluri, David Wong, Kevin D Shih, Kai Fang, Arash Pezhouman, Lingjun Wang, Ali Daraei, Matthew D Tran, Elle M Rathbun, Kimberly N Burgos Villar, Maria L Garcia-Hernandez, Thanh Td Pham, Charles J Lowenstein, M Luisa Iruela-Arispe, S Thomas Carmichael, Eric M Small, Reza Ardehali May 2023

Cardiac Pericytes Mediate The Remodeling Response To Myocardial Infarction, Pearl Quijada, Shuin Park, Peng Zhao, Kamal Ss Kolluri, David Wong, Kevin D Shih, Kai Fang, Arash Pezhouman, Lingjun Wang, Ali Daraei, Matthew D Tran, Elle M Rathbun, Kimberly N Burgos Villar, Maria L Garcia-Hernandez, Thanh Td Pham, Charles J Lowenstein, M Luisa Iruela-Arispe, S Thomas Carmichael, Eric M Small, Reza Ardehali

Faculty, Staff and Students Publications

Despite the prevalence of pericytes in the microvasculature of the heart, their role during ischemia-induced remodeling remains unclear. We used multiple lineage-tracing mouse models and found that pericytes migrated to the injury site and expressed profibrotic genes, coinciding with increased vessel leakage after myocardial infarction (MI). Single-cell RNA-Seq of cardiac pericytes at various time points after MI revealed the temporally regulated induction of genes related to vascular permeability, extracellular matrix production, basement membrane degradation, and TGF-β signaling. Deleting TGF-β receptor 1 in chondroitin sulfate proteoglycan 4-expressing (Cspg4-expressing) cells reduced fibrosis following MI, leading to a transient improvement in the cardiac …

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The Impact Of Chronic Morphine Exposure On The Intrinsic Electrical Properties Of Orexin Neurons, Elizabeth Berry May 2023

The Impact Of Chronic Morphine Exposure On The Intrinsic Electrical Properties Of Orexin Neurons, Elizabeth Berry

NYMC Student Theses and Dissertations

Addiction to drugs of abuse is a growing problem in today’s society and current treatments often fail to adequately manage the negative withdrawal symptoms that drive relapse. Therefore, development of more effective therapies is a high priority. The orexin neuropeptide system is a key regulator of reward processes and is therefore an attractive therapeutic target. However, the precise impact of chronic drug exposure on orexin neuron function remains largely unknown. Data from a recent publication found that human post-mortem brains from opiate users have smaller but more numerous orexin immunoreactive neurons. Since decreased neuronal soma area suggests increased excitability, we …

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Modulating Fast Skeletal Muscle Contraction Protects Skeletal Muscle In Animal Models Of Duchenne Muscular Dystrophy, Alan J. Russell, Twlya I. Juehne, Jinsheng Yu, Et Al. May 2023

Modulating Fast Skeletal Muscle Contraction Protects Skeletal Muscle In Animal Models Of Duchenne Muscular Dystrophy, Alan J. Russell, Twlya I. Juehne, Jinsheng Yu, Et Al.

2020-Current year OA Pubs

Duchenne muscular dystrophy (DMD) is a lethal muscle disease caused by absence of the protein dystrophin, which acts as a structural link between the basal lamina and contractile machinery to stabilize muscle membranes in response to mechanical stress. In DMD, mechanical stress leads to exaggerated membrane injury and fiber breakdown, with fast fibers being the most susceptible to damage. A major contributor to this injury is muscle contraction, controlled by the motor protein myosin. However, how muscle contraction and fast muscle fiber damage contribute to the pathophysiology of DMD has not been well characterized. We explored the role of fast …

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Characterization Of Lps As A Virulence Factor In Burkholderia Cepacia During Plant And Human Infection, Jack Klahr, Elizabeth Danka May 2023

Characterization Of Lps As A Virulence Factor In Burkholderia Cepacia During Plant And Human Infection, Jack Klahr, Elizabeth Danka

Biology Senior Theses

Burkholderia cepacia is a gram-negative bacterium first characterized as the causative agent of sour skin in onion crops. More recently, B. cepacia has become a clinical concern as an opportunistic pathogen that can colonize the upper respiratory tract of cystic fibrosis patients and increase mortality in these patients. Infection is exacerbated by the intrinsic resistance to antibiotics found in this genus of organisms. Additional virulence factors help the bacteria persist in the host during infection. However, few of these factors have been described. In this work, we characterized a putative virulence factor that was first identified through an onion infection …

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#Notyourmammy: Explicating The Experiences Of Black Women Graduate Students As Learners And Laborers In American Academia, Kristian Ashley Contreras May 2023

#Notyourmammy: Explicating The Experiences Of Black Women Graduate Students As Learners And Laborers In American Academia, Kristian Ashley Contreras

Dissertations - ALL

The #NotYourMammyStudy explored the ways Black women are expected to engage in affective work – the production of feelings or affects that prioritize the needs/expectations of others – while learning in and laboring for White Serving Institutions in American higher education. This interdisciplinary qualitative study utilized a Transnational Black Feminist Framework to draw on the experiences of 28 Black women pursuing terminal graduate degrees at White Serving Institutions (WSIs) with a consideration of how the university exploits Black women through the colonial trope of the Mammy figure. The #NotYourMammyStudy offers an incisive critique of the structures of exploitation within American …

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This Memory Is Redacted But Not Gone, Wanda-Marie Rana May 2023

This Memory Is Redacted But Not Gone, Wanda-Marie Rana

Theses - ALL

In this paper, This memory is redacted but not gone, I discuss how my artistic practice, my time in graduate school, and my own life experiences have led me to create my thesis project. The paper is split up into chapters describing the work I made while in graduate school along with my themes; memory, family, home, and identity, and methods; archive, collage, and investigation, of working. I then dedicate a chapter specifically to my thesis work before concluding the paper with my plans to continue my practice after graduate school.

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The Body Knows: Embodiment And Whiteness A Rhetorical Analysis Of White Bodies Engaged In Antiracism Work, Otsego County, New York, Kerry Lynn Mess May 2023

The Body Knows: Embodiment And Whiteness A Rhetorical Analysis Of White Bodies Engaged In Antiracism Work, Otsego County, New York, Kerry Lynn Mess

Theses - ALL

Multiculturalism, diversity, inclusion, equity, antiracism, belonging… The humanities, social sciences, and rhetorical scholarship have all slowly given attention to questions of race and racism. Situated at the intersection of somatic psychology and rhetorical studies, this thesis uses a somatic theory lens to explore how symbolic systems, specifically language and bodies, are intertwined to understand the embodied or material effects of racism we have not yet accounted for. I borrow Karma Chávez’s language of “abstract” and “actual” (2018) to observe the rhetorical dynamics, patterns and strategies, of white bodies accounting for themselves and apply Resmaa Menakem and Douglas Robinson’s somatic theories …

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Hematopoietic Growth Factors Promote The Proliferation And Differentiation Of Oligodendrocyte Progenitor Cells, Songruo Li May 2023

Hematopoietic Growth Factors Promote The Proliferation And Differentiation Of Oligodendrocyte Progenitor Cells, Songruo Li

Theses - ALL

Severe traumatic brain injury (TBI) causes severe damage in the white matter, leading to long-term disability and increased mortality. Demyelination, characterized by the damage of myelin sheaths and oligodendrocyte cell death, is a major pathological change in white matter injury after TBI, resulting in persistent neurological deficits. Previous studies have demonstrated that co-treatments with stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) (SCF+G-CSF) in the chronic phase of severe TBI improve neurological function recovery and enhance remyelination in the white matter. The SCF+G-CSF-enhanced remyelination is positively correlated with the proliferation of oligodendrocyte progenitor cells (OPCs) in the subventricular zone. …

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Legacies Of Empire: Museums, Neocolonialism, And Repatriation, Kailey Smith May 2023

Legacies Of Empire: Museums, Neocolonialism, And Repatriation, Kailey Smith

Theses - ALL

“Legacies of Empire: Museums, Neocolonialism, and Repatriation” examines four European museums and their presentation of African cultural heritage. Analysis of the British Museum, Louvre, Musée du Quai Branly, and the AfricaMuseum uses qualitative methods and is grounded in both critical museology and decolonial theory. In conducting this analysis, I argue that these museums are engaged in various forms of memory manipulation regarding their colonial empires and that the consequent refusal of these spaces to return African cultural heritage taken during the colonial empire perpetuates the supremacy and violence of their taking. Through analysis of the museums themselves, this thesis considers …

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The Passing Intensities Of A Neighborhood. Sensing Atmospheres In La Boca, Gabriel Tomas O'Rourke May 2023

The Passing Intensities Of A Neighborhood. Sensing Atmospheres In La Boca, Gabriel Tomas O'Rourke

Theses - ALL

The neighborhood of La Boca, located in the city of Buenos Aires, is an urban space burdened with a story and a unique aesthetic that differentiates it from other barrios in the city. In 2022, I visited this area to walk its streets, with the goal of understanding what elements marked this urban area as a distinctive place in the city. Situated within the rhetoric of space and place, this study relies on the concept of atmospheres developed by Gernot Böhme to account for the way the experience of place is constituted by an interplay between bodies, materiality and spaces. …

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Role Of Fish Oil In Paternal Obesity And In Offspring Skeletal Muscle Health, Ligeng Xiong May 2023

Role Of Fish Oil In Paternal Obesity And In Offspring Skeletal Muscle Health, Ligeng Xiong

Theses - ALL

This study investigates the effects of fish oil in father male mice and how it could potentially affect skeletal muscle health of the next generation. Thirty male mice were fed either a low fat diet (LF), High-Fat Diet (HF), and a High-Fat diet supplemented with fish oil (FO) for 10 weeks to mimic paternal obesity. They were then mated with female mice on chow diet and all mice consumed chow diet during gestation and lactation. Offspring mice were supplemented with chow diet for 16 weeks and half of the mice were sacrificed at 8-weeks and rest at 16-weeks to study …

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With-In-Through, Rumpelstiltskin Anne Morgan May 2023

With-In-Through, Rumpelstiltskin Anne Morgan

Theses - ALL

I invite you to join me on a wandering into/besides/returning with ecological-attunement through gatherings, exercises, reflections, and poetry; conversing with the prior as they are as present as the current. Everything has a way of oozing together, losing perceived independence and joining in inter-dependent choreographies.

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