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Surfactant Protein A Attenuates Generalized And Localized Neuroinflammation In Neonatal Mice, Caroline E Crocker, Romana Sharmeen, Thu T Tran, Amir M Khan, Wen Li, Joseph L Alcorn May 2023

Surfactant Protein A Attenuates Generalized And Localized Neuroinflammation In Neonatal Mice, Caroline E Crocker, Romana Sharmeen, Thu T Tran, Amir M Khan, Wen Li, Joseph L Alcorn

Faculty, Staff and Student Publications

Surfactant protein A (SP-A) has important roles in innate immunity and modulation of pulmonary and extrapulmonary inflammation. Given SP-A has been detected in rat and human brain, we sought to determine if SP-A has a role in modulating inflammation in the neonatal mouse brain. Neonatal wildtype (WT) and SP-A-deficient (SP-A−/−) mice were subjected to three models of brain inflammation: systemic sepsis, intraventricular hemorrhage (IVH) and hypoxic-ischemic encephalopathy (HIE). Following treatment, RNA was isolated from brain tissue and expression of cytokine and SP-A mRNA was determined by real-time quantitative RT-PCR analysis. In the sepsis model, expression of most cytokine mRNAs was …

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Correction Of T-Cell Repertoire And Autoimmune Diabetes In Nod Mice By Non-Myeloablative T-Cell Depleted Allogeneic Hsct, Rakefet Sidlik Muskatel, Bar Nathansohn-Levi, Shlomit Reich-Zeliger, Michal Mark, Liat Stoler-Barak, Chava Rosen, Irit Milman-Krentsis, Esther Bachar Lustig, Robert Pete Gale, Nir Friedman, Yair Reisner May 2023

Correction Of T-Cell Repertoire And Autoimmune Diabetes In Nod Mice By Non-Myeloablative T-Cell Depleted Allogeneic Hsct, Rakefet Sidlik Muskatel, Bar Nathansohn-Levi, Shlomit Reich-Zeliger, Michal Mark, Liat Stoler-Barak, Chava Rosen, Irit Milman-Krentsis, Esther Bachar Lustig, Robert Pete Gale, Nir Friedman, Yair Reisner

Faculty, Staff and Student Publications

The induction of partial tolerance toward pancreatic autoantigens in the treatment of type 1 diabetes mellitus (T1DM) can be attained by autologous hematopoietic stem cell transplantation (HSCT). However, most patients treated by autologous HSCT eventually relapse. Furthermore, allogeneic HSCT which could potentially provide a durable non-autoimmune T-cell receptor (TCR) repertoire is associated with a substantial risk for transplant-related mortality. We have previously demonstrated an effective approach for attaining engraftment without graft versus host disease (GVHD) of allogeneic T-cell depleted HSCT, following non-myeloablative conditioning, using donor-derived anti-3rd party central memory CD8 veto T cells (Tcm). In the present study, we investigated …

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The Efficacy Of Conservation Practices In Reducing Floods And Improving Water Quality, Shivendra Srivastava, Andrea D. Basche, Elbert Traylor, Tirthankar Roy May 2023

The Efficacy Of Conservation Practices In Reducing Floods And Improving Water Quality, Shivendra Srivastava, Andrea D. Basche, Elbert Traylor, Tirthankar Roy

Department of Civil and Environmental Engineering: Faculty Publications

Conservation practices such as crop rotation, filter strips, and constructed wetlands are nature-based approaches intended to safeguard natural resources in agricultural landscapes. In this study, we reviewed the literature on how conservation practices, both at watershed and field scales, have been proven to subdue flood peaks, surface runoff, soil erosion, sediment transport, and nutrient loss. We classified different conservation practices based on the mode of their application (i.e., in-field, edge-of-field, and structural practices) and described what prior research efforts have concluded about the efficacy of different practices. At the field scale, practices such as reduced or no-till farming, grassed waterways, …

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Secondary Immunohistochemical Analysis Of Viable Cells As Determined By Hematoxylin And Eosin Staining, Bonnie Carney, Cameron D'Orio, Jeffrey Shupp, Jeffrey Carter, William Hickerson, James Holmes, Herbert Phelan May 2023

Secondary Immunohistochemical Analysis Of Viable Cells As Determined By Hematoxylin And Eosin Staining, Bonnie Carney, Cameron D'Orio, Jeffrey Shupp, Jeffrey Carter, William Hickerson, James Holmes, Herbert Phelan

School of Medicine Faculty Publications

55th Annual Meeting of the American Burn Association, ABA 2023, May 16 - 19, 2023, Dallas, TX

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The Criminalization Of Female Genital Mutilation In Ohio: A Social And Political Analysis, Madsyn Selph May 2023

The Criminalization Of Female Genital Mutilation In Ohio: A Social And Political Analysis, Madsyn Selph

Undergraduate Honors Theses

This research examines the public attitudes towards the criminalization of female genital mutilation (“FGM”) in Ohio in 2018 with the passage of S.B. 214. Content from The Columbus Dispatch, testimony in favor of the bill, and an oral history with a current Ohio Senator who was a House Representative in 2018 were used as data in this research. Data are examined using group threat theory to better understand the attitudes of the Columbus public towards trends in immigration and FGM. Results find that anti-Islam and anti-African sentiments (and specifically anti-Somali sentiments) were widely found in these data, as well as …

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Adipose Derived Stem Cell Paracrine Factor Release In Smokers Vs Non Smokers With Burn Injuries, Paige Deville, Alison Smith, Herbert Phelan, Jeffrey Carter, Olivia Warren, Cameron Fontenot May 2023

Adipose Derived Stem Cell Paracrine Factor Release In Smokers Vs Non Smokers With Burn Injuries, Paige Deville, Alison Smith, Herbert Phelan, Jeffrey Carter, Olivia Warren, Cameron Fontenot

School of Medicine Faculty Publications

55th Annual Meeting of the American Burn Association, ABA 2023, May 16 - 19, 2023, Dallas, TX

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The Effects Of Aluminum Ion Exposure On Planarian Photophobic Response To Different Wavelengths Of Light, Anden J. Velez May 2023

The Effects Of Aluminum Ion Exposure On Planarian Photophobic Response To Different Wavelengths Of Light, Anden J. Velez

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Aluminum exposure has been linked to the development of neurological diseases (Kim et al., 2021). It has increased in quantity in the environment due to industrial activity in producing personal care products and fast food (Tietz et al., 2019). The freshwater invertebrate planarian flatworm Giardia dorotocephala (G. dorotocephala) serves as a model organism. Humans and planarians both express the ion channel transient receptor potential ankyrin 1 (TRPA1), which is responsible for thermotaxis, locomotive response to heat, and pain reception (Arenas et al., 2017). Aluminum exposure can exert ion channel-related toxicity via the TRPA1 protein. It has been found …

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Expressive Marks: Art In The Age Of Augmented Reality, Carson G. Levine May 2023

Expressive Marks: Art In The Age Of Augmented Reality, Carson G. Levine

Dartmouth College Master’s Theses

Augmented reality (AR) and non-fungible tokens (NFTs) introduce new considerations for the long-standing debate of what it means for digital art to be “real.” However, the ability to create AR experiences is limited to those who are technically skilled or who can afford to consult someone else. This paper addresses the need for an accessible tool that enables artists of all technical backgrounds to expressively create marks in AR. The solution includes a mobile application called CrayonAR. The system was designed to be modular, minimal, and physically engaging, and was developed in Unity using ARFoundation and Firebase Storage and Realtime …

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Re-Membering The Living Earth: A Year In Rural Sri Lanka, Samuel C. King May 2023

Re-Membering The Living Earth: A Year In Rural Sri Lanka, Samuel C. King

Dartmouth College Master’s Theses

The following thesis tells the story of my year in rural Sri Lanka. After college, I traveled from suburban New York to the highlands of the island country with the hopes of writing an ethnography on agrarian Buddhism. I soon realized, however, that I was not just embarking on an academic project, but an inner journey to explore ways of being that had been lost in the modern culture I had known. My narrative recounts how immersion in a rice cultivating village deepened my sense for what it means to live in reciprocity with the more-than-human world—a world of plants, …

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Evaluating The Impact Of Temperature And Artificial Light At Night On The Growth, Swimming Performance, And Corticosterone Levels Of Southern Leopard Frog (Lithobates Sphenocephalus) Tadpoles, Skylar Alexander May 2023

Evaluating The Impact Of Temperature And Artificial Light At Night On The Growth, Swimming Performance, And Corticosterone Levels Of Southern Leopard Frog (Lithobates Sphenocephalus) Tadpoles, Skylar Alexander

Honors Theses

Anthropogenic activities caused by urbanization have considerably altered our world’s ecosystems which has led to a global amphibian population decline. Encroaching and unyielding urbanization by humans has contributed to a rise in artificial light at night due to light pollution as well as increased temperature due to climate change. Both rising temperatures and artificial light at night (ALAN) have been shown to individually have negative effects on amphibian physiology such as increased stress and decreased behavior. However, due to the drastic nature of human imposition, amphibians typically encounter these anthropogenic stressors in combination. Therefore, it is important to understand how …

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Effects Of Prenatal Pesticide Exposure On The Fetal Brain And Placenta Transcriptomes In A Rodent Model, Corina Lesseur, Kirtan Kaur, Sean D Kelly, Karen Hermetz, Randy Williams, Ke Hao, Carmen J Marsit, W Michael Caudle, Jia Chen May 2023

Effects Of Prenatal Pesticide Exposure On The Fetal Brain And Placenta Transcriptomes In A Rodent Model, Corina Lesseur, Kirtan Kaur, Sean D Kelly, Karen Hermetz, Randy Williams, Ke Hao, Carmen J Marsit, W Michael Caudle, Jia Chen

Faculty, Staff and Student Publications

Organophosphate and pyrethroid pesticides are among the most extensively used insecticides worldwide. Prenatal exposures to both classes of pesticides have been linked to a wide range of neurobehavioral deficits in the offspring. The placenta is a neuroendocrine organ and the crucial regulator of the intrauterine environment; early-life toxicant exposures could impact neurobehavior by disrupting placental processes. Female C57BL/6 J mice were exposed via oral gavage to an organophosphate, chlorpyrifos (CPF) at 5 mg/kg, a pyrethroid, deltamethrin (DM), at 3 mg/kg, or vehicle only control (CTL). Exposure began two weeks before breeding and continued every three days until euthanasia at gestational …

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Surgeons’ Knowledge Regarding Perioperative Pain Management In Patients With Opioid Use Disorder: A Survey Among 260 Members Of The American College Of Surgeons, Caroline E Crocker, Romana Sharmeen, Thu T Tran, Amir M Khan, Wen Li, Joseph L Alcorn May 2023

Surgeons’ Knowledge Regarding Perioperative Pain Management In Patients With Opioid Use Disorder: A Survey Among 260 Members Of The American College Of Surgeons, Caroline E Crocker, Romana Sharmeen, Thu T Tran, Amir M Khan, Wen Li, Joseph L Alcorn

Faculty, Staff and Student Publications

Surfactant protein A (SP-A) has important roles in innate immunity and modulation of pulmonary and extrapulmonary inflammation. Given SP-A has been detected in rat and human brain, we sought to determine if SP-A has a role in modulating inflammation in the neonatal mouse brain. Neonatal wildtype (WT) and SP-A-deficient (SP-A

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“Speechless, Placeless Power”: Affect And Trauma In Moby-Dick And “Bartleby, The Scrivener”, Lauren Colandro May 2023

“Speechless, Placeless Power”: Affect And Trauma In Moby-Dick And “Bartleby, The Scrivener”, Lauren Colandro

Seton Hall University Dissertations and Theses (ETDs)

Herman Melville’s Moby-Dick and “Bartleby, the Scrivener” contain affectively unsound figures such as Captain Ahab and Bartleby that seem to disrupt larger narrative functions, both developing these characteristics in response to prior trauma. However, narrators are not privy to the extent of their feelings because of their idealistic attachments to the disruptive figures. This thesis examines the commonalities of Melville’s disruptive characters in both stories using affect theory, as well as how their disruptions illuminate the effects of repressed trauma in an increasingly capital-driven society.

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Multi-Scalar Contributions To Sex Differences In Brain Tumor Incidence And Outcome, Lauren Broestl May 2023

Multi-Scalar Contributions To Sex Differences In Brain Tumor Incidence And Outcome, Lauren Broestl

Arts & Sciences Graduate Student Theses and Dissertations

Nearly all complex human diseases exhibit some degree of sex difference in incidence, age of onset, disease severity, and/or response to treatment. Sex differences are observed in a wide range of nervous system disorders, including neurodevelopmental disorders, psychiatric diseases, neuroimmunological disorders, neurodegenerative diseases, and central nervous system (CNS) tumors. Males have increased incidence rates for most CNS tumor types. Sex differences in brain tumor incidence rates are observed in studies from around the world, across a wide range of cultures, in both pediatric and adult populations, and even extend to other species. Males also have decreased survival from brain tumors, …

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Assessment Of Cross-Protective Responses To Emerging Variant Viruses, Rita Elaine Chen May 2023

Assessment Of Cross-Protective Responses To Emerging Variant Viruses, Rita Elaine Chen

Arts & Sciences Graduate Student Theses and Dissertations

Viruses pose a great threat to human health. Outbreaks and pandemics due to different viruses occur in all areas of the world. Two viruses, which emerged globally in the 1980s and in 2020, that are still causing ongoing pandemics in 2021 are dengue virus (DENV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), respectively. These viruses circulate widely and currently infect hundreds of millions of people. Immunity from a previous infection may confer protection against subsequent infection of a related virus. Thus, understanding the degree of cross-protection can help define correlates of protection that are necessary to determine which people …

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Leveraging Protein Dynamics To Drug Filovirus Protein-Nucleic Acid Interactions Using Simulations And Experiments, Matthew Alberto Cruz May 2023

Leveraging Protein Dynamics To Drug Filovirus Protein-Nucleic Acid Interactions Using Simulations And Experiments, Matthew Alberto Cruz

Arts & Sciences Graduate Student Theses and Dissertations

Drug discovery targeting protein nucleic acid (PNI) and protein-protein interactions (PPI) remains a difficult task. How to identify druggable conformations and discover compounds binding to these conformations is an unsolved problem. Here, I describe how we apply computational and experimental approaches to probe the conformational landscape of a key immune antagonist protein from the Zaire ebolavirus. Viral Protein 35 (VP35) binds to the viral pathogen associated molecular pattern, double stranded RNA (dsRNA), and blocks activation of the interferon (IFN) response. Long time scale molecular dynamics simulations reveal that VP35 adopts an alternative conformation which opens a pocket absent in experimental …

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Socrates The Expert, Jeremy Samuel Henry May 2023

Socrates The Expert, Jeremy Samuel Henry

Arts & Sciences Graduate Student Theses and Dissertations

I argue that an account of recognizing experts can be drawn from the dialogues of Plato in which Socrates is engaged in the activities he describes in the Apology, that he is an expert in recognizing experts, and that this supports his argument that no one can be an expert in ethics. I also show that his account contains a decision procedure for recognizing experts and a view about the nature of expertise (from which that procedure is derived) that is very plausible for his purpose.

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New Methods Of Selectivity Using Electrochemistry, Qiwei Jing May 2023

New Methods Of Selectivity Using Electrochemistry, Qiwei Jing

Arts & Sciences Graduate Student Theses and Dissertations

This project has been working on introducing new type of method to induce chemoselectivity into electrochemical reactions by modifying the surface of an electrode and then confining chemical reactions to the region of the reaction close to that surface. The goal is to translate the extremely high levels of site-selectivity seen in chemical reactions on a microelectrode array into a tool for preparative synthetic reactions.As a proof-of-principle experiment, Pt-anode was coated with a diblock copolymer that is known to have an affinity for pyrene groups. The electrode is then used in the oxidation of two alcohol substrates: one having the …

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Evolutionary History Of Populations Of Pleistocene Homo With A Focus On East Asia, Catherine Mclean May 2023

Evolutionary History Of Populations Of Pleistocene Homo With A Focus On East Asia, Catherine Mclean

Arts & Sciences Graduate Student Theses and Dissertations

Understanding the evolutionary history of our species is a key objective of paleoanthropology, yet the pattern of hominin evolution in East Asia remains uncertain. This research aimed to evaluate the relationships and evolutionary history of East Asian hominin paleodemes through the Pleistocene. Recent descriptions of Pleistocene East Asian hominins reveal a high degree of morphological variability, mosaics of primitive and derived traits, regionally predominant characteristics, and late surviving archaic morphologies. This study tests two hypotheses explaining the complexity of the East Asian hominin record: 1) Continuity with Hybridization, and 2) the existence of Multiple Hominin Lineages. These models were tested …

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Dual Color Optogenetic Control For Analyzing Cardiac Function In Drosophila, Jiantao Zhu May 2023

Dual Color Optogenetic Control For Analyzing Cardiac Function In Drosophila, Jiantao Zhu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Prolonged consumption of carbohydrate-rich diets and immobile lifestyles frequently cause metabolic disorders and obesity and, as a result, may lead to progressive heart dysfunction among broad social groups of the population. Drosophila melanogaster serves as an essential model organism in cardiovascular disease research due to conserved physiological and genomic traits shared with humans, its genetic and molecular toolbox versatility, and cost-effective maintenance. Here, we combine optogenetics and optical coherence tomography to study cardiovascular function in D. melanogaster. A new optogenetic pacing system has been developed, employing a transgenic line carrying two opsins: ChR2 and NpHR2.0. A custom-built hardware setup …

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3-Dimensional Visualization Of Cardiac Plaque Mapping Data, Phan Ly Vy Nguyen May 2023

3-Dimensional Visualization Of Cardiac Plaque Mapping Data, Phan Ly Vy Nguyen

McKelvey School of Engineering Graduate Student Theses & Dissertations

Atrial Fibrillation (AF) of one of the most prevalent cardiac arrythmia in humans, and also the most studied arrythmias due to its high association with cardiovascular morbidity and mortality. Diagnosis of AF, which is highly dependent on the observation of the irregular signal in the atria, is often challenging since AF is often asymptomatic at the onset. There has been a lot of effort in exploring different cardiac mapping techniques to understand the dynamics of AF for better intervention. This study aims at developing a MATLAB interface that assists the development of a cardiac plaque mapping data acquisition system in …

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Preparing Non-Human Primates To Study Hand-Eye Coordination In Frontal Eye Fields (Fef) During Delayed Movement Task, Juliusz Cydzik May 2023

Preparing Non-Human Primates To Study Hand-Eye Coordination In Frontal Eye Fields (Fef) During Delayed Movement Task, Juliusz Cydzik

McKelvey School of Engineering Graduate Student Theses & Dissertations

ABSTRACT OF THE THESIS Preparing Non-Human Primates to Study Hand-Eye Coordination in Frontal Eye Fields (FEF) During Delayed Movement Task by Juliusz Cydzik Master of Science in Biomedical Engineering Washington University in St. Louis, 2023 Professor Lawrence Snyder, Chair Hand-eye coordination enables humans and non-human primates to use their hands and eyes to perform various tasks. We are interested in coordination at the systems level, where saccades and reaches are encoded. The parietal reach region (PRR), situated at the posterior end of the intraparietal sulcus (IPS) and overlapping portions of the medial intraparietal area (MIP) and V6a, is commonly attributed …

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Restoring The Mechanoresponsiveness Of Aged Bone To Mechanical Loading, Christopher John Chermside-Scabbo May 2023

Restoring The Mechanoresponsiveness Of Aged Bone To Mechanical Loading, Christopher John Chermside-Scabbo

Arts & Sciences Graduate Student Theses and Dissertations

Osteoporosis—a disease of low bone mass and a predisposition to fracture—remains a pressing public health burden. Osteoporotic fractures occur in 1 in 3 women and 1 in 5 men over the age of 50, at a cost of more than $22 billion annually in the US. To prevent osteoporotic fractures, we need additional strategies to increase bone formation and reverse the disease. A potent strategy to increase bone formation is mechanical loading. However, with aging, bone becomes less responsive to the same stimulus. Because we do not fully understand the age-related decrease in bone mechanoresponsiveness, we have been unable to …

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Putting Attentional Control On The Map: An Investigation Of Meaningful Boundaries And Context-Specific Control, Jackson Stuart Colvett May 2023

Putting Attentional Control On The Map: An Investigation Of Meaningful Boundaries And Context-Specific Control, Jackson Stuart Colvett

Arts & Sciences Graduate Student Theses and Dissertations

People can learn and adopt relaxed or focused control settings based on the likelihood of conflict at specific inducer locations, then flexibly retrieve those control settings at nearby unbiased diagnostic locations. Importantly, people can learn that multiple distinct contexts predict conflict, such as specific locations or regions of space (e.g., all locations in the upper left). In realistic visual scenes, meaningful boundaries that demarcate objects or areas of space serve as an important signal that the area inside the boundary is distinct from the area outside the boundary. Recent research (Colvett & Bugg, 2022) indicated a role for meaningful boundaries …

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Immunity To Emerging Rna Viruses, Emma Winkler May 2023

Immunity To Emerging Rna Viruses, Emma Winkler

Arts & Sciences Graduate Student Theses and Dissertations

In the past decade, newly emerged and re-emerged pathogenic RNA viruses such as Ebola, H1N1, and Zika virus have become substantial threats to global health. Two notable examples include the explosive re-appearance of chikungunya virus in the 2000s in Asia and the Western Hemisphere and, more recently, the global COVID-19 pandemic. Therefore, an improved understanding of immunity to emerging RNA viruses is critical for defining host susceptibility and restriction factors to viral infection as well as appropriate vaccine and antiviral therapeutic design. Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that is maintained in an urban epidemic transmission cycle. While most …

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An Evolving View Of Host-Microbiome Co-Development In Healthy And Undernourished Children, Robert Yuzen Chen May 2023

An Evolving View Of Host-Microbiome Co-Development In Healthy And Undernourished Children, Robert Yuzen Chen

Arts & Sciences Graduate Student Theses and Dissertations

Affecting more than 795 million children under the age of 5, childhood undernutrition is one of the greatest impediments to the flourishing of humankind. Current dietary interventions fail to ameliorate many of the long-term sequelae of undernutrition, including immune system dysfunction, impaired vaccine responses, persistent central nervous system (CNS) dysfunction, and early mortality. These shortcomings suggest that our understanding of the biological state of undernutrition is incomplete, and that traditional food therapies fail to target key drivers of undernutrition-dependent pathologies. Recently, work from our lab has provided preclinical evidence demonstrating that impaired development of the distal gut microbiota plays a …

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Iterative Machine Learning Of A Cis-Regulatory Grammar, Ryan Z. Friedman May 2023

Iterative Machine Learning Of A Cis-Regulatory Grammar, Ryan Z. Friedman

Arts & Sciences Graduate Student Theses and Dissertations

Gene regulation allows for the quantitative control of gene expression. Gene regulation is a complex process encoded through cis-regulatory sequences, short DNA sequences containing clusters of transcription factor binding sites. Each binding site can occur millions of times in multicellular genomes, and seemingly similar collections of binding sites can have very different activities. A leading model to explain these degeneracies is that cis-regulatory sequences follow a “grammar” defined by the number, identity, strength, arrangement, and/or context of the underlying binding sites. Understanding cis-regulatory grammar requires high-throughput technology, quantitative measurements, and computational modeling. This thesis describes an iterative machine learning approach …

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Musical And Spiritual Meaning In The Franciscan Works Of Franz Liszt, Jorge Luis Modolell May 2023

Musical And Spiritual Meaning In The Franciscan Works Of Franz Liszt, Jorge Luis Modolell

Arts & Sciences Graduate Student Theses and Dissertations

Liszt’s relationship to St. Francis of Assisi was an integral part of the composer’s identity. His devotion to the saint, cultivated from an early age, served as a constant source of spiritual guidance that only grew stronger over time. Texts by St. Francis and anecdotes from the saint’s life provided the artistic incentive for a number of important works, which form the core of the present study. By examining several of these works together, with full analyses and within a broader cultural framework, this dissertation aims to arrive at a true understanding of the messages Liszt took from this figure …

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Painless Hylomorphism: A Deflationary Metaphysics Of Form, Graham Renz May 2023

Painless Hylomorphism: A Deflationary Metaphysics Of Form, Graham Renz

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation develops and defends a deflationary or minimalist version of hylomorphism, the Aristotelian view according to which objects are composites of matter and form. According to hylomorphists, a house has various material components—bricks and timbers—and a special, non-material or formal component that makes the bricks and timbers to be a house. Hylomorphism is intuitively appealing and explanatorily powerful, but its primary posit—form—is hard to get a firm grip on. Because of this, contemporary hylomorphists have proffered myriad accounts of form. Forms might be structures, relations, principles of unity, inherent character-grounders, abstract offices, functions, emergent powers, configurational states, activities, processes, …

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From Instability To Civil Liberties: Nonviolent Resistance In Afghanistan, Rachel L. Knowles May 2023

From Instability To Civil Liberties: Nonviolent Resistance In Afghanistan, Rachel L. Knowles

Master's Theses

When people have a fundamental issue at stake, giving in is not an option. For these types of conflict, when people’s rights are being violated, when their countries are occupied, or when they are oppressed and humiliated, they need a powerful way to persist and fight back. Oftentimes when people are left with no choice they will use the terrible and destructive nature of violence. For decades nonviolent resistance (NVR) movements have been associated with Gandhi and Martin Luther King, but people have been using nonviolent action for years. In fact, NVR has been a part of political life for …

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