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Articles 78571 - 78600 of 735075
Full-Text Articles in Entire DC Network
Animatronic Monarch Butterfly: Mechanical System, Janine Rae Moreno, Enrico Cruz, Alexia Murphy, Lakshmanan Muthukaruppan
Animatronic Monarch Butterfly: Mechanical System, Janine Rae Moreno, Enrico Cruz, Alexia Murphy, Lakshmanan Muthukaruppan
Mechanical Engineering
This report describes the design, manufacturing, and design verification of an interactive animatronic monarch butterfly created by a team of mechanical and computer engineering students for the Girl Scouts of California's Central Coast. The purpose of the project is to engage Girl Scouts in learning about monarch butterflies and provide hands-on experience in robotics and STEM. The report covers design changes, manufacturing processes, and assembly of various components, including the butterfly body, wings, legs, and electronic housing. The software and electronics used in the project are also briefly discussed, as the computer engineering team was responsible for the software and …
Effect Of Vitamin D Metabolites On Bone Histomorphometry In Healthy Black And White Women: An Attempt To Unravel The So-Called Vitamin D Paradox In Blacks, S Qiu, George Divine, Sudhaker D Rao, Sudhaker D. Rao
Effect Of Vitamin D Metabolites On Bone Histomorphometry In Healthy Black And White Women: An Attempt To Unravel The So-Called Vitamin D Paradox In Blacks, S Qiu, George Divine, Sudhaker D Rao, Sudhaker D. Rao
Endocrinology Articles
An apparent vitamin D paradox, characterized by lower serum 25-hydroxyvitamin D (25(OH)D) levels and higher bone mineral density, is present in black population. In contrast, blacks have higher serum 1,25-dihydroxyvitamin D (1,25(OH)(2)D) levels. The effect of 1,25(OH)(2)D on the skeleton is not fully understood. We examined serum 25(OH)D, 1,25(OH)(2)D and bone histomorphometry in 50 black and white women (25 each) matched for age, menstrual status, and BMI. Histomorphometric indices related to bone structure, remodeling and mineralization were measured in cancellous bone in iliac bone biopsies. Data analyses led to the following results: 1) serum 25(OH)D was significantly lower and 1,25(OH)(2)D …
First Rabbit Haemorrhagic Disease Outbreak In Nigeria: Implications For The Growing Rabbit Production Industry, Oluwafemi Daodu, Oladapo Oludairo, Olatunde Akanbi, Isaac Olorunshola, Oluwakemi Daodu, Julius Aiyedun, Clement Meseko
First Rabbit Haemorrhagic Disease Outbreak In Nigeria: Implications For The Growing Rabbit Production Industry, Oluwafemi Daodu, Oladapo Oludairo, Olatunde Akanbi, Isaac Olorunshola, Oluwakemi Daodu, Julius Aiyedun, Clement Meseko
Mansoura Veterinary Medical Journal
The first outbreak of rabbit haemorrhagic disease (RHD) in Nigeria was reported in 2020 after over three decades of its existence in several parts of the world. In this study, we traced the timeline of the 2020 outbreaks of RHD in Nigeria, assessed the knowledge and practices of farmers about RHD and other infectious diseases of rabbits.Structured questionnaire was administered using Google Forms shared through the rabbit farmers’ social media groups and other professional livestock platforms. Responses were obtained from 114 rabbitries across 15 States in Nigeria. Our findings revealed that the 2020 RHDV outbreak started in February, though its …
Eastern Phoebe Makes Multiple Visits To A White-Tailed Deer, T. David Pitts
Eastern Phoebe Makes Multiple Visits To A White-Tailed Deer, T. David Pitts
The Migrant - Tennessee Ornithological Society
No abstract provided.
Socio-Ecological Challenges Of Hydroelectric Dams Among Ethnic Minorities In Northern Laos, Saleh Ahmed, Paige Liquin
Socio-Ecological Challenges Of Hydroelectric Dams Among Ethnic Minorities In Northern Laos, Saleh Ahmed, Paige Liquin
Global Studies Faculty Publications and Presentations
Globally, hydroelectric dams are increasingly considered to be a sustainable source of renewable energy. Many countries have invested in hydroelectric projects to boost the local and national economies. The findings of recent hydroelectric projects are mixed. Even though the construction of these dams has provided immediate benefits to surrounding communities, long-term negative implications of hydroelectric development have called into question the true sustainability of hydroelectric projects. These negative impacts of hydroelectric dams include the resettlement of marginalized communities, in addition to significant alterations to the local environment and economy. Taking both the positive and negative impacts of hydroelectric development into …
Mechanical Testing Data From Neutron Irradiations Of Pm-Hip And Conventionally Manufactured Nuclear Structural Alloys, Yaqiao Wu
Materials Science and Engineering Faculty Publications and Presentations
This article presents the comprehensive mechanical testing data archive from a neutron irradiation campaign of nuclear structural alloys fabricated by powder metallurgy with hot isostatic pressing (PM-HIP). The irradiation campaign was designed to facilitate a direct comparison of PM-HIP to conventional casting or forging. Five common nuclear structural alloys were included in the campaign: 316L stainless steel, SA508 pressure vessel steel, Grade 91 ferritic steel, and Ni-base alloys 625 and 690. Irradiations were carried out in the Advanced Test Reactor (ATR) at Idaho National Laboratory (INL) to target doses of 1 and 3 displacements per atom (dpa) at target temperatures …
The Dictyostelium Discoideum Genome Lacks Significant Dna Methylation And Uncovers Palindromic Sequences As A Source Of False Positives In Bisulfite Sequencing, Robert Drewell, Tayla C. Cormier, Jacob L. Steenwyk, James St Denis, Javier F. Tabima, Jacqueline Dresch, Denis A. Larochelle
The Dictyostelium Discoideum Genome Lacks Significant Dna Methylation And Uncovers Palindromic Sequences As A Source Of False Positives In Bisulfite Sequencing, Robert Drewell, Tayla C. Cormier, Jacob L. Steenwyk, James St Denis, Javier F. Tabima, Jacqueline Dresch, Denis A. Larochelle
Biology
DNA methylation, the addition of a methyl (CH3) group to a cytosine residue, is an evolutionarily conserved epigenetic mark involved in a number of different biological functions in eukaryotes, including transcriptional regulation, chromatin structural organization, cellular differentiation and development. In the social amoeba Dictyostelium, previous studies have shown the existence of a DNA methyltransferase (DNMA) belonging to the DNMT2 family, but the extent and function of 5-methylcytosine in the genome are unclear. Here, we present the whole genome DNA methylation profile of Dictyostelium discoideum using deep coverage replicate sequencing of bisulfite-converted gDNA extracted from post-starvation cells. We find an overall …
Itentifying Suitable Sites For The Rotating Safe Parking Program In San Luis Obispo, Finnegan James
Itentifying Suitable Sites For The Rotating Safe Parking Program In San Luis Obispo, Finnegan James
City and Regional Planning
This report has been created with the intention of identifying a new Safe Parking location in the City of San Luis Obispo (SLO) for the Rotating Safe Parking Program. SLO currently has two Safe Parking locations, though one is being discontinued due to inadequacy of the site. The City wishes to identify a new location, or locations, that can replace this. This report came to life after coordination with the City to determine how this senior project could best support the City’s efforts to address homelessness in SLO in 2023. My work began when I identified areas in the Homelessness …
Fast-Tracks And Prizes: A Multi-Pronged Approach To Incentivizing Green Technology Innovation, Benjamin Desch
Fast-Tracks And Prizes: A Multi-Pronged Approach To Incentivizing Green Technology Innovation, Benjamin Desch
Washington Law Review
Faced with the ever-worsening climate crisis, many nations—including the United States—have increasingly recognized the urgent need for rapid advancements in green, clean, and sustainable technologies. Patents play a fundamental role in incentivizing technological innovation, but the traditional patent process is too slow to match the urgency of the climate crisis. At the same time, the marketplace significantly undervalues green technology patents because they confer benefits to third parties not involved in the transaction (referred to as “positive externalities”). To address the urgency issue, patent “fast-track” programs have been implemented to speed up the patent application review process. To mitigate the …
Submittal Of Mixed Waste Landfill Annual Long-Term Monitoring & Maintenance Report, April 2022-March 2023 For Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, June 2023, Sandia National Laboratories/Nm
Submittal Of Mixed Waste Landfill Annual Long-Term Monitoring & Maintenance Report, April 2022-March 2023 For Sandia National Laboratories/New Mexico, Epa Id Number Nm5890110518, June 2023, Sandia National Laboratories/Nm
Facilities-Units
The Department of Energy/National Nuclear Security Administration (DOE/NNSA) and Sandia National Laboratories /New Mexico (SNL/NM) personnel submitted the Mixed Waste Landfill (MWL) Annual Long-Term Monitoring and Maintenance Report for the April 2022 through March 2023 reporting period to the New Mexico Environment Department (NMED) in accordance with the requirements of Section 4.8.1 of the MWL Long-Term Monitoring and Maintenance Plan (LTMMP). The LTMMP became effective on January 8, 2014.
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The MWL is a 2.6-acre Solid Waste Management Unit (SWMU 76) located in the north-central portion of SNL/NM Technical Area III that has undergone corrective action. As of March 13, …
The Credibility Effect: Defamation Law And Audiences, Yonathan A. Arbel
The Credibility Effect: Defamation Law And Audiences, Yonathan A. Arbel
Articles
What should be the legal response to false statements? In the context of defamation law, courts try to set a standard that balances the interests of speakers and their potential targets. This article empirically demonstrates an unappreciated effect of such decisions on third parties: a credibility effect. Using a series of lab experiments, I find that defamation law makes individuals more trusting of reports from various media. This credibility effect is desirable when the report is true but can lead to unintended consequences in the case of misinformation. In particular, the credibility effect is shown to cast a stigma on …
Creche Herald Vol. 27, No. 2, Rita B. Bocher
Creche Herald Vol. 27, No. 2, Rita B. Bocher
Creche Herald
The Summer 2023 publication features nativity sets and personal reflections from members in the organization; information about nativities and nativity exhibits; and information about the Friends of the Creche annual meeting.
Evaluation Of Potential Surrogates For Listeria Monocytogenes In Fresh Citrus-Specific Validation Studies, Kimiko Grace Casuga
Evaluation Of Potential Surrogates For Listeria Monocytogenes In Fresh Citrus-Specific Validation Studies, Kimiko Grace Casuga
Master's Theses
The FSMA Produce Safety Rule (PSR) requires citrus packers to more closely assess, manage, and monitor food safety risks. Although there have been no foodborne illness outbreaks and only one recall in fresh citrus, the risk of pathogens coming in on the fruit and cross contamination during washing still exists. Packhouses have dynamic washing systems and in-plant validations may be the only way to demonstrate compliance with the PSR. In-plant validations use surrogates in place of pathogens, and none have been identified or validated for citrus. The aim of this research was to identify a surrogate for use in fresh …
Reducing Scope 3 Emissions By Investing In Regenerative Agriculture In Supply Chains, Stephanie Cain
Reducing Scope 3 Emissions By Investing In Regenerative Agriculture In Supply Chains, Stephanie Cain
Master's Theses
The agricultural industry has an opportunity to shift to a more sustainable practice that helps restore vital topsoil, improve water quality, reduce environmental impact, and sequester atmospheric carbon into the vast soil carbon pool. However, to implement these practices at considerable scale, agricultural producers require access to resources and capital they rarely have and can be difficult to acquire. As a company, investing in regenerative agriculture in supply chains can lead to reduced Scope 3 emissions, more resilient supply chains, and better marketability as an investment fund, an employer, and a brand. Insetting regenerative agriculture can protect supply chains against …
Food For Thought: The Effects Of Feeding On Neurogenesis In The Ball Python, Python Regius, Hannah F. Bow
Food For Thought: The Effects Of Feeding On Neurogenesis In The Ball Python, Python Regius, Hannah F. Bow
Master's Theses
Pythons are a well-studied model of postprandial physiological plasticity. Consuming a meal has been shown by past work to evoke a suite of physiological changes in pythons and elicit one of the largest documented increases in post-feeding metabolic rates relative to resting values. However, little is known about how this plasticity manifests in the brains of ball pythons, Python regius. Previous work using the cell-birth marker 5-bromo-12’-deoxyuridine (BrdU) has shown that cell proliferation in the python brain increases six days following meal consumption. This study aimed to confirm these findings and build on them in the long term by …
Effects Of Mature Recombinant Gdf9 And Bmp15 On In-Vitro Maturation Of Bovine Oocytes And Subsequent Embryo Development And Effects Of Antioxidants On Blastocyst Re-Expansion Rates, Jamie Thompson
Master's Theses
In-vitro produced embryos (IVP) differ greatly from in-vivo derived embryos (IVD) in gene expression, metabolism, development, and cryotolerance which limit the widespread use of this technology. In-vitro maturation (IVM) is one of the most important components for successful in-vitro embryo development. Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) have been found to be essential during oocyte maturation and thus female fertility. These proteins are oocyte secreted factors (OSFs) and are produced with pro- and mature protein regions where the pro-regions are thought to aid in protein folding and dimerization where heterodimerization the two proteins has been …
Parens Patriae After The Pandemic, Meredith Johnson Harbach
Parens Patriae After The Pandemic, Meredith Johnson Harbach
North Carolina Law Review
No abstract provided.
Founding Fathers Of The Modern American Neo-Nazi Movement: The Impacts And Legacies Of Louis Beam, William Luther Pierce, And James Mason, Jon Lewis, Haroro J. Ingram, National Counterterrorism Innovation, Technology, And Education Center, Program On Extremism, George Washington University
Founding Fathers Of The Modern American Neo-Nazi Movement: The Impacts And Legacies Of Louis Beam, William Luther Pierce, And James Mason, Jon Lewis, Haroro J. Ingram, National Counterterrorism Innovation, Technology, And Education Center, Program On Extremism, George Washington University
Reports, Projects, and Research
This study analyzes the leadership style, impact, and enduring legacies of three crucial leaders in the white supremacist and neo-Nazi movements: Louis Beam, William Luther Pierce, and James Mason. It examines the interplay of leadership traits, significant events in the life narratives of the leader, and the legacies of these three key pioneers towards two aims. First, our analysis draws on the CIP Leadership Framework and charismatic leadership studies to assess the respective leadership roles of Beam, Pierce, and Mason. Second, it considers how the leadership traits and ideological impact of these leaders shaped contemporary far-right movements in the United …
Understanding And Applying Sar To Ideological And Nation- State-Sponsored Cybercrimes, Thomas J. Holt, Steve Chermak, Joshua D. Freilich, Emily Greene-Colozzi, National Counterterrorism Innovation, Technology, And Education Center
Understanding And Applying Sar To Ideological And Nation- State-Sponsored Cybercrimes, Thomas J. Holt, Steve Chermak, Joshua D. Freilich, Emily Greene-Colozzi, National Counterterrorism Innovation, Technology, And Education Center
Reports, Projects, and Research
The use of computer hacking, malicious software, and other forms of cyberattacks against U.S. infrastructure has increased dramatically since the 1990s. Many of these attacks target corporations and individuals for instrumental economic gain, such as the theft of personal information for use in fraud. Ideologically motivated attacks also occur, though the degree to which they are understood or documented is generally limited. For instance, jihadi groups have expressed an interest in cyberattacks since the early 2000s (see Holt et al., 2022). Similarly, DHS (2009) noted in the late 2000s that they expected cyberattacks from environmental or animal liberation-focused groups to …
Impact Of Central Bank Of Nigeria Interventions To Agriculture: Evidence From Anchor Borrowers Programme, Sani A. Oshishepo
Impact Of Central Bank Of Nigeria Interventions To Agriculture: Evidence From Anchor Borrowers Programme, Sani A. Oshishepo
Bullion
In an effort to boost agricultural production and non -oil export in the face of unpredictable crude oil earnings and it resultant effect on the revenue profile of Nigeria, the Central Bank of Nigeria (CBN) in line with its developmental function, established the Anchor Borrowers Programme. This paper assesses, the impact, state participation and season positions from inception of the programme. Destock review and indebt interview as well data generated were employed to assess the impact of the programme, Issues surrounding, the distribution model, risks mitigation and challenges of the scheme were also examined. The paper concluded that there is …
Re-Imagining The Duty To Consult: Requiring A Substantive Outcome To Further Reconciliation, Naomi Austin
Re-Imagining The Duty To Consult: Requiring A Substantive Outcome To Further Reconciliation, Naomi Austin
Dalhousie Journal of Legal Studies
The Crown has a duty to consult with Indigenous peoples on actions that may adversely affect claimed Indigenous interests that have not yet been established as recognized rights. Currently, the duty to consult remains a procedural obligation that does not require the consent of the Indigenous claimants to move forward. The crux of the duty to consult is to reconcile Crown and Indigenous interests. This paper explores how the duty to consult can better promote reconciliation by requiring a substantive outcome. Requiring a substantive outcome enhances the ability of Indigenous claimants to protect their own interests in the face of …
Post-Processed Data And Graphical Tools For A Conus-Wide Eddy Flux Evapotranspiration Dataset, J. M. Volk, J. L. Huntington, F. Melton, B. Minor, T. Wang, S. Anapalli, R. G. Anderson, S. Evett, A. French, R. Jasoni, N. Bambach, W. P. Kustas, J. Alfieri, J. Prueger, L. Hipps, L. Mckee, S. J. Castro, M. M. Alsina, A. J. Mcelrone, M. Reba, B. Runkle, M. Saber, C. Sanchez, E. Tajfar, R. Allen, M. Anderson
Post-Processed Data And Graphical Tools For A Conus-Wide Eddy Flux Evapotranspiration Dataset, J. M. Volk, J. L. Huntington, F. Melton, B. Minor, T. Wang, S. Anapalli, R. G. Anderson, S. Evett, A. French, R. Jasoni, N. Bambach, W. P. Kustas, J. Alfieri, J. Prueger, L. Hipps, L. Mckee, S. J. Castro, M. M. Alsina, A. J. Mcelrone, M. Reba, B. Runkle, M. Saber, C. Sanchez, E. Tajfar, R. Allen, M. Anderson
AES Faculty Publications and Presentations
Large sample datasets of in situ evapotranspiration (ET) measurements with well documented data provenance and quality assurance are critical for water management and many fields of earth science research. We present a post-processed ET oriented dataset at daily and monthly timesteps, from 161 stations, including 148 eddy covariance flux towers, that were chosen based on their data quality from nearly 350 stations across the contiguous United States. In addition to ET, the data includes energy and heat fluxes, meteorological measurements, and reference ET downloaded from gridMET for each flux station. Data processing techniques were conducted in a reproducible manner using …
A Study On The Design And Production Of A Desktop Vaccuum Cleaner, Aaryan Manoj Nair, Emanuel Pichardo, Isaiah Ortiz, Naeem Kotadia
A Study On The Design And Production Of A Desktop Vaccuum Cleaner, Aaryan Manoj Nair, Emanuel Pichardo, Isaiah Ortiz, Naeem Kotadia
Publications and Research
The goal of this project was to design a desk-top vacuum cleaner that is compact, portable, and effective in cleaning desktops and tabletops. Two concepts were proposed and compared using Quality Function Deployment (QFD) and various metrics, including in-use purposes and market, technical feasibility, ease of use, durability, and cost. The two concepts were a lifting design with hydraulics and a differently sized offset wheel design. After thorough analysis, it was determined that the lifting design with hydraulics was the better concept due to its adjustability and ability to reach different heights and angles on tabletops. The proposed product title …
Physiological And Hormonal Effects Of Titanium Dioxide Nanoparticles On Thyroid And Kidney Functions, Noori Mohammed Luaibi, Raghda Ali Mohammed
Physiological And Hormonal Effects Of Titanium Dioxide Nanoparticles On Thyroid And Kidney Functions, Noori Mohammed Luaibi, Raghda Ali Mohammed
Baghdad Science Journal
Titanium dioxide nanoparticles (TiO2 NPs) are generally used in different types of applications such as the industry of plastics, paper industry, paints, toothpaste, cosmetics, sunscreens, and in various lifestyles, because of the vast range of applications and our daily exposure to these nanoparticles and a lack of information on animal and human health this study was designed to reveal dose and time-dependent effects of TiO2-NPs on the thyroid gland and kidney functions in male rats. For this study 54, Sprague-Dawley albino adult male rats were classified into three main groups each of 18 rats treated for a particular duration (1,2, …
Child Sexual Assault Prevention And Intervention, Kira Peterson, Amaya Ibuna, Emily Valenzuela
Child Sexual Assault Prevention And Intervention, Kira Peterson, Amaya Ibuna, Emily Valenzuela
Psychology and Child Development
In our paper, we discuss child sexual assault, its risk factors, short and long-term outcomes, as well as prevention and intervention programs that have been shown to be valuable. To limit research, our focus will be on children living in the United States who have been physically sexually assaulted. To spread awareness of child sexual abuse, we also developed a pamphlet (See Appendix) that will be distributed to CASAs, which stands for Court Appointed Special Advocates. The development of the pamphlet is described in the combined Method and Results section. We conclude our project and paper with a Discussion section …
Rapid Composter, Shannon Shinozaki, Avin Atencio, Jonathan Fraser, Lukas Kolbl, Russell Occhipinti
Rapid Composter, Shannon Shinozaki, Avin Atencio, Jonathan Fraser, Lukas Kolbl, Russell Occhipinti
Mechanical Engineering
This project was created with the intent of automatically composting equine bio waste to be reused as plant fertilizer. The system consists of four subsystems: power generation and storage, automatic controls, aeration, and structure. Each subsystem may be manufactured independently, then put together. This system will not have access to power outlets, so it was designed to be solar-powered.
Treadmill Platform For Quadrupedal Robots, Baxter J. Bartlett, Jack F. Butler, Phillip A. Shafik, Tarun S. Ganamur
Treadmill Platform For Quadrupedal Robots, Baxter J. Bartlett, Jack F. Butler, Phillip A. Shafik, Tarun S. Ganamur
Mechanical Engineering
Cal Poly Legged Robots, led by Professor Refvem and Professor Xing, has been leading Cal Poly’s attempts to simulate, produce, and test their legged robots. The initial testing of the locomotion of these robots can be dangerous to the robot since any bugs in the code could cause the robot to fall over and harm itself. Our responsibility as a team was to deliver a portable platform for testing the locomotion capabilities containing a fall prevention mechanism. In short, we have designed a platform for this purpose that consists of a treadmill surrounded by a wheeled chassis with a system …
Data To Action: Community-Based Participatory Research To Address Concerns About Metal Air Pollution In Overburdened Neighborhoods Near Metal Recycling Facilities In Houston, Elaine Symanski, Heyreoun An Han, Sheryl Mccurdy, Loren Hopkins, Juan Flores, Inkyu Han, Mary Ann Smith, James Caldwell, Cecelia Fontenot, Bobbie Wyatt, Christine Markham
Data To Action: Community-Based Participatory Research To Address Concerns About Metal Air Pollution In Overburdened Neighborhoods Near Metal Recycling Facilities In Houston, Elaine Symanski, Heyreoun An Han, Sheryl Mccurdy, Loren Hopkins, Juan Flores, Inkyu Han, Mary Ann Smith, James Caldwell, Cecelia Fontenot, Bobbie Wyatt, Christine Markham
Faculty, Staff and Student Publications
BACKGROUND: Exposures to environmental contaminants can be influenced by social determinants of health. As a result, persons living in socially disadvantaged communities may experience disproportionate health risks from environmental exposures. Mixed methods research can be used to understand community-level and individual-level exposures to chemical and nonchemical stressors contributing to environmental health disparities. Furthermore, community-based participatory research (CBPR) approaches can lead to more effective interventions.
OBJECTIVES: We applied mixed methods to identify environmental health perceptions and needs among metal recyclers and residents living in disadvantaged neighborhoods near metal recycling facilities in Houston, Texas, in a CBPR study, Metal Air Pollution Partnership …
Russian L2 Learners' And Teachers' Perceptions Of Learning Affordances, Marina Tsylina, Jose Luis Garrido Rivera, Hadis Ghaedi
Russian L2 Learners' And Teachers' Perceptions Of Learning Affordances, Marina Tsylina, Jose Luis Garrido Rivera, Hadis Ghaedi
Russian Language Journal
The environment offers a variety of resources for language learning and teaching. However, students and teachers might not recognize the same affordances or may perceive them differently. The mismatch between instructors’ and learners’ perceived affordances may result in ineffective use of time for both students and teachers, lower student motivation, and retard the language learning process. The study draws on the ecological approach (van Lier, 2000) to second language acquisition to investigate L2 Russian learners’ and teachers’ perceptions of language learning affordances, i.e., any physical objects, online materials, humans, and other resources which are embedded in the environment, and emerge …
Chronic, Mild Hypothermic Environmental Temperature Does Not Ameliorate Cognitive Deficits In An Alzheimer's Disease Mouse., Samuel Mcfadden, Lindsey N Sime, Makayla F Cox, Caleigh A Findley, Mackenzie R Peck, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R Hascup, Kevin N Hascup
Chronic, Mild Hypothermic Environmental Temperature Does Not Ameliorate Cognitive Deficits In An Alzheimer's Disease Mouse., Samuel Mcfadden, Lindsey N Sime, Makayla F Cox, Caleigh A Findley, Mackenzie R Peck, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R Hascup, Kevin N Hascup
Articles
Metabolic dysfunction increases with age and is a contributing factor to Alzheimer's disease (AD) development. We have previously observed impaired insulin sensitivity and glucose homeostasis in the APP/PS1 model of AD. To improve these parameters, we chronically exposed male and female mice to mild hypothermic environmental temperature (eT), which positively modulates metabolism. Although a hypothermic eT normalized insulin sensitivity, glucose tolerance was still impaired in both sexes of AD mice. We observed increased plasma glucagon and B-cell activating factor in both sexes, but additional sexually dimorphic mechanisms may explain the impaired glucose homeostasis in AD mice. Hepatic Glut2 was decreased …