Digital Commons Network^™

Residents’ Experience And Training In Obstetric Anal Sphincter Injury Repair In The United States, Sujatha Narayanamoorthy, Kimen Singh Balhotra, Michael Silver, Rodney Mclaren, Elishia Mckay

Department of Obstetrics and Gynecology Faculty Papers

With the reduction in obstetric anal sphincter injuries (OASIS) cases, it is unknown if learning and exposure to their repair is compromised during obstetrics and gynecology (OBGYN) residency in the United States (US). The aim of this study was to evaluate the exposure and confidence level of the US OBGYN residents to OASIS repair. Residents’ education on OASIS repair was also assessed. This was a cross sectional online survey that collected residents’ demographics, characteristics of residency program, the number of deliveries and OASIS repairs performed, the site and technique of OASIS repair, post-repair care provided, residents’ confidence level in OASIS …

Court Cases Turned Trojan Horse: Examining The Future Of The Endangered Species Act And Environmental Protection After Friends Of Animals V. Haaland, Brianna Manobianco

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Studies On Diketopiperazine And Dipeptide Analogs As Opioid Receptor Ligands, Siavash Shahbazi Nia, Mohammad Anwar Hossain, Guangchen Ji, Sravan K Jonnalagadda, Samuel Obeng, Md Ashrafur Rahman, Ali Ehsan Sifat, Saeideh Nozohouri, Collin Blackwell, Dhavalkumar Patel, Jon Thompson, Scott Runyon, Takato Hiranita, Christopher R Mccurdy, Lance Mcmahon, Thomas J Abbruscato, Paul C Trippier, Volker Neugebauer, Nadezhda A German

Faculty, Staff and Student Publications

Using the structure of gliotoxin as a starting point, we have prepared two different chemotypes with selective affinity to the kappa opioid receptor (KOR). Using medicinal chemistry approaches and structure-activity relationship (SAR) studies, structural features required for the observed affinity were identified, and advanced molecules with favorable Multiparameter Optimization (MPO) and Ligand Lipophilicity (LLE) profiles were prepared. Using the Thermal Place Preference Test (TPPT), we have shown that compound2 blocks the antinociceptive effect of U50488, a known KOR agonist. Multiple reports suggest that modulation of KOR signaling is a promising therapeutic strategy in treating neuropathic pain (NP). As a …

Enhancing User Learning Experience Of A New Therapeutic Approach For Scleroderma Using Vr, Joanne Park

Theses

The transient receptor potential cation 6 (TRPC6) channel is an integral membrane protein that alters the intracellular calcium (Ca2+) concentration and is also responsible for a variety of tissue expression, physiological functions and channel properties (Ong et al., 2016). Recently, researchers at RIT have discovered a new therapeutic approach for scleroderma, also known as skin fibrosis, that involves the inhibition of the TRPC6 channel. To help spread awareness of their research and to enhance the user learning experience, an interactive virtual reality (IVR) experience was created, as well as supplemental 3D animations, that will be available through the researcher’s website. …

Connective Tissue Presentation In Two Families Expands The Phenotypic Spectrum Of Pyroxd1 Disorders, Frances J Evesson, Gregory Dziaduch, Samantha J Bryen, Francesca Moore, Sara Pittman, Beena Devanapalli, Leigh B Waddell, Monique M Ryan, Manoj P Menezes, Conrad C Weihl, Adviye Ayper Tolun, Craig Zaidman, Helen Young, Lesley C Adès, Sandra T Cooper

2020-Current year OA Pubs

Recessive variants in the oxidoreductase PYROXD1 are reported to cause a myopathy in 22 affected individuals from 15 families. Here, we describe two female probands from unrelated families presenting with features of a congenital connective tissue disorder including osteopenia, blue sclera, soft skin, joint hypermobility and neuromuscular junction dysfunction in addition to known features of PYROXD1 myopathy including respiratory difficulties, weakness, hypotonia and oromotor dysfunction. Proband AII:1 is compound heterozygous for the recurrent PYROXD1 variant Chr12(GRCh38):g.21452130A>G;NM_024854.5:c.464A>G;p.(N155S) and Chr12(GRCh38):g.21462019_21462022del;NM_024854.5:c.892_895del;p.(V298Mfs*4) and proband BII:1 is compound heterozygous for Chr12(GRCh38):g.21468739-21468741del;NM_024854.5:c.1488_1490del;p.(E496del) and Chr12(GRCh38):g.21467619del;NM_024854.5:c.1254+1del. RNA studies demonstrate c.892_895del;p.(V298Mfs*4) is targeted by nonsense mediated decay …

Design, Construction, And Testing Of Recombinant Dna-Based Vaccines For Protection Against Salmonella Enterica Subspecies Enterica Serovar Javiana, Ashley Edwards

LSU Doctoral Dissertations

In the United States, Salmonella Javiana is among the top 5 most common nontyphoidal Salmonella serotypes, with a 325% increase in infection rate since 1970. Globally, nontyphoidal Salmonella leads to approximately 93.8 million illnesses and 155,000 deaths annually, with disproportionate impacts in developing countries. In the United States alone, these infections lead to over $4 billion in costs, the majority of which are attributed to those expenses incurred from mortalities. The zoonotic nature of nontyphoidal Salmonellae and their ability to survive on and within vegetation mean huge economic burden potential for various agricultural industries as well, especially since some of …

Integrative Molecular Analysis Of Dna Methylation Dynamics Unveils Molecules With Prognostic Potential In Breast Cancer, Rashid Mehmood, Alanoud Alsaleh, Muzamil Y. Want, Ijaz Ahmad, Sami Siraj, Muhammad Ishtiaq, Faizah A. Alshehri, Muhammad Naseem, Noriko Yasuhara

All Works

DNA methylation acts as a major epigenetic modification in mammals, characterized by the transfer of a methyl group to a cytosine. DNA methylation plays a pivotal role in regulating normal development, and misregulation in cells leads to an abnormal phenotype as is seen in several cancers. Any mutations or expression anomalies of genes encoding regulators of DNA methylation may lead to abnormal expression of critical molecules. A comprehensive genomic study encompassing all the genes related to DNA methylation regulation in relation to breast cancer is lacking. We used genomic and transcriptomic datasets from the Cancer Genome Atlas (TGCA) Pan-Cancer Atlas, …

A High-Dimensional Microfluidic Approach For Selection Of Aptamers With Programmable Binding Affinities, Dingran Chang, Z Wang, Connor D. Flynn, Alam Mahmud, Mahmoud Labib, H Wang, Armin Geraili, Xiangling Li, Jiaqi Zhang, Edward H. Sargent, Shana O. Kelley

Peninsula Medical School

No abstract provided.

Stromal And Therapy-Induced Macrophage Proliferation Promotes Pdac Progression And Susceptibility To Innate Immunotherapy, Chong Zuo, John M Baer, Brett L Knolhoff, Jad I Belle, Xiuting Liu, Angela Alarcon De La Lastra, Graham D Hogg, Natalie L Kingston, Marcus A Breden, Paarth B Dodhiawala, Daniel Cui Zhou, Varintra E Lander, C Alston James, Li Ding, Kian-Huat Lim, Ryan C Fields, William G Hawkins, Jason D Weber, Guoyan Zhao, David G Denardo, Et Al.

2020-Current year OA Pubs

Tumor-associated macrophages (TAMs) are abundant in pancreatic ductal adenocarcinomas (PDACs). While TAMs are known to proliferate in cancer tissues, the impact of this on macrophage phenotype and disease progression is poorly understood. We showed that in PDAC, proliferation of TAMs could be driven by colony stimulating factor-1 (CSF1) produced by cancer-associated fibroblasts. CSF1 induced high levels of p21 in macrophages, which regulated both TAM proliferation and phenotype. TAMs in human and mouse PDACs with high levels of p21 had more inflammatory and immunosuppressive phenotypes. p21 expression in TAMs was induced by both stromal interaction and/or chemotherapy treatment. Finally, by modeling …

Autolysosomal Exocytosis Of Lipids Protect Neurons From Ferroptosis, Isha Ralhan, Jinlan Chang, Matthew J Moulton, Lindsey D Goodman, Nathanael Y J Lee, Greg Plummer, H Amalia Pasolli, Doreen Matthies, Hugo J Bellen, Maria S Ioannou

Faculty, Staff and Students Publications

During oxidative stress neurons release lipids that are internalized by glia. Defects in this coordinated process play an important role in several neurodegenerative diseases. Yet, the mechanisms of lipid release and its consequences on neuronal health are unclear. Here, we demonstrate that lipid-protein particle release by autolysosome exocytosis protects neurons from ferroptosis, a form of cell death driven by lipid peroxidation. We show that during oxidative stress, peroxidated lipids and iron are released from neurons by autolysosomal exocytosis which requires the exocytic machinery VAMP7 and syntaxin 4. We observe membrane-bound lipid-protein particles by TEM and demonstrate that these particles are …

Reimagining The Theory Of Necropolitics In A Modern Lens: Hate Crimes And Violence, Salma Ahmed Abdulmagied Gheita

Future Journal of Social Science

This research paper is testing the validity of the Necropolitics theory and how we can reintroduce its definitions in a modern lens. Though the theory of Necropolitics is extreme and historically was a terminology and paradigm that was used towards more catastrophic and traumatizing events. The main argument that this paper is discussing is how did the idea of Necropolitics evolved into a more institutional, systematic, and legalized manors of exclusion. This is made through critical discourse analysis of the text presented on the term Necropolitics to highlight on the history of this term and what it stood for in …

A Novel Approach To Legacy Donations With Long-Term Benefits Supported By Numerical Illustrations, Daniel Solow, Robin Symes

Faculty Scholarship

Philanthropic donors face challenges in matching the causes to which they donate, the time horizon—and thus impact—of their donations, and the charitable vehicles they choose for making contributions. Wealthier donors may elect to create their own foundations and customize their charitable support. Less wealthy donors have limited choices: they may contribute to a nonprofit's current operations or to existing nonprofit endowments. We present a novel approach for making charitable donations, blending aspects of each of these strategies. Our approach has potential long-term financial benefits, allows donors to control their charitable donations in a convenient and easy-to-implement manner, can be established …

Using Infectious Disease Simulations To Model, Quantify, And Predict The Impact Of Self-Quarantine And Vaccination On Mpox Spread Across The United States, Amar Johanna Scherzer

Quantitative Social Science Undergraduate Senior Theses

In this paper, I build a data-driven theoretical model that reproduces the epidemiological (epi) curve of the mpox outbreak in the United States. The general framework presented in this paper considers the susceptible (S), infected (I), and recovered (R) stages of an mpox infection through an SIR model of disease spread. I use vaccination, transmissibility, recovery, and self isolation rates as parameters in my SIR model as well as a lag-time to account for the delay in vaccination roll-out. By using real-world data to inform estimates of the susceptible population and mpox transmission characteristics, I am able to simulate an …

'Under A Spreading Chestnut Tree', Nicholas Gosling

UNH Today Archive

No abstract provided.

Observed Error Monitoring As An Index Of Theory Of Mind, Kipras Varkala

USF Tampa Graduate Theses and Dissertations

To thrive within our social environment, we must understand and learn from those around us. Theory of Mind (ToM) refers to our ability to put ourselves in other’s shoes to comprehend what they are thinking. Observed error monitoring (OEM) refers to detecting others’ mistakes in real time, which is ultimately thought of as a mechanism that supports our learning from those mistakes without personally having committed them. Current findings suggest that both ToM and OEM are dependent on one another when engaging in social learning. We first emulate the mental state of others to understand their goals motivations. We then …

Archaeogaming And The Re-Use Of Digital Archaeological Materials: Generating Serious Games For The Villas Of Roman Sicily, Kaitlyn Kingsland

USF Tampa Graduate Theses and Dissertations

With 10 million copies sold and 500 million dollars of revenue, the 11th installment of Ubisoft’s Assassin’s Creed series, Assassin’s Creed Odyssey (2018), showed how a videogame based on ancient Greek history and archaeology can make a splash in popular culture and that the distant past can become an extinguishable source of infinite engaging gaming narratives. As pedagogic and research counterparts to videogames of this kind, serious games and archaeogames focusing on Greek and Roman civilizations move from different premises, though aspiring to the same level of success. Serious games, created for a primary purpose other than sole entertainment, have …

Machine Kinship: The Impossible Duet, Diana Sanchez

Masters Theses

Machine Kinship: The impossible duet What does it mean to vanish from earth when you are the last of your kind? In 1987 the Kauai OO was recorded singing his final song. It was meant to be a duet, but as the last of his kind his song hangs in the air, unanswered. The other half of the duet is forever lost. Built to sing at dawn, birds must wake up earlier to hear each other before human chaos interferes. So here, it is always almost sunrise. As a parallel past-future response, the last birdsong was fed into a machine …

Finding The Balance, Danyang Song

Masters Theses

Translating different invisible emotions, feelings and symbiotic relationships. Explore the Traditional Chinese Humanistic Philosophy of 'Tian Ren He Yi'.

The interwoven relationship between human, nature and machine is complicated yet beautiful. I explores how visceral emotion, feeling, language and communication all play an important part of how our bodies react, to visualize this invisible feeling. I attempts to visualize the mystery of the human body and society through various ceramic and glass techniques, such as hand-building, blowing and ceramic 3D printing. Using different methods of combining and stressing the material, capturing that resistance and embracing the outcome through a series …

Cyberflesh: The Me I'Ve Made For You, Jordan Metz

Masters Theses

This thesis deals with the impact of digital life on individuals by examining how real things become virtual bodies of information. Throughout this text, I weave key theoretical and literary references between my own thoughts and experiences which led to the work that appears in this book. I find it useful to attend to the spaces in between entities, theories, and technolo- gies. In these undefined spaces lies the spiritual dimension of media, the everyday magic that makes digital life possible. These ‘in-betweens’ are the site of transcendence granted by technology. In my practice, I’ve learned that things have a …

To Melt, Huanzhe Hu

Masters Theses

This thesis focuses on the need for a reevaluation of the relationship between humans and nature in the face of the current ecological crisis. The author argues that the dominant anthropocentric orientation, which sees nature as a resource to be exploited for human benefit, has led to over extraction and resource abuse, disrupting the balance of ecosystems. Instead, the author suggests adopting an ethical framework based on mutual understanding and appreciation, breaking the "hunter's gaze" and fostering empathy for non-human life forms. This thesis also explores the potential for new forms of communication and engagement with nature, such as through …

Design: A Path To Agency, Design Thinking: An Educational Imperative, Seva Simone

Masters Theses

Design(ing) and Design Thinking are valuable frameworks that should be used to drive agency: This thesis explores what design and design thinking are and builds a case for incorporating design into art education.

Design isn’t a mainstream subject of study in public school curricula. Design offers a unique body of knowledge that is highly relevant to the inner-workings of our world: knowledge imperative to teach if we want to succeed in solving wicked problems like global warming and mitigating global injustices. Studying design allows students to connect academic learning to the world outside the ivy, bridging the gap between the …

Movement, Mechanization, And Coexistence, Yukyung Chung

Masters Theses

A movement is a tool that expresses the subject I pursue, ‘mechanization of human beings’. There are many technologies that replace humans these days, such as artificial intelligence. This makes me skeptical and afraid of being replaced as an artist in the future. Paradoxically, people, including myself, are enthusiastic about it, indicating that we do embrace the mechanization process as a society.

I will reveal this phenomenon of coexistence by demonstrating the possibility that machines cannot replace us, through motion experiments where rules increase, first starting with the reliance on intuition. I will explore not only the things that machines …

Green + White = Pink, Dora Chen

Masters Theses

My thesis seeks to explore the unknown forces that are constantly shaping our lives. I am intrigued by the intangible connections that link people, objects, and places together, and how they manifest across space and time. As a ceramicist emphasizing both interiority and tactility, my work will dissect layered ideas of closeness and disruption in order to reveal a nuanced understanding of how we exist in perpetuity with what can’t be seen. I wish to explore this topic through carefully directed installations that emphasize intimacy and engagement among audience members. Through inspiration from my past experience, childhood memories, as well …

The Enduring Influence Of Emerson's Ideas On American Management Literature From The Lens Of Dale Carnegie’S How To Win Friends And Influence People, Taylor M. Dalton

Undergraduate Honors Theses

This thesis considers how the essays of Ralph Waldo Emerson may be seen as an important precursor to Dale Carnegie’s How to Win Friends and Influence People. Through a side-by-side analysis of four key topics—creativity, intention, action, and the idea of a non-hierarchal society—it becomes clear that the independent and creative mindset envisioned by Emerson in essays like “Self-Reliance” and “The American Scholar” finds a full and practical expression in the pages of Carnegie’s famous book. A close reading of these texts will reveal how Carnegie’s application of the philosophical ideas put forth by Emerson served as the foundation …

In Vivo Tissue Distribution Of Microplastics And Systemic Metabolomic Alterations After Gastrointestinal Exposure, Marcus M. Garcia, Aaron S. Romero, Seth D. Merkley, Jewel L. Meyer-Hagen, Charles Forbes, Eliane El Hayek, David P. Sciezka, Rachel Templeton, Jorge Gonzalez-Estrella, Yan Jin, Haiwei Gu, Angelica Benavidez, Russell P. Hunter, Selita Lucas, Guy Herbert, Kyle Joohyung Kim, Julia Yue Cui, Rama Gullapalli, Julie G. In, Matthew J. Campen, Eliseo F. Castillo

Pathology Research and Scholarship

Global plastic use has consistently increased over the past century with several different types of plastics now being produced. Much of these plastics end up in oceans or landfills leading to a substantial accumulation of plastics in the environment. Plastic debris slowly degrades into microplastics (MPs) that can ultimately be inhaled or ingested by both animals and humans. A growing body of evidence indicates that MPs can cross the gut barrier and enter into the lymphatic and systemic circulation leading to accumulation in tissues such as the lungs, liver, kidney, and brain. The impacts of mixed MPs exposure on tissue …

Microbiological Safety And Quality Of Ceviche, Poke, And Sushi Dishes Sold At Retail Outlets In Orange County, Ca, Grace E. Marquis, Samantha M. Covaia, Amanda M. Tabb, Courtney J. Kitch, Rosalee S. Hellberg

Food Science Faculty Articles and Research

Raw, ready-to-eat (RTE) seafood products, such as ceviche, poke, and sushi, have experienced growing demand globally; however, these products have the potential to be contaminated with foodborne pathogens. The objective of this study was to determine the prevalence of Escherichiacoli/coliforms, Salmonella, and Listeria in ceviche, poke, and sushi dishes sold at the retail level in Orange County, CA, USA. Additional organisms detected during testing were also considered in the results. A total of 105 raw, RTE samples of ceviche, poke, and sushi were collected from restaurants and grocery stores in Orange County, CA. Samples were tested for Salmonella …

I, Others, World - A Glass Circuit, Ariel Aravot

Masters Theses

In the summer of 2022, I had an epiphany about what an art-work is in its most expansive form: a circuit, activated by art creation, between self and others, and between them to wider worlds, and back to the self. ‘A GLASS CIRCUIT’ is the tale of my ongoing exploration of myself as a glass artist, the conscious discovery of my path, which is both consistent and incessantly changing. My works are the stepping stones that sustain my creative process as a glass blower and at the same time introduce experimentality, new questions, and new research topics.

The circuit is …

Rebuild Relationships Between City, Agriculture And Ecosystem In The World Of The Drought, Ninghao Wang

Masters Theses

The drought is a threat to our planet and our way of life, causing serious consequences for both people and the environment. These consequences include crop failures, food shortages, water conflicts, and so on. Arizona is currently at the center of the water crisis affecting the American West. The state depends on the Colorado River for a third of its agricultural and urban water needs. However, the river is shrinking due to drought, leading to water scarcity in the region. Rebuilt Relationships Between Agriculture, Ecosystem, and City in the World of the Drought: rethinking regenerative landscape practices in the drought-prone …

Soft City: Reclaiming Urban Public Spaces For Play, Jennifer Pham

Masters Theses

This thesis explores the relationship between children’s play and urban public spaces. What kinds of play are prioritized, and consequently, what ways of learning are celebrated above others? How are public spaces serving or not serving to nurture children’s development and joy?

The thesis design project is a strategic plan for spatial activism. Using a “guerilla architecture” approach, I am developing a series of workshops with the local community that culminate in collectively designed urban installations. This participatory design process enables people to perceive public spaces in new ways, and it invites community members and children to become active parts …

Elusive Geometry, Lauren Richards

Masters Theses

All I have is a collection of parts. Fragments and pieces, segmented and turned over in my mind and in my hands as I try to understand them, stack them together and try to find a system. It seemed so simple at first - I just want to know how it works, of course I can put it back together again. Sometimes it’s a constant dissection, and the tide of incoming information is impossible to keep track of. But it’s alright to sit down and think about where they go and what they’re made of. What structures do I know? …