Digital Commons Network^™

Using The Hands To Learn About The Brain: Testing Action-Based Instruction In Brain Anatomy, Fey Parrill

Faculty Scholarship

Brain anatomy is typically taught using static images. We asked participants to use their own hands to represent the brain and perform gestures during learning. We measured learning via a pretest/postest design. We compared five video trainings in which participants heard similar audio and repeated terminology aloud. Conditions were: (1) Image: Participants saw images of a physical model of the brain. (2) Physical model: Participants saw hands pointing to the physical model. (3) Physical model + action: Participants performed actions on the physical model. (4) Hand model: Participants saw images of hands being used to represent the brain. (5) Hand …

Stories That Kill: Masculinity And Capital Prosecutors' Closing Arguments, Pamela A. Wilkins

Cleveland State Law Review

The American death penalty is a punishment by, for, and about men: Both historically and today, most capital prosecutors are men, most capital defendants are men, and killing itself is strongly coded male. Yet despite—or perhaps because of—the overwhelming maleness of the institution of capital punishment, the subject of masculinity is largely absent from legal discourse about the death penalty. This Article addresses that gap in the legal discourse by applying the insights of masculinities theory, an offshoot of feminist theory, to capital prosecutors’ closing arguments. This Article hypothesizes that capital prosecutors’ masculinity is strongly influenced both by white Southern …

Pentadesma Butyracea In Ghana – Indigenous Knowledge, Uses, And Seed Characterization, Josephine Akuba Timtey, Francis Alemawor, William Otoo Ellis, Nana Baah Pepra-Ameyaw, Jacob K. Agbenorhevi

Food Science Faculty Articles and Research

This study ascertained the indigenous knowledge and uses of Pentadesma butyracea plant through a focus group study. The proximate, mineral, antinutritional compositions, and antioxidant activity of P. butyracea seed were also determined using standard analytical methods. The results of the focus group study showed that P. butyracea is essentially used for its butter which is prepared by women processors who hand down the skill of butter processing to their children. The butter is used for cooking, frying, and preparing traditional delicacies, and the plant is known to possess some therapeutic potential. The seed recorded the following mean proximate values: fat …

Comics Art, Cultural Norms, And The Social Consciousness Of Activism In American Democracy, Jeffrey Lewis

Cleveland State Law Review

The comic art form’s impact on cultural norms can engender new understandings of rights and shape conceptions of equality in our shared consciousness as a society. Drawing on the 1960s era of social change, this Article examines how comics can produce activism by shaping cultural norms which are reframed, contested, or contextualized to help generate new shared understandings of rights and equality in American democracy. The comic art form should be taken seriously as a medium for activism that can influence changes in social consciousness, illustrated in this Article with examples as diverse as the quiet revolution of the Peanuts …

A Review Of Isomirs In Colorectal Cancer, Molly A. Lausten, Bruce M. Boman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

As advancements in sequencing technology rapidly continue to develop, a new classification of microRNAs has occurred with the discovery of isomiRs, which are relatively common microRNAs with sequence variations compared to their established template microRNAs. This review article seeks to compile all known information about isomiRs in colorectal cancer (CRC), which has not, to our knowledge, been gathered previously to any great extent. A brief overview is given of the history of microRNAs, their implications in colon cancer, the canonical pathway of biogenesis and isomiR classification. This is followed by a comprehensive review of the literature that is available on …

Impact Of Social Media And Multimedia Platforms: View From The Jacc: Case Reports Some Editors, Estefania Oliveros, Yevgeniy Brailovsky, Alessandro Beneduce, Hooman Bakshi, Edoardo Zancanaro, Indah Sukmawati, Mrinali Shetty, Gina Lundberg

Division of Cardiology Faculty Papers

No abstract provided.

Plumbing Mysterious Rnas In “Dark Genome” For The Conquest Of Human Diseases, Lisa A Huang, Chunru Lin, Liuqing Yang

Faculty, Staff and Student Publications

Next-generation sequencing has revealed that less than 2% of transcribed genes are translated into proteins, with a large portion transcribed into noncoding RNAs (ncRNAs). Among these, long noncoding RNAs (lncRNAs) represent the largest group and are pervasively transcribed throughout the genome. Dysfunctions in lncRNAs have been found in various diseases, highlighting their potential as therapeutic, diagnostic, and prognostic targets. However, challenges, such as unknown molecular mechanisms and nonspecific immune responses, and issues of drug specificity and delivery present obstacles in translating lncRNAs into clinical applications. In this review, we summarize recent publications that have explored lncRNA functions in human diseases. …

More Than Text: Examining Embodied Practice In The Classroom, Susan Nash

Honors Projects

This Honors project aims to answer the questions surrounding best practices of engaging with theatrical texts in K-12 English Language Arts (ELA) classrooms in the United States. This project uses the texts of Shakespeare as a case study to analyze the benefits of embodied practice as a methodology in the classroom, paying specific attention to the ways in which embodied practice encourages student agency.

This thesis specifically argues for the incorporation of embodied practice in ELA curricula engage with playtexts and finds that embodied practice can help students better relate to a playtext, assists in humanizing its history, themes, and …

Patrolling The Border: Billfish Exploit The Hypoxic Boundary Created By The World's Largest Oxygen Minimum Zone, Ryan Logan, Jeremy J. Vaudo, Brad Wetherbee, Mahmood Shivji

Biology Faculty Articles

Pelagic predators must contend with low prey densities that are irregularly distributed and dynamic in space and time. Based on satellite imagery and telemetry data, many pelagic predators will concentrate horizontal movements on ephemeral surface fronts—gradients between water masses—because of enhanced local productivity and increased forage fish densities.
Vertical fronts (e.g. thermoclines, oxyclines) can be spatially and temporally persistent, and aggregate lower trophic level and diel vertically migrating organisms due to sharp changes in temperature, water density or available oxygen. Thus, vertical fronts represent a stable and potentially energy rich habitat feature for diving pelagic predators but remain little explored …

The Effects And Reversibility Of Combination Inhaled Corticosteroids On Phonation Threshold Pressure (Ptp) And Phonation Threshold Flow (Ptf) In Ex Vivo Rabbit Larynges, Melanie Elizabeth Blauer

Theses and Dissertations

Although combination inhaled corticosteroids (ICs) are known to cause voice disorders in otherwise vocally healthy individuals, it is unknown whether those adverse effects can be reversed by the cessation of treatment. Quantitative aerodynamic measures such as phonation threshold pressure (PTP) and phonation threshold flow (PTF) can be used to identify the development of, and recovery from, vocal pathologies. We examined the effects and reversibility of ICs on laryngeal aerodynamics. This study was a mid-project investigation as part of a larger ongoing project. The 18 larynges were from rabbits that received ICs, a control condition, or no treatment. Experimental group rabbits …

Exploring Posttraumatic Growth In Aphasia: A Qualitative Investigation, Camille Williams

Theses and Dissertations

This study explored posttraumatic growth (PTG) in people with aphasia and is the qualitative arm of a larger mixed-methods study. After an initial experimental session, 23 people with aphasia (PWA; 12 females and 11 males) completed a 60-minute semi-structured interview during which participants expanded on previously-given questionnaire responses and then answered five additional open-ended questions about communication in their daily life. Interviews were transcribed orthographically and coded using reflexive codebook analysis. A stakeholder with aphasia was consulted to gain insight from an insider's perspective about whether codes and themes captured the experiences of aphasia. Reflexive codebook analysis revealed two themes. …

Understanding The Experiences Of Mothers Of Children With Stunting In Two Egyptian Communities Focusing On The First 1000 Days, Rana Abdelgawad

Theses and Dissertations

Introduction: Egypt’s stunting prevalence is 13% with multiple initiatives and programs tackling child malnutrition. While many of them are promising, not all address the child’s first 1000 days, in addition to missing the cultural aspect for the Egyptian population which affects their dietary practices and health seeking behaviors.

Goal: Determine what challenges mothers face for their child’s nutrition and what learnings from exemplars countries can help Egypt reduce the malnutrition and stunting problem

Aim: Finding insights about the factors influencing child nutrition during 1st 1000 days and what programs can be implemented based on successful past experiences in exemplar countries. …

Recovery Journey Of Diverse Populations Using Design Thinking Method: Recommendations For Practitioners And Policymakers, Lawrence Bryant, Monica Nandan, Sherrie Cade, Bianca Anderson

Journal of Social, Behavioral, and Health Sciences

Through a state grant-funded multicultural needs assessment, researchers from a U.S. southeastern state university captured the voices of underserved populations related to their unmet needs and recovery journey from the non-medical use of opioids and other substances. Specific voices of African Americans, Latinx, mature adults, veterans, people who are homeless, college students, and individuals within the lesbian, gay, bisexual, trans, and queer (LGBTQ+) communities were captured utilizing design thinking protocol in focus groups. Participants recommended that providers be culturally responsive in disseminating information and providing affirming care. Moreover, participants felt that counselors and other professionals should be more empathetic and …

Hist 104: America Since 1865, Douglas Manson

Open Educational Resources

This history course utilizes materials that are open sourced

Environmentally Friendly New Catalyst Using Waste Alkaline Solution From Aluminum Production For The Synthesis Of Biodiesel In Aqueous Medium, Sandro L. Barbosa, David Lee Nelson, Lucas Paconio, Moises Pedro, Wallans Torres Pio Dos Santos, Alexandre P. Wentx, Fernando L. P. Pessoa, Foster A. Agblevor, Daniel A. Bortoleto, Maria B. De Freitas-Marques, Lucas D. Zanatta

Biological Engineering Faculty Publications

Red mud (RM) is composed of a waste alkaline solution (pH = 13.3) obtained from the production of alumina. It contains high concentrations of hematite (Fe₂O₃), goethite (FeOOH), gibbsite [Al(OH)₃], a boehmite (AlOOH), anatase (Tetragonal–TiO₂), rutile (Ditetragonal dipyramidal–TiO₂), hydrogarnets [Ca₃Al₂(SiO₄)_3-x(OH)_4x], quartz (SiO₂), and perovskite (CaTiO₃). It was shown to be an excellent catalytic mixture for biodiesel production. To demonstrate the value of RM, an environmentally friendly process of transesterification in aqueous medium using waste cooking oil …

Decoding The Regulatory Roles Of Non-Coding Rnas In Cellular Metabolism And Disease, Yuru Zong, Xuliang Wang, Bing Cui, Xiaowei Xiong, Andrew Wu, Chunru Lin, Yaohua Zhang

Faculty, Staff and Student Publications

Non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), are being studied extensively in a variety of fields. Their roles in metabolism have received increasing attention in recent years but are not yet clear. The regulation of glucose, fatty acid, and amino acid metabolism is an imperative physiological process that occurs in living organisms and takes part in cancer and cardiovascular diseases. Here, we summarize the important roles played by non-coding RNAs in glucose metabolism, fatty acid metabolism, and amino acid metabolism, as well as the mechanisms involved. We also summarize the therapeutic advances for non-coding …

The Reversibility Of Effects Of Combination Inhaled Corticosteroids On Sustained Phonation Pressure And Flow In Ex Vivo Rabbit Larynges, Elisabeth Barlow

Theses and Dissertations

The purpose of this thesis is to investigate the reversibility of the adverse effects of combination inhaled corticosteroids (ICs) on vocal fold health as part of a five-year study. This pilot study tested the hypothesis that the adverse effects of ICs may be induced and then reversed, using a benchtop model and rabbit larynges measuring sustained subglottic pressure and airflow. Eighteen rabbits were assigned randomly to 5 subgroups, including baseline, induction experimental, induction control, reversibility experimental, and reversibility control. Baseline rabbits did not receive any treatment. Both experimental groups, induction and reversibility, were administered Advair until visual-perceptual ratings were noted. …

Remarks On Manifesting Justice: Wrongly Convicted Women Reclaim Their Rights, Amber Baylor, Valena Beety, Susan Sturm

Articles by Maurer Faculty

The following are remarks from a panel discussion co-hosted by the Columbia Journal of Gender and Law and the Center for Gender and Sexuality Law on the book Manifesting Justice: Wrongly Convicted Women Reclaim Their Rights.

Playful Mouth-To-Mouth Interactions Of Belugas (Delphinapterus Leucas) In Managed Care, Jackson R. Ham, Malin K. Lilley, Riley J. Winchenski, Jesus Miranda, Ángel G. Velarde Dediós, Katie Kolodziej, Sergio M. Pellis, Heather M. Manitzas Hill

All Faculty Scholarship (Archived)

Belugas (Delphinapterus leucas) engage in many forms of play (e.g., object, water, locomotor), but no play is quite as curious as the unusual form of cooperative social play involving mouth-to-mouth interactions. These playful interactions are characterized by two belugas approaching each other head-to-head and interlocking their jaws, clasping one another, as if they were shaking hands. Observed in belugas both in the wild and in managed care, it is seemingly an important type of social play that offers a unique way of socializing with conspecifics. To describe this unusual behavior, a group of belugas in managed care was …

Switching From Sucrose-Formulated Rfviii To Octocog Alfa (Bay 81-8973) Prophylaxis Improves Bleed Outcomes In The Leopold Clinical Trials., Gili Kenet, Thomas Moulton, Brian M. Wicklund, Sanjay P. Ahuja, Miguel Escobar, Johnny Mahlangu

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Previous clinical trials established the efficacy and safety of sucrose-formulated recombinant factor (F) VIII (rFVIII-FS/Kogenate FS®/Helixate FS®) and octocog alfa (BAY 81-8973/Kovaltry®; LEOPOLD trials).

AIM: To report the results of a post hoc subgroup analysis assessing efficacy and safety outcomes in patients with hemophilia A who were receiving rFVIII-FS prior to enrolling into the LEOPOLD I Part B and LEOPOLD Kids Part A clinical trials and switching to octocog alfa.

METHODS: LEOPOLD I Part B (NCT01029340) and LEOPOLD Kids Part A (NCT01311648) were octocog alfa Phase 3, multinational, open-label studies in patients with severe hemophilia A aged 12-65 years …

The Origins Of Covid-19 — Why It Matters (And Why It Doesn’T), Lawrence O. Gostin, Gigi K. Gronvall

Georgetown Law Faculty Publications and Other Works

When Health emergencies arise, scientists seek to discover the cause — such as how a pathogen emerged and spread — because this knowledge can enhance our understanding of risks and strategies for prevention, preparedness, and mitigation. Yet well into the fourth year of the Covid-19 pandemic, intense political and scientific debates about its origins continue. The two major hypotheses are a natural zoonotic spillover, most likely occurring at the Huanan Seafood Wholesale Market, and a laboratory leak from the Wuhan Institute of Virology (WIV). It is worth examining the efforts to discover the origins of SARS-CoV-2, the political obstacles, and …

Preliminary Data Of Potentially Hazardous Radon Concentrations In Modrič Cave (Croatia), Robert Lončarić, Vanja Radolić, Maša Surić, Igor Miklavčić, Matea Šatalić, Dalibor Paar, Lukrecija Obšivač

International Journal of Speleology

Instigated by relatively high cave-air CO₂ concentrations in Modrič Cave (Croatia) recorded for the purpose of speleothem-based paleoclimate research, we established preliminary monitoring of radon (²²²Rn) concentrations within the cave for a 4.5-year period (2018–2022). As radioactive geogenic gas, radon, which often correlates with cave-air CO₂ concentrations, presents a potential health hazard in cases of longer exposure time in high concentration conditions. Since the Modrič Cave is open to tourists and long-term scientific research has been performed within, a safety assessment for radon concentrations was essential. The integrated measurements of radon concentrations were performed by passive …

Skeletal Muscle Delimited Myopathy And Verapamil Toxicity In Sur2 Mutant Mouse Models Of Aims, Conor Mcclenaghan, Maya A Mukadam, Jacob Roeglin, Robert C Tryon, Manfred Grabner, Anamika Dayal, Gretchen A Meyer, Colin G Nichols

2020-Current year OA Pubs

ABCC9-related intellectual disability and myopathy syndrome (AIMS) arises from loss-of-function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP-sensitive potassium (K

The Novel Uncompetitive Nmda Receptor Antagonist Esmethadone (Rel-1017) Has No Meaningful Abuse Potential In Recreational Drug Users, Megan J Shram, Jack E Henningfield, Glen Apseloff, Charles W Gorodetzky, Sara De Martin, Frank L Vocci, Frank L Sapienza, Thomas R Kosten, Jeff Huston, August Buchhalter, Judy Ashworth, Ryan Lanier, Franco Folli, Andrea Mattarei, Clotilde Guidetti, Stefano Comai, Cedric O'Gorman, Sergio Traversa, Charles E Inturrisi, Paolo L Manfredi, Marco Pappagallo

Faculty, Staff and Students Publications

Esmethadone (REL-1017) is the opioid-inactive dextro-isomer of methadone and a low-affinity, low-potency uncompetitive NMDA receptor antagonist. In a Phase 2, randomized, double-blind, placebo-controlled trial, esmethadone showed rapid, robust, and sustained antidepressant effects. Two studies were conducted to evaluate the abuse potential of esmethadone. Each study utilized a randomized, double-blind, active-, and placebo-controlled crossover design to assess esmethadone compared with oxycodone (Oxycodone Study) or ketamine (Ketamine Study) in healthy recreational drug users. Esmethadone 25 mg (proposed therapeutic daily dose), 75 mg (loading dose), and 150 mg (Maximum Tolerated Dose) were evaluated in each study. Positive controls were oral oxycodone 40 mg …

Candida Auris: Another Frontier In The Battle Against Antimicrobial Resistance, Tina L. Joshi

Peninsula Dental School

The spread of multidrug resistant Candida auris in the US is a worrying development, but we can take action now to curb its spread, writes Tina L Joshi

Skeletal Muscle Delimited Myopathy And Verapamil Toxicity In Sur2 Mutant Mouse Models Of Aims, Conor Mcclenaghan, Maya A Mukadam, Jacob Roeglin, Robert C Tryon, Manfred Grabner, Anamika Dayal, Gretchen A Meyer, Colin G Nichols

2020-Current year OA Pubs

ABCC9-related intellectual disability and myopathy syndrome (AIMS) arises from loss-of-function (LoF) mutations in the ABCC9 gene, which encodes the SUR2 subunit of ATP-sensitive potassium (K

The Ruling Of Cosmetic Injections: A Jurisprudential Study, Ali Suleiman Al Saleh Dr.

مجلة جامعة الإمارات للبحوث القانونية UAEU LAW JOURNAL

Cosmetic injections are a medical procedure, completely different from surgery, where a long-term change occurs in the body. The materials used in this procedure varies by source, whether a human, animal or mineral, which would require to study the ruling of utilizing them in cosmetic or medication.

The research concluded that the ruling of using cosmetic injections varies by functions in terms of filling in facial wrinkles and organs, causing paralysis in muscles, or feeding and motivating the skin. It also varies according to the materials injected into the body in terms of generating them from human, animal or otherwise. …

Cognitive, Ideological, And Goal-Pursuit Barriers To Ethical Decision Making, Jeffrey J. Bailey

Mountain Plains Journal of Business and Technology

This paper brings together diverse research findings to suggest that there are several cognitive, ideological, and goal-pursuit barriers that often get in the way of ethical decision-making. The barriers lead managers to give little or no conscious attention to the ethical implications of their actions. The barriers that I categorize and describe are overconfidence, cognitively “filling-in” of missing information, social norm beliefs, ethical fixed mindsets, metaphors in-use, fairness and justice ideology, behavioral scripts, goal-fever (teleopathy), and goal framing. I describe the processes and mechanisms that underlie these barriers to increase awareness of them so that the willing manager may be …

Is There A Role For Conflict Photography In Conflict Resolution? It's Complicated, Joseph Clift

Pepperdine Dispute Resolution Law Journal

In this essay, I argue that conflict photography has an important and useful role in conflict understanding and resolution. While conflict images’ usefulness has been debated, I argue that its importance has not. I start with a description of conflict photography and then provide a short historical account of the camera and its use in documenting conflicts. Next, I discuss conflict resolution and present examples of conflict resolution strategies. I then present evidence of how conflict photography can be a useful tool to support some of those strategies. Afterwards, I discuss the complicated nature of conflict photography’s usefulness. I conclude …

Deterrence Defeats Doping: How Arbitration Can Resolve Major League Baseball's Performance-Enhancing Drug Problem, Brice Barnes

Pepperdine Dispute Resolution Law Journal

This article analyzes MLB’s PED policy and proposes amending the policy by arbitrating the agreement to create one that further deters players from using PEDs. The remainder of this article is divided into five parts: Part II discusses the significance of the PED issue and why resolution is necessary; Part III discusses the history of PED use in baseball and the efforts by the League to address it; Part IV proposes the solution of arbitration and explains how the process might work; Part V addresses potential objections to that solution; and finally, Part VI concludes.