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Molecular Investigation Confirms Myotis Genus Bats As Common Hosts Of Polychromophilus In Brazil, Bruno Da Silva Mathias, Guilherme Augusto Minozzo, Alexander Welker Biondo, Jaciara De Oliviera Jorge Costa, Herbert Sousa Soares, Arlei Marcili, Lilian De Oliviera Guimaraes, Carolina Clares Dos Anjos, Andrea Pires Dos Santos, Irina Nastassja Riediger, Alan Fecchio, Marina Galvao Bueno, Joao Batista Pinho, Karin Kirchgatter Jun 2023

Molecular Investigation Confirms Myotis Genus Bats As Common Hosts Of Polychromophilus In Brazil, Bruno Da Silva Mathias, Guilherme Augusto Minozzo, Alexander Welker Biondo, Jaciara De Oliviera Jorge Costa, Herbert Sousa Soares, Arlei Marcili, Lilian De Oliviera Guimaraes, Carolina Clares Dos Anjos, Andrea Pires Dos Santos, Irina Nastassja Riediger, Alan Fecchio, Marina Galvao Bueno, Joao Batista Pinho, Karin Kirchgatter

Purdue University Libraries Open Access Publishing Fund

Plasmodium spp. and some other blood parasites belonging to the order Haemosporida are the focus of many epidemiological studies worldwide. However, haemosporidian parasites from wild animals are largely neglected in scientific research. For example, Polychromophilus parasites, which are exclusive to bats, are described in Europe, Asia, Africa, and Oceania, but little is known about their presence and genetic diversity in the New World. In this study, 224 samples of bats from remaining fragments of the Atlantic Forest and Pantanal biomes, as well as urbanized areas in southern and southeastern Brazil, were analyzed for the presence of haemosporidian parasites by PCR …

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Bone Growth Induction In Mucopolysaccharidosis Iva Mouse, Estera Rintz, Angélica María Herreño-Pachón, Betul Celik, Fnu Nidhi, Shaukat Khan, Eliana Benincore-Flórez, Shunji Tomatsu Jun 2023

Bone Growth Induction In Mucopolysaccharidosis Iva Mouse, Estera Rintz, Angélica María Herreño-Pachón, Betul Celik, Fnu Nidhi, Shaukat Khan, Eliana Benincore-Flórez, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is caused by a deficiency of the N-acetylgalactosamine-6-sulfate-sulfatase (GALNS) enzyme, leading to the accumulation of glycosaminoglycans (GAG), keratan sulfate (KS) and chondroitin-6-sulfate (C6S), mainly in cartilage and bone. This lysosomal storage disorder (LSD) is characterized by severe systemic skeletal dysplasia. To this date, none of the treatment options for the MPS IVA patients correct bone pathology. Enzyme replacement therapy with elosulfase alpha provides a limited impact on bone growth and skeletal lesions in MPS IVA patients. To improve bone pathology, we propose a novel gene therapy with a small peptide as a growth-promoting …

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Virginia Woolf & Ecologies: Selected Papers From The 32nd Annual International Conference On Virginia Woolf, Full Issue, Shilo Mcgiff, Laci Mattison Jun 2023

Virginia Woolf & Ecologies: Selected Papers From The 32nd Annual International Conference On Virginia Woolf, Full Issue, Shilo Mcgiff, Laci Mattison

Virginia Woolf: Selected Papers

No abstract provided.

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Ecologies Of Illness In The Voyage Out And Flush, Caylee Weintraub Jun 2023

Ecologies Of Illness In The Voyage Out And Flush, Caylee Weintraub

Virginia Woolf: Selected Papers

No abstract provided.

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Seaweeding With Virginia Woolf, Jeanne Dubino Jun 2023

Seaweeding With Virginia Woolf, Jeanne Dubino

Virginia Woolf: Selected Papers

No abstract provided.

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Nonhuman Beings, Existential Anxiety, And Schopenhauer In Virginia Woolf’S Work, Yoshiki Tajiri Jun 2023

Nonhuman Beings, Existential Anxiety, And Schopenhauer In Virginia Woolf’S Work, Yoshiki Tajiri

Virginia Woolf: Selected Papers

No abstract provided.

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Ecologies Of Madness: Reading Virginia Woolf’S Life And Work Through Deleuze And Guattari, Kimberly Jackson Jun 2023

Ecologies Of Madness: Reading Virginia Woolf’S Life And Work Through Deleuze And Guattari, Kimberly Jackson

Virginia Woolf: Selected Papers

No abstract provided.

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Speculating On Obscurity: Virginia Woolf’S Fictionalization Of Real Lives As An Alternative To Hegemonic Tellings Of History, Mariana Muniz Pivanti Jun 2023

Speculating On Obscurity: Virginia Woolf’S Fictionalization Of Real Lives As An Alternative To Hegemonic Tellings Of History, Mariana Muniz Pivanti

Virginia Woolf: Selected Papers

No abstract provided.

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Virginia Woolf And Deep Ecology, Kathryn Van Wert Jun 2023

Virginia Woolf And Deep Ecology, Kathryn Van Wert

Virginia Woolf: Selected Papers

No abstract provided.

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Tea In The Library: Leonard And Virginia Woolf And The Ecologies Of Tea, Diane F. Gillespie Jun 2023

Tea In The Library: Leonard And Virginia Woolf And The Ecologies Of Tea, Diane F. Gillespie

Virginia Woolf: Selected Papers

No abstract provided.

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Floral Transformations: Humanoid Flowers And Floral Humans, Or Floral Erections And Decapitations: Woolf’S Armies Of The Upright And The Whacked, Elisa Kay Sparks Jun 2023

Floral Transformations: Humanoid Flowers And Floral Humans, Or Floral Erections And Decapitations: Woolf’S Armies Of The Upright And The Whacked, Elisa Kay Sparks

Virginia Woolf: Selected Papers

No abstract provided.

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Some (Early) Versions Of Pastoral: Virginia Woolf And Ecologies Of Form, Shilo Mcgiff Jun 2023

Some (Early) Versions Of Pastoral: Virginia Woolf And Ecologies Of Form, Shilo Mcgiff

Virginia Woolf: Selected Papers

No abstract provided.

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“Moments Of Being” As Ecological Epiphany, Leanna Lostoski-Ho Jun 2023

“Moments Of Being” As Ecological Epiphany, Leanna Lostoski-Ho

Virginia Woolf: Selected Papers

No abstract provided.

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“I Do Not Cling To Life. I Shall Be Brushed Like A Beefrom A Sunflower”: Posthuman Extinction And The Long Now In The Waves, Oliver Case Jun 2023

“I Do Not Cling To Life. I Shall Be Brushed Like A Beefrom A Sunflower”: Posthuman Extinction And The Long Now In The Waves, Oliver Case

Virginia Woolf: Selected Papers

No abstract provided.

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A Few Remarks On “Sensuous Pedagogies”, Benjamin D. Hagen Jun 2023

A Few Remarks On “Sensuous Pedagogies”, Benjamin D. Hagen

Virginia Woolf: Selected Papers

No abstract provided.

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Essential And Recurrent Roles For Hairpin Rnas In Silencing De Novo Sex Chromosome Conflict In Drosophila Simulans, Jeffrey Vedanayagam, Marion Herbette, Holly Mudgett, Ching-Jung Lin, Chun- Ming Lai, Caitlin Mcdonough-Goldstein, Stephen Dorus, Benjamin Loppin, Colin D. Meiklejohn, Raphaëlle Dubruille, Eric C. Lai Jun 2023

Essential And Recurrent Roles For Hairpin Rnas In Silencing De Novo Sex Chromosome Conflict In Drosophila Simulans, Jeffrey Vedanayagam, Marion Herbette, Holly Mudgett, Ching-Jung Lin, Chun- Ming Lai, Caitlin Mcdonough-Goldstein, Stephen Dorus, Benjamin Loppin, Colin D. Meiklejohn, Raphaëlle Dubruille, Eric C. Lai

School of Biological Sciences: Faculty Publications

Meiotic drive loci distort the normally equal segregation of alleles, which benefits their own transmission even in the face of severe fitness costs to their host organism. However, relatively little is known about the molecular identity of meiotic drivers, their strategies of action, and mechanisms that can suppress their activity. Here, we present data from the fruitfly Drosophila simulans that address these questions. We show that a family of de novo, protamine- derived X-linked selfish genes (the Dox gene family) is silenced by a pair of newly emerged hairpin RNA (hpRNA) small interfering RNA (siRNA)-class loci, Nmy and Tmy. …

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The Impact Of Biophilic Attributes On University Students Level Of Satisfaction: Using Virtual Reality Simulation, Amira Mohamed Mahrous, Khaled Dewidar, Mostafa Refaat, Ashraf Nessim Jun 2023

The Impact Of Biophilic Attributes On University Students Level Of Satisfaction: Using Virtual Reality Simulation, Amira Mohamed Mahrous, Khaled Dewidar, Mostafa Refaat, Ashraf Nessim

Architectural Engineering

Biophilic design is a new approach that can enhance human psychological well-being. Most recent studies focus on applying biophilic design to hospitals or office buildings, not academic buildings. While usually ignored, students' level of satisfaction is one of the most important key indicators for a successful learning environment. This paper aims to identify the biophilic design attributes that can potentially contribute to enhancing the students' level of satisfaction. This will be done through an experimental research design using virtual reality in a design studio at The British University in Egypt. Each participant (N = 52) was exposed to the existing …

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The Influence Of Metaphorical And Literal Language On Conspiracy Theory Belief: The Role Of Language And Individual Differences, Gabrielle Toups Jun 2023

The Influence Of Metaphorical And Literal Language On Conspiracy Theory Belief: The Role Of Language And Individual Differences, Gabrielle Toups

College of Science and Health Theses and Dissertations

Although conspiracy theories have long existed, they are of current interest due to their widespread nature on social media (Enders et al., 2021). Research has shown the impact of informational framing on overall conspiracy theory believability (Swami et al., 2013). Informational framing can influence overall public perception of conspiracy theories (Butler et al., 1995; Hameleers, 2020; Enders et al., 2021), showing the impact of the language used in spreading conspiracy theories. Individual difference measures have been shown to impact overall conspiracy theory belief (Swami et al., 2010; Swami et al., 2013; Douglas, 2019). However, research has not explored the relationship …

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The Interplay Between Language And Culture In J.R.R. Tolkien's Middle-Earth, Mackenzie Wangberg Jun 2023

The Interplay Between Language And Culture In J.R.R. Tolkien's Middle-Earth, Mackenzie Wangberg

Masters Theses

The construction of detailed languages was a lifelong passion of J.R.R. Tolkien. While creating the world of Middle-earth, he assigned different languages to the various cultures which inhabit this fantasy landscape. He carefully matched languages and cultures to try to elicit particular responses from his audience. It is well known that J.R.R. Tolkien wanted certain languages of Middle-earth to sound beautiful and others to sound ugly. Research so far, however, has not answered why the specific phonemes, or sounds, which Tolkien chose for these languages might cause the specific reactions he intended. I have used Tolkien’s influences to explain why …

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2023 Belknap County Fair Book, Karen Deighan Jun 2023

2023 Belknap County Fair Book, Karen Deighan

UNH Cooperative Extension

No abstract provided.

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Chronic Basal Forebrain Activation Improves Spatial Memory, Boosts Neurotrophin Receptor Expression, And Lowers Bace1 And Aβ42 Levels In The Cerebral Cortex In Mice, Jacob Kumro, Ashutosh Tripathi, Yun Lei, Jeremy Sword, Patrick Callahan, Alvin Terry, Xin-Yun Lu, Sergei A Kirov, Anilkumar Pillai, David T Blake Jun 2023

Chronic Basal Forebrain Activation Improves Spatial Memory, Boosts Neurotrophin Receptor Expression, And Lowers Bace1 And Aβ42 Levels In The Cerebral Cortex In Mice, Jacob Kumro, Ashutosh Tripathi, Yun Lei, Jeremy Sword, Patrick Callahan, Alvin Terry, Xin-Yun Lu, Sergei A Kirov, Anilkumar Pillai, David T Blake

Faculty, Staff and Student Publications

The etiology of Alzheimer’s dementia has been hypothesized in terms of basal forebrain cholinergic decline, and in terms of reflecting beta-amyloid neuropathology. To study these different biological elements, we activated the basal forebrain in 5xFAD Alzheimer’s model mice and littermates. Mice received 5 months of 1 h per day intermittent stimulation of the basal forebrain, which includes cholinergic projections to the cortical mantle. Then, mice were behaviorally tested followed by tissue analysis. The 5xFAD mice performed worse in water-maze testing than littermates. Stimulated groups learned the water maze better than unstimulated groups. Stimulated groups had 2–3-fold increases in frontal cortex …

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A Novel Role For Enos In Regulating Lymphatic Valve Development During Embryogenesis, Drishya Iyer Jun 2023

A Novel Role For Enos In Regulating Lymphatic Valve Development During Embryogenesis, Drishya Iyer

USF Tampa Graduate Theses and Dissertations

Lymphedema is a disease that occurs when lymph flow is impaired, resulting in tissue swelling, fibrosis, chronic inflammation and recurrent secondary infections. Lymphatic valves play a critical role in maintaining unidirectional lymph flow and evidence for valve defects have been reported in lymphedema patients. The lack of drugs that can correct lymphatic valve defects warrants a better understanding of the molecular regulators of lymphatic valve development and maintenance. Lymphatic valves first develop during embryogenesis in response to mechanotransduction signaling pathways triggered by oscillatory lymph flow. Since eNOS (gene name: Nos3) is a well characterized mechanotransduction signaling molecule in blood vessels, …

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Targeting Neddylation And Sumoylation In Chemoresistant Triple Negative Breast Cancer, Wei Ruan, Jiwen Li, Seungwon Choi, Xinxin Ma, Yafen Liang, Ragini Nair, Xiaoyi Yuan, Tingting W Mills, Holger K Eltzschig Jun 2023

Targeting Neddylation And Sumoylation In Chemoresistant Triple Negative Breast Cancer, Wei Ruan, Jiwen Li, Seungwon Choi, Xinxin Ma, Yafen Liang, Ragini Nair, Xiaoyi Yuan, Tingting W Mills, Holger K Eltzschig

Faculty, Staff and Student Publications

Previous studies implicate extracellular adenosine signaling in attenuating myocardial ischemia and reperfusion injury (IRI). This extracellular adenosine signaling is terminated by its uptake into cells by equilibrative nucleoside transporters (ENTs). Thus, we hypothesized that targeting ENTs would function to increase cardiac adenosine signaling and concomitant cardioprotection against IRI. Mice were exposed to myocardial ischemia and reperfusion injury. Myocardial injury was attenuated in mice treated with the nonspecific ENT inhibitor dipyridamole. A comparison of mice with global Ent1 or Ent2 deletion showed cardioprotection only in Ent1-/- mice. Moreover, studies with tissue-specific Ent deletion revealed that mice with myocyte-specific Ent1 deletion (Ent1loxP/loxP …

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A Qualitative Exploration Of Substance Use Treatment Among Gender Diverse Community Members, Hannah Colgonis Jun 2023

A Qualitative Exploration Of Substance Use Treatment Among Gender Diverse Community Members, Hannah Colgonis

Electronic Theses and Dissertations Archive

The present study is a qualitative analysis of interviews with gender diverse community members about existing treatment conditions for gender diverse adults and potential suggestions for tailoring care to better reach and retain gender diverse populations. Eleven transgender and gender diverse (TGD) participants, aged 18-64, who had considered or participated in substance use treatment completed a brief questionnaire and an interview that explored their substance use histories and treatment experiences. Interviews were then reviewed and coded by a team of graduate students using Braun and Clarke’s (2006) guidelines. Interview data was coded into four overarching themes including barriers, problems, successes, …

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Cruisin' The Coast: A Practice In Passionate Observation, Laura Jean Keriazakos Jun 2023

Cruisin' The Coast: A Practice In Passionate Observation, Laura Jean Keriazakos

Masters Theses

The term Passionate Observation is presented as an ability that improves creative writing. It requires a writer to absorb details, noticed or perceived, with intense imagination and reasoning. I present a three-pronged case for acceptance and development of this skill for writing mystery fiction. Examined in this paper are the literary talents of Agatha Christie and Sir Arthur Conan Doyle, along with the supposition both authors were passionate observers. Moreover, through the lens of education, I connect visual literacy, kinesthetic research, and passionate observation. Then, I show the philosophical correlation between observation in science and passionate observation in creative writing. …

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Preserving The Craft: An Exploration Of The Performance Techniques Of Marching Bands At Historically Black Colleges And Universities, Freamon Mcnair Iii Jun 2023

Preserving The Craft: An Exploration Of The Performance Techniques Of Marching Bands At Historically Black Colleges And Universities, Freamon Mcnair Iii

Doctoral Dissertations and Projects

Many high school marching bands in urban school districts across the United States incorporate the marching style used by Historically Black Colleges and University (HBCU) programs. This research aims to investigate the details of teaching the HBCU marching style and provide recommendations on developing more instructional materials and scholarly resources on teaching the marching style. This study will benefit music educators who need more experience in the HBCU style and HBCU music education graduates who are novices in teaching. The band directors of the high school band programs are commonly HBCU graduates who traditionally follow the philosophy taught at their …

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This Too Shell Pass: Investigating The Function Of B Cells During An Immune Response In The Red-Eared Slider, Trachemys Scripta, Christen Renee Fairow Jun 2023

This Too Shell Pass: Investigating The Function Of B Cells During An Immune Response In The Red-Eared Slider, Trachemys Scripta, Christen Renee Fairow

Theses and Dissertations

B cells are crucial components of the immune system during an infection that produce antibodies. It is not known how B cells function or if different cell subsets exist in reptiles. Understanding how B cells function in reptiles can help protect endangered species by clarifying how their immune system may be different from other vertebrates but may also allow for the development of new human medicines. First, we aimed to identify turtle leukocytes based on their morphological characteristics. Blood smears were made and photos were taken on a light microscope equipped with a digital camera. Using this method, we were …

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Equine Navicular Syndrome, Kylie Stephens, Karl Hoopes Jun 2023

Equine Navicular Syndrome, Kylie Stephens, Karl Hoopes

All Current Publications

Equine navicular syndrome has a large effect on the horse industry by accounting for up to one third of all chronic forelimb lamenesses. While the exact cause and development of this disease is still widely controversial, there are noticeable and significant changes to the internal anatomy and structures that could contribute to the possible onset of lameness. Three main causes are proposed that could play a role in the progression of this syndrome: biomechanical forces, vascular alterations, and chronic inflammation. The clinical signs of navicular syndrome can range from short choppy strides to intermittent lameness, as well as gait changes …

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Stable Isotopes And Foraging Behaviors Support The Role Of Antipredator Benefits In Driving The Association Between Two Marine Fishes, Christopher R. Haak, Michael Power, Alexander D.M. Wilson, Andy J. Danylchuk Jun 2023

Stable Isotopes And Foraging Behaviors Support The Role Of Antipredator Benefits In Driving The Association Between Two Marine Fishes, Christopher R. Haak, Michael Power, Alexander D.M. Wilson, Andy J. Danylchuk

School of Biological and Marine Sciences

No abstract provided.

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The Effect Of Dnaaf5 Gene Dosage On Primary Ciliary Dyskinesia Phenotypes, Amjad Horani, Deepesh Kumar Gupta, Jian Xu, Huihui Xu, Lis Del Carmen Puga-Molina, Celia M. Santi, Sruthi Ramagiri, Steven K. Brennan, Jiehong Pan, Jeffrey R. Koenitzer, Tao Huang, Rachael M. Hyland, Sean P. Gunsten, Shin-Cheng Tzeng, Jennifer M. Strahle, Pleasantine Mill, Moe R. Mahjoub, Susan K Dutcher, Steven L Brody Jun 2023

The Effect Of Dnaaf5 Gene Dosage On Primary Ciliary Dyskinesia Phenotypes, Amjad Horani, Deepesh Kumar Gupta, Jian Xu, Huihui Xu, Lis Del Carmen Puga-Molina, Celia M. Santi, Sruthi Ramagiri, Steven K. Brennan, Jiehong Pan, Jeffrey R. Koenitzer, Tao Huang, Rachael M. Hyland, Sean P. Gunsten, Shin-Cheng Tzeng, Jennifer M. Strahle, Pleasantine Mill, Moe R. Mahjoub, Susan K Dutcher, Steven L Brody

2020-Current year OA Pubs

DNAAF5 is a dynein motor assembly factor associated with the autosomal heterogenic recessive condition of motile cilia, primary ciliary dyskinesia (PCD). The effects of allele heterozygosity on motile cilia function are unknown. We used CRISPR-Cas9 genome editing in mice to recreate a human missense variant identified in patients with mild PCD and a second, frameshift-null deletion in Dnaaf5. Litters with Dnaaf5 heteroallelic variants showed distinct missense and null gene dosage effects. Homozygosity for the null Dnaaf5 alleles was embryonic lethal. Compound heterozygous animals with the missense and null alleles showed severe disease manifesting as hydrocephalus and early lethality. However, animals …

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