Digital Commons Network^™

Working Paper No. 75, The Utopian Socialists Reconsidered, Aden Quenemoen

Working Papers in Economics

This inquiry seeks to establish that efforts to formulate utopian solutions to societal challenges are deserving of reconsideration, especially when the national and international solutions influenced by one Karl Marx and his followers appear to have reached their nadir as the Soviet experiment ended by the start of the 1990s. Such requires us to look back in time prior to Marx by considering contributions advanced by the likes of: Henri de Saint-Simon, Robert Owen, and Charles Fourier. What is stressed is that all three of these authors advanced novel ideas, with some of their ideas deemed important and enduring, while …

A Historic Review Of Community Policing & The Implementation Issues We Have Faced, Emily Bell

University Honors Theses

Community Policing has existed around the world for decades, despite becoming increasingly popular in the later 1990s and early 2000s in the United States. There have been multiple ways that the United States has tried to implement community policing, which this paper will review. Starting in the 1960s when the 12th street race riots caused Lyndon B. Johnson to publish government reports calling for an overhaul of policing and an increased focus on community relations, and looking all the way to 2014, when President Barack Obama created the Task Force on 21st Century Policing, which also put out a report …

The Egyptian Private-Climate Nexus: Private Sector Perceptions On The Green Transition, Yehia Shaheen

Theses and Dissertations

The issue of climate change poses the most pressing threat for humanity. This is especially the case amongst developing countries who, while emitting the minority of global emissions, are forecast to bear the most damage. Such is the case with Egypt, who suffers from marked water scarcity and is vulnerable to climate change driven detriments across a number of levels. As climate finance and private sector investments are key towards the green transition; transitioning to a green economy to fight the adverse impacts of climate change, this thesis aims to analyze the perceptions of private sector actors on the issue …

Incubation With Porcine Urinary Bladder Matrix Yields A Late-Stage Wound Transcriptome In Endothelial Cells And Keratinocytes Isolated From Both Diabetic And Non-Diabetic Subjects, John T. Paige, Daniel J. Lightell, Hunter F. Douglas, Natasha C. Klingenberg, Thaidan Pham, T. Cooper Woods

School of Medicine Faculty Publications

Proper wound closure requires the functional coordination of endothelial cells (ECs) and keratinocytes. In the late stages of wound healing, keratinocytes become activated and ECs promote the maturation of nascent blood vessels. In diabetes mellitus, decreased keratinocyte activation and impaired angiogenic action of ECs delay wound healing. Porcine urinary bladder matrix (UBM) improves the rate of wound healing, but the effect of exposure to UBM under diabetic conditions remains unclear. We hypothesized that keratinocytes and ECs isolated from both diabetic and non-diabetic donors would exhibit a similar transcriptome representative of the later stages of wound healing following incubation with UBM. …

Neuropharmacology Of Human [Tera2.Cl.Sp12] Stem Cell-Derived Neurons In Ultra-Long-Term Culture For Antiseizure Drug Discovery, Hamed Salmanzadeh, Ankita Poojari, Atefeh Rabiee, Benjamin D. Zeitlin, Robert F. Halliwell

School of Pharmacy Faculty Articles

Modeling the complex and prolonged development of the mammalian central nervous system in vitro remains a profound challenge. Most studies of human stem cell derived neurons are conducted over days to weeks and may or may not include glia. Here we have utilized a single human pluripotent stem cell line, TERA2.cl.SP12 to derive both neurons and glial cells and determined their differentiation and functional maturation over 1 year in culture together with their ability to display epileptiform activity in response to pro-convulsant agents and to detect antiseizure drug actions. Our experiments show that these human stem cells differentiate in vitro …

Atomistic Assessment Of Drug-Phospholipid Interactions Consequent To Cancer Treatment: A Study Of Anthracycline Cardiotoxicity, Yara Elsayed Ahmed

Theses and Dissertations

Despite being one of the most effective chemotherapeutic agents developed to date, Anthracyclines are notorious for their cardiotoxicity. Their clinical use is frequently limited both in dosage and in prescription due to the severe cardiac damage they cause. The mechanism of anthracycline-induced cardiotoxicity is not yet fully understood. However, it is hypothesized that interactions with the myocardial membrane play an important role in imparting cardiotoxicity. In this study, we use molecular dynamics simulations and density functional theory calculations to study the anthracycline drug molecules and the interactions that they have with the myocardial membrane. We construct a myocardial membrane model …

Colocalization Of Linezolid Resistance (Cfr) And Virulence Factors Cytolysin And Hemolysin (Cln And Hln) On A Plasmid In Enterococcus Faecalis, Nikita V Singh, Kavindra V Singh, An Q Dinh, Cesar A Arias, William C Shropshire, Blake M Hanson, Barbara E Murray

Faculty, Staff and Student Publications

No abstract provided.

Growing Brine Shrimp (Artemia) In Desalination Brine Water, Khaled Madkour

Theses and Dissertations

Water scarcity is one of the main issues in the recent and coming decades that resulted from the growing population, increasing agricultural lands, and other current challenges. This problem led to finding alternatives to provide fresh water for domestic usage. Desalination is one of these solutions, especially in the MENA region, which has more than half of the desalination plants in the world. The desalination process has two main outputs: freshwater and highly concentrated saline water (brine water). The brine water discharge can be done in various approaches, including deep-well injection, surface water disposal, land application, effluent disposal, and evaporation …

Review Of Intersections Of Open Educational Resources And Information Literacy, Laura M. Bernhardt

Communications in Information Literacy

Review of Cullen, M. A., & Dill, E. (Eds.). (2022). Intersections of open educational resources and information literacy. Association of College and Research Libraries.

Attention Visual, Baris Dingil

College of Computing and Digital Media Dissertations

This research presents an innovative approach to improving visual-spatial attention using a research tool based on the web. Recognizing the significant role visual-spatial attention plays in everyday life and cognitive function for humans, this research was undertaken with the aim of developing a user-friendly, accessible web-based tool called Attention Visual (attentionvisual.com) to enhance this crucial cognitive skill. This tool also facilitates data collection, potentially accelerating the pace and enhancing the quality of related research. Both qualitative and quantitative methods were utilized for data collection and analysis. In order to stimulate improvements in visual-spatial attention, the tool’s algorithm was structured to …

Anatomy Of China’S Maritime Strategy: Threatening The Maritime Order Through Its National Legislation And Self-Centered Interpretation Of Unclos, Shigeki Sakamoto

International Law Studies

While the 1982 United Nations Convention on the Law of the Sea (UNCLOS) establishes an objective framework for the coordinated handling of the use of the sea by States in the exercise of their legislative, judicial, and executive powers, China’s legislative bodies, in enacting domestic laws for the fulfillment of treaty obligations, distort obligations in its domestic laws to secure their own national interests. For example, Article 6.2 of China’s Territorial Sea Law violates articles of UNCLOS by denying the right of innocent passage. In addition, China is extending its jurisdiction over security to the contiguous zone with Article 13 …

Science Paper Or Big Data? Assessing Invasion Dynamics Using Observational Data, Charlotte H. Clubley, Louise B. Firth, Louisa E. Wood, David T. Bilton, Tiago A.M. Silva, Antony M. Knights

School of Biological and Marine Sciences

Non-native species are spreading at an unprecedented rate over large spatial scales, with global environmental change and growth in commerce providing novel opportunities for range expansion. Assessing the pattern and rate of spread is key to the development of strategies for safeguarding against future invasions and efficiently managing existing ones. Such assessments often depend on spatial distribution data from online repositories, which can be spatially biased, imprecise, and lacking in quantity. Here, the influence of disparities between occurrence records from online data repositories and what is known of the invasion history from peer-reviewed published literature on non-native species range expansion …

Empowering Deep Learning Based Organizational Decision Making: A Survey, Mona Mohamed

Sustainable Machine Intelligence Journal

The advent of deep learning has revolutionized the landscape of organizational decision-making by offering powerful tools for data analysis and prediction. In this comprehensive survey, we explore the intersection of deep learning and organizational decision-making, elucidating the theoretical underpinnings, empirical evidence, and practical implications of this synergy. Theoretical foundations and research hypotheses are rigorously examined, providing a solid framework for understanding the role of deep learning models in enhancing decision-making processes. We delve into the systematic survey, which encompasses a wide spectrum of applications across various industries and domains, showcasing how deep learning empowers decision support systems, augments data-driven decision-making, …

Ohsv-P10 Reduces Glioma Stem Cell Enrichment After Oncolytic Hsv Therapy, Upasana Sahu, Matthew P Mullarkey, Guangsheng Pei, Zhongming Zhao, Bangxing Hong, Balveen Kaur

Faculty, Staff and Student Publications

Longstanding evidence implicate glioma stem-like cells as the main drivers contributing toward glioblastoma (GBM) therapy resistance and tumor recurrence. Although oncolytic herpes simplex virus (oHSV) viral therapy is a promising biological therapy recently approved for melanoma (in the United States and Europe) and GBM (in Japan); however, the impact of this therapy on GBM stem-like cells (GSCs) is understudied. Here we show that post-oHSV virotherapy activated AKT signaling results in an enrichment of GSC signatures in glioma, which mimics the enrichment in GSC observed after radiation treatment. We also uncovered that a second-generation oncolytic virus armed with PTEN-L (oHSV-P10) decreases …

Gonadotropin-Dependent Precocious Puberty: Single-Center Experience From Western India, Aditya Phadte, Vijaya Sarathi, Sweta Budyal, Anurag Lila, Saba Samad Memon, Manjiri Karlekar, Virendra Patil, Nalini Shah, Tushar Bandgar

Faculty, Staff and Student Publications

Objective: To describe the characteristics of gonadotropin-dependent precocious puberty (GDPP) in Indian children.

Methods: Clinical profiles of GDPP (n=78, 61 females) and premature thelarche (n=12) from a single center in Western India were retrospectively studied.

Results: Pubertal onset was earlier in boys than girls (29 vs 75 months, respec-tively; P=0.008). The basal luteinizing hormone (LH) was ≥0.3 mIU/mL, except 18% of GDPP girls. At 60 minutes after GnRHa-stimulation, all patients (except one girl) had LH ≥5 mIU/mL. The GnRHa-stimulated LH/FSH ratio was ≥0.34 at 60 minutes in girls with GDPP unlike premature thelarche. Only one girl had an allergic reaction …

Stroke Survivors' Telemedicine Experiences During The Covid-19 Pandemic: A Phenomenological Investigation, Irene N Kasumba, Kit Tilly, Tao Lin, Steven J Norris, Patricia A Rosa

Faculty, Staff and Student Publications

The highly segmented genome of Borrelia burgdorferi, the tick-borne bacterium that causes Lyme disease, is composed of a linear chromosome and more than 20 co-existing endogenous plasmids. Many plasmid-borne genes are unique to B. burgdorferi and some have been shown to provide essential functions at discrete points of the infectious cycle between a tick vector and rodent host. In this study, we investigated the role of bba40, a highly conserved and differentially expressed gene on a ubiquitous linear plasmid of B. burgdorferi. In a prior genome-wide analysis, inactivation of bba40 by transposon insertion was linked with a …

Association Of Gut Microbiota Composition With Alzheimer’S-Like Disease In A Rat Model, Hana Heiba

Theses and Dissertations

With many countries turning ‘grey’ and facing an issue with aging populations, the risk of developing one form of neurodegenerative disease is increasing. Dementia, being the most common syndrome resulting from neurodegeneration, severely affects memory and cognitive functions. Alzheimer’s disease (AD) is the most common neurodegenerative disorder, with an estimated 615,000 new cases will be added to the existing 5.7 million by 2030 (Alkasir et al., 2017).

In the current study, we establish a sporadic AD-like rat model by injecting STZ intracerebrally. Stool samples were collected at two time points; after three weeks for the acute stage, and 3 months …

Building Envelope Retrofits For Achieving Thermal Comfort In Naturally Ventilated Buildings In Future Climates: A Case Study Of Social Housing In Egypt, Donna Nader Kamel Ebeid

Theses and Dissertations

Envelope thermal insulation has a significant impact on a scale from global to individual interest. It contributes to indoor thermal comfort, provides economic benefit through reduced electricity bills, increases energy efficiency of buildings through reduced energy consumption, and protects against the change in Earth’s climate through reduced greenhouse gas emissions. In 2021, building operations accounted for 30% of global energy consumption, 27% of annual global CO₂ emissions and 35% of building energy use accounted for electricity consumption which is used to create comfortable indoor living conditions. In Egypt, electricity consumption in residential sector has been steadily increasing, among other …

Evaluation Of Green Roof Technology In Egypt, Hend Abada

Theses and Dissertations

A green roof is a well-known technology worldwide that provides many social, economic, and environmental benefits. In Egypt, green roofs are still a new construction practice where most stakeholders lack business and technical expertise within this emerging industry. This research is concerned with assessing this emerging technology within its contemporary context, Egypt, and testing its feasibility within the physical condition of the Egyptian buildings and the social and economic conditions of the Egyptians. This study starts by presenting intensive information about green roof technology and reviewing the literature on green roofs within the Egyptian context. A grounded methodology is used …

The Impact Of Slavery And Colonialism On The Black Consciousness: Narrative Of The Life Of Frederick Douglass, The Confessions Of Nat Turner, And Incidents In The Life Of A Slave Girl, Mariam Badawi

Theses and Dissertations

According to the German author, essayist, and empirical psychologist Karl Philipp Moritz, to be able to analyze someone psychologically, we have to be able to analyze ourselves as one would know oneself better than one would know anyone else. Therefore, he proposed the study of autobiographies to be able to delve into a writer's "innermost soul"; through their knowledge of themselves" (qtd. in Schlumbohm 32). Moreover, "the psychological effect that the ideology of white supremacy and European imperialism, in the form of slavery and colonialism, has had on Africa and her people has never been fully addressed and understood" (Nobles …

The Death And Rebirth Of The Feminine Muse: Edgar Allan Poe And Sylvia Plath, Noha Ibrahim

Theses and Dissertations

While drawing on mythology and a literary history that associated women with death as well as creativity, Edgar Allan Poe and Sylvia Plath experimented with binary oppositions such as masculine/feminine, composition/decomposition, and death/(re)birth. They gained inspiration from the same source, the dead muse, but how do they transform traditions that derive from classical and medieval literary precedent, perhaps in ways that are inherently critical of patriarchal modes of gender dynamics? Why is Poe fixated on a feminine dead muse while Plath is inspired by what she calls her “father-sea-god muse”? How do both authors represent the female body, and how …

A Qualitative Exploration Of Food Literacy In International Schools In Egypt, Amy Pugsley

Theses and Dissertations

Food literacy is an essential part of good physical and psychological health, however, food literacy is not a mandatory part of K-12 education in all schools. Many factors can influence food literacy levels including familial culture, socioeconomic status, and education levels. This research seeks to examine perceptions of food literacy in high school students and educators at two private American international schools located in Cairo, Egypt. Through the use of observations and interviews, the researcher used a qualitative approach to understand the self-perceptions of food literacy in students studying the American curriculum. The study revealed that students from high-socio-economic backgrounds …

Assessing The Correlation Between The Socioeconomic Level And Cognitive Function Among Older Adults In Egypt, Macy Abougabal

Theses and Dissertations

The number of older adults is increasing worldwide at an unprecedented rate. Some countries began to understand the challenges of aging, while others are still at the stage of comprehending the true dimensions of the situation. There is a global focus on aging research to appropriately mitigate the negative impact of aging and cognitive decline. Not only that dementia add economic pressure on governments, it also increase the psychological and physical burden of the caregivers. Scholars have previously studied socioeconomic level in three variables, namely work, education, and income, and their relationship with cognitive function. It was concluded that the …

History Of Childhood Physical Abuse Is Associated With Gut Microbiota Diversity Among Adult Psychiatric Inpatients, Jessica C Rohr, Katelynn A Bourassa, Dominique S Thompson, J Christopher Fowler, B Christopher Frueh, Benjamin L Weinstein, Joseph Petrosino, Alok Madan

Faculty, Staff and Students Publications

BACKGROUND: Traumatic life events are associated with the development of psychiatric and chronic medical illnesses. This exploratory study examined the relationship between traumatic life events and the gut microbiota among adult psychiatric inpatients.

METHODS: 105 adult psychiatric inpatients provided clinical data and a single fecal sample shortly after admission. A modified version of the Stressful Life Events Screening Questionnaire was used to quantify history of traumatic life events. 16S rRNA gene sequencing was used to analyze the gut microbial community.

RESULTS: Gut microbiota diversity was not associated with overall trauma score or any of the three trauma factor scores. Upon …

Generative Phonology Models Of Universal Grammar: Constraint-Based Optimality Theory As Opposed To The Rule-Based Spe Model, Ahmed Hamid Abdulrazzaq

Alustath Journal for Human and Social Sciences

Current linguistic theory presumes languages to be essentially similar because individuals have a genetic inclination to acquire language. Linguists strive to create a model of this abstract universal grammar that captures the core commonalities among different languages while allowing room for all the subtle differences that naturally occur in human speech. This all-encompassing theory of universal grammar would accurately distinguish between possible grammars and impossible grammars. This paper examines the main tenets of the two major generative phonology models of universal grammar: SPE’s Generative Phonology theory representing rule-based, derivational universal grammar models, and Optimality Theory as a representative of constraint-based …

Reading Suffering Between The Lines: Trauma And Witnessing In Old And Middle English Literature, Anca Olguta Giorgiana Garcia

USF Tampa Graduate Theses and Dissertations

Both literary trauma theorists and medieval literature scholars generally avoid analyzing Old and Middle English literature through the lens of trauma studies. There are multiple reasons for this reluctance, and perhaps the most elementary one is the misconception that medieval society was numb to pain because they experienced it more often than people today do. Another reason is the fact that trauma in general is seen as a product of the Industrial Revolution and of the interactions between humans and machines. Its terminology and diagnostic methods have only developed in the last two centuries, so applying modern concepts on medieval …

Gene Therapy Ameliorates Spontaneous Seizures Associated With Cortical Neuron Loss In A Cln2r207x Mouse Model, Keigo Takahashi, Elizabeth M. Eultgen, Sophie H. Wang, Nicholas R. Rensing, Hemanth R. Nelvagal, Joshua T. Dearborn, Olivier Danos, Nicholas Buss, Mark S. Sands, Michael Wong, Jonathan D. Cooper

2020-Current year OA Pubs

Although a disease-modifying therapy for classic late infantile neuronal ceroid lipofuscinosis (CLN2 disease) exists, poor understanding of cellular pathophysiology has hampered the development of more effective and persistent therapies. Here, we investigated the nature and progression of neurological and underlying neuropathological changes in Cln2R207X mice, which carry one of the most common pathogenic mutations in human patients but are yet to be fully characterized. Long-term electroencephalography recordings revealed progressive epileptiform abnormalities, including spontaneous seizures, providing a robust, quantifiable, and clinically relevant phenotype. These seizures were accompanied by the loss of multiple cortical neuron populations, including those stained for interneuron markers. …

Poly(Adp-Ribose) Polymerase 9 Mediates Early Protection Against Mycobacterium Tuberculosis Infection By Regulating Type I Ifn Production, Shyamala Thirunavukkarasu, Mushtaq Ahmed, Bruce A. Rosa, Mark Boothby, Sung Hoon Cho, Javier Rangel-Moreno, Stanley K. Mbandi, Valérie Schreiber, Ananya Gupta, Joaquin Zuniga, Makedonka Mitreva, Deepak Kaushal, Thomas J. Scriba, Shabaana A. Khader

2020-Current year OA Pubs

The ADP ribosyltransferases (PARPs 1-17) regulate diverse cellular processes, including DNA damage repair. PARPs are classified on the basis of their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylation (MARylation). Although PARP9 mRNA expression is significantly increased in progressive tuberculosis (TB) in humans, its participation in host immunity to TB is unknown. Here, we show that PARP9 mRNA encoding the MARylating PARP9 enzyme was upregulated during TB in humans and mice and provide evidence of a critical modulatory role for PARP9 in DNA damage, cyclic GMP-AMP synthase (cGAS) expression, and type I IFN production during TB. Thus, Parp9-deficient mice were susceptible …

Neutrosophic Framework For Assessment Challenges In Smart Sustainable Cities Based On Iot To Better Manage Energy Resources And Decrease The Urban Environment's Ecological Impact, Samah Ibrahim Abdel Aal

Neutrosophic Systems with Applications

Sustainable smart cities based on the Internet of Things (IoT) technology provide promising prospects for improving quality of life. However, in order to facilitate the widespread implementation of IoT-based smart city solutions, there is a need to concern about data privacy and security, standardization, interoperability, scalability, and sustainability. Reducing the environmental effect of urban activities, optimizing the management of energy resources, and designing novel services and solutions for inhabitants are all examples of how the smart city concept is inextricably linked to sustainability. There is a need to assess challenges in smart sustainable cities based on IoT. This paper is …

Balsam Woolly Adelgid, Liz Rideout, Kate V. Richardson, Diane G. Alston, Ryan Davis, Darren Mcavoy, Lori R. Spears, Danielle Malesky, Liz Herbertson, Colleen Keyes

All Current Publications

This fact sheet describes balsam woolly adelgid, a tiny sucking insect that is a serious pest of true firs in forests, landscapes, and in seed and Christmas tree production. It includes a description of tree injury and symptoms, life history and identification, monitoring, management, and implications to forest health.