Digital Commons Network^™

An Early Pliocene Fish Assemblage From The Southern Appalachians: Ichthyofauna Of The Gray Fossil Site, Shay Maden

Electronic Theses and Dissertations

The Gray Fossil Site (GFS) preserves an early Pliocene sinkhole pond that accumulated a rich flora and vertebrate fauna. Fossils of fish are incredibly common at GFS, representing thousands of specimens recovered to date. Comparison with extant species reveals a depauperate freshwater fish fauna consisting of only two species: Lepomis sp. and Micropterus sp. The absence of fishes that are ubiquitous in modern streams suggests no perennial surface hydrologic connection between the Gray Fossil Site and the nearby Holston River. Limited opportunities for dispersal into the pond and deleterious conditions such as eutrophy and high competition may have resulted in …

Prairie Protector: Student Development Of Systems Thinking Habits In The Context Of Agroecosystems, Erin Ingram, Jennifer Keshwani

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Introduction: The Great Plains ecosystem offers an opportunity for young people to gain knowledge about intricate systems through practical learning. The spread of woody plants into grasslands, known as the “Green Glacier,” poses a risk to biodiversity and animal production. Although effective management strategies exist, some land managers are reluctant to use them. It is critical to cultivate a scientifically literate population that can think systematically and make informed decisions based on STEM principles to address such complex agroecosystem problems.

Methods: In this study, semi-structured focus group discussions with high school students were analyzed to determine whether Prairie …

Business Cycle Downturn Estimation For Ciudad Juarez: 1991-2022, Steven L. Fullerton, Thomas M. Fullerton Jr.

Border Region Modeling Project

A monthly frequency metropolitan business cycle downturn likelihood equation is estimated for Ciudad Juarez. The binary index of economic conditions is based upon monthly IMMEX export oriented manufacturing employment. A dynamic probit methodology is used for parameter estimation. Continuous explanatory variables include a 1-year minus 1-month Mexico interest rate spread, a 2015 = 100 weighted real exchange rate index, and a 10-year minus 3-month USA interest rate spread. Parameter estimation results confirm the various hypotheses examined. However, model simulation outcomes are less favorable with the results indicating that accurate forecasting of the post-2010 business cycles may require additional refinement to …

Comparing The Effectiveness Of Different Boosting Algorithms For Ground Water Quality In Telangana Region, Divy Jot

Electronic Theses, Projects, and Dissertations

This culminating experience research project explores the parameters needed to predict the water quality levels for use in different climatic conditions pre and post monsoon from 2018 to 2020 in Telangana State, India. A study was conducted on the water quality analysis by using linear regression with water quality Index in Telangana region. However, in this study we are replicating the water quality analysis by using stack model and machine learning algorithms such as Light Gradient Boosting Machine, Random Forest and Artificial Neural Network. The research Questions are: (Q1) What are the sources of the significant parameters that impact groundwater …

Exogenous Exposure To Dihydroxyacetone Mimics High Fructose Induced Oxidative Stress And Mitochondrial Dysfunction, Raj Mehta

Honors Theses

Dihydroxyacetone (DHA) is a three-carbon sugar that is the active ingredient in sunless tanning products and a by-product of electronic cigarette (e-cigarette) combustion. Increased use of sunless tanning products and e-cigarettes has elevated exposures to DHA through inhalation and absorption. Studies have confirmed that DHA is rapidly absorbed into cells and can enter into metabolic pathways following phosphorylation to dihydroxyacetone phosphate (DHAP), a product of fructose metabolism. Recent reports have suggested metabolic imbalance and cellular stress results from DHA exposures. However, the impact of elevated exposure to DHA on human health is currently under-investigated. We propose that exogenous exposures to …

A Case For Educational Communication On Sustainable Stormwater Management Sites Using Interpretive Methods: Applications For Utah State University, Lilian Taft

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Humans are increasingly urbanizing landscapes, lowering the land’s ability to infiltrate stormwater, increasing surface water runoff. This, combined with decreasing water availability in the Intermountain West, produces the issue of sustainable stormwater management. Professionals are moving toward green stormwater infrastructure (GSI), but public is often not aware of stormwater’s impacts on natural environments or what the purpose of GSI is. Stormwater management design techniques are evolving to use visible, sustainable methods celebrating stormwater, rather than treating the valuable resource as a disposable nuisance, channeling it underground and out of sight. Artful Rainwater Design (ARD), a technique coined by Stuart Echols …

The Ecological Risk Assessment Of Mercury Contamination In A Mangrove Ecosystem Of The Segara Anakan Cilacap, Indonesia, Endang Hilmi, Teuku Junaidi, Arif Mahdiana, Rose Dewi

Baghdad Science Journal

Ecological risk assessment of mercury contaminant has a means to analyze the ecological risk aspect of ecosystem using the potential impact of mercury pollution in soil, water and organism. The ecological risk assessment in a coastal area can be shown by mangrove zonation, clustering and interpolation of mercury accumulation. This research aims to analyze ecological risk assessment of potential mercury (including bioaccumulation and translocation) using indicators of species distribution, clustering, zonation and interpolation of mercury accumulation. The results showed that the Segara Anakan had a high risk of mercury pollution, using indicators like as the potential of mercury contaminant in …

First Record Of Peregrine Shrimp Metapenaeus Stebbingi Nobili, 1904 (Crustacea, Decapoda: Penaeidae) In The Iraqi Waters, North-West Arabian Gulf, Tariq H Y Al-Maliky, Raghad Zaidan Khalaf, Adib H Zeini

Baghdad Science Journal

One male specimen of the species Metapenaeus stebbingi Nobili, 1904 was first recorded in November 2021 from the Iraqi territorial waters, Northwest of the Arabian Gulf. Therefore, the investigated shrimp species nominally corresponds to the original description of M. stebbing through the main diagnostic features. It must be adopted in the spread and expansion of species, a new record of the area, and a distinctive addition to the species of commercial shrimp within the Iraqi marine waters.

Phytochemical Composition, Total Phenolic Content And Antioxidant Activity Of Anadara Granosa (Linnaeus, 1758) Collected From The East Coast Of South Sumatra, Indonesia, Rozirwan, Nanda, Redho Yoga Nugroho, Gusti Diansyah, Muhtadi, Fauziyah, Wike Ayu Eka Putri, Andi Agussalim

Baghdad Science Journal

Anadara granosa is a species of the class bivalve commonly found on the east coast of South Sumatra as a fishery commodity. This species has not been widely studied as a source of new bioactive compounds that have antioxidant abilities. This study aims to analyze the antioxidant ability of A. granosa against DPPH radicals and its phytochemical profile qualitatively. Samples were taken at the fishing port of Sungsang Village, South Sumatra, Indonesia. Furthermore, the samples were extracted using ethanol as a solvent and tested for antioxidants against DPPH radicals, total phenol analysis, and preliminary phytochemical test. Based on the antioxidant …

Restaurant Management Website, Akhil Sai Gollapudi

Electronic Theses, Projects, and Dissertations

In the ever-evolving corporate landscape of today, it is crucial to respond to customer needs as efficiently and in a timely manner as possible. The project's primary objective is to create a method for clients to make reservations for restaurants online. This makes life easier for busy customers in their daily life.

Today, people are looking for comfort thanks to rapidly developing technology. As we can see, people invent and implement new technologies in all fields according to customer needs.

We got a unique restaurant idea that helps people save time. People prefer quick methods to get things done. With …

Sales And Stock Management System, Rashmika Gaddam Ms

Electronic Theses, Projects, and Dissertations

ABSTRACT

Grocery stores using Excel for managing sales and stock management could involve maintaining separate sheets for sales and stock data, with revenue/cost. This system could provide a basic level of tracking and analysis, allowing the grocery store to monitor sales trends and stock levels. However, using Excel for this purpose is not without its challenges. For example, the manual nature of data entry in excel can result in errors and inconsistencies, particularly if multiple people are involved in maintaining the sheets. Additionally, as the volume of sales and stock data grows, the Excel spreadsheet can become unwieldy and slow, …

Building Buy-In: A Qualitative Study Seeking To Understand Stakeholder Perceptions Of A University Extension System Through The Lens Of External Branding, Anissa M. Zagonel, Lauri Baker, Ricky Telg

Journal of Human Sciences and Extension

A brand is an organization’s link to its audiences. When the audience is asked to participate in building a brand culture, they are more likely to hold a favorable attitude toward the brand and be loyal to the brand long term. The purpose of this study was to understand the UF/IFAS Extension brand’s image from the perspective of the brand’s stakeholders, specifically focusing on brand awareness, audience groups, and potential future obstacles for the brand. A series of six online focus groups were conducted during the spring/summer of 2021 using Zoom. Major themes identified were a public knowledge gap related …

A Case Study Comparing The Life Skills Development And Knowledge In Youth Participants Of Horseless And Traditional Horse Programs In Utah, Haley M. Johnson, Kelsey L. Hall, Benjamin Scow

Journal of Human Sciences and Extension

This study compared four horseless and seven traditional horse participants from Washington County 4-H in Utah for horse knowledge gained and for the development of 10 life skills from Hendricks’s Targeting Life Skills Model: leadership, teamwork, self-responsibility, personal safety, problem-solving, decision-making, critical thinking, goal setting, communication, and concern for others. This study’s mixed methods design employed interviews to learn about life skill development and quantitative data from a 20-item horse knowledge quiz and demographic survey. The traditional horse youth showed greater development of leadership, self-responsibility, decision-making, goal setting, and communication than the horseless youth. Roughly half of the participants in …

Heterogeneity Among Harveyi Clade-Specific Virulence Genes And Attribution Of These Genes To Possible Environmental Carriers, Cameron Brown

Biology Theses

In the face of global warming, waterborne pathogens are evolving rapidly and expanding geographically. The Vibrio Harveyi clade encompasses a number of human and aquatic organism pathogens, and due to their physiology, they may benefit from ongoing changes in the temperature, pH, and salinity of the global Ocean. With this, the Southeastern United States might become an accommodating environment for Harveyi clade species, and it is imperative to monitor for their abundance and distribution in the environment. A qPCR assay was developed for the detection and quantification of clade-specific virulence genes toxRvh, hly, toxR, luxR, srp, vhha, vhh, and vhp …

Eclipses, Aaron Steinhauer

Myth and Science, 2023-24

This lesson includes a series of four slide sets designed to cover increasingly specific eclipse content. Specifically, the slide sets cover the phases of the moon, lunar eclipses, solar eclipses generally, and a specific set for information about Geneseo's April 8, 2024, total solar eclipse.

August 2023 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

The Antagonistic Anatomy Of Anti-Shippers: A Thematic Analysis, Adrian A. Stone

Student Theses

Within the transformative fandom community is an ideologically-affiliated group known as anti-shippers, whose rhetoric contends that fictional interests are an indication of those held in reality. Anti-shippers focus solely on fictional material perceived to be sexual in nature and make frequent references to pedophilia. This rhetoric is used to justify harassment against individuals who do not share in their beliefs. As this population primarily operates on social media, this study was designed to conduct an exploratory investigation into themes gleaned from posts authored by anti-shippers on Twitter. Utilizing latent content analysis, a total of 187 posts from 222 unique users …

An Application Of The Coercive Control Framework To Cults, Sarah E. Feliciano

Student Theses

The present study utilized the coercive control framework to systematically assess coercion in cults. Former cult members (N=52) of various groups (e.g., psychological & self-help related) were interviewed via telephone for 1.5 to 3 hours. The sample was 67.31% female, 67.31% Caucasian, and 63.46% American; age ranged from 24-68 years old. An existing codebook was used by multiple coders with high intercoder reliability (89.66%). Coercive control tactics were present in all 52 narratives. Manipulation, intimidation, and microregulation were the tactics most frequently utilized. Sexual coercion/abuse, deprivation, and degradation were used least. Data also provided coercive subtactics specific to cults but …

Western Water Network: A Case Study In Water Network Formation, Travis Warziniak, Robert Heinse, Alexander Fernald, Michael Gaffney, Kristiana Hansen, Bret Hess, Lyla Houglum, Ginger Paige, Qin Zhang

Journal of Contemporary Water Research and Education

Increased water scarcity and drought frequency are creating water management challenges for many communities in the western U.S. In response, the Western Association of Agricultural Experiment Station Directors sponsored a virtual summit in August 2020 to develop a framework for identifying and addressing the most pressing water issues in the western United States (the West). Summit attendees were research scientists, university extension specialists and professionals, and federal/state agency representatives with knowledge and expertise of water management in the West. The summit elicited opinions from 54 experts on pressing water issues and possible methods for addressing them. A follow-on survey of …

Smc Staff Handbook, Saint Mary's College Of California

Employee & Staff Handbook

No abstract provided.

Interrogations Of The Tumor Microenvironment Using Magnetic Resonance Imaging, Tianzhe Li

Dissertations and Theses (Open Access)

Both tumor acidosis and tumor hypoxia are characteristics commonly found in the microenvironment of solid malignant tumors. Accurate characterization of the two phenomena could provide important information to clinicians for devising suitable treatment plans. Tumor acidosis and hypoxia are closely linked to each other. Tumor acidosis is caused by the inclination of cancer cells towards anaerobic respiration, and one of the main contributing factors for the avoidance of aerobic respiration is tumor hypoxia. Both phenomena can indicate the high metastatic potential of cancers and can also cause resistance of the cancer systems against anti-cancer therapies. Therefore, developing novel molecular imaging …

Role Of Phosphorylated Dicer1 In Tumor Progression, Raisa Reyes-Castro

Dissertations and Theses (Open Access)

DICER1 is a multidomain enzyme discovered and widely recognized for its function in small non-coding microRNA (miRNA) synthesis. In cancer development, DICER1 functions as a haploinsufficient tumor suppressor which regulates miRNAs and Epithelial-to-Mesenchymal Transition (EMT). The Arur laboratory discovered that DICER1 is phosphorylated by active ERK and that ERK-mediated phosphorylation triggers DICER1 to translocate from the cytoplasm to the nucleus of cells in worms, mice and humans. Further, a heterozygous allele of a genetically engineered mouse model of phosphomimetic Dicer1 when combined with heterozygous Kras oncogenic background contributes to lung tumor progression in vivo. Mechanisms through which phosphomimetic Dicer1 …

Genetic Analysis Of Crossover Defective Mouse Spermatocytes Reveals Discrete Crossover Precursor Intermediates, Tolkappiyan Prem Kumar

Dissertations and Theses (Open Access)

In healthy, non-replicating somatic cells of diploid organisms, like humans and mice, there are two copies of each chromosome, one from each parent. However, the germ cells of these organisms, the oocytes, and the sperm, have only one copy of each chromosome, thus ensuring that when haploid oocytes and sperm fuse to form a zygote, a diploid number of chromosomes is restored. The reduction of a diploid number of chromosomes to a haploid number of chromosomes takes place during meiosis. The meiotic cell cycle consists of two rounds of cell division, Meiosis I and Meiosis II. Meiosis I create haploid …

Therapeutic Potential Of Prmt5 And Mat2a As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors, Yasaman Barekatain

Dissertations and Theses (Open Access)

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is a frequent genetic alteration found in approximately 15% of all human cancers, including glioblastoma, pancreatic cancer, mesothelioma, urothelial bladder carcinoma, and lung squamous cell carcinoma. MTAP is a critical metabolic enzyme in the methionine salvage pathway responsible for the breakdown of methylthioadenosine (MTA). As a result, MTAP-deleted cells cannot metabolize MTA, leading to the accumulation of MTA. High levels of MTA in MTAP-deleted cells partially inhibit the activity of protein arginine methyltransferase 5 (PRMT5), making these cells sensitive to PRMT5 and MAT2A inhibition. Although elevated levels of MTA in …

Isolation Of Therapeutic Antibodies Against Microseminoprotien To Potentially Overcome Resistance To Anti-Angiogenic Therapy, Mason Ruiz

Dissertations and Theses (Open Access)

High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer. Angiogenesis is a vital function for both wound healing and oxygen homeostasis and is one of the hallmarks of cancer in solid tumors. To combat the formation of tumors, an anti-VEGF drug, bevacizumab, is used to starve tumors of blood that provide essential nutrients. While platinum-taxane doublet therapy in addition to cytoreductive surgery has been the gold standard treatment for patients with ovarian cancer, greater than 70% of patients will develop relapsed disease and be burdened with a terminal …

Unveiling Immune Checkpoint Therapy Resistance Mechanisms In The Tumor Microenvironment Using High-Dimensional Analyses, Swetha Anandhan

Dissertations and Theses (Open Access)

The advent of immune checkpoint therapy (ICT) has transformed cancer treatment, but its effectiveness is limited in certain cancers like pancreatic ductal adenocarcinoma (PDAC), which exhibit resistance to this therapy. To overcome this challenge, it is crucial to understand the underlying mechanisms that determine tumor response to ICT and develop rational therapeutic combinations. The tumor microenvironment (TME), including suppressive myeloid cells, regulatory T cells (Tregs), and cancer-associated fibroblasts (CAFs), plays a pivotal role in ICT responses. Leveraging single-cell technologies, this study explores the role and function of immune subsets in the TME that induce therapy resistance.

Using single-cell RNA sequencing …

Protein L Functionalized Microparticles For Early Detection Of Surface Markers In Heterogeneous Colorectal Lesions, Saleh Ramezani

Dissertations and Theses (Open Access)

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths among both men and women worldwide, a statistic that can be improved with early detection. Increased understanding of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and cancerous tissue lining the colonic lumen. Use of antibodies conjugated to nano/micromaterials offers a means to detect these antigens, however, the heterogeneous nature of tumors makes it unlikely that antibodies against a single antigen will have sufficient sensitivity and specificity to detect all tumors. A versatile micromaterial able to be functionalized with more than one targeting …

Role Of Il-17/Il-17ra Signaling In The Pancreatic Tumor Microenvironment, Susana Castro Pando, Susana Castro Pando

Dissertations and Theses (Open Access)

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related deaths. PDAC is characterized by the early establishment of a highly immunosuppressive fibro-cellular tumor microenvironment (TME). Our research has revealed the important role of IL-17 in the development and progression of pancreatic cancer, yet the specific cellular compartment responsible for IL-17-mediated tumor promotion remains unknown. We generated a transgenic mouse model with pancreatic KrasG12D activation and selective deletion of IL-17RA in the epithelial vs. immune component using either genetic manipulation or bone marrow transplantation. Deletion of IL17RA from the pancreatic epithelial compartment delayed premalignant lesion development …

Composite And Polymer Formulation Employing Sulfur And Bio-Olefin Feedstocks, Claudia V. Lopez

All Dissertations

Environmental sustainability represents a challenge for society since industrial growth has a direct impact on natural resources and waste production. New technologies that effectively incorporate waste into renewable resources are critical to the development of a sustainable and circular economy. The manufacturing of structural materials like Portland cement (OPC) is responsible for >8% of the global anthropogenic emissions of carbon dioxide, with ~ 1 kg of CO₂ released to the atmosphere for every kilogram of OPC produced. For instance, the development of sustainable structural materials is a key factor to reduce the greenhouse emissions and to attenuate the climate …

Elucidating Acetate Metabolism: Identification Of Transporters And Enzymes Required For Acetate Utilization In The Fungal Pathogen Cryptococcus Neoformans, Perry L. Kezh

All Dissertations

Cryptococcus neoformans is the leading cause of fungal meningitis world-wide. While exposure to this environmental sporophyte is common during childhood, those who are immune compromised are at risk of infection. Following inhalation, this basidiomycetous fungus subsequently colonizes other organs though hematogenous dissemination, eventually crossing the blood brain barrier and colonizing the brain where it causes as cryptococcal meningitis. Changes in the availability of carbon sources stemming from the movement from soil to the lungs induce changes in fungal metabolism. Specifically, alveolar macrophages, which present a first line of defense against infection, provide a glucose-/amino acid-poor environment. As such, the use …