Digital Commons Network^™

Restaurant Management Website, Akhil Sai Gollapudi

Electronic Theses, Projects, and Dissertations

In the ever-evolving corporate landscape of today, it is crucial to respond to customer needs as efficiently and in a timely manner as possible. The project's primary objective is to create a method for clients to make reservations for restaurants online. This makes life easier for busy customers in their daily life.

Today, people are looking for comfort thanks to rapidly developing technology. As we can see, people invent and implement new technologies in all fields according to customer needs.

We got a unique restaurant idea that helps people save time. People prefer quick methods to get things done. With …

Sales And Stock Management System, Rashmika Gaddam Ms

Electronic Theses, Projects, and Dissertations

ABSTRACT

Grocery stores using Excel for managing sales and stock management could involve maintaining separate sheets for sales and stock data, with revenue/cost. This system could provide a basic level of tracking and analysis, allowing the grocery store to monitor sales trends and stock levels. However, using Excel for this purpose is not without its challenges. For example, the manual nature of data entry in excel can result in errors and inconsistencies, particularly if multiple people are involved in maintaining the sheets. Additionally, as the volume of sales and stock data grows, the Excel spreadsheet can become unwieldy and slow, …

Building Buy-In: A Qualitative Study Seeking To Understand Stakeholder Perceptions Of A University Extension System Through The Lens Of External Branding, Anissa M. Zagonel, Lauri Baker, Ricky Telg

Journal of Human Sciences and Extension

A brand is an organization’s link to its audiences. When the audience is asked to participate in building a brand culture, they are more likely to hold a favorable attitude toward the brand and be loyal to the brand long term. The purpose of this study was to understand the UF/IFAS Extension brand’s image from the perspective of the brand’s stakeholders, specifically focusing on brand awareness, audience groups, and potential future obstacles for the brand. A series of six online focus groups were conducted during the spring/summer of 2021 using Zoom. Major themes identified were a public knowledge gap related …

A Case Study Comparing The Life Skills Development And Knowledge In Youth Participants Of Horseless And Traditional Horse Programs In Utah, Haley M. Johnson, Kelsey L. Hall, Benjamin Scow

Journal of Human Sciences and Extension

This study compared four horseless and seven traditional horse participants from Washington County 4-H in Utah for horse knowledge gained and for the development of 10 life skills from Hendricks’s Targeting Life Skills Model: leadership, teamwork, self-responsibility, personal safety, problem-solving, decision-making, critical thinking, goal setting, communication, and concern for others. This study’s mixed methods design employed interviews to learn about life skill development and quantitative data from a 20-item horse knowledge quiz and demographic survey. The traditional horse youth showed greater development of leadership, self-responsibility, decision-making, goal setting, and communication than the horseless youth. Roughly half of the participants in …

Heterogeneity Among Harveyi Clade-Specific Virulence Genes And Attribution Of These Genes To Possible Environmental Carriers, Cameron Brown

Biology Theses

In the face of global warming, waterborne pathogens are evolving rapidly and expanding geographically. The Vibrio Harveyi clade encompasses a number of human and aquatic organism pathogens, and due to their physiology, they may benefit from ongoing changes in the temperature, pH, and salinity of the global Ocean. With this, the Southeastern United States might become an accommodating environment for Harveyi clade species, and it is imperative to monitor for their abundance and distribution in the environment. A qPCR assay was developed for the detection and quantification of clade-specific virulence genes toxRvh, hly, toxR, luxR, srp, vhha, vhh, and vhp …

Eclipses, Aaron Steinhauer

Myth and Science, 2023-24

This lesson includes a series of four slide sets designed to cover increasingly specific eclipse content. Specifically, the slide sets cover the phases of the moon, lunar eclipses, solar eclipses generally, and a specific set for information about Geneseo's April 8, 2024, total solar eclipse.

August 2023 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

The Antagonistic Anatomy Of Anti-Shippers: A Thematic Analysis, Adrian A. Stone

Student Theses

Within the transformative fandom community is an ideologically-affiliated group known as anti-shippers, whose rhetoric contends that fictional interests are an indication of those held in reality. Anti-shippers focus solely on fictional material perceived to be sexual in nature and make frequent references to pedophilia. This rhetoric is used to justify harassment against individuals who do not share in their beliefs. As this population primarily operates on social media, this study was designed to conduct an exploratory investigation into themes gleaned from posts authored by anti-shippers on Twitter. Utilizing latent content analysis, a total of 187 posts from 222 unique users …

An Application Of The Coercive Control Framework To Cults, Sarah E. Feliciano

Student Theses

The present study utilized the coercive control framework to systematically assess coercion in cults. Former cult members (N=52) of various groups (e.g., psychological & self-help related) were interviewed via telephone for 1.5 to 3 hours. The sample was 67.31% female, 67.31% Caucasian, and 63.46% American; age ranged from 24-68 years old. An existing codebook was used by multiple coders with high intercoder reliability (89.66%). Coercive control tactics were present in all 52 narratives. Manipulation, intimidation, and microregulation were the tactics most frequently utilized. Sexual coercion/abuse, deprivation, and degradation were used least. Data also provided coercive subtactics specific to cults but …

Western Water Network: A Case Study In Water Network Formation, Travis Warziniak, Robert Heinse, Alexander Fernald, Michael Gaffney, Kristiana Hansen, Bret Hess, Lyla Houglum, Ginger Paige, Qin Zhang

Journal of Contemporary Water Research and Education

Increased water scarcity and drought frequency are creating water management challenges for many communities in the western U.S. In response, the Western Association of Agricultural Experiment Station Directors sponsored a virtual summit in August 2020 to develop a framework for identifying and addressing the most pressing water issues in the western United States (the West). Summit attendees were research scientists, university extension specialists and professionals, and federal/state agency representatives with knowledge and expertise of water management in the West. The summit elicited opinions from 54 experts on pressing water issues and possible methods for addressing them. A follow-on survey of …

Smc Staff Handbook, Saint Mary's College Of California

Employee & Staff Handbook

No abstract provided.

Interrogations Of The Tumor Microenvironment Using Magnetic Resonance Imaging, Tianzhe Li

Dissertations and Theses (Open Access)

Both tumor acidosis and tumor hypoxia are characteristics commonly found in the microenvironment of solid malignant tumors. Accurate characterization of the two phenomena could provide important information to clinicians for devising suitable treatment plans. Tumor acidosis and hypoxia are closely linked to each other. Tumor acidosis is caused by the inclination of cancer cells towards anaerobic respiration, and one of the main contributing factors for the avoidance of aerobic respiration is tumor hypoxia. Both phenomena can indicate the high metastatic potential of cancers and can also cause resistance of the cancer systems against anti-cancer therapies. Therefore, developing novel molecular imaging …

Role Of Phosphorylated Dicer1 In Tumor Progression, Raisa Reyes-Castro

Dissertations and Theses (Open Access)

DICER1 is a multidomain enzyme discovered and widely recognized for its function in small non-coding microRNA (miRNA) synthesis. In cancer development, DICER1 functions as a haploinsufficient tumor suppressor which regulates miRNAs and Epithelial-to-Mesenchymal Transition (EMT). The Arur laboratory discovered that DICER1 is phosphorylated by active ERK and that ERK-mediated phosphorylation triggers DICER1 to translocate from the cytoplasm to the nucleus of cells in worms, mice and humans. Further, a heterozygous allele of a genetically engineered mouse model of phosphomimetic Dicer1 when combined with heterozygous Kras oncogenic background contributes to lung tumor progression in vivo. Mechanisms through which phosphomimetic Dicer1 …

Genetic Analysis Of Crossover Defective Mouse Spermatocytes Reveals Discrete Crossover Precursor Intermediates, Tolkappiyan Prem Kumar

Dissertations and Theses (Open Access)

In healthy, non-replicating somatic cells of diploid organisms, like humans and mice, there are two copies of each chromosome, one from each parent. However, the germ cells of these organisms, the oocytes, and the sperm, have only one copy of each chromosome, thus ensuring that when haploid oocytes and sperm fuse to form a zygote, a diploid number of chromosomes is restored. The reduction of a diploid number of chromosomes to a haploid number of chromosomes takes place during meiosis. The meiotic cell cycle consists of two rounds of cell division, Meiosis I and Meiosis II. Meiosis I create haploid …

Therapeutic Potential Of Prmt5 And Mat2a As Synthetic Lethal Targets In Mtap-Deficient Gbm Tumors, Yasaman Barekatain

Dissertations and Theses (Open Access)

Homozygous deletion of methylthioadenosine phosphorylase (MTAP) is a frequent genetic alteration found in approximately 15% of all human cancers, including glioblastoma, pancreatic cancer, mesothelioma, urothelial bladder carcinoma, and lung squamous cell carcinoma. MTAP is a critical metabolic enzyme in the methionine salvage pathway responsible for the breakdown of methylthioadenosine (MTA). As a result, MTAP-deleted cells cannot metabolize MTA, leading to the accumulation of MTA. High levels of MTA in MTAP-deleted cells partially inhibit the activity of protein arginine methyltransferase 5 (PRMT5), making these cells sensitive to PRMT5 and MAT2A inhibition. Although elevated levels of MTA in …

Isolation Of Therapeutic Antibodies Against Microseminoprotien To Potentially Overcome Resistance To Anti-Angiogenic Therapy, Mason Ruiz

Dissertations and Theses (Open Access)

High-grade serous ovarian carcinoma (HGSC) is an aggressive subtype of epithelial ovarian carcinoma (EOC) and remains the most lethal gynecologic cancer. Angiogenesis is a vital function for both wound healing and oxygen homeostasis and is one of the hallmarks of cancer in solid tumors. To combat the formation of tumors, an anti-VEGF drug, bevacizumab, is used to starve tumors of blood that provide essential nutrients. While platinum-taxane doublet therapy in addition to cytoreductive surgery has been the gold standard treatment for patients with ovarian cancer, greater than 70% of patients will develop relapsed disease and be burdened with a terminal …

Unveiling Immune Checkpoint Therapy Resistance Mechanisms In The Tumor Microenvironment Using High-Dimensional Analyses, Swetha Anandhan

Dissertations and Theses (Open Access)

The advent of immune checkpoint therapy (ICT) has transformed cancer treatment, but its effectiveness is limited in certain cancers like pancreatic ductal adenocarcinoma (PDAC), which exhibit resistance to this therapy. To overcome this challenge, it is crucial to understand the underlying mechanisms that determine tumor response to ICT and develop rational therapeutic combinations. The tumor microenvironment (TME), including suppressive myeloid cells, regulatory T cells (Tregs), and cancer-associated fibroblasts (CAFs), plays a pivotal role in ICT responses. Leveraging single-cell technologies, this study explores the role and function of immune subsets in the TME that induce therapy resistance.

Using single-cell RNA sequencing …

Protein L Functionalized Microparticles For Early Detection Of Surface Markers In Heterogeneous Colorectal Lesions, Saleh Ramezani

Dissertations and Theses (Open Access)

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths among both men and women worldwide, a statistic that can be improved with early detection. Increased understanding of the tumor landscape has identified surface antigens that can be utilized to distinguish normal and cancerous tissue lining the colonic lumen. Use of antibodies conjugated to nano/micromaterials offers a means to detect these antigens, however, the heterogeneous nature of tumors makes it unlikely that antibodies against a single antigen will have sufficient sensitivity and specificity to detect all tumors. A versatile micromaterial able to be functionalized with more than one targeting …

Role Of Il-17/Il-17ra Signaling In The Pancreatic Tumor Microenvironment, Susana Castro Pando, Susana Castro Pando

Dissertations and Theses (Open Access)

Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second leading cause of cancer-related deaths. PDAC is characterized by the early establishment of a highly immunosuppressive fibro-cellular tumor microenvironment (TME). Our research has revealed the important role of IL-17 in the development and progression of pancreatic cancer, yet the specific cellular compartment responsible for IL-17-mediated tumor promotion remains unknown. We generated a transgenic mouse model with pancreatic KrasG12D activation and selective deletion of IL-17RA in the epithelial vs. immune component using either genetic manipulation or bone marrow transplantation. Deletion of IL17RA from the pancreatic epithelial compartment delayed premalignant lesion development …

Composite And Polymer Formulation Employing Sulfur And Bio-Olefin Feedstocks, Claudia V. Lopez

All Dissertations

Environmental sustainability represents a challenge for society since industrial growth has a direct impact on natural resources and waste production. New technologies that effectively incorporate waste into renewable resources are critical to the development of a sustainable and circular economy. The manufacturing of structural materials like Portland cement (OPC) is responsible for >8% of the global anthropogenic emissions of carbon dioxide, with ~ 1 kg of CO₂ released to the atmosphere for every kilogram of OPC produced. For instance, the development of sustainable structural materials is a key factor to reduce the greenhouse emissions and to attenuate the climate …

Elucidating Acetate Metabolism: Identification Of Transporters And Enzymes Required For Acetate Utilization In The Fungal Pathogen Cryptococcus Neoformans, Perry L. Kezh

All Dissertations

Cryptococcus neoformans is the leading cause of fungal meningitis world-wide. While exposure to this environmental sporophyte is common during childhood, those who are immune compromised are at risk of infection. Following inhalation, this basidiomycetous fungus subsequently colonizes other organs though hematogenous dissemination, eventually crossing the blood brain barrier and colonizing the brain where it causes as cryptococcal meningitis. Changes in the availability of carbon sources stemming from the movement from soil to the lungs induce changes in fungal metabolism. Specifically, alveolar macrophages, which present a first line of defense against infection, provide a glucose-/amino acid-poor environment. As such, the use …

Consumer Valuation Of Rice Quality In Colombia, Juliann Phillips

Graduate Theses and Dissertations

Rice is a crucial contributor to global food security and is an important staple for over half the world’s population. In Colombia, total rice consumption has grown by 25% in the last decade (2011-2021), reaching 1.9 MMT in 2021, yet in 2021 around 15.5 million Colombians were classified as food insecure. Colombia is the third largest rice producer in Latin America, producing 1.8 million metric tons (milled basis) in 2021. Increasing rice consumption coupled with high levels of food insecurity highlights the necessity that rice markets effectively price rice according to consumer preferences. Therefore, the goal of this study focuses …

The Roles Of Estrogen Receptor Alpha-Interacting Rnas And Exosomes In Breast Cancer, And E-Cadherin In Carcinomas, Brihget Catalina Sicairos-Meza

Graduate Theses and Dissertations

Carcinomas are malignancies of epithelial cells and account for >80% of cancer-related deaths. Approximately 75% of breast cancers express estrogen receptor alpha (ERα). ERα promotes breast cancer progression by enhancing cancer cell proliferation. Tamoxifen is commonly used to treat ERα-positive breast cancers but can result in endocrine therapy resistance. The mechanisms underlying endocrine therapy resistance remain elusive. The Du lab recently found that ERα is an RNA-binding protein. However, the significance of the ERα-RNA interaction is unknown. We fractionated ERα-positive MCF7 cells into cytoplasmic and nuclear fractions, followed by immunoprecipitation of ERα with associated RNAs and RNA-sequencing. We identified many …

The Lived Experience Of Counseling Students In Natural Disaster, Amy M. Sirocky-Meck

Dissertations, 2020-current

After natural disaster, survivors may experience moderate to severe signs and symptoms of emotional distress which may subside or worsen as time passes (Substance Abuse and Mental Health Services Administration, 2022). Adults pursuing higher education when natural disaster strikes experience an additional array of unique issues which may exacerbate symptoms of emotional distress (Wilkinson et al.,2013). To create and improve curricular and co-curricular structures that meet the needs of their students, educators in many health and mental health disciplines can draw from a variety of quantitative and qualitative studies, particularly those focused on how their disciplines’ students navigate the experience …

Ber Analysis Of Bpsk Modulation Scheme For Multiple Combining Schemes Over Flat Fading Channel, Zuhaib Nishtar, Jamil Afzal

Neutrosophic Systems with Applications

Focus of the study was to provide error-free communication in mobile communication with higher data rates, spectral efficiency, and energy efficient. Basically, work was done to investigate the performance of the Binary Phase Shift Keying (BPSK) modulation technique for multiple combining schemes and the behavior of signal in wireless communication where multipath propagation and uncertainty in the system. We use the Multiple-input Multiple-output (MIMO) and antenna diversity to get many copies of the same signal; some of them were faded, but some had sufficient information. Then the next step was to combine or select the best signal to achieve the …

Generalized Double Statistical Convergence Sequences On Ideals In Neutrosophic Normed Spaces, Jeyaraman M., Iswariya S., Pandiselvi R.

Neutrosophic Systems with Applications

In this present research, having view in the Neutrosophic norm (u, v, w), which we presented I2-lacunary statistical convergence and I2-lacunary convergence strongly, looked into interactions between them, and made a few findings regarding the respective categories. At least went further to look at how both of such case approaches relate to I2-statistical convergence within the relevant Neutrosophic normed space.

Lsd1-Mediated Epigenetic Reprogramming Driving Prostate Cancer Progression, Zifeng Wang

Graduate Doctoral Dissertations

Prostate cancer (PCa) is a leading cause of cancer-related deaths in men worldwide. Alterations in epigenetic regulation of gene expression have emerged as key contributors to PCa development, treatment resistance and disease progression. My thesis focuses on investigating the role of lysine-specific demethylase 1 (LSD1), a critical histone modifier, in mediating epigenetic reprogramming that drives PCa progression. The dissertation comprises three projects that elucidate the mechanisms by which LSD1 can regulate PCa progression. The first project shows that LSD1 can activate the PI3K/AKT pathway in PCa cells independent of its well-established androgen receptor (AR) coactivator function. The study identifies the …

The Impact Of Campus Culture On Undergraduate Civic Engagement Outcomes, Kevin M. Kraft

Graduate Doctoral Dissertations

One purpose of higher education is to prepare students to participate in a democratic society. This mission is particularly relevant today as the institutions of democracy and the ideas that underpin them are in recession. Despite this, evidence shows that higher education is not achieving its stated goal of fostering civic engagement. The creation and maintenance of an institutional culture can be an effective way to teach civic engagement.

The Carnegie Community Engagement Classification (CEC) signifies that a college or university has institutionalized community engagement. By comparing student civic engagement outcomes at institutions that earned the classification to a control …

Individual Inspiration: Stories Of Lawyers And Legal Figures Through Time (Anti-Heroes Included), Wolf Law Library, William & Mary Law School

Library Book Displays

On display in the Wolf Law Library August - November 2023.

Pride Month: A Brief Overview Of Lgbtq+ Legal Issues, Wolf Law Library, William & Mary Law School

Library Book Displays

On display in the Wolf Law Library June-August 2023.