Digital Commons Network^™

Addressing Psychosocial Client Factors In People With Cancer: An Occupational Therapy Guidebook, Hannah Marlette

Student Capstone Papers

People with cancer experience a variety of physical, cognitive, and psychosocial impacts that affect their quality of life, occupational performance, and occupational engagement. Occupational therapy (OT) practitioners are well-equipped to address these impacts, however, OT is an underused service in the cancer population, resulting in a limited amount of literature addressing OT interventions in cancer care. OT interventions in the literature are focused on addressing an individual’s physical client factors. The focus on physical client factors is causing people with cancer to report that their psychosocial client factors are not being addressed. The literature demonstrates that OT practitioners do not …

A Biologic-Device Combination Product Delivering Tumor-Derived Antigens Elicits Immunogenic Cell Death-Associated Immune Responses Against Glioblastoma, Christopher Cultrara, Christopher Uhl, Kenneth Kirby, Essam Abed Elrazaq, Amelia Zellander, David W. Andrews, Charles B. Scott, Lorenzo Galluzzi, Mark A. Exley, Jenny Zilberberg

Department of Neurosurgery Faculty Papers

Background IGV-001 is a personalized, autologous cancer cell-based immunotherapy conceived to deliver a tumor-derived antigenic payload in the context of immunostimulatory signals to patients with glioblastoma (GBM). IGV-001 consists of patient-derived GBM cells treated with an antisense oligodeoxynucleotide against insulin-like growth factor 1 receptor (IGF1R) and placed in proprietary biodiffusion chambers (BDCs). The BDCs are then exposed to 5–6 Gy radiation and implanted at abdominal sites for ~48 hours. IGV-001 has previously been shown to be generally safe with promising clinical activity in newly diagnosed GBM patients.

Methods Mouse (m) or human (h) variants of IGV-001 …

Roles Of Type I Interferon Signaling In Drug Resistant Mycobacterium Tuberculosis Infection, Suhas Bobba

Arts & Sciences Graduate Student Theses and Dissertations

Tuberculosis (TB) is a global health threat, with 10 million people developing active TB disease and a million deaths attributed to TB annually. Emergence of drug resistance in Mycobacterium tuberculosis (Mtb), the causative agent of TB, has led to half a million cases of drug resistant (DR) TB annually. Further, clinical reports suggest dysregulation and suppression of immune responses in DR TB patients as compared with DS TB patients. However, we do not understand how acquisition of drug resistance-conferring mutations can drive broad and systemic differences in immune responses of DR TB patients. We found that rpoB-H445Y a specific DR …

“We’Re Not A Band That Everybody Gets”: Parsing The Spectacle Of They Might Be Giants, Rachel Eliza Jones

Arts & Sciences Graduate Student Theses and Dissertations

After releasing twenty-three studio albums and performing together for four decades under the name They Might Be Giants—first as a duo and then, beginning in 1992, with a full backing band—John Flansburgh and John Linnell have certainly established a niche for themselves within the world of alternative rock. The band achieved a brief glimpse of mainstream commercial success in 1990 with the release of their third album, Flood, and in the years since, they’ve maintained a foothold in popular culture through their music for film and television, as well as the release of four children’s albums, one of which earned …

Ocean-Based Climate Action And Human Rights Implications Under The International Climate Change Regime, Elisa Morgera, Mitchell Lennan, Kati Kulovesi, Bianca G La, Holly J. Niner, Ellycia Harrould-Kolieb, Piva E Recio, Jeremy Hills, Mara Ntona, Alana Malinde Sn Lancaster, Mia Strand, Bernadette Snow, Kira Erwin, Lynne Shannon, Sian Rees, Kieran Hyder, Georg Engelhard, Kerry Howell

School of Biological and Marine Sciences

After drawing attention to the crucial role of marine biodiversity, including that of deep-sea ecosystems, in current scientific understanding of the ocean-climate nexus, this article highlights the limited extent to which the international climate change regime has so far addressed the ocean. The focus then shifts to how the international climate change regime could contribute to the protection of marine biodiversity as part of mitigation, adaptation and finance, taking into account human rights impacts and standards, drawing a comparison with REDD+. The article concludes with an original proposal, inspired by the Climate and Clean Air Coalition, to develop urgent, synergistic …

Frights And Forests: The Hellish Landscape Of The Dark Forest, From Sleepy Hollow To The Forest Of Arden, Minna Nizam

Online Midwinter Seminar (OMS)

This paper seeks to explore forest settings in fantasy, and its hellish landscapes. From the headless horseman in Washington Irving’s The Legend of Sleepy Hollow, to the frights and horrors of mythical creatures in fantasy settings placed in forests. The purpose of this study is to dive deep into the fear of the forest, its early days in storytelling, to more modern renditions. Sources used will be primarily books, and texts within books, such as The Legend of Sleepy Hollow, The Lord of the Rings, and much more.

Political Demons: Society As Hell In Hellblazer And Sandman, Andrew Burt

Online Midwinter Seminar (OMS)

In the Hellblazer and Sandman comic book universes, hell depends on the writer’s worldview and often on the decade in which they are writing, appearing as a twisted version of a dreary regular world. Thus, this hell is often related to the contemporary Western political and cultural landscape as seen through Judeo-Christian conceptions of hell, demonology, and fears of everlasting torment and damnation, just like Dante’s Inferno and many other representations for centuries. In creating a hell that mirrors the modern world and accounts for contemporary folklore about the supernatural, the creators humanize the character’s quests and reify the fruitlessness …

Pullman’S Problematic Paradise: Dissolving Into Dust, David E. Isaacs

Online Midwinter Seminar (OMS)

In the His Dark Materials trilogy, Phillip Pullman has openly positioned himself as the anti-C.S. Lewis who attempts to embed the gospel of atheism through his fantasy novels. Pullman recasts classics such as Paradise Lost and Blake’s The Marriage of Heaven & Hell so that humans triumph over the oppressive Authority by learning that sinning is simply enjoying life. This paper will specifically explore Pullman’s depictions of the underworld and his alternative vision of Hell, Purgatory, and Heaven in The Amber Spyglass, examining Pullman’s attempts to assure readers that by rejecting Christian views of the final translation, one can …

Hellish Landscapes In J.R.R. Tolkien’S Legendarium, Willow Dipasquale

Online Midwinter Seminar (OMS)

J.R.R. Tolkien’s Legendarium is rich with magical and mythological elements—enchanted rings, powerful wizards, stories told long ago—and near-Biblical struggles of good over evil, power over life and death, and the inexorable passage of time. The Halls of Mandos in Valinor even have echoes of the “afterlife,” serving as a liminal place for the spirits of Elves to await their next destination. Interestingly, though, a “hell” in the classic sense (that is, a spiritual region of eternal torment and suffering) does not seem to truly exist in Tolkien’s imagined worlds. However, Tolkien does fill those worlds with hellish landscapes: Utumno and …

Only In Dying Life: The Production Of Hope And Peace, Taylor Johnson Guinan

Online Midwinter Seminar (OMS)

Unlike fantasy authors of previous generations like C.S. Lewis and J.R.R. Tolkien who wrote depictions of an afterlife that mirrored their personal faiths, modern children’s fantasy authors of the last thirty years, such as Neil Gaiman, Ursula K. Le Guin, Phillip Pullman, Rick Riordan, J.K. Rowling, Jonathan Stroud, and Garth Nix, often merely use religious concepts as a way to depict the land of the dead. In their depictions, the land of the dead is a dark, terrible, and uninviting place. However, rather than ending on that dark point, these authors transition from fear to a sense of peace, acceptance, …

Quercetin As An Anticancer Candidate For Glioblastoma Multiforme By Targeting Akt1, Mmp9, Abcb1, And Vegfa: An In Silico Study, Muhammad Hermawan Widyananda, Setyaki Kevin Pratama, Arif Nur Muhammad Ansori, Yulanda Antonius, Viol Dhea Kharisma, Ahmad Affan Ali Murtadlo, Vikash Jakhmola, Maksim Rebezov, Mars Khayrullin, Marina Derkho, Emdad Ullah, Raden Joko Kuncoroningrat Susilo, Suhailah Hayaza, Alexander Patera Nugraha, Annise Proboningrat, Amaq Fadholly, Mada Triandala Sibero, Rahadian Zainul

Karbala International Journal of Modern Science

Quercetin, a natural compound present in various fruits and vegetables, shows promise as a potential inhibitor for glioblastoma multiforme (GBM) development. This study aims to examine the anti-GBM potential of Quercetin. The protein target of Quercetin is identified and analyzed using databases such as NCBI, SEA, CTD, and STRING. Protein-protein interaction (PPI) and functional annotation are carried out based on the obtained target proteins. Molecular docking and dynamics simulations are employed using AutoDock Vina and WebGro tools to analyze the interaction between Quercetin and its target proteins. The prediction of protein targets reveals that Quercetin directly targets four proteins associated …

Elucidation Of Antibacterial, Synergistic, Antioxidant, And Anticancer Activities Of Green Synthesized Copper Oxide Nanoparticles Against Human Breast Cancer Cells, Ravindran Muthukumarasamy, Muhammad Luqman Bin Nisa, Nur Absarina Binti Rosli, Nurul Syazwani Binti Kamaruddin, Mohammad Danish, Afzan Binti Mahmad, M.N. Mohamad Ibrahim, Shahnaz Majeed

Karbala International Journal of Modern Science

The study conducted biosynthesis of copper oxide nanoparticles using an aqueous extract of Aspergillus niger and in-vestigated their potential biomedical applications. The nanoparticles were characterized using various techniques in-cluding UV-Vis, SEM, TEM, and EDX, revealing their spherical to crystalline shape with sizes ranging from 21 nm to 48 nm. The nanoparticles demonstrated notable antimicrobial activity against Staphylococcus aureus with a zone of 8 mm and Escherichia coli recorded high synergistic activity with 20.93%, as well as antioxidant properties. Furthermore, selective cytotoxicity towards breast cancer cells was observed with an IC50 of 107.81 ug/ml and an IC50 of 250.93 ug/ml on …

Remote Sensing: A Cubesat Study, Thomas Mylotte

Small Satellite Conference

The purpose of this study is to inform small research groups on the potential Earth observation (EO) and remote sensing missions that are feasible and beneficial that can be conducted on small 1-2U CubeSats. The first steps are to identify the gaps in the current Earth observation missions run by the likes of NASA and ESA for example. By understanding the limitations of conventional satellites, we can match EO and remote sensing missions to the capabilities of CubeSat technology. Four potential EO missions are outlined describing the benefits of utilizing CubeSats alongside traditional satellites.

The Nasa Cygnss Smallsat Constellation, Christopher Ruf, Darren Mckague, Clara Chew, April Warnock, William Wells

Small Satellite Conference

The NASA Cyclone Global Navigation Satellite System (CYGNSS) is a constellation of eight microsatellites in low earth orbit at ~525 km altitude and 35 deg inclination. CYGNSS was launched in December 2016 for a planned 2 year mission and 7 of the 8 spacecraft continue to operatue nominally as of May 2023. Each microsatellites carries a bistatic radar receiver to measure reflected GPS signals from the Earth surface. The measurements can be converted to surface wind speed and latent and sensible heat flux over the ocean, and to surface soil moisture and wetland extent over land. Measurements penetrate through all …

The Garden Of Eatin', Jerry Zezima

Erma Bombeck Writers' Workshop Blog

My wife has ants in her plants. She also has rabbits and squirrels and birds, oh, my!

New Statistical Methodology For Capacitor Data Analysis Via Lcr Meter, Usama Afzal, Muhammad Aslam

Neutrosophic Systems with Applications

This research work introduces a novel methodology to establish the relationship between capacitance and resistance when dealing with imprecise data obtained from LCR meters. The proposed relationship is based on the principles of neutrosophic statistics, enabling the utilization of interval data of resistance or capacitance without losing the indeterminacy of the intervals. By employing this relationship, we can accurately determine capacitance values from interval data of resistance, thereby generating more flexible and informative graphs. Additionally, we have applied the neutrosophic analysis method to the interval data of resistance to further enhance our findings. The comparative analysis demonstrates the superiority of …

New Types Of Soft Sets” Hypersoft Set, Indetermsoft Set, Indetermhypersoft Set, And Treesoft Set”: An Improved Version, Florentin Smarandache

Neutrosophic Systems with Applications

This is an improved paper of [10], where we recall the definitions together with practical applications of the Soft Set and its extensions to HyperSoft Set, IndetermSoft Set, IndetermHyperSoft Set, and TreeSoft Set.

Hell In Anime And Manga, From Go Nagai’S Devilman, Kentaro Miura’S Berserk, Hell Girl Project’S Hell Girl, The Works Of Junji Ito And Everything In Between, Minna Nizam

Online Midwinter Seminar (OMS)

This paper will explore the influence of Hell in Anime and Manga. The discussion will begin with Go Nagai’s Devilman then lead into other examples of anime/manga with the same theme. The focus will be on the titular character, Akira Fudo, his transformation, and the villains throughout the story. Then a larger discussion on Kentaro Miura’s Berserk and his interpretation of hell will be taken into account. From Griffith’s transformation to Femto, to the iconography of the monsters Guts battles. Then another popular anime franchise will be discussed: Hell Girl and its impact on modern media. The story of revenge …

The Road To Hell: Rebirth And Relevance In Musical Adaptations Of Katabatic Myth, Jarrod Deprado

Online Midwinter Seminar (OMS)

Adapting Greek mythology provides a framework to reapproach classic works through a contemporary lens to better understand the present. Of particular interest is the depiction of characters traveling to Hell in search of a better future. Looking at two myth-inspired musicals—The Frogs by Stephen Sondheim and Burt Shevelove and Hadestown by Anaïs Michell—we see two disparate journeys to the Underworld given contemporary relevance. The Frogs (1974) depicts Dionysus’ journey to Hades to bring back a poet (originally Euripides, now George Bernard Shaw). However, it was not until the 2004 Broadway adaptation that overtly anti-authoritarian messages were added, aimed at …

Re-Visioning Underland: C. S. Lewis’S The Silver Chair As Dystopian Fiction, William Thompson

Online Midwinter Seminar (OMS)

In C. S. Lewis’s The Silver Chair, Jill, Eustace, and Puddleglum follow the four signs given to them by Aslan and descend into the underworld in order to rescue the lost prince. They find the enchanted Prince Rilian, along with thousands of Earthmen, enslaved to the Green Lady, who has a plan to subjugate the people and creatures of Narnia. Michael Ward, in Planet Narnia: The Seven Heavens and the Imagination of C. S. Lewis, takes a primarily Christological approach to the Narnia series, but finds a further analogue to Underland of The Silver Chair in the underworld …

Panel: “Hell Is Other People: Looking At The Political Rage Machine In Tolkien Fan Spaces And Media”, Alicia Fox-Lenz, Grace Moone, Cara Marta Messina

Online Midwinter Seminar (OMS)

Following the backlash against the Tolkien Society’s “Tolkien and Diversity” seminar and the airing of the first season of Rings of Power, social media fan spaces for Tolkien remain politically charged and reactionary. Building on the foundation of Mythcon 51’s Roundtable “Race, Racisms, and Tolkien,” and Craig Franson’s work showcased there and on the podcast “American Id,” we will discuss the current state of Tolkien discourse on social media and how to navigate the landscape as safely as possible.

The Green Future And The Golden Past: Issues And Approaches Regarding The Sustainability Of Historical Structures And Sites, Steven Moctezuma

Pace Environmental Law Review

This Article illustrates the harmonies and conflict between historic preservation and environmental law in the context of urgently meeting climate change challenges. The Article presents an overarching analysis of the relationship between historic preservation and environmentalism, discerning unifying aspects and modern conflicts through statutory laws and case studies. It begins with detailing the parallel goals between the two causes, drawing on key similarities between the National Historic Preservation Act and the National Environmental Policy Act, the main tools for ensuring federal review for each field, and highlighting sustainable refurbishment as a prime example on achieving both ends with the same …

The Need To Reconceptualize Wild Animals Post-Covid 19: Miscoordination Of Wildlife Regulations In China’S Food Legal Order, Yi Seul Kim

Pace Environmental Law Review

Today, China is one of the largest markets for wild animal trading. Yet, wild animals are in a regulatory grey area. There is an increasing need to revisit how wild animals are simultaneously but differently regulated in the food and wildlife protection regimes. Rarely do attempts to understand these two regimes occur, making this article's analysis of miscoordination in these bodies of law crucial in addressing the hindrance of nationwide food safety improvement efforts.

Animated Dancing To Hell And Back: Disney’S Fantasia, Matthew Elfenbein

Online Midwinter Seminar (OMS)

Imaginative images of Heaven and Hell capture the sociocultural engagement with Walt Disney’s Fantasia (1940), which demonstrates animated dancing bodies to represent the descent and passage of the hero’s journey. This journey is presented with many different forms of conflict and images that become unique through the qualities of the animated screendance. This form of dance on film is accentuated by the visualization of imaginative bodies, a conflict between knowledge and curiosity, and the spectacle of layering images on top of symbolic meanings to emphasize the power of identification with the audience. The spectators of this film are engaged with …

Denethor’S Descent Into Hell, Craig Boyd

Online Midwinter Seminar (OMS)

One character in Tolkien’s Legendarium stands out as one of the more morally sad and complicated individuals: Denethor, the Steward of Gondor. Although he tries to defend the kingdom he cares for, his own significant moral weaknesses subvert even the best of his intentions. His despair, provoked by the death of his favorite son—and the apparent death of his other son—sends him into a spiral of self-destructive harm from which there is no return. What accounts for this are three factors. First, his self-imposed isolation from others cuts him off from the necessary fellowship that could sustain his character; his …

The Underworld As The Heroine’S Journey Home: Marvel, Xena, And Mythic Reimaginings, Valerie Estelle Frankel

Online Midwinter Seminar (OMS)

Hell is traditionally a place of torment, where the young heroine, like Persephone or Eurydice, is kidnapped by the patriarchy, leaving others to rescue her. The last few decades, however, have offered a model closer to Sumerian Inanna, in which the heroine is enlightened by hell or even conquers it. Angela, Queen of Hel: Journey to the Funderworld by Marguerite Bennett (2016) gives its heroine this path. Winning back her beloved, Angela, sister of Thor and Loki, becomes queen of the underworld but then prefers to bring Sera back to earth in a flip on Eurydice. The Xena episode “Fallen …

Infernal Landscape In Jacob’S Ladder (1990) In Light Of Carl G. Jung’S Theory Of Individuation, Fryderyk Kwiatkowski

Online Midwinter Seminar (OMS)

Carl G. Jung’s conception of the human psyche as an inner realm that gives access to profound, numinous experiences inspired many artists and popular culture authors to portray heaven and hell as symbolic expressions of the opposite forces within the human psyche rather than cosmological or supernatural regions. In my paper, I will concentrate on how the Hollywood film Jacob’s Ladder (1990) directed by Adrian Lyne, by portraying the main character’s descent into a deathbed vision depicted as hellish reality, reflects Jung’s theory of individuation, a process of self-realization that aims at reconciling various elements of the psyche and achieving …

Saturn: A Technological Demonstration Mission For Distributed Sar Imaging, Matteo Battilana, Giulia Capuani, Vito Lamarca, Luca Maioli, Vincenzo Mancini, Maria Lucia Tampellini, Fabio Gerace, Davide Giudici, Pietro Guccione, Julien Marini, Luciano D’Agristina, Domenico Di Lanzo, Andrea Monti Guarnieri, Alberto Fedele, Roberto Luciani, Francesco Tataranni, Silvia Natalucci

Small Satellite Conference

The OHB-Italia S.p.A-led consortium is in the midst of Phase B of SATURN (Synthetic AperTure radar cUbesat foRmation flyiNg), part of ALCOR, an Italian Space Agency (ASI) programme promoting the development of the next generation Italian CubeSats. SATURN is a demonstration mission that features Multiple-Input-Multiple-Output (MIMO) technology applied to a Swarm of CubeSats equipped with Synthetic Aperture Radar (SAR) for Earth Observation. MIMO is based on cooperative active sensors, where each one transmits signals and receives the illuminated common area backscatter related to the entire swarm, increasing measurement performances with a trend approximatively equal to the square of …

The Righteousness Of The Damned In Jeffrey Konvitz’S The Sentinel, Raymond G. Falgui

Online Midwinter Seminar (OMS)

The paper will examine the nature of the damned in Jeffrey Konvitz’s 1970s pulp horror novel The Sentinel by using a framework utilized by C.S. Lewis in The Great Divorce, wherein damnation involves a species of spiritual blindness that masquerades as righteousness and shields the damned (for a time) from an awareness of their ultimate condition. Specifically, the paper will provide a character analysis of the co-protagonist Michael, arguably one of Konvitz’s more complex literary creations, and the role he plays in briefly elevating a generic genre-contrived plot into the realm of true spiritual horror. While making such a …

Control Of Small Spacecraft By Optimal Output Regulation: A Reinforcement Learning Approach, Joao Leonardo Silva Cotta, Omar Qasem, Paula Do Vale Pereira, Hector Gutierrez

Small Satellite Conference

The growing number of noncooperative flying objects has prompted interest in sample-return and space debris removal missions. Current solutions are both costly and largely dependent on specific object identification and capture methods. In this paper, a low-cost modular approach for control of a swarm flight of small satellites in rendezvous and capture missions is proposed by solving the optimal output regulation problem. By integrating the theories of tracking control, adaptive optimal control, and output regulation, the optimal control policy is designed as a feedback-feedforward controller to guarantee the asymptotic tracking of a class of reference input generated by the leader. …