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Articles 76861 - 76890 of 742529
Full-Text Articles in Entire DC Network
On-Farm Information: A Valuable Tool For The Sustainable Management Of Mountain Pastures In Protected Natural Areas, N. Mandaluniz, A. Bernués, A. Igarzabal, I. J. L. Riedel, R. Ruiz, A. Sanz, I. Casasús, L. M. Oregui
On-Farm Information: A Valuable Tool For The Sustainable Management Of Mountain Pastures In Protected Natural Areas, N. Mandaluniz, A. Bernués, A. Igarzabal, I. J. L. Riedel, R. Ruiz, A. Sanz, I. Casasús, L. M. Oregui
IGC Proceedings (1977-2023)
Mountain pastures have traditionally been maintained by livestock. The analysis of data concerning farms' characteristics, productive-reproductive management and land use of commercial farms can constitute a real approach to study these systems and the changes that are occurring. This information is necessary to develop new utilisation guidelines, making compatible livestock production and conservation of natural resources. This paper describes a methodological framework to study the issues described above through some examples taken out from a wider research project (Mandaluniz et al., 2003).
Disappearance Of Residual Dry Matter On Annual Grassland In The Absence Of Grazing, W. E. Frost, J. W. Bartolome, K. R. Churches
Disappearance Of Residual Dry Matter On Annual Grassland In The Absence Of Grazing, W. E. Frost, J. W. Bartolome, K. R. Churches
IGC Proceedings (1977-2023)
Residual dry matter (RDM) is a standard used by grassland managers for assessing the level of grazing use on annual grasslands and associated savannas and woodlands. Residual dry matter is the old plant material left standing or on the ground at the beginning of a new growing season. It indicates the combined effects of the previous season's forage production and its consumption by grazing animals of all types. The standard assumes that the amount of RDM remaining in the fall, subject to site conditions and variations in weather, will influence subsequent species composition and forage production, in addition to providing …
The Impact Of Concentrate Price On The Utilization Of Grazed And Conserved Grass, P. Crosson, P. O'Kiely, F. P. O'Mara, M. J. Drennan, M. Wallace
The Impact Of Concentrate Price On The Utilization Of Grazed And Conserved Grass, P. Crosson, P. O'Kiely, F. P. O'Mara, M. J. Drennan, M. Wallace
IGC Proceedings (1977-2023)
A linear programming model was designed and constructed to facilitate the identification of optimal beef production systems under varying technical and policy scenarios. The model operates at a systems level and most activities that could occur in Irish spring-calving, suckler beef production systems are included. In this paper, the components of the model are described together with a simple application of the model involving changing concentrate prices.
Pâtur’In: A User-Friendly Software Tool To Assist Dairy Cow Grazing Management, Luc Delaby, J. L. Peyraud, P. Faverdin
Pâtur’In: A User-Friendly Software Tool To Assist Dairy Cow Grazing Management, Luc Delaby, J. L. Peyraud, P. Faverdin
IGC Proceedings (1977-2023)
The feeding of dairy cows at pasture presents many technical, economic and environmental advantages, while benefiting from a very favourable image. However, the management of grazed land is a complex game of strategy in which the farmer applies decisions in order to manage two unstable and uncertain fluxes of change: growth of grass and intake of the herd. Many tools (platemeter, etc.) and overall methods (local stocking rate references, farm cover, etc.) have been developed as aids to grazing management. Nevertheless, few decision-support systems are currently available that make it possible to anticipate and assess the consequences of a given …
External Validation In Northwest Spain Of A Decision Support System For Grazing Dairy Cows (Grazemore), Antonio González-Rodríguez, J. López Díaz, O. P. Vázquez Yáñez
External Validation In Northwest Spain Of A Decision Support System For Grazing Dairy Cows (Grazemore), Antonio González-Rodríguez, J. López Díaz, O. P. Vázquez Yáñez
IGC Proceedings (1977-2023)
A model to predict intake and milk production of cows on grazed grass (Grazemore) was developed (Mayne et al., 2004) for farmers to increase reliance on the grassland resources of the farm and reduce the tendency towards intensive dairy production in most countries of the Atlantic Arc of Europe (González, 2003). Climatic conditions and fertiliser use is the basis of the herbage growth model, but under practical conditions the estimation of the nutrient supply to cows is much affected by management, number of cows and the area of each paddock grazed. The intake capacity of the animal and the …
Allocating Grazing Resources With Kansasgrazer® And Making Management Decisions In A Stocker Operation, Joseph L. Moyer, J. O. Fritz
Allocating Grazing Resources With Kansasgrazer® And Making Management Decisions In A Stocker Operation, Joseph L. Moyer, J. O. Fritz
IGC Proceedings (1977-2023)
Management decisions for forage-beef cattle production systems are complex because of the many interrelated factors in the plant-animal complex. Evaluation of a system and effects of any changes to it are critical, however, because of the impact that any factor may have on the operation. A computer program to evaluate forage-beef cattle systems would enable producers to make more informed management decisions. Several such programs are available in Kansas, but they are not widely used because of their limited scope, user-friendliness and/or flexibility. Thus, an earlier program derived from the KYBEEF model by Bullock et al. (1983) was modified …
Enhancing Grasslands Education With Decision Support Tools, Helen G. Daily, J. M. Scott, J. M. Reid
Enhancing Grasslands Education With Decision Support Tools, Helen G. Daily, J. M. Scott, J. M. Reid
IGC Proceedings (1977-2023)
We have successfully used Decision Support Tools (DST) relevant to the management of grazing enterprises to enhance problem solving skills of undergraduates in Australia. Tools such as GrassGrotm (Moore et al., 1997) and GrazFeedtm (Freer et al., 1997) are accessed from a central server by authorised users at many widely dispersed Universities across Australia using remote access to thin-client technology via an Internet portal. This has been supplemented with training for lecturers. Experience in developing appropriate teaching and learning materials and the reliable delivery of simulation software to many clients has enhanced learning outcomes at tertiary …
Forecasting Forage Yields Using The Arima Model In Pastoral Areas Of East Africa, Robert J. Kaitho, J. W. Stuth, Jay Angerer, A. A. Jama
Forecasting Forage Yields Using The Arima Model In Pastoral Areas Of East Africa, Robert J. Kaitho, J. W. Stuth, Jay Angerer, A. A. Jama
IGC Proceedings (1977-2023)
Predicting forage supply is an age old quest for pastoralists, particularly in fragile and drought- prone areas of Africa. Traditional methods of forecasting forage used by many communities have become less effective due to climate change, frequent droughts and decline of grazing areas. Conflicts relating to available forage and water resources are increasing, because more marginal lands are put to crop production. A new forage forecasting technology has been developed that provides a comprehensive view of current forage condition (Stuth et al., 2004). A multiple species grazing land plant growth hydrology based model (PHYGROW) was parameterised with site-specific soil, …
A Model To Evaluate Buying And Selling Policies For Growing Lambs On Pasture, P. C. H. Morel, B. Wildbore, I. M. Brookes, Paul R. Kenyon, R. W. Purchas, S. Ramaswami
A Model To Evaluate Buying And Selling Policies For Growing Lambs On Pasture, P. C. H. Morel, B. Wildbore, I. M. Brookes, Paul R. Kenyon, R. W. Purchas, S. Ramaswami
IGC Proceedings (1977-2023)
In pastoral sheep finishing systems, farmers aim to maximize profitability by deciding on when and how many animals to buy and/or sell, while taking into account feed availability and current prices. This paper describes a stochastic lamb growth simulation model with a set of heuristic rules, which has been developed to financially evaluate different management strategies for growing lambs on pasture.
An Internet-Based Tool For Use In Assessing The Likely Effect Of Intensification On Losses Of Nitrogen To The Environment, N. J. Hutchings, B. M. Petersen, I. S. Kristensen, N. Detlefsen, M. S. Jørgensen
An Internet-Based Tool For Use In Assessing The Likely Effect Of Intensification On Losses Of Nitrogen To The Environment, N. J. Hutchings, B. M. Petersen, I. S. Kristensen, N. Detlefsen, M. S. Jørgensen
IGC Proceedings (1977-2023)
The EU Nitrates, Habitat and National Emissions Ceilings directives and the Kyoto Agreement mean that agricultural losses of NO3, NH3 and N2O are under scrutiny by national and international environmental authorities. When farmers wish to intensify their operations, the authorities must then assess the likely environmental impact of the change in operation. The FARM-N internet tool was developed to help farmers and authorities agree how the farm will be structured and managed in the future, and to provide an objective assessment of the environmental losses that will result.
N-Mineralisation And Phosphorous: Important Elements In Decision Support For Grassland Systems, A. Lisbeth Nielsen, C. C. Hoffmann
N-Mineralisation And Phosphorous: Important Elements In Decision Support For Grassland Systems, A. Lisbeth Nielsen, C. C. Hoffmann
IGC Proceedings (1977-2023)
Leaching of N and P from extensively managed grasslands on organic soils varies considerably. In environmentally sensitive areas it is important to diminish leaching by appropriate agricultural management. In Denmark low grazing intensity and management without fertilisation have been given a high priority. The type of soil has not been equally in focus, and it seems that the effect of cutting, compared to grazing, resulting in a higher removal of nutrients (e.g. Benke et al., 1992) can be used more strategically. The objective of this case study was to combine data from management strategies with data from leaching examinations …
Artturi Assists Finnish Advisers And Farmers To Succeed In Grass-Based Dairy Production, Marketta Rinne, Pekka Huhtanen, Kaisa Kuoppala, H. Nikander, J. Nousiainen, M. Hellämäki, L. Nyholm, J. Helminen, K. Lampinen, M. Maisi, M. Korhonen
Artturi Assists Finnish Advisers And Farmers To Succeed In Grass-Based Dairy Production, Marketta Rinne, Pekka Huhtanen, Kaisa Kuoppala, H. Nikander, J. Nousiainen, M. Hellämäki, L. Nyholm, J. Helminen, K. Lampinen, M. Maisi, M. Korhonen
IGC Proceedings (1977-2023)
Artturi is a collective name for a wide range of services. It is a common tool for different bodies who share an interest in strengthening grass-based dairy production in Finland: research, advisory service and industries. The Service is named after A. I. (Artturi Ilmari) Virtanen, the Finnish scientist who was awarded the Nobel prize in 1945, partly based on his work in developing the ensiling process of grass. The Artturi web site is available in Internet at: http://www.agronet.fi/artturi. Access to Artturi Services is free and no registration is required. The language used is Finnish. During summer 2003, 15,000 visits were …
Involvement Of Maasai Pastoralists In Participatory Rangeland Management Planning And Implementation, Evelyne Kiptot, W, Ego, D. Ochieng, A. Mohamed
Involvement Of Maasai Pastoralists In Participatory Rangeland Management Planning And Implementation, Evelyne Kiptot, W, Ego, D. Ochieng, A. Mohamed
IGC Proceedings (1977-2023)
The pastoral Maasai lifestyle was and still is traditionally based on subsistence dairy and meat production. But with population increase, the rangelands can no longer sustainably support livestock production systems. Most of the rangelands which are used for grazing have been subdivided and partially cleared to pave way for cultivation, because of increased population pressure (Ego et al., 1999). This has led to a tendency to overgraze, thus impacting negatively on secondary production from the range. In order to effectively reverse this trend, the users of the rangeland resources were brought together to analyse constraints and opportunities for sustainable …
Management Of Pasture Quality For Sheep On New Zealand Hill Country, D. I. Gray, J. I. Reid, P. D. Kemp, I. M. Brookes, D. Horne, Paul R. Kenyon, C. Matthew, S. T. Morris, I. Valentine
Management Of Pasture Quality For Sheep On New Zealand Hill Country, D. I. Gray, J. I. Reid, P. D. Kemp, I. M. Brookes, D. Horne, Paul R. Kenyon, C. Matthew, S. T. Morris, I. Valentine
IGC Proceedings (1977-2023)
The control of pasture quality over spring is central to the achievement of high levels of sheep performance on hill country. Despite this, with the exception of the work of Lambert et al. (2000), little is known about how farmers actually manage pasture quality. The purpose of this research was to describe how a high performing hill country farmer manages pasture quality on their sheep area over spring and from this develop a framework that will assist other farmers improve their pasture management.
Decision Support System For Grassland-Based Sheep Production In The Chilean Patagonia, R. R. Vera, S. Morales, C. Aguilar
Decision Support System For Grassland-Based Sheep Production In The Chilean Patagonia, R. R. Vera, S. Morales, C. Aguilar
IGC Proceedings (1977-2023)
Temporal decision-making in sheep production systems of the Chilean Patagonia is influenced by forage availability in existing paddocks, which in turn is determined by previous use, localisation, climate and soil. Also, production strategies are evolving, with a trend towards fat lamb production, introduction of new breeds and a reduction in the importance of wool production. The objective of this study was to develop an initial version of a spatial empirical simulation model based on extremely limited information, to predict forage growth and sheep production so that decision-makers can assess alternative production strategies.
A Decision Support System For Monitoring Livestock Diet Quality And Performance: Verification Study On Cattle, Adami Tulu, Ethiopia, A. A. Jama, G. Tolleson, J. W. Stuth, Abule Ebro, K. Zander, Robert J. Kaitho
A Decision Support System For Monitoring Livestock Diet Quality And Performance: Verification Study On Cattle, Adami Tulu, Ethiopia, A. A. Jama, G. Tolleson, J. W. Stuth, Abule Ebro, K. Zander, Robert J. Kaitho
IGC Proceedings (1977-2023)
Fecal profiling technology based on near infrared spectroscopy (NIRS) has been widely used in the U.S. to predict the diet quality and performance of free-ranging animals (e.g. Leite & Stuth 1995, Lyons & Stuth 1992, Lyons et al., 1993, Stuth et al., 1999, Tolleson et al., 2001). This technology is linked with the Nutritional Balance Analyzer (NUTBAL-PRO) model to form the core of a nutritional advisory system for livestock producers in the United States. This model predicts changes in body weight and condition for a broad range of livestock classes for cattle, sheep and goats. To test …
Irish Grassland Association: Delivering The Benefits From Grassland, S. Flanagan
Irish Grassland Association: Delivering The Benefits From Grassland, S. Flanagan
IGC Proceedings (1977-2023)
The Irish Grassland Association (IGA) is Ireland's leading forum for discussing the science of grass and animal production, the economics and finances of dairy, beef cattle and sheep farm enterprises. Membership is 800 and is a lively mix of progressive farmers (70%), research scientists, advisers and agribusiness personnel. The IGA is a member of the European Grassland Federation and has close ties with the Ulster Grassland Society, Fermanagh Grassland Club and the British Grassland Society.
Targeting Nociceptive And Cholinergic Nerves In Irradiated Oropharyngeal Cancer Model Reveals Novel Mechanism For Dysphagia, Blake Myers, Shajedul Islam, Frederico O. Netto, Kala Debnath, Snigdha Srivastava, Tongxin Xie, Shamima Akhter, Adewale Adebayo, Josiah M. Miller, Sahana Lothumalla, Hinduja Sathishkumar, Moran Amit
Targeting Nociceptive And Cholinergic Nerves In Irradiated Oropharyngeal Cancer Model Reveals Novel Mechanism For Dysphagia, Blake Myers, Shajedul Islam, Frederico O. Netto, Kala Debnath, Snigdha Srivastava, Tongxin Xie, Shamima Akhter, Adewale Adebayo, Josiah M. Miller, Sahana Lothumalla, Hinduja Sathishkumar, Moran Amit
Summer Experience 2023
No abstract provided.
The Synthesis And Characterization Of Gadolinium Alginate Spheres And Potential Uses As A Contrast-Enhancing Anti-Cancer Material, Tyler C. Owens, Marvin Bernardino, Archana Mishra, Allan John Barcena, Isias Workeneh, Erin San Valentin, Marites P. Melancon
The Synthesis And Characterization Of Gadolinium Alginate Spheres And Potential Uses As A Contrast-Enhancing Anti-Cancer Material, Tyler C. Owens, Marvin Bernardino, Archana Mishra, Allan John Barcena, Isias Workeneh, Erin San Valentin, Marites P. Melancon
Summer Experience 2023
No abstract provided.
4th Industrial Revolution And Library-Related Scientific Production From 2010-2021: A Bibliometric Analysis, Md. Monirul Islam, Dil Ruksana Basunia, Md. Nurul Islam, Rupak Chakrabarty
4th Industrial Revolution And Library-Related Scientific Production From 2010-2021: A Bibliometric Analysis, Md. Monirul Islam, Dil Ruksana Basunia, Md. Nurul Islam, Rupak Chakrabarty
Library Philosophy and Practice (e-journal)
The main purpose of the study is to analyze the scientific productions published in scientific databases on Industrial Revolution (4IR) and libraries. The researchers investigated the scientific productions that were produced during the last decade (2010 to 2021) and indexed them in the Scopus database. The databases were inspected by VOSviewer and Biblioshiny software for those documents related to the 4IR and library. The keywords are used “Industrial Revolution*” AND “Librar*” in searching. The database’s total results are 178. The selection of years shrinks the outputs to 98 publications. Published articles in English, 4IR, and libraries met several important inclusion …
Ada News - 08/07/2023, American Dental Association, Publishing Division
Ada News - 08/07/2023, American Dental Association, Publishing Division
ADA News
Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.
Novel Enhanced Recovery After Surgery Pathway Reduces Length Of Stay And Postoperative Opioid Usage In Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion, Kristen Spisak, Matthew Thomas, Zachary J. Sirois, Alvin Jones, Lucinda M. Brown, Andrew W. Froehle, Michael Albert
Novel Enhanced Recovery After Surgery Pathway Reduces Length Of Stay And Postoperative Opioid Usage In Adolescent Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion, Kristen Spisak, Matthew Thomas, Zachary J. Sirois, Alvin Jones, Lucinda M. Brown, Andrew W. Froehle, Michael Albert
School of Health and Exercise Sciences Faculty Publications
Purpose: The goal of this study was to compare our institution’s recently implemented enhanced recovery after surgery (ERAS) protocol to previous post-operative management for adolescent idiopathic scoliosis patients undergoing posterior spinal fusion, specifically assessing length of stay, opioid consumption, and pain scores.
Methods: This is a retrospective analysis that compares the length of stay, opioid consumption, and pain scores of patients undergoing posterior spinal fusion for adolescent idiopathic scoliosis. Patients were analyzed prior to the implementation of our ERAS protocol, deemed the traditional pain pathway (TPP), to those who underwent the ERAS pathway. All patients undergoing posterior spinal fusion for …
Metabolic Liver Cancer: Associations Of Rare And Common Germline Variants In One-Carbon Metabolism And Dna Methylation Genes, Samuel O Antwi, Michael Heckman, Launia White, Irene Yan, Vivekananda Sarangi, Kimberly P Lauer, Joseph Reddy, Fowsiyo Ahmed, Swathi Veliginti, Ellis D Mejías Febres, Rikita I Hatia, Ping Chang, Laura Izquierdo-Sanchez, Loreto Boix, Angela Rojas, Jesus M Banales, Maria Reig, Per Stål, Manuel Romero Gómez, Amit G Singal, Donghui Li, Manal M Hassan, Lewis R Roberts, Tushar Patel
Metabolic Liver Cancer: Associations Of Rare And Common Germline Variants In One-Carbon Metabolism And Dna Methylation Genes, Samuel O Antwi, Michael Heckman, Launia White, Irene Yan, Vivekananda Sarangi, Kimberly P Lauer, Joseph Reddy, Fowsiyo Ahmed, Swathi Veliginti, Ellis D Mejías Febres, Rikita I Hatia, Ping Chang, Laura Izquierdo-Sanchez, Loreto Boix, Angela Rojas, Jesus M Banales, Maria Reig, Per Stål, Manuel Romero Gómez, Amit G Singal, Donghui Li, Manal M Hassan, Lewis R Roberts, Tushar Patel
Faculty, Staff and Student Publications
Animal studies implicate one-carbon metabolism and DNA methylation genes in hepatocellular carcinoma (HCC) development in the setting of metabolic perturbations. Using human samples, we investigated the associations between common and rare variants in these closely related biochemical pathways and risk for metabolic HCC development in a multicenter international study. We performed targeted exome sequencing of 64 genes among 556 metabolic HCC cases and 643 cancer-free controls with metabolic conditions. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for multiple comparisons. Gene-burden tests were used for rare variant associations. Analyses were performed in …
Heavy Metals Within The Hawaiian Islands Archipelago As Evidenced In The Hawaiian Monk Seal And Their Prey, Yvanna M. Strait
Heavy Metals Within The Hawaiian Islands Archipelago As Evidenced In The Hawaiian Monk Seal And Their Prey, Yvanna M. Strait
All HCAS Student Capstones, Theses, and Dissertations
The Hawaiian monk seal (HMS) is an endangered, endemic seal native to the Northwestern Hawaiian Islands (NWHI). During the 21st century, members of the HMS population have established residency within the Main Hawaiian Islands (MHI). This habitat shift may increase exposure of the animals to greater anthropogenic (urban industrialization, agricultural practices, and military activity) and natural (volcanic activity) heavy metal contaminants. Induced coupled plasma mass spectroscopy (ICPMS) analysis compared 16 heavy metal concentrations in HMS bone segregated by region, age, and sex. In additions, metal concentrations from potential prey items from the southern extent of the Northwestern Hawaiian Islands …
Evaluating The Osteogenic Potential Of Raspberry Ketone And Simvastatin Dual-Loaded Electrospun Chitosan Membranes On Preosteoblasts, Matthew T. Atwill
Evaluating The Osteogenic Potential Of Raspberry Ketone And Simvastatin Dual-Loaded Electrospun Chitosan Membranes On Preosteoblasts, Matthew T. Atwill
Electronic Theses and Dissertations Archive
This study evaluated the osteogenic potential of dual-loading raspberry ketone (RK) and simvastatin (SMV) onto electrospun chitosan membranes (ESCMs) to impart bioactivity onto guided bone regeneration (GBR) membranes and give them a more active role in osteodifferentiation. In this study, W-20-17 cells in media exposed to 12-100µg/ml RK in combination with 75-150ng/ml SMV resulted in increased basal alkaline phosphatase (ALP) expression, whereas RK groups alone had no effect on ALP expression. Additionally, there was a dose-dependent combinatory cytotoxic effect in which SMV in combination with increasing concentrations of RK resulted in decreased viability and vice versa. RK+SMV combinations were loaded …
Mike Colletta, Oral History Interview, 2022, Matt Jones
Mike Colletta, Oral History Interview, 2022, Matt Jones
Oral Histories
Mike Colletta was an active member of the Arm of Honor Fraternity from 1965 until 1969, and is now a member of the Arm of Honor Alumni Chapter. A first generation Detroiter born to Sicilian immigrants, Colletta describes his time at Allen Park High School and Michigan State University before coming to EMU with a friend to visit. Colletta talks about meeting with Dean of Students Ralph Gilden, the lost sense of community on the EMU campus, a failed Marine enlistment, and having a student deferment plus a married deferment from the armed services. Colletta describes meeting the Arms for …
Ultrasonographic Features Of Gallbladder Wall Thickening In Dogs With Hypoalbuminemia., Masahiro Murakami, Hock Gan Heng, Sarah Steinbach, Mario Sola
Ultrasonographic Features Of Gallbladder Wall Thickening In Dogs With Hypoalbuminemia., Masahiro Murakami, Hock Gan Heng, Sarah Steinbach, Mario Sola
Purdue University Libraries Open Access Publishing Fund
Hypoalbuminemia has been considered as a cause of gallbladder wall thickening in humans and dogs. Recent study revealed that gallbladder wall thickening in dogs with hypoalbuminemia may not be associated with serum albumin/plasma levels within 48 h of ultrasound study. However, gallbladder wall edema may change within 48 h, and the ultrasonographic features of gallbladder wall thickening in dogs with hypoalbuminemia have not been reported. The purpose of this study is to describe the relationship between serum albumin levels within 24 h of ultrasound and gallbladder wall thickening, and to describe the ultrasonographic features of thickened gallbladder walls in dogs …
Analyzing The Impact Of Process-Oriented Technology In Programming Education, Kate Arendes
Analyzing The Impact Of Process-Oriented Technology In Programming Education, Kate Arendes
Theses
Currently, there exist several factors in programming education that deter novice programmers. Computer science students are often significantly penalized for programs that do not compile, reflecting how current teaching standards are focused on the product of the student’s efforts, rather than the independent pieces of code that would otherwise execute properly. Novice programmers struggle with interpreting error messages that identify where and why a program failed, but are written with the assumption that the author already has mastered the fundamental concepts that they are trying to implement. In the classroom, educators may show presentations with pre-written code or perform live …
Fan1 Removes Triplet Repeat Extrusions Via A Pcna- And Rfc-Dependent Mechanism, Ashutosh S. Phadte, Mayuri Bhatia, Hope Ebert, Haaris Abdullah, Essam Abed Elrazaq, Konstantin E. Komolov, Anna Pluciennik
Fan1 Removes Triplet Repeat Extrusions Via A Pcna- And Rfc-Dependent Mechanism, Ashutosh S. Phadte, Mayuri Bhatia, Hope Ebert, Haaris Abdullah, Essam Abed Elrazaq, Konstantin E. Komolov, Anna Pluciennik
Department of Biochemistry and Molecular Biology Faculty Papers
Human genome-wide association studies have identified FAN1 and several DNA mismatch repair (MMR) genes as modifiers of Huntington’s disease age of onset. In animal models, FAN1 prevents somatic expansion of CAG triplet repeats, whereas MMR proteins promote this process. To understand the molecular basis of these opposing effects, we evaluated FAN1 nuclease function on DNA extrahelical extrusions that represent key intermediates in triplet repeat expansion. Here, we describe a strand-directed, extrusion-provoked nuclease function of FAN1 that is activated by RFC, PCNA, and ATP at physiological ionic strength. Activation of FAN1 in this manner results in DNA cleavage in the vicinity …
Metabolic Liver Cancer: Associations Of Rare And Common Germline Variants In One-Carbon Metabolism And Dna Methylation Genes, Samuel O Antwi, Michael Heckman, Launia White, Irene Yan, Vivekananda Sarangi, Kimberly P Lauer, Joseph Reddy, Fowsiyo Ahmed, Swathi Veliginti, Ellis D Mejías Febres, Rikita I Hatia, Ping Chang, Laura Izquierdo-Sanchez, Loreto Boix, Angela Rojas, Jesus M Banales, Maria Reig, Per Stål, Manuel Romero Gómez, Amit G Singal, Donghui Li, Manal M Hassan, Lewis R Roberts, Tushar Patel
Metabolic Liver Cancer: Associations Of Rare And Common Germline Variants In One-Carbon Metabolism And Dna Methylation Genes, Samuel O Antwi, Michael Heckman, Launia White, Irene Yan, Vivekananda Sarangi, Kimberly P Lauer, Joseph Reddy, Fowsiyo Ahmed, Swathi Veliginti, Ellis D Mejías Febres, Rikita I Hatia, Ping Chang, Laura Izquierdo-Sanchez, Loreto Boix, Angela Rojas, Jesus M Banales, Maria Reig, Per Stål, Manuel Romero Gómez, Amit G Singal, Donghui Li, Manal M Hassan, Lewis R Roberts, Tushar Patel
Faculty, Staff and Student Publications
Animal studies implicate one-carbon metabolism and DNA methylation genes in hepatocellular carcinoma (HCC) development in the setting of metabolic perturbations. Using human samples, we investigated the associations between common and rare variants in these closely related biochemical pathways and risk for metabolic HCC development in a multicenter international study. We performed targeted exome sequencing of 64 genes among 556 metabolic HCC cases and 643 cancer-free controls with metabolic conditions. Multivariable logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for multiple comparisons. Gene-burden tests were used for rare variant associations. Analyses were performed in …