Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 76441 - 76470 of 742666

Full-Text Articles in Entire DC Network

Unh Spearheads Multi-University Tick Surveillance System Project, Nicholas Gosling Aug 2023

Unh Spearheads Multi-University Tick Surveillance System Project, Nicholas Gosling

UNH Today Archive

No abstract provided.


The Free Press Vol. 55, Issue 1, 08-21-2023, Deklin Fitzgerald Aug 2023

The Free Press Vol. 55, Issue 1, 08-21-2023, Deklin Fitzgerald

Free Press, The

A Presidential Welcome--Hard Lessons+Good Times--Portland Ribbon Cutting--SEAL--News from WMPG--A Welcome from the ROCC--Portland Parking Changes--Free Press Celebrates 50 Years


Identifying The Reactive Metabolites Of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using Lc-Ms-Based Metabolomic Approaches, John M Hakenjos, Si Chen, Saleh M Khalil, Sung Yun Jung, Damian W Young, Lei Guo, Feng Li Aug 2023

Identifying The Reactive Metabolites Of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using Lc-Ms-Based Metabolomic Approaches, John M Hakenjos, Si Chen, Saleh M Khalil, Sung Yun Jung, Damian W Young, Lei Guo, Feng Li

Faculty, Staff and Students Publications

Pexidartinib (PEX, TURALIO), a selective and potent inhibitor of the macrophage colony-stimulating factor-1 receptor, has been approved for the treatment of tenosynovial giant cell tumor. However, frequent and severe adverse effects have been reported in the clinic, resulting in a boxed warning on PEX for its risk of liver injury. The mechanisms underlying PEX-related hepatotoxicity, particularly metabolism-related toxicity, remain unknown. In the current study, the metabolic activation of PEX was investigated in human/mouse liver microsomes (HLM/MLM) and primary human hepatocytes (PHH) using glutathione (GSH) and methoxyamine (NH2OMe) as trapping reagents. A total of 11 PEX-GSH and 7 PEX-NH2OMe adducts were …


How Can Patients Be In Control Of Their Healthcare If They Are Not In Control Of Their Online Health Information?, M Hägglund, A Kharko, J Hagström, M Johansen, Et Al Aug 2023

How Can Patients Be In Control Of Their Healthcare If They Are Not In Control Of Their Online Health Information?, M Hägglund, A Kharko, J Hagström, M Johansen, Et Al

Peninsula Medical School

No abstract provided.


Northerly Range Expansion And First Confirmed Records Of The Smalltooth Sand Tiger Shark, Odontaspis Ferox, In The United Kingdom And Ireland, David J. Curnick, Phil Hosegood Aug 2023

Northerly Range Expansion And First Confirmed Records Of The Smalltooth Sand Tiger Shark, Odontaspis Ferox, In The United Kingdom And Ireland, David J. Curnick, Phil Hosegood

School of Biological and Marine Sciences

Three Odontaspis ferox (confirmed by mtDNA barcoding) were found in the English Channel and Celtic Sea in 2023 at Lepe, UK (50.7846, −1.3508), Kilmore Quay, Ireland (52.1714, −6.5937), and Lyme Bay, UK (50.6448, −2.9302). These are the first records of O. ferox in either country, and extend the species' range by over three degrees of latitude, to >52° N. They were ~275 (female), 433 (female), and 293 cm (male) total length, respectively. These continue a series of new records, possibly indicative of a climate change−induced shift in the species' range.


Leucocytozoon Cariamae N. Sp. And Haemoproteus Pulcher Coinfection In Cariama Cristata (Aves: Cariamiformes): First Mitochondrial Genome Analysis And Morphological Description Of A Leucocytozoid In Brazil, Lis Marques De C. Vieira, Pedro Henrique O. Pereira, Daniel Ambrózio Da Rocha Vilela, Irène Landau, M. Andreína Pacheco, Ananias A. Escalante, Francisco C. Ferreira, Érika Martins Braga Aug 2023

Leucocytozoon Cariamae N. Sp. And Haemoproteus Pulcher Coinfection In Cariama Cristata (Aves: Cariamiformes): First Mitochondrial Genome Analysis And Morphological Description Of A Leucocytozoid In Brazil, Lis Marques De C. Vieira, Pedro Henrique O. Pereira, Daniel Ambrózio Da Rocha Vilela, Irène Landau, M. Andreína Pacheco, Ananias A. Escalante, Francisco C. Ferreira, Érika Martins Braga

Harold W. Manter Laboratory of Parasitology: Library Materials

The distribution of avian haemosporidians of the genus Leucocytozoon in the Neotropics remains poorly understood. Recent studies confirmed their presence in the region using molecular techniques alone, but evidence for gametocytes and data on putative competent hosts for Leucocytozoon are still lacking outside highland areas. We combined morphological and molecular data to characterize a new Leucocytozoon species infecting a non-migratory red-legged seriema (Cariama cristata), the first report of a competent host for Leucocytozoon in Brazil. Leucocytozoon cariamae n. sp. is distinguished from the Leucocytozoon fringillinarum group by its microgametocytes that are not strongly appressed to the host cell …


Dna Barcoding Of Springsnails (Mollusca, Gastropoda, Caenogastropoda) Endemic To The Trans-Pecos Region Of Texas (Usa), Kathryn E. Perez, Vanessa Saenz, Natalia Salazar-Lozano, Benjamin F. Schwartz, Benjamin T. Hutchins Aug 2023

Dna Barcoding Of Springsnails (Mollusca, Gastropoda, Caenogastropoda) Endemic To The Trans-Pecos Region Of Texas (Usa), Kathryn E. Perez, Vanessa Saenz, Natalia Salazar-Lozano, Benjamin F. Schwartz, Benjamin T. Hutchins

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

In desert environments, unique communities depend on groundwater from springs, including a diverse radiation of small (<5 >mm) snails found in the desert across the southwestern United States. Nearly all springsnail species are considered critically imperiled with their existence depending on maintenance of spring-flows in regions of declining water availability. Extant, endemic springsnails in the Trans-Pecos region of Texas include one species of Pseudotryonia Hershler, 2001, five nominal Tryonia W. Stimpson, 1865 (Cochliopidae) and seven Pyrgulopsis Call & Pilsbry, 1886 (Hydrobiidae). Four of these are classified as endangered under the US Endangered Species Act. Surveys for springsnails were conducted at …


Stability Analyses On The Effect Of Vaccination And Contact Tracing In Monkeypox Virus Transmission, Solomon Eshun, Richmond Essieku, James Ladzekpo Aug 2023

Stability Analyses On The Effect Of Vaccination And Contact Tracing In Monkeypox Virus Transmission, Solomon Eshun, Richmond Essieku, James Ladzekpo

School of Mathematical & Statistical Sciences Faculty Publications

Monkeypox is a significant health concern due to its potential for morbidity and occasional mortality. Vaccination and effective contact tracing play pivotal roles in controlling infectious diseases, including monkeypox. This study aims to contribute to our understanding of monkeypox dynamics by developing a comprehensive mathematical model that incorporates key factors such as vaccination, quarantining, and contact tracing. Through rigorous sensitivity analysis, we explore the impact of varying vaccination coverage and contact tracing on the disease’s dynamics. In particular, we investigate the dynamics of the disease in relation to variable vaccination coverage and contact tracing. Our findings highlight the critical role …


A Longitudinal Resource For Population Neuroscience Of School-Age Children And Adolescents In China, Xue-Ru Fan, Yin-Shan Wang, Da Chang, Ning Yang, Meng-Jie Rong, Zhe Zhang, Ye He, Xiaohui Hou, Quan Zhou, John Blangero Aug 2023

A Longitudinal Resource For Population Neuroscience Of School-Age Children And Adolescents In China, Xue-Ru Fan, Yin-Shan Wang, Da Chang, Ning Yang, Meng-Jie Rong, Zhe Zhang, Ye He, Xiaohui Hou, Quan Zhou, John Blangero

School of Medicine Publications

During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The developing Chinese Color Nest Project (devCCNP, 2013–2022), the first ten-year stage of the lifespan CCNP (2013–2032), is a two-stages project focusing on brain-mind development. The project aims to create and share a large-scale, longitudinal and multimodal dataset of typically developing children and adolescents (ages 6.0–17.9 at enrolment) in the Chinese population. The devCCNP houses not only phenotypes measured by demographic, biophysical, psychological and behavioural, cognitive, affective, and ocular-tracking assessments but also …


Temporal Progression Of Aortic Valve Pathogenesis In A Mouse Model Of Osteogenesis Imperfecta., Kaitlyn Thatcher, Carol R Mattern, Daniel Chaparro, Veronica Goveas, Michael R Mcdermott, Jessica Fulton, Joshua D Hutcheson, Brian Hoffmann, Joy Lincoln Aug 2023

Temporal Progression Of Aortic Valve Pathogenesis In A Mouse Model Of Osteogenesis Imperfecta., Kaitlyn Thatcher, Carol R Mattern, Daniel Chaparro, Veronica Goveas, Michael R Mcdermott, Jessica Fulton, Joshua D Hutcheson, Brian Hoffmann, Joy Lincoln

Faculty Research 2023

Organization of extracellular matrix (ECM) components, including collagens, proteoglycans, and elastin, is essential for maintaining the structure and function of heart valves throughout life. Mutations in ECM genes cause connective tissue disorders, including Osteogenesis Imperfecta (OI), and progressive debilitating heart valve dysfunction is common in these patients. Despite this, effective treatment options are limited to end-stage interventions. Mice with a homozygous frameshift mutation in col1a2 serve as a murine model of OI (oim/oim), and therefore, they were used in this study to examine the pathobiology of aortic valve (AoV) disease in this patient population at structural, functional, and molecular levels. …


In Silico Prediction Of Acute Chemical Toxicity Of Biocides In Marine Crustaceans Using Machine Learning, Rama Krishnan, Ian S. Howard, Sean Comber, Awadhesh N. Jha Aug 2023

In Silico Prediction Of Acute Chemical Toxicity Of Biocides In Marine Crustaceans Using Machine Learning, Rama Krishnan, Ian S. Howard, Sean Comber, Awadhesh N. Jha

School of Engineering, Computing and Mathematics

Biocides are a heterogeneous group of chemical substances intended to control the growth or kill undesired organisms. Due to their extensive use, they enter marine ecosystems via non-point sources and may pose a threat to ecologically important non-target organisms. Consequently, industries and regulatory agencies have recognized the ecotoxicological hazard potential of biocides. However, the prediction of biocide chemical toxicity on marine crustaceans has not been previously evaluated. This study aims to provide in silico models capable of classifying structurally diverse biocidal chemicals into different toxicity categories and predict acute chemical toxicity (LC50) in marine crustaceans using a set of calculated …


Investigating The Salinity Tolerance Of The Swordtail (Xiphophorus Hellerii), Alexandra Megan Krak Aug 2023

Investigating The Salinity Tolerance Of The Swordtail (Xiphophorus Hellerii), Alexandra Megan Krak

College of Science and Health Theses and Dissertations

The swordtail, Xiphophorus hellerii, is a freshwater fish species native to Mexico and Central America and is commonly used in the tropical aquarium trade. Swordtails have been shown to have limited survival in 6 ‰ salinity (Nanda et al., 2016), suggesting they may have a greater salinity tolerance than previously expected. Using a gradual acclimation method, we examined the salinity tolerance and swim performance of this species. Freshwater-reared female swordtails were housed in 29-gallon aquaria. A control group was held in freshwater throughout the experiment. For the experimental group, the salinity was increased by 2 ‰ every week until 30 …


Aum314.2 Music For Non-Linear Narrative Example 1, Sae University College Aug 2023

Aum314.2 Music For Non-Linear Narrative Example 1, Sae University College

Exemplars

HD / Exceeds Specification exemplar for AUM314.2: Music for Linear Narrative


Impact Of Retinoic Acid Receptor Alpha Conditional Knockout On Ovarian Follicle Development In The Mouse, Zlata Bogin Aug 2023

Impact Of Retinoic Acid Receptor Alpha Conditional Knockout On Ovarian Follicle Development In The Mouse, Zlata Bogin

College of Science and Health Theses and Dissertations

When there is abnormal endocrine signaling in the follicles, infertility, and ovarian diseases such as polycystic ovarian syndrome (PCOS), premature ovarian failure (POF), and different types of ovarian cancers may occur. Retinoic acid (RA), a biologically active derivative of vitamin A, is a critical signaling molecule that plays a vital role in various physiological processes, including embryonic development, tissue differentiation, and reproductive function. RA has been observed to influence granulosa cell proliferation through a cell signaling cascade involving Retinoic Acid Receptors (RARs), which have three isoforms alpha, beta, and gamma. We characterized a new retinoic acid receptor alpha (RARA) conditional …


Characterization Of The Immune Deficiency Pathway During Female Meiosis In Drosophila Melanogaster, Sarah Mashburn Aug 2023

Characterization Of The Immune Deficiency Pathway During Female Meiosis In Drosophila Melanogaster, Sarah Mashburn

College of Science and Health Theses and Dissertations

Organisms can defend against pathogens by significantly increasing the diversity of their progeny, so that some progeny are more likely to survive infection. This led to the prediction that infection should cause an increase in recombination rates which was seen in a previous study. However, the mechanism that regulates recombination rates in response to infection is not understood and in that study they did not provide a mechanism for how that can occur. In an RNAi screen, our lab found the gene mustard (mtd) is required for normal recombination rates. This gene was previously shown to be part of the …


Targeting S. Maltophilia Biofilms With Phage Bfi2, Lydia Walther Aug 2023

Targeting S. Maltophilia Biofilms With Phage Bfi2, Lydia Walther

College of Science and Health Theses and Dissertations

Stenotrophomonas maltophilia is a multidrug resistant bacterium which can cause severe infections of the respiratory tract, soft tissue, and bloodstream, and its ability to form biofilms on medical implants and devices contributes to its role as a hospital-acquired pathogen (Brooke, 2021; Flores-Treviño et al., 2019). The rise of antibiotic resistance has prompted the search for new treatments against bacteria. Bacteriophages, or phages, are a promising alternative to antibiotics because they infect and kill bacteria (Ling et al., 2022). Phage therapy has gained recent attention as a life-saving treatment for antibiotic resistant infections (Racenis et al., 2023; Schooley et al., 2017). …


Neutrosophic Multi-Criteria Decision Making For Sustainable Procurement In Food Business, Mahmoud Ismail, Ahmed M. Ali, Ahmed Abdelhafeez, Ahmed Abdel-Rahim Ei-Douh, Mahmoud Ibrahim, Ayman H. Abdel-Aziem Aug 2023

Neutrosophic Multi-Criteria Decision Making For Sustainable Procurement In Food Business, Mahmoud Ismail, Ahmed M. Ali, Ahmed Abdelhafeez, Ahmed Abdel-Rahim Ei-Douh, Mahmoud Ibrahim, Ayman H. Abdel-Aziem

Neutrosophic Sets and Systems

No abstract provided.


Verifying Empirical Predictive Modeling Of Societal Vulnerability To Hazardous Events: A Monte Carlo Experimental Approach, Yi Victor Wang, Seung Hee Kim, Menas C. Kafatos Aug 2023

Verifying Empirical Predictive Modeling Of Societal Vulnerability To Hazardous Events: A Monte Carlo Experimental Approach, Yi Victor Wang, Seung Hee Kim, Menas C. Kafatos

Institute for ECHO Articles and Research

With the emergence of large amounts of historical records on adverse impacts of hazardous events, empirical predictive modeling has been revived as a foundational paradigm for quantifying disaster vulnerability of societal systems. This paradigm models societal vulnerability to hazardous events as a vulnerability curve indicating an expected loss rate of a societal system with respect to a possible spectrum of intensity measure (IM) of an event. Although the empirical predictive models (EPMs) of societal vulnerability are calibrated on historical data, they should not be experimentally tested with data derived from field experiments on any societal system. Alternatively, in this paper, …


Research On China’S Marine Protected Areas Policy Based On Kunming-Montreal Global Biodiversity Framework 2030 Targets, Ke Duan, Xiulin Wang Aug 2023

Research On China’S Marine Protected Areas Policy Based On Kunming-Montreal Global Biodiversity Framework 2030 Targets, Ke Duan, Xiulin Wang

Bulletin of Chinese Academy of Sciences (Chinese Version)

The Kunming-Montreal Global Biodiversity Framework adopted by the United Nations Convention on Biological Diversity (CBD) at the Conference of Parties (COP15) has set a series of targets, including protecting at least 30% of the oceans by 2030 worldwide. In China, how to build a marine ecological civilization in synergy with the targets has become an important issue. This study analyzes the necessity of accelerating the construction of marine protected areas in China from the perspectives of adapting to international trends, fulfilling the responsibilities of international conventions, safeguarding maritime rights and interests, and implementing the maritime power and strategy. The feasibility …


Smart Assessment Of Wheat Suppliers Via Marcos-Based Mcdm Modelling Under A Neutrosophic Scenario, Reda M. Hussien, Amr A. Abohany, Karam M. Sallam, Ahmed Salem Aug 2023

Smart Assessment Of Wheat Suppliers Via Marcos-Based Mcdm Modelling Under A Neutrosophic Scenario, Reda M. Hussien, Amr A. Abohany, Karam M. Sallam, Ahmed Salem

Neutrosophic Sets and Systems

No abstract provided.


An Effective Decision-Making Framework For Evaluating The Intelligent Logistics Development Scenarios Performance, Karam M. Sallam, Amr A. Abohany, Ahmed Salem, Reda M. Hussien Aug 2023

An Effective Decision-Making Framework For Evaluating The Intelligent Logistics Development Scenarios Performance, Karam M. Sallam, Amr A. Abohany, Ahmed Salem, Reda M. Hussien

Neutrosophic Sets and Systems

No abstract provided.


Evaluation The Impact Potentials Of Materials And Systems With Specific Criteria Under Neutrosophic Set, Ayman H. Abdel-Aziem, Tamer H.M. Soliman, Ahmed M.Ali, Ahmed Abdelhafeez Aug 2023

Evaluation The Impact Potentials Of Materials And Systems With Specific Criteria Under Neutrosophic Set, Ayman H. Abdel-Aziem, Tamer H.M. Soliman, Ahmed M.Ali, Ahmed Abdelhafeez

Neutrosophic Sets and Systems

No abstract provided.


Threads, Buckets, And Impact: A Framework For Tool Accelerated Machine Learning Courses, Jonathan Adam Niemirowski Aug 2023

Threads, Buckets, And Impact: A Framework For Tool Accelerated Machine Learning Courses, Jonathan Adam Niemirowski

Doctoral Dissertations

Artificial intelligence and machine learning (ML) have exploded in use, accessibility, and awareness in the past few years, particularly with the release of ChatGPT in late 2022. Advances in end-user ML tools are accelerating the development of ML applications, lowering the technical barrier of entry for users outside of the computer science (CS) community. Access to ML education within STEM is mostly limited to upper-level computer science courses that have deep pre-requisite requirements or to introductory workshops that yield limited ML skills. Despite the critical need for ML education, there is a lack of guidance in instructional design for applied …


Intravenous Dexmedetomidine Use In Total Hip Arthroplasty May Lead To Elevated Rates Of Hypotension., Christopher T. Holland, Andrew J. Meyers, Zachary C. Lum, Hailee Tougas, Mauro Giordani, John P. Meehan Aug 2023

Intravenous Dexmedetomidine Use In Total Hip Arthroplasty May Lead To Elevated Rates Of Hypotension., Christopher T. Holland, Andrew J. Meyers, Zachary C. Lum, Hailee Tougas, Mauro Giordani, John P. Meehan

HPD Articles

Purpose Enhanced recovery protocols for total hip arthroplasty (THA), using opioid-sparing techniques have become widely used. Reports of novel additions to multimodal pain control regimens have been published, however, a paucity of literature exists on the use of intravenous dexmedetomidine. In this study, we analyzed our experience with intravenous dexmedetomidine and hypothesized that it would reduce postoperative opioid use. Secondary outcomes were also examined, including post-operative hypotension, hemoglobin, length of stay, and discharge disposition. Methods All patients who underwent primary THA at a single tertiary-level center between January 1, 2016, and September 1, 2019, underwent investigation. Diagnosis, surgical approach, anesthetic …


Transcranial Focused Ultrasound-Induced Blood‒Brain Barrier Opening In Mice Without Shaving Hairs, Lu Xu, Yan Gong, Chih-Yen Chien, Eric Leuthardt, Hong Chen Aug 2023

Transcranial Focused Ultrasound-Induced Blood‒Brain Barrier Opening In Mice Without Shaving Hairs, Lu Xu, Yan Gong, Chih-Yen Chien, Eric Leuthardt, Hong Chen

2020-Current year OA Pubs

Acoustic coupling through hairs remains a challenge to performing transcranial-focused ultrasound procedures. Here, we demonstrated that this challenge could be addressed by using oil as the coupling medium, leveraging oil's high affinity to hairs due to their inherent hydrophobicity. We compared focused ultrasound-induced blood-brain barrier opening (FUS-BBBO) outcomes in mice under three coupling conditions: oil with hairs ("oil + hairs"), ultrasound gel with hair shaving ("ultrasound gel + no hair"), and ultrasound gel with hairs ("ultrasound gel + hairs"). The quality of the coupling was evaluated by [Formula: see text]-weighted magnetic resonance imaging (MRI) and passive cavitation detection (PCD). The …


Nh Agricultural Experiment Station’S New Create Grants Promote Multidisciplinary Science, Nicholas Gosling Aug 2023

Nh Agricultural Experiment Station’S New Create Grants Promote Multidisciplinary Science, Nicholas Gosling

UNH Today Archive

No abstract provided.


Multiomic Investigations Into Lung Health And Disease, Mohan Pammi Aug 2023

Multiomic Investigations Into Lung Health And Disease, Mohan Pammi

Faculty, Staff and Students Publications

Diseases of the lung account for more than 5 million deaths worldwide and are a healthcare burden. Improving clinical outcomes, including mortality and quality of life, involves a holistic understanding of the disease, which can be provided by the integration of lung multi-omics data. An enhanced understanding of comprehensive multiomic datasets provides opportunities to leverage those datasets to inform the treatment and prevention of lung diseases by classifying severity, prognostication, and discovery of biomarkers. The main objective of this review is to summarize the use of multiomics investigations in lung disease, including multiomics integration and the use of machine learning …


Ultrasound Assisted Comparative Study Of Fucolam And So-Dium Alginate And Impact On Their Physiochemical Proper-Ties Using Box-Behnken Design, Uday Bagale, Ammar Kadi, Artem Malinin, Varisha Anjum, Irina Potoroko Aug 2023

Ultrasound Assisted Comparative Study Of Fucolam And So-Dium Alginate And Impact On Their Physiochemical Proper-Ties Using Box-Behnken Design, Uday Bagale, Ammar Kadi, Artem Malinin, Varisha Anjum, Irina Potoroko

Karbala International Journal of Modern Science

The article discusses about the possibility of comparing the impact of ultrasonic treatment on fucolam and sodium algi-nate. The purpose was to study the effect of micronization on the sulfated heteropolysaccharide fucolam, analyzing its dispersed state and accessibility by reducing its molecular weight and increasing antioxidant activity. The optimization of the micronization process was carried out using the Box-Behnken Design (BBD) method, with a sonication time ranging from 15 to 45 min, power ranging from 50 to 100 W/cm2, and temperature between 30 °C and 40 °C. The fixed lower fucolam concentration was 0.1%. The results illustrated that sonochemical treatment …


"The Trees Act Not As Individuals"--Learning To See The Whole Picture In Biology Education And Remote Sensing Research, Rebeka A.F. Greenall Aug 2023

"The Trees Act Not As Individuals"--Learning To See The Whole Picture In Biology Education And Remote Sensing Research, Rebeka A.F. Greenall

Theses and Dissertations

To increase equity and inclusion for underserved and excluded Indigenous students, we must make efforts to mitigate the unique barriers they face. As their knowledge systems have been historically excluded and erased in Western science, we begin by reviewing the literature on the inclusion of Traditional Ecological Knowledge (TEK) in biology education and describe best practices. Next, to better understand how Native Hawaiian and other Pacific Islander (NHPI) students integrate into the scientific community, we used Social Influence Theory as a framework to measure NHPI student science identity, self-efficacy, alignment with science values, and belonging. We also investigated how students …


Additive Effects Of Cyclic Peptide [R4w4] When Added Alongside Azithromycin And Rifampicin Against Mycobacterium Avium Infection, Melissa Kelley, Kayvan Sasaninia, Arbi Abnousian, Ali Badaoui, James Owens, Abrianna Beever, Nala Kachour, Rakesh Kumar Tiwari, Vishwanath Venketaraman Aug 2023

Additive Effects Of Cyclic Peptide [R4w4] When Added Alongside Azithromycin And Rifampicin Against Mycobacterium Avium Infection, Melissa Kelley, Kayvan Sasaninia, Arbi Abnousian, Ali Badaoui, James Owens, Abrianna Beever, Nala Kachour, Rakesh Kumar Tiwari, Vishwanath Venketaraman

Pharmacy Faculty Articles and Research

Mycobacterium avium (M. avium), a type of nontuberculous mycobacteria (NTM), poses a risk for pulmonary infections and disseminated infections in immunocompromised individuals. Conventional treatment consists of a 12-month regimen of the first-line antibiotics rifampicin and azithromycin. However, the treatment duration and low antibiotic tolerability present challenges in the treatment of M. avium infection. Furthermore, the emergence of multidrug-resistant mycobacterium strains prompts a need for novel treatments against M. avium infection. This study aims to test the efficacy of a novel antimicrobial peptide, cyclic [R4W4], alongside the first-line antibiotics azithromycin and rifampicin in reducing M. avium survival. Colony-forming unit (CFU) …