Digital Commons Network^™

The Return Of Malaria To The Usa: Did God Create Parasites To Make Us Sick?, Alan L. Gillen

Faculty Publications and Presentations

Summer 2023, the Centers for Disease Control and Prevention reported several cases of locally acquired malaria in Florida, Texas, and Maryland, meaning that patients were infected within the US—the first such cases in over two decades (CDC 2023). The significance of the cases and how individuals and public health officials should respond to the situation is still unknown. The CDC is collaborating with state health departments on an investigation of seven locally acquired cases of Plasmodium vivax malaria in Sarasota County, Florida, and one case in Cameron County, Texas, and Maryland near Washington DC. There is no evidence to suggest …

Microglial Rev-Erbα Regulates Inflammation And Lipid Droplet Formation To Drive Tauopathy In Male Mice, Jiyeon Lee, Julie M Dimitry, Jong Hee Song, Minsoo Son, Patrick W Sheehan, Melvin W King, G Travis Tabor, Young Ah Goo, Mitchell A Lazar, Leonard Petrucelli, Erik S Musiek

2020-Current year OA Pubs

Alzheimer's disease, the most common age-related neurodegenerative disease, is characterized by tau aggregation and associated with disrupted circadian rhythms and dampened clock gene expression. REV-ERBα is a core circadian clock protein which also serves as a nuclear receptor and transcriptional repressor involved in lipid metabolism and macrophage function. Global REV-ERBα deletion has been shown to promote microglial activation and mitigate amyloid plaque formation. However, the cell-autonomous effects of microglial REV-ERBα in healthy brain and in tauopathy are unexplored. Here, we show that microglial REV-ERBα deletion enhances inflammatory signaling, disrupts lipid metabolism, and causes lipid droplet (LD) accumulation specifically in male …

Ddx173.2 User Centred Design: U1 Design Example 1, Sae University College

Exemplars

UI design: This presentation showcases how the website's user interface (UI) design correlates with the insights gathered from the user experience (UX) report, and how it adheres to the established principles of UX design. The design process follows the Design Thinking Framework and conforms to the established principles of UX design.

Camkii: A Link Between Metabolic Disorders And Cardiac Arrhythmias, Marilen Federico, C.A. Valverde, L.A. Gonano, J. Palomeque, A. Matiazzi

Center for Translational Medicine Faculty Papers

The prevalence of metabolic diseases -such as obesity, prediabetes, metabolic syndrome or diabetes-has increased globally over the years. These diseases, mainly diabetes mellitus (DM), are among the leading causes of mortality and morbidity worldwide, with increased risk of diabetic cardiomyopathy (DC), cardiac arrhythmias, and heart failure (HF). In metabolic diseases several steps and proteins involved in excitation-contraction coupling (ECC) are compromised, precluding an efficient and rhythmic cardiac contraction; moreover, calcium/calmodulin-dependent protein kinase II (CaMKII) a kinase involved in ECC, is upregulated in several metabolic maladies and significantly contributes to cardiac remodeling and arrhythmias, among which are calcium (Ca2+)-triggered arrhythmias. CaMKII …

Gibberellic Acid Data, Amber Johnson

ScholarsArchive Data

This dataset contains plant emergence and survival data collected from a field study which focused on overcoming seed dormancy. Seed dormancy can present a challenge within a restoration scenario where rapid establishment is required. Soaking seeds in gibberellic acid (GA₃) can overcome dormancy and increase germination but this treatment may not be effective outside the laboratory. An easier and potentially more effective method to apply this hormone is to coat seeds with a GA₃-impregnated polymer, which provides a slow release of GA₃. Seed dormancy can also be mitigated by creating a favorable microsite with …

Application Of 3d Scanned Big Data Of Large-Scale Cultural Heritage Objects Based On Noise-Robust Transparent Visualization, Tanaka Satoshi

Journal of System Simulation

Abstract: Three-dimensional (3D) scanning technology has undergone remarkable developments in recent years. Data acquired by 3D scanning have the form of 3D point clouds. The 3D scanned point clouds have data sizes that can be considered big data. They also contain measurement noise inherent in measurement data. These properties of 3D scanned point clouds make many traditional CG/visualization techniques difficult. This paper reviewed our recent achievements in developing varieties of high-quality visualizations suitable for the visual analysis of 3D scanned point clouds. We demonstrated the effectiveness of the method by applying the visualizations to various cultural heritage objects. The main …

2023-08-25, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

Cytokine Data For Cytokine Profile Assessment From Peruvian Pinniped (Arctocephalus Australis And Otaria Byronia) Plasma, Mykenzee Munaco, Milton Levin, Michael Adkesson, Susana Cárdenas-Alayzad, Dimitrios G. Giarikos, Amy C. Hirons

SECLER Data

Large colonies of two vulnerable, sympatric pinniped species, Peruvian fur seals (Arctocephalus australis Peruvian subpopulation; PFS) and South American sea lions (Otaria byronia; SASL), reside and reproduce in Punta San Juan, Peru (PSJ) where they are exposed to stressors such as contaminants and El Niño Southern Oscillation (ENSO) events. The use of cytokines as immune biomarkers can be indicative of an animal’s health and function by allowing for the assessment of an individual's cytokine balance as type I helper T cells (Th1) or type II helper T cells (Th2) dominant. Utilizing archived pinniped plasma samples from 2009-2019 …

Urban And Rural Comparisons Of Attitudes Toward Medically Assisted Treatment For Pregnant And Postpartum Women With Oud In Appalachia, Anna Reeves

Online Theses and Dissertations

The opioid crisis has plagued the United States but disproportionately affects the often-overlooked Appalachian region. This area faces unique barriers preventing better access to quality Opioid Use Disorder (OUD) treatment facilities despite opioid-related deaths continuing to rise. An especially vulnerable population in this region are pregnant and postpartum women who face even more challenges acquiring proper drug treatment. Medically Assisted Treatment (MAT), also called Medications for Opioid Use Disorder (MOUD), is considered the standard of treatment for OUD and reduces the effects of NAS, yet it is heavily stigmatized and underutilized in populations who could benefit from the medication. This …

2014 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Eighth Annual GREAT Day.

2019 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Thirteenth Annual GREAT Day.

2018 Great Day Program, State University Of New York At Geneseo

GREAT Day Programs

SUNY Geneseo’s Twelfth Annual GREAT Day.

Monitoring Method Research On Passenger Behavior On Escalator Based On Digital Twin, Nan Lü, Qibing Wang, Lu Jiawei, Juntong Chen, Gang Xiao

Journal of System Simulation

Abstract: In order to solve the problems that the traditional escalator cannot be monitored and analyzed in real time during operation, the management and maintenance only on escalator equipment side, and the lack of monitoring passenger dangerous behavior, a monitoring method of passenger behavior on escalator based on digital twin is proposed. By constructing the digital twin of escalators, a visual interface is designed to map the escalator running status and passenger behavior data. Through passenger video surveillance, the improved OpenPose posture recognition algorithm is used to obtain the key point data of human body. Posture recognition is classified to …

Summer Internships Immerse Students In Career Experiences, Julia Perez

News and Events (Discontinued Series)

No abstract provided.

Ant-Dependent Mptp Underlies Necrotic Myofiber Death In Muscular Dystrophy, Michelle A Sargent, Jason Karch, Jeffery D Molkentin

Faculty, Staff and Students Publications

Mitochondrial permeability transition pore (MPTP) formation contributes to ischemia-reperfusion injury in the heart and several degenerative diseases, including muscular dystrophy (MD). MD is a family of genetic disorders characterized by progressive muscle necrosis and premature death. It has been proposed that the MPTP has two molecular components, the adenine nucleotide translocase (ANT) family of proteins and an unknown component that requires the chaperone cyclophilin D (CypD) to activate. This model was examined in vivo by deleting the gene encoding ANT1 (Slc25a4) or CypD (Ppif) in a δ-sarcoglycan (Sgcd) gene–deleted mouse model of MD, revealing …

"There Was A Child Went Forth": College, Receptivity, And Understanding, Erica Stonestreet

Philosophy Faculty Publications

This was the CSB and SJU Convocation Address for 2023-24 academic year.

In Type 1 Diabetes, Verapamil Prevents Decline Of Igf-1 And Promotes Beta-Cell Igf-1 Signaling, Public Relations

Browse All News

No abstract provided.

Targeting Breast Cancer: The Familiar, The Emerging, And The Uncharted Territories, Hamidreza Montazeri Aliabadi, Arthur Manda, Riya Sidgal, Co Chung

Pharmacy Faculty Articles and Research

Breast cancer became the most diagnosed cancer in the world in 2020. Chemotherapy is still the leading clinical strategy in breast cancer treatment, followed by hormone therapy (mostly used in hormone receptor-positive types). However, with our ever-expanding knowledge of signaling pathways in cancer biology, new molecular targets are identified for potential novel molecularly targeted drugs in breast cancer treatment. While this has resulted in the approval of a few molecularly targeted drugs by the FDA (including drugs targeting immune checkpoints), a wide array of signaling pathways seem to be still underexplored. Also, while combinatorial treatments have become common practice in …

The Evolving Definition Of Plant Cell Type, Sahand Amini, Jeffrey J. Doyle, Marc Libault

Department of Agronomy and Horticulture: Faculty Publications

In 1665 Robert Hooke, looking at cork through his microscope, discovered that plants are composed of elementary structures he named “cells”. Variation in the expression of a single genome in a complex eukaryotic organism guides the initiation, maturation, physiology, and biochemistry of cells with different shapes and sizes, playing different structural and functional roles in space and time. How many kinds of cells—”cell types”— an organism possesses of course depends on the organism’s cellular complexity, but the plasticity within a cell type fuels the emergence of the concept of cell state (Figure 1). The transition between cell states is driven …

Genetic Modifiers Of Mendelian Monogenic Collagen Iv Nephropathies In Humans And Mice, Constantinos Deltas, Gregory Papagregoriou, Stavroula F Louka, Apostolos Malatras, Frances Flinter, Daniel P Gale, Susie Gear, Oliver Gross, Julia Hoefele, Rachel Lennon, Jeffrey H Miner, Alessandra Renieri, Judy Savige, A Neil Turner

2020-Current year OA Pubs

Familial hematuria is a clinical sign of a genetically heterogeneous group of conditions, accompanied by broad inter- and intrafamilial variable expressivity. The most frequent condition is caused by pathogenic (or likely pathogenic) variants in the collagen-IV genes,

Sustainable Development For Mobile Health Apps Using The Human-Centered Design Process, Qingfan An, Marjorie M Kelley, Audra Hanners, Po-Yin Yen

2020-Current year OA Pubs

Well-documented scientific evidence indicates that mobile health (mHealth) apps can improve the quality of life, relieve symptoms, and restore health for patients. In addition to improving patients' health outcomes, mHealth apps reduce health care use and the cost burdens associated with disease management. Currently, patients and health care providers have a wide variety of choices among commercially available mHealth apps. However, due to the high resource costs and low user adoption of mHealth apps, the cost-benefit relationship remains controversial. When compared to traditional expert-driven approaches, applying human-centered design (HCD) may result in more useable, acceptable, and effective mHealth apps. In …

Antibiotic Resistance Mediated By Escherichia Coli In Kuwait Marine Environment As Revealed Through Genomic Analysis, Ha Al-Sarawi, Nazima Habibi, Saif Uddin, Awadhesh N. Jha, Ma Al-Sarawi, Brett P. Lyons

School of Biological and Marine Sciences

Antibiotic-resistance gene elements (ARGEs) such as antibiotic-resistance genes (ARGs), integrons, and plasmids are key to the spread of antimicrobial resistance (AMR) in marine environments. Kuwait’s marine area is vulnerable to sewage contaminants introduced by numerous storm outlets and indiscriminate waste disposal near recreational beaches. Therefore, it has become a significant public health issue and warrants immediate investigation. Coliforms, especially Gram-negative Escherichia coli, have been regarded as significant indicators of recent fecal pollution and carriers of ARGEs. In this study, we applied a genome-based approach to identify ARGs’ prevalence in E. coli isolated from mollusks and coastal water samples collected in …

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

The "Decapitation" Of Shiz, Gary M. Hadfield, John W. Welch

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Ether 15:29-32 describes the gory end of the last Jaredite battle. Exhausted, Coriantumr propped himself up with his own sword, gathered his last ounce of strength, and "smote off the head of Shiz," his arch-rival who had fainted beside him from the loss of blood. The smitten Shiz then "raised upon his hands and fell; and after that he had struggled for breath, he died," and Coriantumr himself collapsed.

Issue 425: August 24-September 7, 2023, The Local Voice

The Local Voice

No abstract provided.

Assessing Threats To Plant Populations: Linking Pollinator Differences To Patterns Of Plant Fitness And Population Genetics, Rieka Yu

Dissertations

Land use change is a major driver of biodiversity loss and consequently has led to the loss of genetic diversity in many plant populations due to declines in population sizes and an increase in spatial isolation. However, not all plant populations respond similarly to land-use change, suggesting there are additional mechanisms mediating plant population genetic patterns. Here, I examine the role of pollinators as this mediating factor. In Chapter 1 I conducted a meta-analysis to investigate how different types of pollinators drive changes in gene flow for plant populations in disturbed habitats, finding that different types of pollinators mediate different …

Island Blue Spaces: A Deeper Exploration, Nicole Kras, Jennifer Keenan

New Community College

Preliminary research has shown that blue spaces provide many benefits to health and well-being. In response to the call for a deeper investigation into this area of inquiry, the current study seeks input from those (N=37) who live on islands in the Northeast region of the United States. Previous findings about the significance of having access to nature, identifying it as a favorite part and most influential reason for living on an island, were reaffirmed. Distinctions between island and mainland life were highlighted, emphasizing the importance of community. This study also brought to light participants’ grave concerns about issues such …

The Indiana Statesman, August 24, 2023, Indiana State University

Student Newspaper

Back to School: Dr. Curtis addresses first day; MA police under fire; Tropical Storm Harold vs. Texas

Technical Aspects And Clinical Limitations Of Sperm Dna Fragmentation Testing In Male Infertility: A Global Survey, Current Guidelines, And Expert Recommendations, Ashok Agarwal, Ala'a Farkouh, Ramadan Saleh, Taha Abo-Almagd Abdel-Meguid Hamoda, Gianmaria Salvio, Florence Boitrelle, Ahmed M. Harraz, Ramy Abou Ghayda, Parviz Kavoussi, Murat Gül, Tuncay Toprak, Giorgio Ivan Russo, Damayanthi Durairajanayagam, Amarnath Rambhatla, Ponco Birowo, Rossella Cannarella, Nguyen Ho Vinh Phuoc, Armand Zini, Mohamed Arafa, Christine Wyns, Kelton Tremellen, Selçuk Sarıkaya, Sheena Lewis, Donald P. Evenson, Edmund Ko, Aldo E. Calogero, Fahmi Bahar, Marlon Martínez, Rafael F. Ambar, Giovanni M. Colpi, Mustafa Emre Bakircioglu, Ralf Henkel, Hussein Kandil, Ege Can Serefoglu, Abdullah Alfakhri, Akira Tsujimura, Alireza Kheradmand, Angelo Marino, Aram Adamyan, Birute Zilaitiene, Cevahir Ozer, Edoardo Pescatori, Paraskevi Vogiatzi, Gian Maria Busetto, Giancarlo Balercia, Haitham Elbardisi, Hamed Akhavizadegan, Hesamoddin Sajadi, Hisanori Taniguchi, Hyun Jun Park, Israel Maldonado Rosas, Mohamed Al-Marhoon, Mohammad Ali Sadighi Gilani, Naif Alhathal, Nguyen Quang, Germar-Michael Pinggera, Priyank Kothari, Sava Micic, Sheryl Homa, Tran Quang Tien Long, Wael Zohdy, Widi Atmoko, Wael Ibrahim, Marjan Sabbaghian, Saad Mohammed Abumelha, Eric Chung, Muhammet Rasit Ugur, Mehmet Serkan Ozkent, Osama Selim, Mahsa Darbandi, Shinichiro Fukuhara, Mounir Jamali, Jean De La Rosette, Shinnosuke Kuroda, Ryan P. Smith, Aykut Baser, Arif Kalkanli, Nicholas N. Tadros, Kaan Aydos, Tiago Cesar Mierzwa, Kareim Khalafalla, Vineet Malhotra, Mohamad Moussa, Federica Finocchi, Rinaldo Indra Rachman, Carlo Giulioni, Tomer Avidor-Reiss, Oguzhan Kahraman, Gökhan Çeker, Cătălina Zenoaga-Barbăroşie, Trenton L. Barrett, Mehmet Yilmaz, Ates Kadioglu, Sunil Jindal, Huda Omran, Kadir Bocu, Vilvapathy Senguttuvan Karthikeyan, Giorgio Franco, Jesús Fernando Solorzano, Ranjit B. Vishwakarma, Eko Arianto, Nicolas Garrido, Divyanu Jain, Nazim Gherabi, Ioannis Sokolakis, Ayad Palani, Gokhan Calik, Deniz Kulaksiz, Vaida Simanaviciene, Mara Simopoulou, Nur Dokuzeylül Güngör, Gideon Blecher, Marco Falcone, Davor Jezek, Mirko Preto, Edouard Amar, Tan V. Le, Sun Tae Ahn, Andri Rezano, Keerti Singh, Lucia Rocco, Missy Savira, Osvaldo Rajmil, Sara Darbandi, Emrullah Sogutdelen, Luca Boeri, Guadalupe Hernández, Lukman Hakim, Yoshiharu Morimoto, Andrian Japari, Nikolaos Sofikitis, Baris Altay, Asli Metin Mahmutoglu, Manaf Al Hashimi, Imad Ziouziou, Christina Anagnostopoulou, Haocheng Lin, Rupin Shah

Urology Articles

PURPOSE: Sperm DNA fragmentation (SDF) is a functional sperm abnormality that can impact reproductive potential, for which four assays have been described in the recently published sixth edition of the WHO laboratory manual for the examination and processing of human semen. The purpose of this study was to examine the global practices related to the use of SDF assays and investigate the barriers and limitations that clinicians face in incorporating these tests into their practice.

MATERIALS AND METHODS: Clinicians managing male infertility were invited to complete an online survey on practices related to SDF diagnostic and treatment approaches. Their responses …

Advancement & Communications Committee Meeting - Open Session Packet 08/24/2023, Uc Law Sf

2023 Board of Directors Agenda and Materials

No abstract provided.