Digital Commons Network^™

Safety And Efficacy Of Riluzole In Acute Spinal Cord Injury Study (Riscis): A Multi-Center, Randomized, Placebo-Controlled, Double-Blinded Trial, Michael G Fehlings, Wilson Z Ray, Et Al.

2020-Current year OA Pubs

Riluzole is a sodium-glutamate antagonist that attenuates neurodegeneration in amyotrophic lateral sclerosis (ALS). It has shown favorable results in promoting recovery in pre-clinical models of traumatic spinal cord injury (tSCI) and in early phase clinical trials. This study aimed to evaluate the efficacy and safety of riluzole in acute cervical tSCI. An international, multi-center, prospective, randomized, double-blinded, placebo-controlled, adaptive, Phase III trial (NCT01597518) was undertaken. Patients with American Spinal Injury Association Impairment Scale (AIS) A-C, cervical (C4-C8) tSCI, and <12 h from injury were randomized to receive either riluzole, at an oral dose of 100 mg twice per day (BID) for the first 24 h followed by 50 mg BID for the following 13 days, or placebo. The primary efficacy end-point was change in Upper Extremity Motor (UEM) scores at 180 days. The primary efficacy analyses were conducted on an intention to treat (ITT) and completed cases (CC) basis. The study was powered at a planned enrolment of 351 patients. The trial began in October 2013 and was halted by the sponsor on May 2020 (and terminated in April 2021) in the face of the global COVID-19 pandemic. One hundred ninety-three patients (54.9% of the pre-planned enrolment) were randomized with a follow-up rate of 82.7% at 180 days. At 180 days, in the CC population the riluzole-treated patients compared with placebo had a mean gain of 1.76 UEM scores (95% confidence interval: -2.54-6.06) and 2.86 total motor scores (CI: -6.79-12.52). No drug-related serious adverse events were associated with the use of riluzole. Additional pre-planned sensitivity analyses revealed that in the AIS C population, riluzole was associated with significant improvement in total motor scores (estimate: standard error [SE] 8.0; CI 1.5-14.4) and upper extremity motor scores (SE 13.8; CI 3.1-24.5) at 6 months. AIS B patients had higher reported independence, measured by the Spinal Cord Independence Measure score (45.3 vs. 27.3; d: 18.0 CI: -1.7-38.0) and change in mental health scores, measured by the Short Form 36 mental health domain (2.01 vs. -11.58; d: 13.2 CI: 1.2-24.8) at 180 days. AIS A patients who received riluzole had a higher average gain in neurological levels at 6 months compared with placebo (mean 0.50 levels gained vs. 0.12 in placebo; d: 0.38, CI: -0.2-0.9). The primary analysis did not achieve the predetermined end-point of efficacy for riluzole, likely related to insufficient power. However, on pre-planned secondary analyses, all subgroups of cervical SCI subjects (AIS grades A, B and C) treated with riluzole showed significant gains in functional recovery. The results of this trial may warrant further investigation to extend these findings. Moreover, guideline development groups may wish to assess the possible clinical relevance of the secondary outcome analyses, in light of the fact that SCI is an uncommon orphan disorder without an accepted neuroprotective treatment.

The Effect Of Fibre Cell Remodelling On The Power And Optical Quality Of The Lens, J Rodriguez, Q Tan, H Šikić, L A. Taber, S Bassnett

2020-Current year OA Pubs

Vertebrate eye lenses are uniquely adapted to form a refractive index gradient (GRIN) for improved acuity, and to grow slowly in size despite constant cell proliferation. The mechanisms behind these adaptations remain poorly understood. We hypothesize that cell compaction contributes to both. To test this notion, we examined the relationship between lens size and shape, refractive characteristics and the cross-sectional areas of constituent fibre cells in mice of different ages. We developed a block-face imaging method to visualize cellular cross sections and found that the cross-sectional areas of fibre cells rose and then decreased over time, with the most significant …

Fluorescence-Guided Surgical System Using Holographic Display: From Phantom Studies To Canine Patients, Mebin B. George, Benjamin Lew, Zuodong Liang, Steven Blair, Zhongmin Zhu, Nan Cui, Jamie Ludwig, Mohamed Zayed, Laura Selmic, Viktor Gruev

2020-Current year OA Pubs

SIGNIFICANCE: Holographic display technology is a promising area of research that can lead to significant advancements in cancer surgery. We present the benefits of combining bioinspired multispectral imaging technology with holographic goggles for fluorescence-guided cancer surgery. Through a series of experiments with 43D-printed phantoms, small animal models of cancer, and surgeries on canine patients with head and neck cancer, we showcase the advantages of this holistic approach.

AIM: The aim of our study is to demonstrate the feasibility and potential benefits of utilizing holographic display for fluorescence-guided surgery through a series of experiments involving 3D-printed phantoms and canine patients with …

Neutralization, Effector Function And Immune Imprinting Of Omicron Variants, Amin Addetia, James Brett Case, Suzanne M Scheaffer, Bradley Whitener, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Currently circulating SARS-CoV-2 variants have acquired convergent mutations at hot spots in the receptor-binding domain

Neuroinflammation In The Amygdala Is Associated With Recent Depressive Symptoms, Wei Zhang, Jerrel Rutlin, Sarah A Eisenstein, Yong Wang, Deanna M Barch, Tamara Hershey, Ryan Bogdan, Janine D Bijsterbosch

2020-Current year OA Pubs

BACKGROUND: Converging evidence suggests that elevated inflammation may contribute to depression. Yet, the link between peripheral inflammation and neuroinflammation in depression is unclear. Here, using data from the UK Biobank, we estimated associations among depression, C-reactive protein (CRP) as a measure of peripheral inflammation, and neuroinflammation as indexed by diffusion basis spectral imaging-based restricted fraction (DBSI-RF).

METHODS: DBSI-RF was derived from diffusion-weighted imaging data (N = 11,512) for whole-brain gray matter (global-RF), and regions of interest in the bilateral amygdala (amygdala-RF) and hippocampus (hippocampus-RF), and CRP was estimated from blood (serum) samples. Self-reported recent depression symptoms were measured using a …

Safety And Tolerability Of Moxidectin And Ivermectin Combination Treatments For Lymphatic Filariasis In Côte D'Ivoire: A Randomized Controlled Superiority Study, Catherine M. Bjerum, Benjamin G. Koudou, Allassane F. Ouattara, Daphne Lew, Charles W. Goss, Pascal T. Gabo, Christopher L. King, Peter U. Fischer, Gary J. Weil, Philip J. Budge

2020-Current year OA Pubs

BACKGROUND: Moxidectin is a macrocyclic lactone registered for the treatment of human onchocerciasis. The drug has a good safety profile, large volume of distribution and a long elimination half-life. This paper reports tolerability data from the first use of moxidectin in persons with Wuchereria bancrofti infection.

METHODS: In this randomized, open-label, masked-observer superiority trial, adults with Wuchereria bancrofti microfilaremia in Côte d'Ivoire were randomized to 1 of 4 treatment arms: ivermectin + albendazole (IA), moxidectin + albendazole (MoxA), ivermectin + diethylcarbamazine (DEC) + albendazole (IDA), or moxidectin + DEC + albendazole (MoxDA). As part of a larger efficacy trial, all …

Reed Bamboos Drive Skull Shape Evolution In Bush Frogs Of The Western Ghats, Peninsular India, Kalpana Das, Mark-Oliver Rödel, Edward Stanley, Achyuthan N. Srikanthan, Kartik Shanker, Seenapuram Palaniswamy Vijayakumar

Student Publications [Scholarly]

Reed bamboo is a major ecological and economic resource for many animals, including humans. Nonetheless, the influence of this plant's evolutionary role on the morphology of animal species remains unexplored. Here, we investigated the significance of bamboo habitats as ecological opportunities in shaping the skull morphology of bush frogs (Raorchestes) from the Western Ghats, Peninsular India. We applied a three-dimensional (3D) geometric morphometric approach to capture the skull shape of 55 species of bush frogs. We visualized the skull shape variables in phylomorphospace with principal component analysis and performed phylogenetic generalized least-squares analysis to assess the impact of cranial size …

Nephroprotective Roles Of L-Cysteine, Silymarin And Ursodeoxycholic Acid, Against Carbon Tetrachloride Induced Nephrotoxicity In Male Albino Rats, Hero H. Muhammed Saed, Sarwar N. Jafar, Zeyan A. Ali, Treefa F. Ismail

Polytechnic Journal

The comparison of histopathological and biochemical effects of L-cysteine, silymarin and ursodeoxycholic acid which have a protective effect on kidney function against CCl4 induce nephrotoxicity were investigated in this study. Twenty adult male rats were divided into 5 groups and treated as follows, the control group was administrated 1.5 ml/kg. B.W physiological solution (0.9%) orally, Carbon Tetrachloride group (CCl4 1.5 ml/kg. B.W), L-cysteine (100mg/kg B.W.) +CCl4 group, ursodeoxycholic acid (50 ml/kg B.W.) +CCl4 group, and the last group was Silymarin 100 mg/kg. B.W with CCl4, the experiment lasted 30 days. Oxidative stress caused by CCl4 caused increasing in Creatinine and …

Protective Effect Of Fenugreek Supplementation Against Mercury Toxicity On Sperm Parameters, Serum Testosterone And Testicular Tissue In The Rat, Jalal A. Karim, Karim R. Hamad

Polytechnic Journal

Background and objectives:The purpose of the current study was to investigate the effects of fenugreek supplementation against toxic effect of mercuric chloride (HgCl2)on Body weight (B.W), testis and epididymis weight, some sperm parameters, serum testosterone, serum MDA, and testis histology in the rat.Methods: Twenty eight male albino rats weights ranging from 254 to 302 gm and were divided randomly and equally into 4 groups. Group I: control, Group II: Rats received drinking water contained HgCl2 100 mg/L ad libitum, Group III: Rats received drinking water contained HgCl2 100 mg/L ad libitum, and fenugreek (F1) 0.75 mg/kg/day orally by gavage, Group …

Mapping Lesion-Related Epilepsy To A Human Brain Network, Frederic L. Schaper, Janne Nordberg, Alexander L. Cohen, Christopher Lin, Joey Hsu, Andreas Horn, Michael A. Ferguson, Shan H. Siddiqi, William Drew, Anderson M. Winkler

School of Medicine Publications

Importance: It remains unclear why lesions in some locations cause epilepsy while others do not. Identifying the brain regions or networks associated with epilepsy by mapping these lesions could inform prognosis and guide interventions.

Objective: To assess whether lesion locations associated with epilepsy map to specific brain regions and networks.

Design, setting, and participants: This case-control study used lesion location and lesion network mapping to identify the brain regions and networks associated with epilepsy in a discovery data set of patients with poststroke epilepsy and control patients with stroke. Patients with stroke lesions and epilepsy (n = 76) or no …

Tennessee Farm Bureau News - September 2023, Tennessee Farm Bureau Federation

Tennessee Farm Bureau News

No abstract provided.

Evaluating Impacts Of R3 Workshops For First-Time Hunters At Universities Across The United States, Richard Von Furstenberg, Victoria R. Vayer, Lincoln R. Larson, M. Nils Peterson, Kangjae Jerry Lee, Kathryn Stevenson, Adam A. Ahlers, Christine Anhalt-Depies, Taniya Bethke, Brian Clark, Kiley M. Davan, Ashley A. Dayer, Todd E. Fisher, Benjamin Ghasemi, Larry Gigliotti, Kris Irwin, Samuel J. Keith, Matt Kelly, Gerard Kyle, Elizabeth Metcalf, Mark D. Needham, Neelam C. Poudyal, Michael Quartuch, Shari L. Rodriguez, Chelsie Romulo, Ryan L. Sharp, William Siemer, Matthew T. Springer, Richard Stedman, Taylor Stein, Timothy R. Van Deelen

Michigan Tech Publications

Declines in hunter numbers across the United States make hunter recruitment, retention, and reactivation (R3) a high priority for wildlife management. As wildlife management agencies and nongovernmental organizations seek to reach new audiences, college campuses present a unique opportunity to cultivate nontraditional path hunters. Despite recent proliferation of R3 initiatives, little research has evaluated effects of hunting programs on knowledge, attitudes, and behaviors of new hunters. We designed and implemented Getting Started Outdoors: Hunting 101 workshops specifically targeting college students without previous hunting experience, and we assessed workshop efficacy with a theoretically-grounded approach to workshop evaluation. Using quantitative and qualitative …

Rico’S Long Arm, Randy D. Gordon

South Carolina Journal of International Law and Business

RICO has for over 50 years presented something of a parlor game for lawyers, mostly because its text leaves wide latitude in interpretation. And, as is often the case with RICO, resolution of one question begets more. The Supreme Court’s recent decision in Yegiazaryan v. Smagin proves no exception. Here, the Court brought some clarity to a question left open by RJR Nabisco: viz, what must one plead and prove to satisfy the “domestic injury” requirement necessary to invoke an extraterritorial application of RICO. The Court held that a foreign plaintiff can indeed, given the right facts and circumstances, establish …

The Dangers Of Staphylococcus Aureus And Antimicrobial Resistance, Madison Pines

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Methicillin-resistant Staphylococcus aureus (MRSA) is the etiological agent responsible for many problematic infections. The signs and symptoms of an infection caused by MRSA differ based on the route of transmission and type of infection. Staphylococcus aureus can secrete toxins that act as virulence factors and aid host invasion. Obesity, old age, being a health care worker, playing contact sports, living in a crowded place, hospitalization, recent antibiotic use, and HIV patients are more at risk of developing an infection caused by MRSA. An abundance of factors has contributed to antimicrobial resistance, like misuse of antibiotics in clinical and agricultural settings …

2022 (34th) Report Of The Nou Records Committee, Mark A. Brogie

Nebraska Bird Review

The functions and methods of the Nebraska Ornithologists’ Union Records Committee (NOURC) are described in its bylaws (NOURC 2010). The committee’s purpose is to provide a procedure for documenting unusual bird sightings and to establish a list of all documented birds for Nebraska. Species for which the NOURC seeks documentation (NOURC Review List) can be found at the NOU website www.NOUbirds.org. Starting in 2020, the NOURC decided to deal mainly with those species deemed as Accidental on the “Official List of the Birds of Nebraska.” Casual species and out-of-range species are now summarized in the “Seasonal Reports” of the …

Summer Field Report, June–July 2023, W. Ross Silcock

Nebraska Bird Review

There were no new species for Nebraska. This was also a lean season for records of species with few Nebraska records. Probably most significant were continuing Common Ravens in two Sioux Co locations, and possibly the first summer records of Baird’s Sparrow, a recording of the latter currently under NOURC review.

Within-state breeders nesting at new locations. There were several instances of nesting reported away from known breeding areas. These include documented records of first nesting Black-necked Stilts in Cherry Co, Least Terns off river at Offutt Base Lake in Sarpy Co, Mississippi Kite in Adams Co, Yellow-throated Vireo in …

Comparison Of The Effects Of Alpha Lipoic Acid And Dexpanthenol In An Experimental Tracheal Reconstruction Animal Model, Murat Kuru, Tamer Altınok, Bayram Metin, Hacı Hasan Esen

Saudi Medical Journal

Objectives: To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats. Methods: The study was carried out at Necmettin Erbakan University, Konya, Turkey, from January 2014-2019. A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. For the experiment, rats were randomly divided into 3 groups: ALA group (n=10), DXP group (n=10), and control group (n=10). After trachea surgery, 100 mg/kg/day ALA was given to group ALA and 100 mg/kg/day intraperitoneal DXP to group DXP for 15 days, and the rats …

Appellant's Reply Brief, Zack Greenamyre, Gerald R. Weber Jr., John A. Meiser, Meredith Holland Kessler

Court Briefs

No. 23-10332
Rev. Stephen Jarrard v. Sheriff of Polk County

Appeal from the United States District Court for the Northern District of Georgia No. 4:20-cv-00002-MLB

From the Argument

A jury could easily find that Moats and Sharp excluded Jarrard from the ministry program because they disfavor his religious expression.

Clarifying The Application Of The Temple Metaphor In Christian Education, Donald Roth

Pro Rege

No abstract provided.

The Joy Of Knowing And Being Known: Commencement Address 2023, Mark Christians

Pro Rege

No abstract provided.

From Materialization Of Science To Denying God: A Pipeline, Audra Kooi

Pro Rege

Audra Kooi, a Dordt University sophomore, majoring in Psychology and Health & Human Performance, and a member of the Kuyper Honors Program, submitted this essay to the Lambertus Verburg Excellence in Kuyperian Scholarship competition, 2023.

Fisheries Science Update - Western Australian Salmon Resource - September 2023, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Science Updates

Key points: 2023 stock assessment outcomes:

• The latest weight of evidence stock assessment for Western Australian salmon indicates the status of the stock is adequate and the risk to the stock is low. This means that there are no sustainability concerns for the stock.
• The Department of Primary Industries and Regional Development (DPIRD) tracks our aquatic resources by undertaking weight of evidence stock assessments on a regular basis.
• This science update follows on from the previous Western Australian salmon update in 2017.
• Detailed information on the latest stock assessment is available in Fisheries Research Report No. 336.

Associations Between Birth Weight And Adult Sleep Characteristics: A Cross-Sectional Analysis From The Uaehfs, Nirmin F. Juber, Abdishakur Abdulle, Amar Ahmad, Andrea Leinberger-Jabari, Ayesha S.Al Dhaheri, Fatma Al-Maskari, Fatme Alanouti, Mohammad Al-Houqani, Mohammed Hag Ali, Omar El-Shahawy, Scott Sherman, Syed M. Shah, Tom Loney, Youssef Idaghdour, Raghib Ali

All Works

Abnormal birth weight, particularly low birth weight (LBW), is known to have long-term adverse health consequences in adulthood, with disrupted sleep being suggested as a mediator or modifier of this link. We thus aimed to assess the associations between birth weight and self-reported adult sleep characteristics: sleep duration, difficulty waking up in the morning, daily nap frequency, sleep problems at night, snoring, daytime tiredness or sleepiness, and ever-stop breathing during sleep. This cross-sectional analysis used the United Arab Emirates Healthy Future Study data collected from February 2016 to March 2023 involving 2124 Emiratis aged 18–61 years. We performed a Poisson …

Development Of Dibenzofuran Linkers And Phenazine-Based Redox-Responsive Foldamers, Ruth Son

Arts & Sciences Graduate Student Theses and Dissertations

Our group has demonstrated the feasibility of utilizing phenazine-1,6-dicarboxamides as redox-responsive molecular switches: changes in the oxidation state of the phenazine core forces the secondary amide arms to rotate between the doubly folded form when oxidized and the unfolded form when reduced to its dihydrophenazine form. To construct phenazine-based oligomers, we have developed dibenzofuran linkers that can easily be decorated with different solubilizing groups and incorporated into the foldamer backbone. In our initial attempts, we used xanthene linkers. However, problems with limited solubility and preference for cyclization prompted us to consider an alternative cisoid linker with a wider bite angle. …

Atypical Squamous Verrucous Lesions Of The Oral Cavity: Challenges In Interpretation Of Small Incisional Biopsies, Ryland Richards, Shweta Agarwal

Pathology Research and Scholarship

BACKGROUND: Squamous verrucous proliferative lesions of oral cavity can pose a diagnostic challenge for the general pathologist, especially on small biopsies. The superficial nature of incisional biopsies and inconsistent histologic terminologies used for these lesions contribute to often-discrepant clinical diagnosis, resulting in delayed treatment. This study aims to explore the proliferative squamous lesions of oral cavity, correlate biopsy & resection diagnoses, and evaluate possible reasons for discrepant diagnosis (if any).

DESIGN: A retrospective review of oral verrucous squamous lesions was undertaken. Pathology database was searched for oral cavity biopsies from January2018 through August2022 with the keywords: atypical, verrucous, squamous, and …

Models Of Social Activity Of Protestant Churches In The Context Of Russia's Military Aggression Against Ukraine, Ihor Lutsan

Occasional Papers on Religion in Eastern Europe

The main focus of our research intention is to outline constructive models of social activity of religious communities in the context of Russia-Ukraine war. The subject of the study is the Protestant denominations of Ukraine and their socially relevant activities, which today, having acquired a multi-vector orientation, are most clearly expressed and most noticeable in such forms: missionary work, charity, volunteer movement, in particular, assistance to the army; organizing and providing social services to individuals and groups in need of assistance to ensure their holistic development, and thus providing spiritually oriented social and psychological rehabilitation of military personnel, demobilized combatants …

Gross Hematuria And Lower Urinary Tract Symptoms Associated With Military Burn Pits Exposures In Us Veterans Deployed To Iraq And Afghanistan, Mosammat M. Perveen, Henry E. Mayo-Malasky, Mary F. Lee-Wong, Julie M. Tomaska, Edward Forsyth, Amy Gravely, Mark A. Klein, Janeen H. Trembley, Tammy A. Butterick, Robert A. Promisloff, Pamela K. Ginex, Paul Barach, Anthony M. Szema

College of Population Health Faculty Papers

OBJECTIVE: The aim of the study is to describe rates of hematuria and other lower urinary tract symptoms, including self-reported cancer rates, among veterans postburn pits emissions exposure during deployment to Iraq and Afghanistan.

METHODS: US post-9/11 veterans with burn pits emissions exposure confirmed via DD214 forms in the Burn Pits360.org Registry were sent a modified survey. Data were deidentified and anonymously coded.

RESULTS: Twenty-nine percent of the 155 respondents exposed to burn pits self-reported seeing blood in their urine. The average index score of our modified American Urological Association Symptom Index Survey was 12.25 (SD, 7.48). High rates of …

A Bkbx Frankenstein

Theatre and Performance Studies Programs

Made for adventurous audience members ages 12+, the show remixes and riffs on the themes found in Mary Shelley's gothic horror classic: technology, creation, and modern monsters. Stitching together a mix of favorite restaged repertoire with a new cast and fresh interstitials, "A BKBX Frankenstein" is a contemporary delight on an ancient form of storytelling.

You Don’T Even Need The Ghosts: A Writer’S Look At The Turn Of The Screw, Andrea M. Schenkel

Dissertations, Theses, and Capstone Projects

The novella Turn of the Screw by Henry James was first published in 1898 as a serialized novel in Collier's Magazine. The short novel is characterized by its concise language. James chooses words carefully and consciously. The linguistic compression forces the reader to deal intensively with the main protagonists of the novel: the Governess, the children, Miles and Flora, and Mrs. Grose. Nothing is as it seems. James aims to challenge the reader by forcing them to constantly question what they read.

Countless essays have been written about the text since the novel was published. The figures, especially those …

Visualizing Dopamine Activity In Deletion Of D2 Receptors In Medium Spiny Neurons, Kunhee Lee

Dissertations, Theses, and Capstone Projects

Dopamine has been implicated in motivated behaviors and reinforcement learning. In this study, we are looking at the role of dopamine in allocating efforts when obtaining reward. Using Cre recombinase genetic tool, D2 receptors in striatal indirect pathway neurons were selectively deleted, and dopamine signal was recorded in ventral striatum using fiber photometry. Behaviorally, D2 receptor deletion resulted in less effort in a Progressive Ratio (PR) paradigm shown by decreased breakpoint, number of presses, and reward pellets earned. Due to the previous evidence that dopamine positively modulates effort, we hypothesized that there would be less dopamine release in D2 deleted …