Digital Commons Network^™

Development Of New Radiotracers For Positron Emission Tomography Targeting C-X-C Chemokine Receptor Type 4 In Cancers, Piyapan Suwattananuruk

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to develop novel positron emission tomography (PET) tracers for C-X-C chemokine receptor type 4 (CXCR4) imaging. [68Ga]Ga-TD-01 and [18F]PICO-F were designed as PET tracers based on the molecular scaffolds of two potent CXCR4 antagonists, TIQ15 and PICO. TIQ15 was used to prepare a bifunctional (BFC) to facilitate 68Ga-labeling while structural modification of PICO was made to obtain a precursor, PICO-Br for 18F-labeling. The BFC, TD-01 was obtained in a moderately high yield (61%) via the conjugation of TIQ15 with a chelator derivative and successfully radiolabeled with 68Ga to yield [68Ga]Ga-TD-01, a PET tracer. For 18F-based tracer, the …

Native Forbs Provide Pollinator Resources And Improve Forage Nutrient Composition, Animal Performance, And Pasture Productivity, Jessica L. Prigge, Eric Bisangwa, Jonathan D. Richwine, Virginia R. Sykes, Jennie Lz Ivey, Patrick D. Keyser

Faculty Publications

Pollinator declines and expectations for more sustainable agriculture, including pasture-based enterprises, bring attention to strategies to enhance the habitat value of grazing lands. We evaluated native warm-season grass (NWSG) pastures with (FORB) and without (CONT) interseeded native forbs in 2021–2023. An analysis was conducted using R with the significance set at p ≤ 0.05. The grass appeared to be weakened predominantly by grazing management practices. Forb density and mass had an inverse relationship in seasons two and three. Total forage mass declined in response to increased grazing days and weakened stands. The forage nutritive compositions differed, with more stable, season-long …

Building A Human Digital Twin (Hdtwin) Using Large Language Models For Cognitive Diagnosis: Algorithm Development And Validation, Gina Sprint, Maureen Schmitter-Edgecombe, Diane Cook

Computer Science Faculty Scholarship

Background: Human digital twins have the potential to change the practice of personalizing cognitive health diagnosis because these systems can integrate multiple sources of health information and influence into a unified model. Cognitive health is multifaceted, yet researchers and clinical professionals struggle to align diverse sources of information into a single model. Objective: This study aims to introduce a method called HDTwin, for unifying heterogeneous data using large language models. HDTwin is designed to predict cognitive diagnoses and offer explanations for its inferences. Methods: HDTwin integrates cognitive health data from multiple sources, including demographic, behavioral, ecological momentary assessment, n-back test, …

Research And Design A Lifeboat Virtual Reality Simulation System For Maritime Safety Training In Vietnam, Nguyen Dinh Thach, Nguyen Van Hung

Journal of Marine Science and Technology–Taiwan

Ensuring maritime safety and security is crucial for all nations. Training trainees and operational officers in this field aims to enhance their professional skills and ability to manage and resolve incidents at sea. This article outlines the development of a lifeboat simulation system that integrates Virtual Reality (VR) technology in accordance with international maritime regulations. It describes the creation of an algorithm designed to optimize data transmission between simulation systems using the ant colony optimization technique in conjunction with intelligent control algorithms on Unity 3D software for human interaction. In particular, the system combines training with a maritime simulation framework …

Periodontal Regeneration Related To Periodontitis Treated By Garden Cress And Ozone Therapy. (Randomized Clinical &Experimental Study), Zienab S. Farid, Doaa Adel Habba, Gihan Adel Balbola, Noura Mohammed Bakr

Journal of Medicine in Scientific Research

Objective: In this article, garden cress and ozone were evaluated for their potential therapeutic properties of PDL and resorption of alveolar bone in the periodontal tissues based on rats' experimental periodontitis and to assess the clinical effectiveness of local application of garden cress and ozone for treatment and management of periodontitis patients using scaling and root planing. Methodology: Thirty mature Wistar male albino rats. Three groups of rats were formed; periodontitis without treatment, periodontitis with garden cress, and periodontitis plus ozone therapy. The present study also included thirty periodontitis Patients were randomly allocated to one of three groups of ten …

The Rage Gene Crucial Function In The Etiology And Consequences Of Type I Diabetes, Amal A. Mohamed, Mohamed O. Mahmoud, Gamil M. Abdallah, Nada S. Ali, Mona Abdelmotaleb Abdelfatah Hussein, Ibrahim T. Ibrahim

Journal of Medicine in Scientific Research

Type I Diabetes, among the ten greatest causes of mortality worldwide, is estimated to afflict 642 million individuals by 2040. It is an auto-immune illness brought on by an association of environmental and genetic variables. that cause T lymphocytes to destroy insulin-producing β-cells. Its prevalence continues to rise by 3-4% annually worldwide, enhancing the risk of mortality. So, the idea of diabetic kidney disease (DKD) is widely established, and systemic treatment is essential. RAGEs are linked to inflammatory disorders that exist in a variety of TID-related cells; especially T cells. Variations in circulating RAGE concentrations have been linked to a …

Oral Collagen Supplementation In 2nd Degree Burn And Chronic Pressure Ulcers, Wesam Ibrahem Homouda, Helmy Ahmed Soliman, Esayed Hussien Elmokadem

Journal of Medicine in Scientific Research

Background: Healing of wounds requires adequate intake of protein, iron, Vitamin-C and zinc. In case of deficiency in the dietary intake, supplements may be prescribed. Collagen-peptide supplements can enhance skin hydration, elasticity, and reduce wrinkles. Burns, caused by various agents, severely damage skin layers. Pressure ulcers occur when prolonged pressure on the skin leads to tissue ischaemia, disrupting nutrition and oxygen supply, resulting in tissue necrosis. Systematic reviews show that oral collagen, either intact or hydrolyzed, effectively improves skin health.

Objectives: This article aim to evaluate the effect of oral collagen intake as a healing promoting supplementation in management of …

Pierre V. Midland Credit Management, Inc., Syma Birenbaum

NYLS Law Review

No abstract provided.

Strategies Of Utilizing Sex-Sorted Semen To Improve Beef Cattle Herd Production And Using Lasia Spinosa Thw. And Zinc Supplementation To Improve Semen Quality Of Bulls And Boars With Poor Semen Profile, Supitcha Kaewma

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of the thesis were i) to improve the success of using sex-sorted semen and ii) to enhance the semen quality in low semen quality bulls and boars. Four experiments were conducted to test the hypothesis as 1) on-farm factors influence the success of sexed semen artificial insemination (AI) in cattle herds, 2) estrus synchronization protocols can be integrated in sex-sorted semen AI in cattle herd, 3) Lasia spinosa Thw. (LST) supplementation for improving semen quality in bull and boar sires with poor semen quality, 4) zinc supplementation for improving semen quality in subfertile boar. Study 1: Experiment 1, …

Research On The Soft Power Of Thai Traditional Food Culture Under The Process Of Globalization, Lu Han

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research explores the role of Thai traditional food culture as a form of soft power in the context of globalization. According to Joseph S. Nye, Soft power operates through the resources of culture, political ideals, and foreign policies. Influenced by factors such as history, geography, climate, and social development, Thai traditional food culture has integrated the characteristics of multiple cultures with its inclusive and innovative ideas to form a unique culture. Through globalization, Thai food culture has gained widespread popularity. This research analyzes the mechanisms by which Thai food culture promotes Thailand’s soft power, including nation branding, gastro-diplomacy, tourism, …

A Study Of Developing Artificial Coral Innovation In Line With The Context Of Promoting Thailand’S Economy And Society, Chawin Poomee

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aimed to develop innovative artificial reef technology to align with the context of promoting the Thai economy and society. The objectives were to understand the development direction of artificial reefs to meet the needs of tourists and conservationists, explore the feasibility of introducing new technology into artificial reef production, and study methods to reduce environmental destruction caused by reef deployment. The research employed exploratory and qualitative research methods, including in-depth interviews with a target group of 10 individuals and questionnaire surveys to study consumer behavior and product acceptance among a general consumer group of 100 individuals. Data analysis …

Using Machine Learning Algorithms To Enhance Iot System Security, M. Samir Abou El-Seoud

Computer Science

The term “Internet of Things” (IoT) refers to a system of networked computing devices that may work and communicate with one another without direct human intervention. It is one of the most exciting areas of computing nowadays, with its applications in multiple sectors like cities, homes, wearable equipment, critical infrastructure, hospitals, and transportation. The security issues surrounding IoT devices increase as they expand. To address these issues, this study presents a novel model for enhancing the security of IoT systems using machine learning (ML) classifiers. The proposed approach analyzes recent technologies, security, intelligent solutions, and vulnerabilities in ML IoT‑based intelligent …

Understanding Angler Responses To Fish Stocking Programs Across South Dakota, Riley L. Mounsdon

Electronic Theses and Dissertations

Fisheries management is a complex process that often requires consideration of many factors to be implemented effectively. Stocking is one of the most often used fisheries management techniques for addressing a myriad of issues in the fisheries field. Stocking is also one of the largest expenses for many fisheries management agencies. Due to license sale declines, management actions including stocking, are being evaluated by many agencies to determine if there are ways to improve efficiency and effectiveness to reduce costs and enhance angler participation. For my second chapter, I evaluated the current fish stocking decision-making process within South Dakota Game, …

Hsp70 Is A Critical Regulator Of Hsp90 Inhibitor's Effectiveness In Preventing Hcl-Induced Chronic Lung Injury And Pulmonary Fibrosis, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Betsy Gregory, Michael Osei-Nkansah, Christiana Dimitropoulou, John D. Catravas

Bioelectrics Publications

Exposure to hydrochloric acid (HCl) can provoke acute and chronic lung injury. Because of its extensive production for industrial use, frequent accidental exposures occur, making HCl one of the top five chemicals causing inhalation injuries. There are no Food and Drug Administration (FDA)-approved treatments for HCl exposure. Heat shock protein 90 (HSP90) inhibitors modulate transforming growth factor-β (TGF-β) signaling and the development of chemical-induced pulmonary fibrosis. However, little is known on the role of Heat Shock Protein 70 (HSP70) during injury and treatment with HSP90 inhibitors. We hypothesized that administration of geranylgeranyl-acetone (GGA), an HSP70 inducer, or gefitinib (GFT), an …

Honk!: Meaning And Activism In 21st Century American Street Bands, Isaac Maupin

Theses and Dissertations--Music

In this dissertation, I explore activism, music, and meaning through the lens of HONK! Bands in the United States. HONK! A Festival of Activist Street Bands began in Sommerville, Massachusetts, in 2006. Since its inception, the festivals have grown on a national and global scale. The festivals, however, operate as a convenient organizing structure for the bands themselves and are not a primary focus of this work. Instead, I examine activism, learning, and value as systems within the HONK! culture (each topic with a devoted chapter) to, through a phenomenological lens, better understand how HONK! bands fit within American culture. …

Ecuadorian Vocal Anthology In Four Rhythms, Wagner Mauricio Pástor Pazmiño Dr.

Theses and Dissertations--Music

Ecuador is a pluricultural and multilingual territory with four natural regions, several musical genres, and interpretations. Amazon, Galápagos, Mountain Range, and Coastal region. In the following dissertation, the author develops concepts of four traditional rhythms, their composers, and harmonic and phonetic characteristics from the mountain range region of his homeland, Ecuador.

The present document is a descriptive study of vocal Andean music and the application of the operatic style in classical vocal technique for performance practice.

The dissertation will support a lecture recital to fulfill the doctoral program's requirement in voice performance from the University of Kentucky.

Blending European And Latin Sounds: A Study Of French Horn Repertoire In Mexico, Aj Bernal

Theses and Dissertations--Music

As a first generation Mexican-American, it is crucial that I advocate and promote music of the culture I grew up in. This project aims to unearth Mexican compositional techniques that derive from the fusion of European and Indigenous roots in an effort to promote diversity within the realm of Western Classical music. Music in Mexico is characterized by a unique blend of indigenous rhythms, European classical structures, and regional folk influences. This project will discuss how the bold timbre of the French horn intertwines with traditional Mexican and indigenous melodies, rhythms, and forms that create a unique style. The horn’s …

Influence Of Reduced Salt In Fully Cooked Ham And Sausage Cured With Natural Celery Powder On The Growth Of Listeria Monocytogenes At 4⁰C, Anne Sherod

Electronic Theses and Dissertations

This research evaluated the influence of reducing salt on outgrowth of L. monocytogenes on ready to eat (RTE) deli-style sliced ham cured with natural celery powder, fully cooked sausage links cured with traditional sodium nitrite and sausage links cured with natural celery powder, vacuum packaged and stored at 4⁰C on the outgrowth of L. monocytogenes. Experiment 1 evaluated L. monocytogenes outgrowth on ham over 153 days on the following treatments, current retail ham (HC) 2.0% salt; reduced salt 1 (HRS1) 1.5% salt; reduced salt 2 (HSR2) 1.35% salt; and reduced salt 2 without antimicrobials (HRS2WA) 1.35% salt without potassium lactate …

Scaffold Hopping For The Lead Optimization Of The Orally Active Antileishmanial Pyrrolo-Quinazoline Alkaloid Natural Product Peganine, Sunitha Jada

Electronic Theses and Dissertations

Leishmaniasis is a protozoan parasitic disease caused by the species Leishmania that affects millions of people around the world. It is a serious public health concern in the developing world with about 1 million cases and 70,000 fatalities occurring each year. It has several forms with visceral, and cutaneous leishmaniasis being the most common forms of the disease. Visceral leishmaniasis, caused by the Leishmania donovani occurs mainly in Brazil, Eastern Africa, and India, and is fatal if left untreated. The current treatments for leishmaniasis such as pentavalent antimonials, amphotericin B, miltefosine, paromomycin, pentamidine, and some azoles suffer from serious drawbacks. …

Contrastive Learning, With Application To Forensic Identification Of Source, Cole Ryan Patten

Electronic Theses and Dissertations

Forensic identification of source problems often fall under the category of verification problems, where recent advances in deep learning have been made by contrastive learning methods. Many forensic identification of source problems deal with a scarcity of data, an issue addressed by few-shot learning. In this work, we make specific what makes a neural network a contrastive network. We then consider the use of contrastive neural networks for few-shot learning classification problems and compare them to other statistical and deep learning methods. Our findings indicate similar performance between models trained by contrastive loss and models trained by cross-entropy loss. We …

Role Of Production Systems On Carcass And Palatability Attributes Of Bison, Lydia Margaret Hite O'Sullivan

Electronic Theses and Dissertations

The overall objective of this dissertation was to determine the impact of finishing systems on carcass and palatability attributes of bison. The specific objectives were 1) determine the influence of finishing system (grain-finished vs. grass-finished) on the mechanisms of tenderness formation in the longissimus lumborum of bison bulls, 2) determine the influence of diverse finishing systems on carcass characteristics and proximate composition of bison heifers, and 3) determine the influence of diverse finishing systems on palatability of striploin steaks from bison heifers. Results indicate that finishing systems differentially influence carcass characteristics, tenderness, and flavor attributes of bison. Specifically, this is …

Optimizing Large Language Models And Multimodal Approaches For Biomedical Publication And Satellite Imagery, Youngsun Jang

Electronic Theses and Dissertations

This dissertation comprises two main sections: the first focuses on natural language processing (NLP) for extracting key information from scientific literature using large language models (LLMs), and the second addresses remote sensing for detecting natural disasters, such as floods, from satellite imagery using a multimodal approach. The first section investigates methods to enhance Transformer-based models in classifying and extracting information from biomedical scientific publications. Key contributions include the development of a custom dataset for classification and Question and Answering (Q&A) tasks, fine-tuning Transformer models like the Bidirectional Encoder Representations from Transformers (BERT) and addressing multi-span answer issues with the TAg-based …

Genetic And Ecologic Effects Of Seed Dormancy Genes On Seed Aging, Soil Seedbank Longevity, And Microbiome In An Isogenic Background Of Rice ( Oryza Sativa L.), Bhupinder Singh Batth

Electronic Theses and Dissertations

No abstract provided.

Whole Genome Crispr-Cas9 Screens Identify Genes Contributing To Viral Entry And Phagocytosis, Md Saddam Hossain

Electronic Theses and Dissertations

CRISPR/Cas9 is a revolutionary technique for genome editing where Cas9 nucleases can be targeted to specific genomic sites by single-guide RNAs (sgRNAs) containing roughly 20-nucleotide sequences that are complementary to the target region. Double strand breaks created by Cas9 are repaired through non-homologous end-joining (NHEJ) in most cells, resulting in insertions and deletions leading to frame shift mutations in coding regions. Thus, the CRISPR-Cas9 system can be exploited for systematic evaluation of gene function relationships by whole genome screening. We also developed a CRISPR whole‐genome screen and counter‐screen strategy based on a pseudoviral platform that allowed identification of genes specific …

Analysis Of Toxic Chemical Agents And Therapeutics For Toxic Inhaled Agents’ Exposure, Khadija Bilkis

Electronic Theses and Dissertations

When inhaled, toxic inhalation agents (TIAs) such as cyanide (CN), ammonia and sulfur compounds (e.g. methanethiol (MeSH)) can be fatal. Many TIAs cause cellular hypoxia, cytotoxic anoxia, apnea, respiratory failure, neurodegenerative disorder, circulatory collapse, seizures, and potential death by blocking mitochondrial cytochrome c oxidase. All TIA’s have the potential to be employed as chemical warfare agents, terrorist weapons, or dangerous occupational gases. Although many TIAs are potential threats, there are minimal FDA-approved treatments for these substances useful in a mass-casualty situation. Recently, cobinamide (Cbi) has come to light as a potential antidote for MeSH poisoning. However, methods for analyzing MeSH …

กระบวนการสื่อสารในการรวมกลุ่มของวัยรุ่น Gen Z ต่อสื่อการ์ตูนญี่ปุ่นในประเทศไทย, ชญานนท์ ครองบุญชู

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยครั้งนี้มีวัตถุประสงค์เพื่อวิเคราะห์และศึกษารูปแบบกลยุทธ์ กระบวนการ และการสื่อสารที่ก่อให้เกิดอิทธิพลในการรวมกลุ่มของวัยรุ่น Gen Z ในบริบทของสื่อการ์ตูนญี่ปุ่นที่ส่งผลต่อพฤติกรรมการบริโภคและการตอบสนองต่อกลยุทธ์การสื่อสารของบริษัทนำเข้าสื่อการ์ตูนญี่ปุ่น การวิจัยใช้ระเบียบวิธีวิจัยเชิงคุณภาพด้วยวิธีการสัมภาษณ์เชิงลึกกับกลุ่มตัวอย่างทั้งสิ้น 30 คน โดยแบ่งออกเป็น 2 ประเภท ได้แก่ ผู้ที่เป็นส่วนหนึ่งต่อการสร้างอิทธิพลในการรวมกลุ่มของสื่อการ์ตูนญี่ปุ่นในประเทศไทย จำนวน 9 คน และผู้รับชมสื่อการ์ตูนญี่ปุ่นที่เกิดในปี พ.ศ. 2540-2549 จำนวน 21 คน การวิเคราะห์ข้อมูลเชิงคุณภาพดำเนินการด้วยเทคนิคการวิเคราะห์แก่นสารผลการวิจัยพบว่า กระบวนการการรวมกลุ่มประกอบด้วย 4 ขั้นตอนหลัก ได้แก่ ขั้นตอนการค้นพบ ขั้นตอนการเรียนรู้ ขั้นตอนการมีส่วนร่วม และขั้นตอนการสร้างอัตลักษณ์ วงการการ์ตูนญี่ปุ่นในไทยมีการรวมกลุ่มแบบผสมผสานระหว่างสื่อออนไลน์และออฟไลน์ กลยุทธ์การสื่อสารที่มีประสิทธิภาพต้องเน้นหลักการ 3T ได้แก่ ความจริงใจในการสื่อสารที่ซื่อสัตย์และไม่มีการปิดบัง ความโปร่งใสในการเปิดเผยข้อมูลและกระบวนการที่จำเป็น และความรวดเร็วในการตอบสนองและอัปเดตข้อมูลอย่างทันท่วงที ผลการวิจัยยังพบว่าผู้บริโภค Gen Z ที่มีประสบการณ์แตกต่างกันมีพฤติกรรมและความต้องการในการรวมกลุ่มแตกต่างกัน การรวมกลุ่มมักเกิดขึ้นในพื้นที่ออนไลน์แล้วจึงนำไปสู่การรวมกลุ่มแบบออฟไลน์ ผ่านแฟนการ์ตูนญี่ปุ่นในโลกออนไลน์ที่มีบทบาทในฐานะผู้ร่วมผลิตที่ขับเคลื่อนวัฒนธรรม

What Does It Mean To Create Art? Intellectual Property Rights For Artificial Intelligence Generated Artworks, Zachary Bozard

South Carolina Journal of International Law and Business

No abstract provided.

Scalp Fast Oscillation As A Predictor For Epilepsy In Critically Ill Patients With Periodic Discharges, Kongpop Sutantikorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Periodic discharges (PDs) in critically ill patients due to diverse pathologies are not uncommon and carry varied prognosis. Scalp fast oscillations (SFOs) have been increasingly studied its association with clinical outcomes in many conditions. However, none has assessed its values in prognostication of the critically ill patients. Objectives: To assess the prognostic values of SFOs in prediction of short and long-term clinical outcomes in critically ill patients with PDs. Materials and Methods: All patients aged > 15 years with detection of PDs during 2014-2022 were recruited. Converted electroencephalography (EEG) files to the standard format were used for analysis. Time-frequency analysis …

Prediction Of Recurrent Lateral Ankle Sprain And Ankle Pain Using Applied Care Strategies And Patient-Reported Outcomes, Ryan S. Mccann, Elisabeth Ohrnberger, Kyle B. Kosik, Phillip A. Gribble

Rehabilitation Sciences Faculty Publications

Context

Patients with lateral ankle sprains (LASs) often have deficient patient-reported outcomes (PROs) at return to activity (RTA), potentially increasing risk for recurrent LAS and ankle pain. Additionally, applied care strategies are known to correct impairments, but their ability to mitigate risk for long-term consequences remains unknown.

Objective

To determine if applied care strategies and PRO scores at RTA and 6 months after RTA predict recurrent LAS and ankle pain 12 months after an acute LAS. DESIGN: Prospective cohort study.

Setting

Online survey.

Patients or Other Participants

We enrolled 63 individuals within 1 week of sustaining an acute LAS.

Main …

Effects Of Water Chemistry On Interaction Between Organic Contaminants And Microplastics And Their Passage In Microfiltration Membrane, Chutiporn Inchana

Chulalongkorn University Theses and Dissertations (Chula ETD)

The agricultural activity is a critical source of organic contaminants and microplastics (MPs). Typically, the agricultural soil is contaminated by an abundance of MPs, leaching chemicals during weathering process, and pesticides, which subsequently end up in surface water through agricultural runoff. Polymers that are most frequently used in crop production and detected in surface water are PE and PET MPs. Bisphenol (A) and atrazine are frequently detected in surface water. Nevertheless, the fate and distribution of organic pollutants in water treatment as a consequent on MP-aided transport is constrained by little knowledge on photoaged PE and PET MPs. In this …