Digital Commons Network^™

Assessing The Feasibility Of Seaweed Farm-Offshore Wind Co-Location In New Jersey, Brianna Delaney Reynolds

Theses, Dissertations and Culminating Projects

New Jersey’s offshore wind energy sector may provide an opportunity to advance the seaweed farming industry through ocean multi-use. Yet, opportunities, constraints, and knowledge gaps for seaweed farm-offshore wind co-location remain largely uninvestigated. Here, I determine the suitability of native seaweed species for offshore cultivation in New Jersey and conduct a quick scoping review (QSR) to assess the knowledge base surrounding seaweed farm-offshore wind multi-use. Saccharina latissima and Fucus vesiculosus were identified as native species with commercial value for cultivation in New Jersey. Yet, offshore waters at the location of a wind development site had insufficient nutrients to meet the …

Course List - Fall 2024, Office Of Registrar

Semester Schedules and Information

No abstract provided.

Assessment Of The Impact Of Various Feature Extraction Techniques On The Effectiveness Of Music Genre Classification In Neural Network Models., Sabhdh Grace

ICT

This research focuses on Music Genre Classification (MGC) using Convolutional Neural Networks (CNNs) and various datasets, including raw audio files (WAV) and extracted features such as Mel Spectrograms (MS), Mel-Frequency Cepstral Coefficients (MFCC), and Chroma Features (CF). The study employs Explanatory Sequential Mixed Methods (ESMM), combining qualitative research and experimental analysis to explore different model inputs and their performance. Several CNN-based models, including 2D CNN, 2D CNN-LSTM, 1D CNN, and 1D CNN-LSTM, were tested. However, the models generally underperformed, with most achieving accuracy of 10% or lower, and the best model (raw audio 1D CNN) reaching only 20%. The research …

Fowl Play And Lame Ducks: How A Three-Headed Circuit Split Confuses Century-Old Migratory Bird Protections, Omer Arain

Kentucky Journal of Equine, Agriculture, & Natural Resources Law

No abstract provided.

Three Essays On Environmental Risk And Policy, Samuel Owens

Theses and Dissertations--Public Policy and Administration

This dissertation comprises three essays that investigate different facets of environmental hazards and their implications for policy and governance. While each essay examines a different topic area, they are all linked by examining how entities respond to incentives at the intersection of environmental risk and public policy. Each chapter informs a distinct literature within environmental policy and utilizes different methodologies to examine largely unexplored research questions.

In the first essay, I examine how individuals respond to the low-visibility, long-term environmental risk presented by radon. I employ radon zone data from the Kentucky Geological Survey and home information from Zillow to …

Astrocyte Ca2+ In The Dorsal Striatum Suppresses Neuronal Activity To Oppose Cue-Induced Reinstatement Of Cocaine Seeking, Navid S. Tavakoli, Samantha G. Malone, Tanner L. Anderson, Ryson E. Neeley, Artin Asadipooya, Michael T. Bardo, Pavel I. Ortinski

Psychology Faculty Publications

Recent literature supports a prominent role for astrocytes in regulation of drug-seeking behaviors. The dorsal striatum, specifically, is known to play a role in reward processing with neuronal activity that can be influenced by astrocyte Ca2+. However, the manner in which Ca2+ in dorsal striatum astrocytes impacts neuronal signaling after exposure to self-administered cocaine remains unclear. We addressed this question following over-expression of the Ca2+ extrusion pump, hPMCA2w/b, in dorsal striatum astrocytes and the Ca2+ indicator, GCaMP6f, in dorsal striatum neurons of rats that were trained to self-administer cocaine. Following extinction of cocaine-seeking behavior, the rats over-expressing hMPCA2w/b showed a …

Elucidating The Role Of Fatty Acid Synthase In Apc-Driven Colorectal Cancer, Courtney O. Kelson

Theses and Dissertations--Toxicology and Cancer Biology

Globally, colorectal cancer (CRC) is the second leading cause of cancer related deaths. Currently, there is a growing incidence rate for individuals aged 20-49 years. Genetic and environmental factors contribute to the risk of this cancer. Early detection of CRC allows for the most effective treatment option in which surgical resection of the primary tumor occurs along with adjuvant chemotherapy. This therapeutic approach contributes to 5-year survival rate of 91%. However, surgical procedures and chemotherapy struggles against metastatic and relapsed CRC resulting in 5-year survival rate of 14%. Inefficacious treatments for relapsed and metastatic diseases emphasizes the need for more …

Project Final Report Watershed Center Of Excellence, Kentucky Water Resources Research Institute

KWRRI Research Reports

With the goal of providing a structured foundational background for watershed management to Kentucky’s watershed coordinators and other water quality professionals, the Kentucky Water Resources Research Institute developed the Kentucky Watershed Academy, a six-module series of core training content. The modules address the following subject areas:

• Module 1: The Clean Water Act & Related Water Quality Laws

• Module 2: Water Quality Basics

• Module 3: Dealing with Data

• Module 4: Land Use Impacts & Related Best Management Practices

• Module 5: Likely Partners

• Module 6: Effective Communications

As a result of this project, a total of …

Institutions Against Art Music-Curation, Rehearsal, And Contemporary Art, G. Douglas Barrett

Media Studies - Open-Access Faculty Scholarship

No abstract provided.

Climate Action Now: How To Fuel A Social Movement, Lama Lteif, Gia Nardini, Tracy Rank-Christman, Lauren Block, Melissa G. Bublitz, Jesse R. Catlin, Samantha N. N. Cross, Anne Hamby, Laura A. Peracchio

Marketing Faculty Publications and Presentations

Our research develops a framework that explores how to fuel the climate movement by accelerating grassroots, community-based climate action. Drawing on insights from consumer psychology, our framework identifies the psychological mechanisms that encourage and motivate people, both individually and collectively, to take climate action, thereby contributing to our understanding of how to advance social action and propel a social movement. Our climate action framework builds on: (1) individuals we describe as climate upstanders who rise up to take climate action with like-minded others, and (2) communities of climate upstanders who engage in collective action aimed at addressing the climate crisis. …

Ce 660 Syllabus: Counseling Theory And Practice, Karen Cathey

Counselor Education Syllabi

This course exposes students to theories of personality development and change, theories of counseling, and counseling techniques. Students practice application of counseling theories in a laboratory setting with simulated situations. Students are encouraged to identify and develop a tentative theory of personality as it relates to an effective counseling approach. A strong emphasis is placed on the ethical standards of the counseling profession and on multicultural issues

Ce 660 Syllabus: Counseling Theory And Practice, Mary Fawcett

Counselor Education Syllabi

This course exposes students to theories of personality development and change, theories of counseling, and counseling techniques. Students practice application of counseling theories in a laboratory setting with simulated situations. Students are encouraged to identify and develop a tentative theory of personality as it relates to an effective counseling approach. A strong emphasis is placed on the ethical standards of the counseling profession and on multicultural issues

Assessment Of Avian Community Structure And Habitat Connectivity In The Fanno Creek Corridor Bird Surveys, Habitat Assessment, And Management Recommendations, Grace Hall

Environmental Science and Management Professional Master's Project Reports

Urbanization can significantly impact habitat quality and connectivity for avian communities, decreasing species richness and diversity. However, in highly fragmented habitats, urban parks and riparian zones can provide important habitat corridors for birds that facilitate movement and access to essential resources. On the west side of greater Portland, Oregon, Fanno Creek may serve as a habitat corridor for birds and other local wildlife.

Fanno Creek is a 25-kilometer tributary of the Tualatin River that runs through the cities of Portland, Beaverton, Tigard, and Durham in northwestern Oregon. The land surrounding the creek includes residential, commercial, and industrial properties as well …

On Willing Surrender As Virtuous Self-Constitution, Bennett B. Gilbert

University Studies Faculty Publications and Presentations

Our cultural situation is to seek a moral form of self-constitution, rather than an ontological or epistemological foundation. Such a moral ground lies in the paradox of willing surrender of the will to do wrong or dysfunctional acts in order to enter temporally-extended processes of moral change. But the paradox of willing surrender of the will requires analysis. The propositional form of it cannot be sustained and must instead give way to willingness as an ongoing choice. The self-reflexivity of the will with which we accomplish this turns out to be a core activity of human activity that seeks openness …

Developmental Change In English-Learning Children’S Interpretations Of Salient Pitch Contours In Word Learning, Carolyn M. Quam, Daniel Swingley

Speech and Hearing Sciences Faculty Publications and Presentations

To efficiently recognize words, children learning an intonational language like English should avoid interpreting pitch-contour variation as signaling lexical contrast, despite the relevance of pitch at other levels of structure. Thus far, the developmental time-course with which English-learning children rule out pitch as a contrastive feature has been incompletely characterized. Prior studies have tested diverse lexical contrasts and have not tested beyond 30 months. To specify the developmental trajectory over a broader age range, we extended a prior study (Quam & Swingley, 2010), in which 30-month-olds and adults disregarded pitch changes, but attended to vowel changes, in newly learned words. …

Annual Report '24, Tennessee. Department Of Disability And Aging

Annual Reports

This document is the annual report of the Department of Disability and Aging for the fiscal year.

Characterizing The Role Of Temperature On West Nile Virus Evolution And Vector-Virus Interactions, Rachel Lucy Fay

Legacy Theses & Dissertations (2009 - 2024)

West Nile virus (WNV) is the most common mosquito-borne disease in the contiguous U.S. WNV is a member of the Flaviviridae family which is group of single stranded positive sense RNA genome viruses. It is commonly vectored by Culex mosquitoes and is found in a transmission cycle between its amplifying hosts of birds. Incidental hosts of WNV include people and animals. WNV is known to cause flu-like illness and in rare cases can become neuroinvasive. There are currently no approved therapeutics on the market for WNV. Since the beginning of the 20th century the earth’s average temperature has increased by …

Musical Memory And Chile’S Late 20th Century, Maxam A.B. Daniels

History Honors Program

This thesis investigates the significance of musical experiences for understanding the evolution of leftist culture across the late 20^th century and contemporary era in Chile. An analysis of the musical experiences of leftist prisoners during the Pinochet era and contemporary protests finds that traditional politico-economic narratives are insufficient for explaining the cultural evolution of the Chilean left. Daily musical experiences across these eras suggests that there may be a long-term cultural habit within the Chilean left that utilizes music for expressing dissent and sustaining solidarity. Political prisoners of the Pinochet era were found to clandestinely use songs to preserve …

‘Making Of A Woman Minister’ Rev. Annis Ford Eastman And Elmira, New York, Mary Lemak

History Honors Program

This paper explores the life and career of one of the United States’ first female ministers, Rev. Annis Ford Eastman (1852-1910). Remembered today as being the author of Mark Twain’s eulogy and as the mother of American writer Max Eastman and co-author of the Equal Rights Amendment Crystal Eastman, the Reverend Eastman had a career that was exceptional in its own right. Reverend Eastman was ordained when it was practically unheard of for a woman to preach. Not only was she ordained but she was invited to speak at national conferences and was frequently published in religious and civic journals. …

The Occult And Elizabeth I: How The Virgin Queen Used Magic As A Political Tool, Aiden Whitehead

History Honors Program

On May 28, 1555, Dr. John Dee was arrested and taken to one of the most infamous prisons in British history: The Tower of London. He was arrested under suspicion of violating the Treasons Act of 1534, which outlawed predicting the death of the monarch, the consort, and any heirs. Why would an Oxford-educated, catholic man of the gentry possibly risk death in predicting the outcome of Queen Mary I’s pregnancy? Because Lady Elizabeth, the heir presumptive, hired him to do so.. This fourth month-long incident was Elizabeth I’s first forte into the realm of political magic, and it almost …

Development Of Small Ligands Targeting Pathogenic Rna Repeats In Neurodegenerative Diseases, Zhihua Chang

Legacy Theses & Dissertations (2009 - 2024)

Pathogenic microsatellite RNA expansions are toxic and can cause neuronal degeneration and dysfunction. Therapeutics that eliminate or neutralize these RNA repeats hold great promise for the treatment of many neurodegenerative diseases because they are uniformly fatal but there is no effective treatment available today. New compounds targeting these pathogenic RNA repeat sequences represent new hope to treat these diseases. The overall goal of my dissertation is to develop a high-throughput screening assay to identify small ligands as potential drug candidates against disease-associated RNA repeats and probe binding mechanisms to guide the design of optimized drug candidates, and eventually validate therapeutic …

Loss Of Courtship Suppression Memory In A Drosophila Melanogaster Model Of Alzheimer’S Disease, Eric Robles, Johannes Berlandi, Chris Ellis, Tianyi Wu, Astrid Jeibmann, Fang-Ju Lin

Biology

Alzheimer’s disease (AD) is the most prevalent and lethal neurodegenerative disease. Memory loss and motor dysfunction are accompanied by pathological hallmarks like neurofibrillary tangles or amyloid plaques. In this study, courtship suppression assay was used to assess learning and memory of a transgenic Drosophila melanogaster (the fruit fly) line expressing human Amyloid beta 42 (Aβ42). At young age (4–6 days old), both parental control and AD flies displayed lower courtship indices during training after being rejected by previously mated females. However, in the subsequent testing phase, young AD flies showed compromised recall memory, unlike that of parental controls. Neither control …

Early Screening Of Alzheimer’S Disease Through Verbal Communication And Using Large Language Models (Llms), Venkatanand Ram Addepalli

Dissertations, Master's Theses and Master's Reports

With advancements in technology and the growth of artificial intelligence, the gap between healthcare challenges and solutions is narrowing. This study explores the use of large language models (LLMs) to screen for Alzheimer's disease through patient-physician conversations. Fine-tuning and instruction-tuning techniques were applied to improve predictions. The performance of fine-tuned open-source models like LLaMA and GPT-3 was compared to smaller models such as TinyLLaMA and retrieval-augmented generation (RAG) models. The models were tested to determine their ability to classify individuals as cognitively normal (CN) or at any stage of Alzheimer's disease (AD). Reinforcement learning through human feedback was used to …

Acquired Treatment Resistance In Prostate Cancer Via The Production Of Radiation Derived Extracellular Vesicles Containing Mitochondrial Proteins, Caitlin Miller

Theses and Dissertations--Toxicology and Cancer Biology

Radiation treatment (RT) is one of the most commonly administered treatments for prostate cancer (PCa) patients, yet the recurrence of tumors after RT remains one of the significant challenges in the eradication of PCa. In addition to induction of DNA damage, ROS production, and cell death, we found that RT promotes Extracellular vesicle (EV) production in PCa cells, at least in part, through H₂O₂ production (Miller CE et al., Antioxidants 2022, PMID 36358489). Since we observed EV production upon RT, EVs and their contents could play a role(s) in cancer survival after RT. By using flow cytometry …

Understanding The Mechanism Of Ferroptosis Susceptibility Variation In Colorectal Cancer, Aziza Alshahrani

Theses and Dissertations--Toxicology and Cancer Biology

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. Despite the use of chemotherapeutic agents, CRCs remains to be difficult to cure at least partially due to their intrinsic and/or acquired resistance to cell death inducers. Ferroptosis is a form of regulated cell death that caused by the accumulation of lipid peroxides. Studies have shown that dysregulation of ferroptotic pathways is associated with the development of resistance to various cancer treatment. Glutathione peroxidase 4 (GPX4) is a known target for inducing ferroptosis due to its critical role in detoxifying lipid hydroperoxides, and ferroptosis suppressor protein (FSP1) also …

Porcupine’S Role In The Enhancement Of Enzalutamide Efficacy In Drug Resistant Prostate Cancer, Katelyn Jones

Theses and Dissertations--Toxicology and Cancer Biology

Androgen receptor (AR) signaling continues to participate as a vital component of castration-resistant prostate cancer (CRPC). Subsequently, this has led to the development of Androgen Signaling Inhibitors (ASI), specifically Enzalutamide (ENZ), which is a direct inhibitor of AR, to clinically manage CRPC. Inevitably, ENZ treatment only provides improvement for approximately two months before advancing to an incurable form, ENZ-resistant CRPC. With PCa ranking as the second leading cause of cancer-related deaths in USA males, there is an urgency and necessity for the discovery and development of novel therapeutic approaches for CRPC. Wnt signaling has been extensively documented in its involvement …

Therapeutic Approaches And Novel Mechansims In Cancer Progression, Kendall Simpson

Theses and Dissertations--Toxicology and Cancer Biology

Prostate cancer (PCa) remains the most diagnosed cancer among men in the United States. There are various therapeutic routes that are implored to combat this fatal disease, and our work aims to increase the options made available to PCa patients. A combination treatment of Enzalutamide (Enz), an FDA approved drug for castration-resistant PCa patients, and Metformin, an FDA approved drug for type 2 diabetes, was utilized to enhance the efficacy of Enz in Enz-resistant PCa, both in vitro and in vivo. Thymic Lymphoma is one of the most common malignancies that can occur in various tissues and organs. Genomic stability …

Delineating Contributions Of Genotype And Lineage To Lung Cancer Therapy Response, Kassandra Jo Naughton

Theses and Dissertations--Toxicology and Cancer Biology

Non-small cell lung cancer (NSCLC) heterogeneity is a major challenge for determining effective treatment strategies. Adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs) are histologically and epigenetically distinct subtypes of NSCLC. Patients with ADC tumors harboring mutations in both KRAS and LKB1 (aka STK11) have lower survival rates than those with KRAS-only tumors. KRAS/LKB1 tumors are not only aggressive, but also respond poorly to immunotherapy. However, these data are limited to ADCs, and it is unclear if SCCs with this genotype are also resistant to immunotherapy. We developed a mouse model of Kras^mut/Lkb1^mut capable of producing …

Rps6kb1 Is A Critical Target For Overcoming Tumor Lineage Plasticity And Therapy Resistance, Saptadwipa Ganguly

Theses and Dissertations--Toxicology and Cancer Biology

Most tumors initially respond to treatment, yet refractory clones subsequently develop owing to resistance mechanisms which can be classified as intrinsic or extrinsic resistance. The intrinsic resistance is usually present prior to any treatment whereas the extrinsic resistance develops as a result of exposure to some kind of therapy. In order to target these “therapy resistant” tumor cells an unbiased screen of an FDA-approved drug library against cancer cells was performed. This was followed by synthesis of chemical analogs of the most effective drug.

The studies led to the identification of a derivative of the antihistamine drug ebastine, designated Super-ebastine …

The Bridge, Volume 21, 2024, Bridgewater State University

the bridge

Designers:

Mollie Rose Burk

Liz Cowden

Zachary Lucius

Colm McDonough

Arlene Perez

Editor-in-Chief

Ashley LaVergne

Editors:

Jaina Hicks

Emma Voelker

Faculty Advisor:

Jessica Melendy

Design Advisor:

Professor Alain Blunt