Digital Commons Network^™

Sphingosine Kinase 2 Depletion Dysregulates Hepatic Redox Metabolism And Enhances Inflammation In Early Metabolic Dysfunction-Associated Steatohepatitis (Mash), Kaitlyn Georgene Jackson

Theses and Dissertations

Metabolic dysfunction-associated steatotic liver disease (MASLD) currently affects one in three people worldwide; its prevalence is growing alongside other cardiometabolic disorders. Aberrations to redox and sphingolipid metabolism contribute to MASLD pathologic progression. Sphingosine-1-phosphate (S1P) is an active lipid, meaning that S1P participates in biochemical processes within the cell. S1P is generated by two distinct isoenzymes, sphingosine kinase (SphK)1 and SphK2. The localization of the SphK enzyme dictates S1P function. While cytosolic SphK1-generated S1P is well-characterized, nuclear and mitochondrial SphK2-generated S1P is less known. Moreover, SphK2 depletion effects on cellular redox processes and inflammation are not well-defined.

This study defines the …

The Role Of Hdac6 In Periodontal Inflammation, Hannah S. Lohner

Theses and Dissertations

Periodontal disease is a polymicrobial infection-induced chronic inflammatory disease and results in irreversible tissue damage and bone loss. While bacteria play a large role in the initiation of this disease, excessive and prolonged inflammatory immune responses are fundamental for its progression, making host directed therapy (HDT) a possible and potentially valuable treatment. Histone Deacetylase 6 (HDAC6) is an enzyme that removes acetyl groups from both histone and non-histone proteins, giving it a potential role in regulating inflammation initiated by pathogenic oral bacteria. Previous studies indicated that HDACs act as a bivalent regulator in inflammatory responses; however, the role that HDAC6 …

Plk1 Overexpression Drives Tumorigenesis In A Prostate Cancer Mouse Model, Emile Kachouh

Theses and Dissertations

Prostate cancer is the leading cause of cancer-related deaths among men worldwide, and the development of resistance to existing treatments necessitates the exploration of new therapeutic strategies, including combination therapies. This study investigates the role of Polo-like kinase 1 (PLK1), located on chromosome 16p12.2, as an oncogene in prostate cancer. We generated a transgenic mouse model with prostate-specific overexpression of PLK1 to closely mimic human prostate cancer progression. Quantitative PCR (qPCR) analysis was employed to characterize the molecular profile of PLK1, revealing its implication in multiple pathways. To further elucidate the functional consequences of PLK1 overexpression, we confirmed phenotypic progression …

A Retrospective Chart Review Of Avulsion Injuries Treated At Virginia Commonwealth University., Ryan Hediger

Theses and Dissertations

A RETROSPECTIVE CHART REVIEW OF AVULSION INJURIES TREATED AT VIRGINIA COMMONWEALTH UNIVERSITY. By: Ryan Hediger, DMD

Objective: Outcomes related to healing following an avulsion injury are multifactorial. However, contemporary literature suggests that tooth survival can be enhanced after such injuries by promptly replanting the tooth and adhering to proper management guidelines. Despite the abundance of resources available, the actions taken immediately after the avulsion injury play a pivotal role in determining the fate of an avulsed tooth. The primary objective of the current investigation is to unveil prognostic factors associated with the survival of avulsed teeth.

Methods: A chart review …

A Critical Perspective On Supporting Parents In Facilitating Informal Steam Learning On Children's Early Literacy Development, Suzanne G. Alexandre

Theses and Dissertations

Considering that parents/caregivers and home environment play an influential role in a child’s school readiness and future academic success, this study sought to support parents in using facilitation strategies to engage their child in informal learning at home. In order to examine if access to support for parents of preschoolers influenced parents’ confidence in their ability to facilitate informal learning at home, the project used informal STEAM learning, for context. The study also examines the potential impact of informal STEAM learning on children's school readiness and early literacy skills and the intersections of parent involvement, STEAM, and school readiness through …

Notes On A Centrifugal Chiller: Listening And Breathing The Boundaries Of Circulatory Architecture, Chrystine Rayburn

Theses and Dissertations

"Notes on a Chiller" unfolds as a series of site responsive and performative exercises that activate, modulate, and translate the immense voice of Virginia Commonwealth University’s Siegel Center water-cooled chiller, a climate control system that regulates the atmosphere of the university’s sports arena. Using individual and collective listening and sound-making practices to harness the building’s noisy system, the piece culminates in a multi-channel, audio-visual installation and performance that explores the multi-sensory exchange and entanglement of listening, breathing, and moving with a building’s circulatory system.

Biophilia: Developing A Taste For Care, Che'leah Shannon

Theses and Dissertations

People in materially developed cultures spend over 90% of their lives in buildings (Evans & McCoy, 1998). Commencing with the industrial revolution these materially developed cultures see most of their populus moving from the countryside to the city in search of work and better lives. The city, an urban and modern development of densely packed peoples, buildings, and infrastructure, has developed as an efficient solution to meet the needs of a cosmopolis.

The city has developed widely without a necessity or place for nature. The ground outside is paved with concrete, efficient and comfortable for travel, buildings are built high …

Threads Unbound, Yuan Xin

Theses and Dissertations

Threads Unbound investigated the formation of biased cognitive patterns within information ecosystems, examining the blend of reality and fiction in human perception. This project turns the 3 dimension space into an experimental field that prompts reflection on the mechanism of constructing narratives based on the subtle yet powerful forces of reading processes.

Moonshine Babies, Arghavan Heydareslam

Theses and Dissertations

Moonshine Babies is a two-screen film made of collage/cut-out stop-motion and live-action. It is a visual poem based on my journals from when I recently started living in the US as an outsider. The experience left me feeling divided between the empty present and memories of the past. suggesting that there are collective memories among a group of interconnected individuals that unite them within a single narrative.

There was a moment when I asked, "If you are your memories, what does it mean to be somewhere you have no memories of and no one has memories of you there?"

Memories …

The Role Of Notch1 Signaling In Regulating Neurogenesis In The Olfactory Bulb Following Traumatic Brain Injury, Sarah A. Baig

Theses and Dissertations

In the United States, more than 20.5 million adults over the age of 40 suffer from olfactory dysfunction, with TBI attributing to 5-17% of all olfactory dysfunction cases. Although often initially undetected and less conspicuous than other cognitive and behavioral impairments, olfactory dysfunction may have a significant negative impact on patients' quality of life and ability to accomplish activities of daily living, therefore the pathophysiology of these disorders should be understood. The production of neural stem cells enhances the repair and regeneration of the injured brain following a TBI. One of the primary endogenous neural stem cell generation sites in …

Unfolding Remembrance: Folding Islamic Principles Into Pondering Machines, Hind Al Saad Al-Kuwari

Theses and Dissertations

Principles of early Islamic art can be surveyed as a precursor to Western computational art. Though produced in different historical and cultural contexts, Islamic art and computational art are connected by underlying structures—arithmetic, harmony, and the concept of the Infinite.

Islamic developments in knowledge, like algebra, contributed to mathematics and mechanics—the building blocks of contemporary technology. Returning to Islam’s traditional harmony between religion and science, my creative practice constructs machines as an act of worship (ʿibadah), folding Islamic principles into the medium of computation.

Selected verses from the Quran are used as the core of each automaton (self-operating machine). Their …

Conservation As Multiple Use, Sandra B. Zellmer

Faculty Law Review Articles

The world is facing unprecedented species extinctions, wrought in large part by climate change. Slashing greenhouse gas emissions is one crucial response to the climate/biodiversity crisis. The conservation of intact ecosystems and the life-sustaining services they provide is another. This goal will be beyond reach if conservation commitments do not cover federal public lands, particularly multiple use lands.

The Bureau of Land Management (“BLM”) has recently proposed a pathbreaking new rule that explicitly defines conservation as a multiple use. In doing so, the Conservation and Landscape Health Public Lands Rule (“Conservation Rule”) puts conservation on par with other statutorily listed …

Evaluating The Performance Of Flukecatcher At Detecting Urogenital Schistosomiasis, Louis Fok, Berhanu Erko, David Brett-Major, Abebe Animut, M. Jana Broadhurst, Daisy Dai, John Linville, Bruno Levecke, Yohannes Negash, Abraham Degarege

Journal Articles: Epidemiology

Urine filtration microscopy (UFM) lacks sensitivity in detecting low-intensity Schistosoma haematobium infections. In pursuit of a superior alternative, this study evaluated the performance of FlukeCatcher microscopy (FCM) at detecting S. haematobium eggs in human urine samples. Urine samples were collected from 572 school-age children in Afar, Ethiopia in July 2023 and examined using UFM and FCM approaches. Using the combined UFM and FCM results as a reference, the sensitivity, negative predictive value, and agreement levels for the two testing methods in detecting S. haematobium eggs in urine samples were calculated. The sensitivity and negative predictive value of detecting S. haematobium …

Antibiotics Misuse And Antimicrobial Resistance Development In Agriculture: A Global Challenge, Baljit Singh, Abhijnan Bhat, Kamna Ravi

Articles

No abstract provided.

Arsenic Contamination Needs Serious Attention: An Opinion And Global Scenario, Abhijnan Bhat, Kamna Ravi, Furong Tian, Singh Baljit

Articles

Arsenic (As) contamination is a serious global concern, polluting our natural resources, including water and soil, and posing a danger to the environment and public health. Arsenic is present in the groundwater of several countries and this contaminated water is used for irrigation, drinking, and food preparation, which poses the greatest threat to public health. Nearly 106 countries are affected by groundwater arsenic contamination and an estimated 230 million individuals worldwide are exposed to its adverse health effects, including increased cancer risks, associated cardiovascular disease and diabetes, skin lesions, neurological effects, kidney damage, and foetal or cognitive-development-related complications. Arsenic is …

Eskape: Navigating The Global Battlefield For Antimicrobial Resistance And Defense In Hospitals, Kamna Ravi, Baljit Singh

Articles

The current healthcare environment is at risk due to the facilitated transmission and empowerment of the ESKAPE pathogens, comprising of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species. These pathogens have posed significant challenges to global public health and the threat has only amplified over time. These multidrug-resistant bacteria have become adept at escaping the effects of conventional antibiotics utilized, leading to severe healthcare-associated infections and compromising immunocompromised patient outcomes to a greater extent. The impact of ESKAPE pathogens is evident in the rapidly rising rates of treatment failures, increased mortality, and elevated healthcare costs. …

The Influence Of Youtube Advertising Value On Consumer Responses, Ratanak Sophal

Chulalongkorn University Theses and Dissertations (Chula ETD)

The objectives of this research are to explore the values of YouTube advertising—namely entertainment, informativeness, credibility, and irritation—and their influence on consumer responses, including perceived advertising value, attitude towards YouTube advertising, and shopping intention. Additionally, the study examines the relationships between perceived advertising value, attitude towards YouTube advertising, and shopping intention. Data were collected via an online survey from 291 Thai respondents, aged 18–55 years, who had been exposed to YouTube advertisements. The results show that YouTube advertisements were perceived as neither highly entertaining (M = 2.75), informative (M = 2.99), nor credible (M = 2.89), and were viewed as …

Spatiotemporal Patterns For Agroforestry Tree Crops In The U.S. Corn Belt For Usda Census Of Agriculture Periods 2012–2022, Andria Caruthers, Justin Dijak, Robin M. Rotman

Faculty Publications

Within the U.S., there is a growing need to integrate environmentally friendly practices into conventional agriculture. Agroforestry enhances environmental and resource stewardship in agricultural landscapes while offering potential economic benefits to farmers. Despite rising interest, limited information on its application in the U.S. hinders development efforts. A spatiotemporal analysis of current farm operations can provide crucial insights. This study examined patterns of agroforestry and tree crop adoption in the U.S. Corn Belt using USDA Census data (2012, 2017, and 2022) and spatial tools (Global Moran’s I, Local Moran’s I, and Moran scatterplots). The tree crops included in the analysis were …

Diagnostic Accuracy Of Cbct In The Differential Diagnosis Of Apical Cysts And Granulomas Using Histopathological Findings As A Reference Standard: A Systematic Revew, Fatima Zohra Rouggani, Chaimaa Kabil, Rachida Mayou, Sidi Mohamed . Bouzoubaa

Health Sciences

Introduction

The periapical lesions represent a complex group. Granulomas and cysts represent the two most frequent forms in routine clinical practice.

Aim: Highlight the diagnostic accuracy of CBCT imaging in the differential diagnosis between a cyst and a granuloma compared to histopathological examination as a reference technique.

Materials and Methods:

Our literature search involved articles published in the following databases: PubMed, Cochrane, science direct and Google scholar.

Our intention was to review recent articles from the last 5 years and to select studies conducted in significantly changed socio-medical contexts that could have a positive impact on the validity of our …

Non-Alcoholic Fatty Liver Disease: Genetic Susceptibility, Shakil A. Saghir, Nicole Shams, Lianette Veliz, Saleh Alfuraih, Yadollah Omidi, Jaleh Barar, Ajay Sharma, Rais Ansari

Pharmacy Faculty Articles and Research

The prevalence of Non-alcoholic Fatty Liver Disease (NAFLD) is increasing, particularly in individuals who consume minimal to no alcohol. Currently, NAFLD affects at least 32% of the global population. Although not all but approximately 5-10% cases of NAFLD progress to non-alcoholic steatohepatitis (NASH), a condition arising from lipotoxicity. Patients with NASH may further develop liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). However, it is important to note that progression from NAFLD to NASH and HCC is not inevitable for all patients. The pathogenesis of HCC in the context of NAFLD and NASH remains poorly understood, however, fat accumulation, often due …

South Dakota State University Undergraduate Catalog 2024-2025, South Dakota State University

South Dakota State University Catalogs and Bulletins: 1935 to present

No abstract provided.

Volume 50, Issue I - Full Combined Issue

Journal of Legislation

No abstract provided.

One Hundred Forty-Seventh Annual Report, Town Of Easton, New Hampshire, Year Ending December 31, 2023., Easton Town Representatives

Easton, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Expect Employment [2024], Tennessee. Employment First Task Force, Tennessee. Department Of Disability And Aging

Expect Employment Report to Governor

This document provides an overview of the progress made towards expanding employment opportunites for Tennesseans with disabilities.

Suitability Analysis Of Public And Institutional Lands For The Oregon Farm To Institution Collaborative, Megan Horst, Maura Paxton

Urban Studies and Planning Faculty Publications and Presentations

This report provides a statewide view of public and institutional lands that may be suitable for farm to institution food production in Oregon. The goal is to assist the Oregon Farm to Institution Collaboration, and particularly the Land Access and Shared Assets Work Group, in identifying possible lands for farmers and food producers to grow food for schools, hospitals, and other institutions.

We start by comparing Oregon to other states, in terms of their public land access efforts around farm to institution or other related agriculture. We also showcase some interesting cases which may serve as inspiration to Oregonians. The …

Integrating Contradictory Perspectives In Latin American Philosophy: A Multialism Approach, Maikel Yelandi Leyva Vázquez, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

This study explores the integration of indigenous philosophies and postcolonial modernist theories within the framework of MultiAlism, highlighting the potential for dialogue and synthesis between these diverse philosophical traditions in Latin America. MultiAlism, a concept developed by Florentin Smarandache, is utilized to bridge the gaps and contradictions between these systems by focusing on areas of neutrality such as cultural diversity and power structure critiques. The research emphasizes the importance of incorporating both ancestral wisdom and modern critiques to foster a deeper understanding and appreciation of Latin America’s rich philosophical heritage. This integrative approach offers practical insights for developing inclusive policies …

A Review At Two Nuclear Reactor Problems In Asia, Victor Christianto, Florentin Smarandache

Branch Mathematics and Statistics Faculty and Staff Publications

The development of nuclear power plants (NPP) is often a heated debate, especially in developing countries [1]. In relation to this, it is worth the public's attention that lately, it seems that there have been increasingly frequent press releases from various parties representing the government regarding plans to build the first nuclear fission reactor in Indonesia in the not too distant future. Reportedly there will be a large amount of additional energy supply planned (around 100 GW to be built in Indonesia within the coming decade). For this reason, the authors would like to invite readers to take a moment …

Indefinite Detention Under Part Xx.1 Of The Criminal Code And Winko V. British Columbia, Jamie Cameron

Articles & Book Chapters

“Indefinite Detention Under Part XX.1 of the Criminal Code and Winko v. British Columbia” is chapter 27 in a textbook titled Canadian Anthology on Mental Health and the Law. It draws on the author’s ten years as a legal member and alternate chair on the Ontario Review Board, as well as on her participation in a research study on perceptions of fairness in ORB proceedings, to provide critical comment on the procedural fairness and constitutionality of forensic detention for mentally disordered criminal offenders (i.e. not criminally responsible (NCR); unfit to stand trial (UST); and dual status offenders …

Biogen Int’L V. Banner Life Scis. Llc: Exploring The Other Possibility That Could Have Resulted, Priyal Patel

UIC Review of Intellectual Property Law

No abstract provided.

Refounding Copyright In The Right To Dialogue. Consequences For Chatgpt And Other Artificial Intelligence Services, Juan Carlos Riofrio

UIC Review of Intellectual Property Law

No abstract provided.