Digital Commons Network^™

Integrative Approaches To Gut Microbiota: Biomarkers, Dysbiosis, And Therapeutic Potential, Zeyad M. Alharbi

Saudi Medical Journal

The human gut contains bacteria, viruses, and archaea that influence health depending on age, diet, and location. An individual harbours about 150 bacterial species. An imbalance of these microorganisms, known as dysbiosis, can negatively impact health. Commensal bacteria maintain microbial homeostasis by building short chain fatty acids. The 2-way communication channel that connects the gut and the brain is referred to as the gut-brain axis. Dysbiosis of the gut leads to some autoimmune diseases. A decline of beneficial bacteria causes the progression of rheumatoid arthritis. Gut dysbiosis increases intestinal permeability, allowing toxins and cytokines to enter the bloodstream and damage …

Treatment Of Odontogenic Sinusitis With Oroantral Communication And Fistula: A Systematic Review And Meta-Analysis, Rana R. Alharbi, Omar F. Alnajar, Reham E. Almahdi, Salman A. Alrougi, Remas A. Alshehri, Ruyuf A. Alotaibi, Shahad S. Alharbi, Manal A Eltahir, Yahya A. Fageeh

Saudi Medical Journal

Objective: To assess the available data regarding medicinal, surgical, and combination therapy approaches for odontogenic sinusitis linked to OAC and OAF. Oroantral communication (OAC), an atypical connection between the oral cavity and maxillary sinus, commonly arises following upper jaw procedures, trauma, or infection. Chronic odontogenic maxillary sinusitis may result from OAC developing into an oroantral fistula (OAF) if treatment is not received. Recurrent infections and functional difficulties can be avoided by managing these illnesses effectively. Methods: A systematic search was conducted in National Library of Medicine's (PubMed [MEDLINE]) and Google Scholar for studies published between 2000 and 2024. A total …

Toward A Technology-Enhanced Project-Based Learning Curriculum For English Language Learners, Lynn Wolfe

MITESOL Journal: An Online Publication of MITESOL

Project-based learning (PBL) has been demonstrated as an effective strategy for millennial and Gen Z students, particularly in K-12 contexts, but this teaching approach is not commonly used in adult ESL classrooms. This paper suggests that a technology-enhanced PBL approach may transform otherwise teacher-centered and outdated ESL classes by helping English language learners (ELLs) develop linguistic fluency along with technological fluency that is essential for the 21st century workplace. Collaborative PBL activities involving the use of digital tools are presented in the areas of listening/speaking, reading/vocabulary, grammar, and writing, providing a foundation for a technology-enhanced PBL curriculum designed for adult …

Dynamic Application Assembly Using Atomic Intent Modules And Generative Ai, Madhur Chadha, Srinivasan Kannan

Defensive Publications Series

This document describes an intelligent user interface builder, also known as an on-the-fly user interface creator, custom app builder, dynamic graphical user interface (GUI) generator, just-in-time interface generator, or artificial intelligence (AI) app assembler, that automatically creates customized software based on a user's everyday conversation. Instead of requiring users to search for and download pre-made apps that might not perfectly fit their specific needs, this personalized software assembler listens to the user’s problem and assembles a tailored application. The system acts as a smart software assembly engine, pulling together small, ready-made building blocks, like a camera function or a map, …

(((Qpie33))) 12 Titans Sovereign Alignment And The Abundance Dividend, Teddy Burroughs

Defensive Publications Series

EXECUTIVE SUMMARY: THE SOVEREIGN PIVOT & THE $33 BILLION MANDATE

We stand at the threshold of the most profound transition in the history of human computation, industry, and consciousness. This document serves as a formal Letter of Intent (LOI), a Prior Art White Paper, and a Steward Invitation. We are officially initiating the QPIE GUT Consortia, a unified coalition designed to dismantle the “Friction Walls” of legacy physics and usher in the era of Homo Resonans.

Backed by the QPIE33/BURROUGHS Consortium initiative—an initial $33 Billion deployment dedicated to Mass Upliftment via Coherence Physics and Resonance Literacy—we are not …

Creating An Unconscious: Toward A New Ethic Of Residential Treatment, Daniel Garcia

Middle Voices

What is currently nominated “residential treatment” for serious mental illness (SMI) has a long and varied history. From its earliest version as houses for the unproductive, to confinement of and with the unruly and criminally dangerous, to asylumdom, residential treatment has always sought to protect society from those it perceives as actively trying to revoke it. Consequently, the remedies prescribed in defense of civilization have also ranged from the gruesome to the utopian and the seat of responsibility for maintenance of the social order has vacillated between the family and the church, the local community and the state, the psychiatric …

"Chinese" And Chinoiserie: Exoticization And Orientalism In The West During The 19th And 20th Century And Its Effects On Museum Practices, Janine Salapantan

Honors Capstones

During the 19th and 20th centuries, the west experienced a keen interest in the lives of the east. In an era of mystery, the people of the west relied on furniture, textiles, and objects to fill in the gaps of their fantasy of the mystical east and its people. This led to the boom of East Asian export and attempts of replication through Chinoiserie, the west’s interpretation of East Asian aesthetics. Chinoiserie and exportquickly filled the homes of affluent families in the west, such as the Ellwood family in Dekalb. This study aims to investigate the origins of various East …

Ar Bubble Car: A Cross-Vehicle Visual Social System For Autonomous Mobility, Bingchang Zhang

Theses

AR Bubble Car argues that in L4/L5 autonomous mobility, or high to fully automated driving, the car should be understood not only as a transportation device but also as a visible social interface in public space. As driving becomes less central, the role of the vehicle shifts from control and movement alone toward passenger experience, expression, and communication. In response, AR Bubble Car proposes a transparent visual bubble around compatible vehicles, allowing passengers to share lightweight content through window-based AR. Rather than treating the car as a private entertainment container, the system explores how vehicles might become moving social nodes …

Livestock Poultry Health Committee Minutes, Clemson University Board Of Trustees, 2026 April 28, Clemson University Board Of Trustees, Clemson University Board Of Trustees

Minutes

No abstract provided.

Using The Flexon Approach To Rnai To Identify Essential Genes That Affect Gonadal Development In C. Elegans, Joyce S. Lefevers

Undergraduate Theses

To elucidate the molecular role of essential genes in the gonadal development of Caenorhabditis elegans (C. elegans) it is necessary to utilize specialized molecular techniques such that the phenotypic effects of gene knockdown can be studied while the viability of the organism is preserved. Shaffer and Greenwald (2022) developed the floxed exon (flexon), a tool that improves upon previous approaches to spatiotemporal control of gene expression. The flexon subunit is made up of an artificial exon with a stop cassette flanked by artificial introns which, when inserted into a gene of interest, prevents the expression of that gene. …

Wavetable Modification In Frequency Domain: Fourier Analysis With Matlab Implementation, Caleb Kortens

Senior Honors Theses

One of the challenges in creating computer generated music is producing life-like sounds. Music produced through computer synthesis can often sound thin and synthetic rather than vibrant and energetic. Wavetable synthesis is a method of waveform generation that uses a wavetable, which is a set of single period waves, or frames, that have varying characteristics. This method allows a synthesizer to transition between waveforms to produce a sound with time varying tone and harmonic characteristics. This adds life and movement to computer generated sounds. Wavetable synthesis is often used to imitate actual instruments, but unique wavetables can be created that …

A Functional Nutrition Literature Review For Brain Fog And Adhd-Like Symptoms In Adults, Natalie Elisani Aldahondo-Matos

Department of Nutrition Student Projects

Attention-deficit/hyperactivity disorder (ADHD) and ADHD-like symptoms, such as difficulty concentrating, mental fatigue, and problems with executive functioning, are increasingly recognized in adults. Although medication is commonly used to manage ADHD, there is growing interest in whether nutrition may also play a role in supporting brain function and attention. Several nutrients involved in brain health including omega-3 fatty acids, vitamin B12, magnesium, iron, and choline  have been suggested as potential contributors to cognitive performance and attention. However, the research examining the connection between diet and ADHD symptoms is still limited and sometimes shows mixed results.

The purpose of this project was …

Lake Sturgeon (Acipenser Fulvescens) Growth And Longevity Estimated From Adult Capture-Mark-Recapture Data, Edward A. Baker, Scott F. Colborne, Nancy A. Auer, Kim T. Scribner, Douglas L. Larson, Andrew S. Briggs, Ronald M. Bruch, Margaret H. Stadig, Michael C. Donofrio

Michigan Tech Publications

Effective fishery management policy depends on accurate life-history data, particularly for harvested species. Longevity is a core life-history trait that is directly related to annual survival and lifetime reproductive potential, but fish longevity is generally not well documented, particularly for long-lived species. We used capture-mark-recapture data spanning 44 years as an alternative method to estimate sex-specific adult lake sturgeon (Acipenser fulvescens) average annual growth and longevity for five populations in the Laurentian Great Lakes. We determined individual fish average annual growth and fit population and sex-specific exponential lines for average annual growth as a function of fish length at initial …

Utilization Of Natural Pumice Stone As A Low-Cost Ion Exchanger For Lead (Pb(Ii)) Removal: A Kinetics, Isotherms And Mechanisms Studies, Ahmad Sulaiman

Baghdad Science Journal

Pumice is one of the raw materials that is widely available, especially in the ``Middle East region and Turkey''. In this research, an ion exchanger was prepared from Syrian pumice by converting it into a low-silica ion exchanger (P_Na) for the removal of Pb²__MATH₀__⁺ uptake was 4.3 mmol/g (308.15 K). Removal efficiency was 100% at low concentrations and >80% at medium/high concentrations. The adsorption kinetics followed a pseudo-first-order model, and the equilibrium data fit well to Langmuir, Freundlich, and Redlich-Peterson isotherms (R² > 0.99).

Evaluation Of Enolase1 And Il-9 As Biomarkers To Determine Stratifying Severity Of Vaginal Candidiasis In Iraqi Women, Shams I. Ali, Teeba H. Mohammad

Baghdad Science Journal

Vaginal candidiasis is an opportunistic fungal infection of the lower female reproductive tract caused by Candida species. This study aimed to investigate the roles of Enolase 1 and Interleukin-9 in the pathophysiology of vaginal candidiasis and examine their correlations with anthropometric and lipid profile parameters. A total of 120 participants were enrolled, including 80 patients with VC and 40 healthy controls. Patients were classified into Candida albicans and non-Candida albicans groups based on clinical and microbiological criteria. Serum and vaginal secretions levels of ENO-1 and IL-9 were measured using ELISA, while lipid profiles were assessed spectrophotometrically. Both ENO-1 and IL-9 …

Molecular Characterization And Virulence Factors Of Streptococcus Mutans Isolated From Dental Caries In Type 2 Diabetic Patients, Tiba Abed Maarij Al-Ogaidi, Shaymaa Ismael Kadhim Al-Juboori

Baghdad Science Journal

Individuals with type 2 diabetes are particularly susceptible to frequent and uncontrolled dental caries. Streptococcus mutans, a main cause of dental caries, impacts millions each year and presents significant oral health challenges. Although extensively studied, the bacterium's pathogenesis remains incompletely understood, underscoring the need for further research. This study aimed to isolate and analyze the molecular characteristics of Streptococcus mutans in patients with type 2 diabetes. It explored the bacterium's capacity to infect, survive, and endure acidic oral environments. Samples were taken from 50 individuals with both type 2 diabetes and dental caries, 50 with dental plaque, and 20 …

Unh Research Aims To Reduce Wildlife-Vehicle Collisions, Scott Ripley

UNH Today Archive

No abstract provided.

Cross-Sectional Associations Of Metabolically Healthy Obesity, Lifestyle Factors, And Steatotic Liver Disease In Adults From The Fels Longitudinal Study, Ariana L Garza, Audrey C Choh, John Blangero, Cici X Bauer, Stefan A Czerwinski, Miryoung Lee

Faculty, Staff and Student Publications

Objective: To examine the associations of metabolic health and obesity phenotypes with liver fat accumulation and hepatic steatosis in adults.

Methods: We analyzed 676 non-Hispanic white adults (18-95 years; 55.8% female) from the Fels Longitudinal Study using a cross-sectional design. Participants were classified into metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO) phenotypes. Metabolically unhealthy status was defined as the presence of ≥1 metabolic dysfunction, consistent with prior epidemiological definitions; secondary analyses using ≥2 were also performed. Obesity was defined using DXA-derived body fat percentage. Liver fat (%) was …

Maternal Genetic Structure Of Iraqi Faili Kurds Revealed Using Whole Mitochondrial Genome Sequencing, Mayyadah Khalid Ibrahim, Suhaili Abu Bakar, Cheah Yoke Kqueen, Majeed Arsheed Sabbah

Baghdad Science Journal

Mitochondrial DNA (mtDNA) is a commonly utilized genetic marker in determining maternal ancestry because of the hypervariable regions in it, as well as haplogroups, which enable scientists to establish ancestral links among populations. This research involved the analysis of the complete mitochondrial genome of 100 Faili Kurd women in different cities in Iraq using the Illumina system. The most common haplogroups were HV14 (53%), H14a (16%), M37e2 (16%), and HV2a1*1 (15%). The pair-wise AMOVA-FST analysis in terms of population revealed that there were various levels of genetic differentiation between Faili Kurds and other populations in Iraq, Iran, and surrounding areas. …

Luteolin Mitigated Neuroinflammation And Glial Activation In Oxaliplatin-Induced Central And Peripheral Neuropathy In Rats, Nourhan Gamal El-Rahmany, Omar Alshazly, Mamdouh F. A. Mohamed, Amira Abd El-Rhman

Baghdad Science Journal

The objective of the current study was to evaluate the potential of luteolin to mitigate the neurotoxic effects of OXL. Oxidative injury, inflammation, and mitochondrial dysfunction are the cardinal factors in OXL-triggered neuropathy. LUT modulates sensory and motor behavioral changes induced by OXL. Notably, LUT treatment significantly (p≤ 0.05) increased antioxidant activity by increasing paraoxonase-1 (PON-1) and heme oxygenase-1 (HO-1) levels, attenuating oxidative damage. Additionally, LUT inhibited neuroinflammation by repressing the levels of toll-like receptor-4 (TLR4) and intracellular adhesion molecule-1 (ICAM-1), while significantly increasing brain-derived neurotrophic factor (BDNF) and downregulating the relative gene expression level of mitogen-activated protein kinase 14 …

A Novel Electrochemical Sensor Based On A Pencil Graphite Electrode Modified Mno2 For Detection Of Pb2+ Metal Ion In Water Samples, Rahmi Wahyuni, Trisna Kumala Sari

Baghdad Science Journal

This research aims to develop an ion Pb²⁺ sensor and determine the optimal conditions for testing Pb²⁺ ions using an MnO₂/PGE modified electrode with the voltammetric method. In this study, the Pencil Graphite Electrode (PGE) was modified using MnO₂ through drop-casting. Next, the optimization of the electrode was carried out by varying the supporting electrolyte type, voltammetric technique, and supporting electrolyte concentration. The results showed that the modified electrode (MnO₂/PGE) provided a better response for Pb²⁺ detection compared to the unmodified electrode (PGE). The optimal experimental conditions were found to be 0.1 …

Clinical Implications Of Circulating Mirna-200a And Mucin 16 In Late-Stage Colorectal Cancer: A Study In Iraqi Patients, Eman Sh. Ali, Ali W. Al-Ani

Baghdad Science Journal

Background: Colorectal cancer, the most common gastrointestinal cancer, is a significant health issue globally. Mucin 16 plays a critical role in cancer signal transduction pathways and is a potential glycoprotein target for cancer therapy. The miRNA-200 family also regulates the expression of numerous genes that play vital roles in cancer cells. This study aimed to investigate the changes in mucin 16 and miRNA-200a in patients with colorectal cancer (CRC). Subjects and Methods: Fifty-six patients with CRC, including 26 in stage 3 and 30 in stage 4, were included in this study, along with 38 healthy volunteers as a control group. …

Synthesis And Characterization Of 1,3-Thiazolidin-4-Ones Using Recyclable, Magnetically Nanocatalyst In The Solvent-Free Microwave Medium, Jawad K. Abaies, Athra G. Sager, Zeena R. Katoof

Baghdad Science Journal

In the present work, an environmentally friendly nano-catalyst (γ Fe₂O₃RHA@SO₃H) was used for the preparation of 1,3-thiazolidin-4-ones analogs (T₁-T₉) from Schiff bases (S1-S9) by microwave irradiation. The recycled catalyst (γ Fe₂O₃RHA@SO₃H) was produced from silica derived from rice husk, which was first modified with ferrite nanoparticles (Fe₂O₃), then with sulfuric acid. The characterization of the (γ Fe₂O₃RHA@SO₃H)) nanocomposite and its characteristics were achieved using various techniques including, XRD, total acidity and basicity utilizing CO …

Docking-Based Virtual Screening Of Bisbenzylisoquinoline Derivatives From Stephania Genus Against Hepatocellular Carcinoma, Aulia Syahfitri, Denny Satria, Poppy Anjelisa Zaitun Hasibuan, Jane Melita Keliat, Syukur Berkat Waruwu, Choo Yeun-Mun

Baghdad Science Journal

Hepatocellular carcinoma (HCC) is one of the most common and aggressive subtypes of liver cancer. It has a poor prognosis, a high rate of recurrence and shows limited response to current therapies. In order to combat this condition, the use of natural products as multitarget anticancer agents is gaining momentum. In this study, we investigated the medicinal value of bisbenzylisoquinoline (BBI) alkaloids from the Stephania genus via an integrative in silico approach. Due to their improved pharmacokinetic profiles and expected low toxicity, we chose 11 BBI derivatives. Network pharmacology analysis revealed 334 overlapped targets between the compounds and HCC. Functional …

Utilization Of Pensi Shell Waste As Hydroxyapatite Composite With Biopolymer From Shrimp Shell And Peg And Its Application, Novesar Jamarun, Nabiila Ayyu Trycahyani, Upita Septiani, Vivi Sisca, Muhammad Refki Novesar, Sri Mulya

Baghdad Science Journal

This study focuses on the synthesis, structural analysis and antibacterial properties of a composite comprising hydroxyapatite (HAp), polyethylene glycol (PEG) and chitosan (CTS). CTS was extracted from shrimp shells, and CaO for Hap was obtained from pensi shell. These composites were synthesized using the sol-gel method in situ by varying the concentrations of PEG (5, 10, 15, 20 and 25%) and CTS (1, 2, 3, 4, and 5%). The synthesized composites were characterized using FTIR, XRD, SEM-EDX, and TGA-DTA analyses, and their antimicrobial activities were also evaluated. The HAp-PEG-Chitosan composite with 5% chitosan and 10% PEG was identified as the …

Analysis Of Phytochemical Compounds From The Leaves Of Kitaibelia Balansae Plant And Their Biological Activity On Some Fungi, Ayten Ozturk, Zerrin Zerenler Caliskan, Fadime Yildirim Dimen, Meysun Ibrahim Abdullah

Baghdad Science Journal

In this work, the preliminary phytochemical screening of the compounds found in the leaf extracts of Kitaibelia balansae Boiss. plant, obtained from solvents of different polarities, was investigated by LC/ESI/QTOF in the negative ion mode, and their biological activity on fungal species was studied. More than sixty compounds were observed, most of which were recognized and identified as flavonoids of all classes. Acids such as shikimic, chlorogenic, jasmonic, and its ester, methyl jasmonate, were also detected. The activity of these extracts on fungi was investigated and the results showed a dual biological effect on fungi Fusarium solani and F. equiseti, …

Isolation And Identification Of Airborne Bacteria Within The University Of Baghdad Campus, Iraq By Using 16s Rrna Gene Technique, Shahad Emad Muheisen, Israa Mohsin Jasim, Fouad K. Mashee Al-Ramahi

Baghdad Science Journal

This study aimed to identify and classify airborne bacteria in outdoor air within the campus of the University of Baghdad, Iraq, using the passive sampling technique. Air samples were collected from ten sites and analyzed by the 16S rRNA gene sequencing technique. The results revealed significant seasonal differences in both microbial and particulate matter concentrations. Bacterial concentrations were considerably higher during the wet season, with 3238.6 CFU/m³ compared to the dry season, with 1872.6 CFU/m³. PM2.5 levels averaged 47.58 μg/m³ in the wet season and declined to 11.33 μg/m³ in the dry season, while PM10 …

Microarray Analysis Of Human Abdominal Aortic Aneurysm With Emphasis On Cardiovascular Genes Revealed Differentially Expressed Genes, Song Lu, Li Ping Li, John V. White, Xiaoying Zhang, Ifeyinwa Nwaneshiudu, Adaobi Nwaneshiudu, Nectaria Ntaoula, John Gaughan, Dimitri S. Monos, Wan-Lu Lin, Charalambos C. Solomides, Emilia L. Oleszak, Chris D. Platsoucas

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND/AIM: We examined gene expression profiles in abdominal aortic aneurysm (AAA) lesions vs. normal aortas by cDNA microarray and real-time quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR).

MATERIALS AND METHODS: Phosphorus (³²P)-labeled cDNA from AAA specimens (mean AAA size 6.65 cm) and normal aortas were hybridized with a 588-gene microarray primarily of the cardiovascular system. The results were validated by qRT-PCR.

RESULTS: A total of 35 out of the 588 genes were differentially expressed, with either log₂ ratio of AAAs/controls ≥1 (upregulated; 20 genes) or ≤-1 (downregulated; 15 genes) in AAA lesions vs. normal aorta, and …

Priority Research Questions To Generate Decision-Grade Data To Enable Coastal Ecosystems To Mitigate The Climate And Nutrient Crises, Gordon J. Watson, John Aldridge, Louise Anderson, Martin J. Attrill, William E.N. Austin, Keisha D. Bahr, Nicola Beaumont, Stefanie Broszeit, Annette Burden, Estela Delgado-Gargiulo, Evangelia G. Drakou, Mike Elliott, Karen Filbee-Dexter, Robinson W. Fulweiler, Angus Garbutt, Boze Hancock, Joerg D. Hardege, Joanna Harley, Ian W. Hendy, Jenny R. Hillman, Tim D. Jickells, Ana I. Lillebø, Mariana D.A.C. Lima, Peter I. Macreadie, Paulina Martinetto, Jackie Mellan, Alf Norkko, Ruth Parker, Michael P. Perring, Bernadette Pogoda

School of Biological and Marine Sciences

Nature-Based Solutions, green-finance instruments and policies are now routinely constructed around carbon sequestration/storage (CSS) and nutrient bioremediation (NB). This integration builds on how Market-Based Instruments (e.g. payments-for-ecosystem-services) are regularly used in policies focused on terrestrial ecosystems. In marine and coastal systems poor understanding of CSS/NB biophysical processes and impacts of ecosystem quality/stressors, combined with methods and governance framework knowledge gaps, generate substantial uncertainty in outcomes. Reductions in output confidence preclude integration into Nature-Based Solutions, stifling market-based investment centred on conserving and restoring temperate coastal ecosystems. To navigate this complex, rapidly evolving area, researchers from six continents engaged in a Priority …

Yap Induces A Prorenewal Metabolic State In Cardiomyocytes, Lin Liu, Jeffrey D Steimle, Chang-Ru Tsai, Fansen Meng, Yuka Morikawa, Yi Zhao, Sandra Carmichael, Xiao Li, James F Martin

Faculty, Staff and Students Publications

BACKGROUND: Cardiomyocytes, as highly specialized and differentiated somatic cells, possess a limited capacity for renewal. Neonatal rodents possess the ability to regenerate cardiomyocytes after injury; however, this regenerative capacity declines rapidly with cardiomyocyte maturation, suggesting an inhibitory network between cellular maturation and cardiomyocyte proliferation. Maturing cardiomyocytes undergo a metabolic shift from predominantly glycolysis in the neonatal state to increased fatty acid oxidation in the mature state, which poses a barrier to cardiomyocyte proliferation and cardiac regenerative repair. YAP, a transcriptional cofactor regulated by the Hippo signaling pathway, promotes cardiac regenerative repair. We investigated the role of YAP in mediating metabolic …