Digital Commons Network^™

Modulating Angiogenesis By Proteomimetics Of Vascular Endothelial Growth Factor, Jianfeng Cai, Sami Abdulkadir

USF Patents

Provided herein are novel VEGF mimics, pharmaceutical compositions thereof, and methods of their use in increasing or reducing angiogenesis.

Colliding Worlds: Visual Culture In France And Colonial Algeria (1918-1962), Lacy Murphy

Arts & Sciences Graduate Student Theses and Dissertations

The decline of French colonialism in Algeria and the Algerian War lay at the fault line of several tectonic forces. World War I, World War II, and the Cold War challenged France’s global stature, destabilized the colonial apparatus, and fostered unprecedented intercolonial intellectual exchange. These events provided the global context for Algeria’s national revolution, a prolonged period of conflict that was all in one a civil war that redefined Algerian identity, a political and military scandal that led to the downfall of the French Fourth Republic in 1958, influenced Cold War politics, and continues to shape national identity in both …

'Never Cry For Food': Food Security, Poverty, And Recurring Themes In News Media Regarding Rabbit Farming In East Africa, Kimberly E. Johnson, Julia Hayes, Patricia Davidson, Chiwoneso B. Tinago, Geoffrey Anguyo

Nutrition Faculty Publications

Rabbit farming is a form of low input agriculture that has potential to address food security and poverty in East Africa and beyond. For low input agriculture, farmers utilize local and affordable farm resources making it accessible across income levels. Understanding barriers and facilitators to rabbit farming could increase effectiveness of this form of low input agriculture in communities struggling with low food security and poverty, particularly for indigenous, smallholder farms. News media is an available source of data about community perceptions and practices on issues such as rabbit farming, food security, and poverty. For this qualitative study, researchers applied …

Autogenic Splenic Implantation Versus Splenectomy In Patients Undergoing Distal Pancreatectomy For Benign Or Low-Grade Malignant Lesions Of The Distal Pancreas: Study Protocol For A Multicentre, Open-Label, Randomized Controlled Trial (Restore), Horacio Asbun

All Publications

Background: The spleen plays a significant role in the clearance of circulating microorganisms. Sequelae of splenectomy, especially immunodeficiency, can have a deleterious effect on a patient's health and even lead to death. Hence, splenectomy should be avoided and spleen preservation during elective surgery has become a treatment goal. However, this cannot be achieved in every patient due to intraoperative technical difficulties or oncological reasons. Autogenic splenic implantation (ASI) is currently the only possible way to preserve splenic function when a splenectomy is necessary. Experience largely stems from trauma patients with a splenic rupture. Splenic immune function can be measured by …

Somali Students In The American Elementary General Music Classroom, Alice L. Charland

Masters Theses

Education must be cognizant of the Somali culture’s inclination to classify music as a morally charged entity. It must also be careful not to forget American cultural values that have defined the music classroom. The purpose of this research was to identify Somali cultural expressions that occur in the American elementary general music classroom and to identify underlying concepts that contribute to these cultural expressions. Additionally, the research sought to bring light to the relationship between the two, so that future music educators might be inspired to create assessments and activities that better suit the needs of all learners.

Indigenous Peoples And Local Communities Report Ongoing And Widespread Climate Change Impacts On Local Social-Ecological Systems, Victoria Sharakhmatova, Victoria Reyes-García, David García-Del-Amo, Santiago Álvarez-Fernández, Petra Benyei, Laura Calvet-Mir, André B. Junqueira, Vanesse Labeyrie, Xiaoyue Li, Sara Miñarro, Vincent Porcher, Anna Porcuna-Ferrer, Anna Schlingmann, Christoph Schunko, Ramin Soleymani, Adrien Tofighi-Niaki, Mariam Abazeri, Emmanuel M.N.A.N. Attoh, Ayansina Ayanlade, Julia Vieira Da Cunha Ávila, Daniel Babai, Rodrigo C. Bulamah, Joao Campos-Silva, Rosario Carmona, Julián Caviedes, Rumbidzayi Chakauya, Mouna Chambon, Zhuo Chen, Fasco Chengula, Esther Conde, Aida Cuní-Sanchez

Faculty Publications

The effects of climate change depend on specific local circumstances, posing a challenge for worldwide research to comprehensively encompass the diverse impacts on various local social-ecological systems. Here we use a place-specific but cross-culturally comparable protocol to document climate change indicators and impacts as locally experienced and analyze their distribution. We collected first-hand data in 48 sites inhabited by Indigenous Peoples and local communities and covering all climate zones and nature-dependent livelihoods. We documented 1,661 site-agreed reports of change corresponding to 369 indicators. Reports of change vary according to climate zone and livelihood activity. We provide compelling evidence that climate …

Common Heart Failure With Preserved Ejection Fraction Animal Models Yield Disparate Myofibril Mechanics, Axel J. Fenwick, Vivek P. Jani, D. Brian Foster, Thomas E. Sharp, Traci T. Goodchild, Kyle Lapenna, Jake E. Doiron, David J. Lefer, Joseph A. Hill, David A. Kass, Anthony Cammarato

School of Medicine Faculty Publications

No abstract provided.

Recommendations To Solve The Problem Of Increased Referrals At The Escambia County Alternative School In Flomaton, Alabama, Ronda Hoffman

Doctoral Dissertations and Projects

The purpose of this research study was to provide recommendations to solve the problem of increased referrals at the Escambia County Alternative School in Flomaton, Alabama. The problem was the number of referrals on file at Escambia County Alternative School increased by 50% from November/December 2021 to January/February 2022. The rationale for this study was the referrals written can impact the students in more ways than the given discipline. The central research question was, How can the problem of increased referrals be solved at the Escambia County Alternative School? Three forms of data collected for this applied research included qualitative …

“Zealous” Professional Ethics: The Transcendence Of Natural Law, Legal Positivism, And The Ethical Stage In The U.S. Legal Ethics System And The Moral Dilemma That Surround Zealous Representation, Sudarsanan Sivakumar, Marshall Maina

St. Mary's Journal on Legal Malpractice & Ethics

The zealous pursuit of law has its own ideals and dogma that sets it apart from the other rules in the Model Rules of Professional Conduct. Decades after many enactments and amendments, there still exists many debates considering its operation as to whether an attorney owes a duty toward society over the representation of the client. This is a Delphi method that has made even the best seasoned ‘Justiciar’ and ‘Legislator’ unable to find the proper guidelines to implement upon the Legal Superstructure. The Model Rules of Professional Conduct attempt to clear the fog around the existing principle of Zealous …

Cell Membrane-Anchored And Tumor-Targeted Il-12 T-Cell Therapy Destroys Cancer-Associated Fibroblasts And Disrupts Extracellular Matrix In Heterogenous Osteosarcoma Xenograft Models, Jiemiao Hu, Alexander J Lazar, Davis Ingram, Wei-Lien Wang, Wendong Zhang, Zhiliang Jia, Dristhi Ragoonanan, Jian Wang, Xueqing Xia, Kris Mahadeo, Richard Gorlick, Shulin Li

Faculty, Staff and Student Publications

Background: The extracellular matrix (ECM) and cancer-associated fibroblasts (CAFs) play major roles in tumor progression, metastasis, and the poor response of many solid tumors to immunotherapy. CAF-targeted chimeric antigen receptor-T cell therapy cannot infiltrate ECM-rich tumors such as osteosarcoma.

Method: In this study, we used RNA sequencing to assess whether the recently invented membrane-anchored and tumor-targeted IL-12-armed (attIL12) T cells, which bind cell-surface vimentin (CSV) on tumor cells, could destroy CAFs to disrupt the ECM. We established an in vitro model of the interaction between osteosarcoma CAFs and attIL12-T cells to uncover the underlying mechanism by which attIL12-T cells penetrate …

Effects Of Kras Genetic Interactions On Outcomes In Cancers Of The Lung, Pancreas, And Colorectum, Isabella N Grabski, John V Heymach, Kenneth L Kehl, Scott Kopetz, Ken S Lau, Gregory J Riely, Deborah Schrag, Rona Yaeger, Rafael A Irizarry, Kevin M Haigis

Faculty, Staff and Student Publications

Background: KRAS is among the most commonly mutated oncogenes in cancer, and previous studies have shown associations with survival in many cancer contexts. Evidence from both clinical observations and mouse experiments further suggests that these associations are allele- and tissue-specific. These findings motivate using clinical data to understand gene interactions and clinical covariates within different alleles and tissues.

Methods: We analyze genomic and clinical data from the AACR Project GENIE Biopharma Collaborative for samples from lung, colorectal, and pancreatic cancers. For each of these cancer types, we report epidemiological associations for different KRAS alleles, apply principal component analysis (PCA) to …

Hypoxia-Activated Prodrug And Antiangiogenic Therapies Cooperatively Treat Pancreatic Cancer But Elicit Immunosuppressive G-Mdsc Infiltration, Arthur Liu, Seth T Gammon, Federica Pisaneschi, Akash Boda, Casey R Ager, David Piwnica-Worms, David S Hong, Michael A Curran

Faculty, Staff and Student Publications

We previously showed that ablation of tumor hypoxia can sensitize tumors to immune checkpoint blockade (ICB). Here, we used a Kras+/G12D TP53+/R172H Pdx1-Cre-derived (KPC-derived) model of pancreatic adenocarcinoma to examine the tumor response and adaptive resistance mechanisms involved in response to 2 established methods of hypoxia-reducing therapy: the hypoxia-activated prodrug TH-302 and vascular endothelial growth factor receptor 2 (VEGFR-2) blockade. The combination of both modalities normalized tumor vasculature, increased DNA damage and cell death, and delayed tumor growth. In contrast with prior cancer models, the combination did not alleviate overall tissue hypoxia or sensitize these KPC tumors to ICB therapy …

Multiple Pathways For Glucose Phosphate Transport And Utilization Support Growth Of Cryptosporidium Parvum, Rui Xu, Wandy L Beatty, Valentin Greigert, William H Witola, L David Sibley

2020-Current year OA Pubs

Cryptosporidium parvum is an obligate intracellular parasite with a highly reduced mitochondrion that lacks the tricarboxylic acid cycle and the ability to generate ATP, making the parasite reliant on glycolysis. Genetic ablation experiments demonstrated that neither of the two putative glucose transporters CpGT1 and CpGT2 were essential for growth. Surprisingly, hexokinase was also dispensable for parasite growth while the downstream enzyme aldolase was required, suggesting the parasite has an alternative way of obtaining phosphorylated hexose. Complementation studies in E. coli support a role for direct transport of glucose-6-phosphate from the host cell by the parasite transporters CpGT1 and CpGT2, thus …

Age-Related Differences In Motor Skill Transfer With Brief Memory Reactivation, Kylie B Tomlin, Brian P Johnson, Kelly P Westlake

2020-Current year OA Pubs

Motor memories can be strengthened through online practice and offline consolidation. Offline consolidation involves the stabilization of memory traces in post-practice periods. Following initial consolidation of a motor memory, subsequent practice of the motor skill can lead to reactivation and reconsolidation of the memory trace. The length of motor memory reactivation may influence motor learning outcomes; for example, brief, as opposed to long, practice of a previously learned motor skill appears to optimize intermanual transfer in healthy young adults. However, the influence of aging on reactivation-based motor learning has been scarcely explored. Here, the effects of brief and long motor …

Clpfudatabase: A Suite Of R Packages For Energy Conversion Chain Analysis, Matthew Kuperus Heun, Zeke Marshall, Emmanuel Aramendia

University Faculty Publications and Creative Works

Energy flowing through societal energy conversion chains (ECCs) enables economic activity and facilitates human flourishing. To understand economic growth and human well-being, the field of societal energy analysis (Common, 1976) evaluates ECCs from the primary stage (resources extracted from the environment, such as coal, oil, natural gas, wind, and solar), to the final stage (energy purchased by consumers, such as refined petroleum and electricity), to the useful stage (energy desired by the end user, such as heat, motion, and light), and sometimes to energy services (such as thermal comfort, transport, and illumination). Societal exergy analysis (SEA) (Ertesvåg, 2001), an extension …

Clpfudatabase: A Suite Of R Packages For Energy Conversion Chain Analysis, Matthew Kuperus Heun, Zeke Marshall, Emmanuel Aramendia

University Faculty Publications and Creative Works

Energy flowing through societal energy conversion chains (ECCs) enables economic activity and facilitates human flourishing. To understand economic growth and human well-being, the field of societal energy analysis (Common, 1976) evaluates ECCs from the primary stage (resources extracted from the environment, such as coal, oil, natural gas, wind, and solar), to the final stage (energy purchased by consumers, such as refined petroleum and electricity), to the useful stage (energy desired by the end user, such as heat, motion, and light), and sometimes to energy services (such as thermal comfort, transport, and illumination). Societal exergy analysis (SEA) (Ertesvåg, 2001), an extension …

Effectiveness Of Emotionally Focused Therapy (Eft) With Chinese Couple Clients: From The Chinese Eft Therapists' Cultural Lens, Yifan Wang

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to understand the Chinese EFT (Emotionally Focused Therapy) therapists’ experiences of working with Chinese couples in EFT sessions, as well as to discover how the cultural factors play a role in the effectiveness of EFT use with Chinese couples. This study was conducted by finding out 10 EFT-oriented therapists and analyzing via online interviews their experiences of working with Chinese couples. The theories guiding this study are based on Emotionally Focused Therapy (EFT). One of the founding therapists of this approach is Dr. Sue Johnson. EFT is heavily influenced by attachment theory, which …

The Mental Health Effects Of Vicarious Trauma, Moral Injury, And Positive Religious Coping With Canine Comfort Handlers, Terri Jeanne O'Brien-Cross

Doctoral Dissertations and Projects

The intention of this study was to examine whether positive religious coping buffered the mental health effects of vicarious trauma and moral injuries in canine comfort handlers. By examining whether positive religious coping would reduce symptoms of posttraumatic stress disorder (PTSD), a better understanding of the mental, emotional, and spiritual effects of volunteer handlers was discovered. Handlers work throughout their communities and deploy to crisis events such as mass shootings and natural disasters. By partnering with highly trained canines, they provide support and comfort to those in need. During these interactions, handlers are often exposed to traumatic situations and may …

Philosophies Of Empirical And Habitual Teaching: Healthy Vocal Methodologies In Higher Education For The Twenty-First Century, Katie Denise Osuamkpe

Doctoral Dissertations and Projects

Despite research done on healthy vocal methodologies, there are continuous changes in how best to prepare collegiate music students, relating to their emotional health through empirical and habitual teachings. This study will show how healthy vocal methodologies can influence higher education vocal students of the twenty-first century. This qualitative study can build a bridge to related topics in an exploratory framework with perspectives on: Dr. William Hettler’s Emotional Well-Being and its seven dimensions, Jean Piaget's Cognitive Construction Theory, Peter Salovey and John Mayer's Emotional Intelligence Theory, Daniel Goleman’s Social Emotional Learning Methodology, Susan Brookhart’s “Classroometrics” Theory, Howard Gardner’s Theory of …

Tfeb Drives Mtorc1 Hyperactivation And Kidney Disease In Tuberous Sclerosis Complex, Nicola Alesi, Damir Khabibullin, Dean M Rosenthal, Elie W Akl, Pieter M Cory, Michel Alchoueiry, Samer Salem, Melissa Daou, William F Gibbons, Jennifer A Chen, Long Zhang, Harilaos Filippakis, Laura Graciotti, Caterina Miceli, Jlenia Monfregola, Claudia Vilardo, Manrico Morroni, Chiara Di Malta, Gennaro Napolitano, Andrea Ballabio, Elizabeth P Henske

Duncan NRI Faculty and Staff Publications

Tuberous Sclerosis Complex (TSC) is caused by TSC1 or TSC2 mutations, leading to hyperactivation of mechanistic target of rapamycin complex 1 (mTORC1) and lesions in multiple organs including lung (lymphangioleiomyomatosis) and kidney (angiomyolipoma and renal cell carcinoma). Previously, we found that TFEB is constitutively active in TSC. Here, we generated two mouse models of TSC in which kidney pathology is the primary phenotype. Knockout of TFEB rescues kidney pathology and overall survival, indicating that TFEB is the primary driver of renal disease in TSC. Importantly, increased mTORC1 activity in the TSC2 knockout kidneys is normalized by TFEB knockout. In TSC2-deficient …

The Immune System And Metabolic Products In Epilepsy And Glioma-Associated Epilepsy: Emerging Therapeutic Directions, Shashwat Tripathi, Cody L Nathan, Matthew C Tate, Craig M Horbinski, Jessica W Templer, Joshua M Rosenow, Timothy L Sita, Charles D James, Benjamin Deneen, Stephen D Miller, Amy B Heimberger

Faculty, Staff and Students Publications

Epilepsy has a profound impact on quality of life. Despite the development of new antiseizure medications (ASMs), approximately one-third of affected patients have drug-refractory epilepsy and are nonresponsive to medical treatment. Nearly all currently approved ASMs target neuronal activity through ion channel modulation. Recent human and animal model studies have implicated new immunotherapeutic and metabolomic approaches that may benefit patients with epilepsy. In this Review, we detail the proinflammatory immune landscape of epilepsy and contrast this with the immunosuppressive microenvironment in patients with glioma-related epilepsy. In the tumor setting, excessive neuronal activity facilitates immunosuppression, thereby contributing to subsequent glioma progression. …

Steeper Size Spectra With Decreasing Phytoplankton Biomass Indicate Strong Trophic Amplification And Future Fish Declines, Angus Atkinson, Axel G. Rossberg, Ursula Gaedke, Gary Sprules, Ryan F. Heneghan, Stratos Batziakas, Maria Grigoratou, Elaine Fileman, Katrin Schmidt, Constantin Frangoulis

School of Geography, Earth and Environmental Sciences

Under climate change, model ensembles suggest that declines in phytoplankton biomass amplify into greater reductions at higher trophic levels, with serious implications for fisheries and carbon storage. However, the extent and mechanisms of this trophic amplification vary greatly among models, and validation is problematic. In situ size spectra offer a novel alternative, comparing biomass of small and larger organisms to quantify the net efficiency of energy transfer through natural food webs that are already challenged with multiple climate change stressors. Our global compilation of pelagic size spectrum slopes supports trophic amplification empirically, independently from model simulations. Thus, even a modest …

Comparing The Effectiveness Of Static And Dynamic Audiovisual In An Additional Geography Lesson In One Pathway College In Jakarta, Erni Adelina, Peny Meliaty Hutabarat

Jurnal Vokasi Indonesia

Students are now used to using audiovisual platforms to learn as they once were forced to adapt to this type of learning due to face-to-face lessons were impossible at that time because of the pandemic. Audiovisual learning resources came out sporadically to accommodate the needs of study at home or anywhere possible. The static audiovisual (enhanced podcast) and dynamic audiovisual (video) are two types of virtual platforms educators continuously harness to support their lesson teachings even though the face-to-face meetings have been allowed gradually. However, there are not many studies conducted to analyze whether one type is more effective in …

Perceived Influence Of Career And Technical Student Organizations On Postsecondary Choices, Deborah K. Marshall

Doctor of Education Program Dissertations

The purpose of this basic qualitative research study was to explore the perceptions of former career and technical student organization (CTSO) members’ postsecondary choices relative to their involvement in CTSOs in a midsize city high school. The research question that guided this qualitative study was:

How do former participants in CTSOs describe the student organization’s influence on their postsecondary choices?

Thirteen former CTSO members participated in this study through semistructured individual interviews. Four themes emerged from the data: (a) use of soft skills, (b) engagement with others, (c) participation in conferences, and (d) leadership preparation. Through data analysis, the themes …

A Survey Of Proximal Sensilla Associated With Denticle Subrows On Scorpion Pedipalp Fingers (Arachnida: Scorpiones), With Observations On Scorpion Fluorescence, Graeme Lowe, Victor Fet

Euscorpius

Sensilla on the dentate margins of scorpion pedipalp fingers, associated with denticle subrows or terminal denticles, were surveyed by white light, UV fluorescence and scanning electron microscopy. A total of 163 species belonging to 103 genera from 19 families were examined, representing all major phylogenetic lineages in the order. In the majority of species (141/152) with dentition organized into linear subrows of median denticles, a small socketed sensillum with a short shaft was observed at the proximal terminus of each subrow, termed a ‘subrow proximal sensilla’ (SPS). With few exceptions, SPS were non-fluorescent (‘Type N’) in buthids, and fluorescent (‘Type …

Developing And Sustaining A Graphic Scholarship Collection For Academic Libraries, Stewart Brower, Toni Hoberecht, Zane Ratcliffe, Bethie Seay

SANE journal: Sequential Art Narrative in Education

In early 2021, the Schusterman Library at the University of Oklahoma-Tulsa satellite campus took a new step towards building a culture of interest by creating the Graphic Scholarship Collection. This new endeavor is a curated collection of graphic novels, primarily non-fiction, aligned with the academic programs on campus, as well as promoting University initiatives in diversity, equity, and inclusion. A new organizational structure for the collection materials and their circulation metrics will be examined in detail. There will also be consideration of the challenges of selection and acquisition by a mixed team of selectors, some of whom have no experience …

Illustrating Thoughts & Feelings: Student-Produced Political Cartoons About Israel, Matt Reingold

SANE journal: Sequential Art Narrative in Education

This paper presents the findings of a qualitative study about the inclusion of arts-based assessment strategies in a 12th grade Israel education classroom. Students were tasked with producing a political cartoon that demonstrated their understandings of contemporary Israeli society. Data was collected from interviews and students' original artwork. The findings revealed that learning through the arts provided students with opportunities to think about and express their feelings about Israel in aesthetically complex and personal ways. The findings also demonstrated the importance of pre-assessment strategies like frequent exposure to the genre of political cartoons and conferencing before submission.

The Utah Statesman, January 8, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Obit - Jerry W. Ellis, Journal-Gazette Times-Courier

EIU in the News

No abstract provided.

General Education Subcommittee Minutes 12-7-2023, Utah State University

Educational Policies Committee

• Call to Order - Matt Sanders
• Approval of Minutes- November2, 2023
• Course Approvals/Removals/Syllabi Approvals
• New Business
• Additional Items
• Adjourn: 9:26