Digital Commons Network^™

Mmwave Rat Optimization: Mac Layer Initial Access Design And Transport Layer Integration, Suresh Srinivasan

Dissertations and Theses

MmWave Radio Access Technology (RAT) is a promising technology for wireless communication due its large bandwidth and is already being deployed in 5G cellular and emerging WiFi technologies. MmWave systems use highly directional beams with narrow beamwidths to overcome the high path loss associated with their frequency bands. A mmWave radio can be used either in a standalone mode (where all radios use the same technology) or simultaneously with other technologies such as LTE and low frequency WiFi in a communication mode commonly referred to as integrated mode. This thesis proposes two methods to optimize mmWave RAT performance in both …

Elucidating Neuroinflammation In Multiple Sclerosis By Network Analysis, Nora C. Welsh

Dartmouth College Ph.D Dissertations

Multiple sclerosis (MS) is a heterogeneous disease, differing on many variables, including disease course, sex, and overall activity. Key characteristics of the disease encompass demyelination, axonal damage, neuronal loss, glial cell activation, and the infiltration of peripheral immune cells. Molecular proxies of these functions are secreted proteins, including cytokines and immunoglobulins, which, in the central nervous system (CNS), can be secreted into the cerebrospinal fluid (CSF). A detailed analysis of these secreted proteins can offer insights into the evolving immunological and neurodegenerative features as the disease progresses. To understand the dynamic biological processes involved in MS, I used network analysis …

Animal Science News (February 13, 2024), Department Of Animal Science

Animal Science Newsletters

No abstract provided.

Real-Time Assessment Of Rodent Engagement Using Aruco Markers: A Scalable And Accessible Approach For Scoring Behavior In A Nose-Poking Go/No-Go Task, Jeffrey R. Capadona

Faculty Scholarship

In the field of behavioral neuroscience, the classification and scoring of animal behavior play pivotal roles in the quantification and interpretation of complex behaviors displayed by animals. Traditional methods have relied on video examination by investigators, which is labor-intensive and susceptible to bias. To address these challenges, research efforts have focused on computational methods and image-processing algorithms for automated behavioral classification. Two primary approaches have emerged: marker-and markerless-based tracking systems. In this study, we showcase the utility of “Augmented Reality University of Cordoba” (ArUco) markers as a marker-based tracking approach for assessing rat engagement during a nose-poking go/no-go behavioral task. …

International Law And Acoustic Antagonism In East Asian Waters, Matt D. Montazzoli, John C. Tramazzo

International Law Studies

This article analyzes a 2023 maritime incident in which the Chinese Navy Ship (CNS) Ningbo employed active sonar in the vicinity of His Majesty’s Australian Ship (HMAS) Toowoomba, while knowing that Toowoomba had divers in the water. The Chinese sonar caused injuries to the Australian divers. The article discusses the employment of acoustic devices to cause harm during peacetime and analyzes whether CNS Ningbo’s actions constituted a failure of "due regard" and other applicable legal regimes and norms. The article concludes that CNS Ningbo’s actions were an unlawful use of force and failed to demonstrate due regard, and that …

Food Systems Under Shock: The Evolution Of Food Security Status Of Karantina Residents After The Beirut Explosion, Mariana Makoukji, Nour El Houda Amhez, Abed Al Kareem Yehya, Hala Ghattas Ph.D., Yaser Abunnasr, Rami Zurayk

Faculty Publications

Robust food systems are crucial for ensuring access to affordable and nutritious food, particularly in times of crisis. Economic instability, currency devaluation, and political turmoil can disrupt food systems, leading to higher food prices, compromised nutrition, and increased vulnerability. Lebanon is a stark example of this, where a catastrophic explosion in Beirut’s Port in 2020 worsened an existing economic and humanitarian crisis. The depreciation of the Lebanese currency led to soaring food prices, impacting people’s ability to buy food, and pushing many into poverty, illustrating the significant impact of the state food systems during crises (FAO, 2021). In times of …

U.S. Cereal Rye Winter Cover Crop Growth Database, Alexandra M. Huddell, Resham Thapa, Guillermo S. Marcillo, Lori J. Abendroth, Victoria J. Ackroyd, Shalamar D. Armstrong, Gautam Asmita, Muthukumar V. Bagavathiannan, Kipling S. Balkcom, Andrea Basche, Shawn Beam, Kevin Bradley, Lucas Pecci Canisares, Heather Darby, Adam S. Davis, Pratap Devkota, Warren A. Dick, Jeffery A. Evans, Wesley J. Everman, Tauana Ferreira De A Lmeida, Michael L. Flessner, Lisa M. Fultz, Stefan Gailans, Masoud Hashemi, Joseph Haymaker, Matthew J. Helmers, Nicholas Jordan, Thomas C. Kaspar, Quirine M. Ketterings, Eileen Kladivko, Alexandra Kravchenko, Eugene P. Law, Lauren Lazaro, Ramon G. Leon, Jeffrey Liebert, John Lindquist, Kristen Loria, Jodie M. Mcvane, Jarrod O. Miller, Michael J. Mulvaney, Nsalambi V. Nkongolo, Jason K. Norsworthy, Binaya Parajuli, Christopher Pelzer, Cara Peterson, Hanna Poffenbarger, Pratima Poudel, Mark S. Reiter, Matt Ruark, Matthew R. Ryan, Spencer Samuelson, John E. Sawyer, Sarah Seehaver, Lovreet S. Shergill, Yogendra Raj Upadhyaya, Mark Vangessel, Ashley L. Waggoner, John M. Wallace, Samantha Wells, Charles White, Bethany Wolters, Alex Woodley, Rongzhong Ye, Eric Youngerman, Brian A. Needelman, Steven B. Mirsky

Department of Agronomy and Horticulture: Faculty Publications

Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States. The dataset includes a total of 5,695 cereal rye biomass observations across 208 site-years between 2001–2022 and encompasses …

Protecting Human And Animal Health: The Road From Animal Models To New Approach Methods, Barbara L F Kaplan, Alan M Hoberman, William Slikker, Mary Alice Smith, Emanuela Corsini, Thomas B Knudsen, M Sue Marty, Sonya K Sobrian, Suzanne C Fitzpatrick, Marcia H Ratner, Donna L Mendrick

Faculty, Staff and Student Publications

Animals and animal models have been invaluable for our current understanding of human and animal biology, including physiology, pharmacology, biochemistry, and disease pathology. However, there are increasing concerns with continued use of animals in basic biomedical, pharmacological, and regulatory research to provide safety assessments for drugs and chemicals. There are concerns that animals do not provide sufficient information on toxicity and/or efficacy to protect the target population, so scientists are utilizing the principles of replacement, reduction, and refinement (the 3Rs) and increasing the development and application of new approach methods (NAMs). NAMs are any technology, methodology, approach, or assay used …

Temporal Relation Between Pubertal Development And Peer Victimization In A Prospective Sample Of Us Adolescents, Jessica A. Marino, Elysia Poggi Davis, Laura M. Glynn, Curt A. Sandman, Jennifer Hahn-Holbrook

Psychology Faculty Articles and Research

Peer victimization typically peaks in early adolescence, leading researchers to hypothesize that pubertal timing is a meaningful predictor of peer victimization. However, previous methodological approaches have limited our ability to parse out which puberty cues are associated with peer victimization because gonadal and adrenal puberty, two independent processes, have either been conflated or adrenal puberty timing has been ignored. In addition, previous research has overlooked the possibility of reverse causality—that peer victimization might drive pubertal timing, as it has been shown to do in non-human primates. To fill these gaps, we followed 265 adolescents (47% female) prospectively across three-time points …

The Prospector, February 13, 2024, Utep Student Publications

The Prospector

No abstract provided.

Rehabilitation Clinicians’ Use Of Mainstream Wireless Technologies In Practice: A Scoping Review, Brad E. Dicianno, Angad Salh, Lindsey Morris, Dan Ding

Student Publications

Purpose

This scoping review was conducted to understand the barriers, facilitators, and education and training needs of rehabilitation clinicians in their use of mainstream wireless technologies (MWT) to support people with disabilities and older adults. It was also conducted to understand the functional skills of clients that were targeted with MWT use.

Materials and methods

This scoping review was reported using PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews) and the Population (or Participants)/Concept/Context) framework. We searched PubMed; ProQuest to access APA PsycINFO; Web of Science Core Collection; and EBSCOhost to access Cumulated Index to …

Moving Toward Elucidating Alternative Motor Pathway Structures Post-Stroke: The Value Of Spinal Cord Neuroimaging, Ramiro Oquita, Victoria Cuello, Sarvani Uppati, Sravani Mannuru, Daniel Salinas, Michael R. Dobbs, Kelsey Potter-Baker

School of Medicine Publications

Stroke results in varying levels of motor and sensory disability that have been linked to the neurodegeneration and neuroinflammation that occur in the infarct and peri-infarct regions within the brain. Specifically, previous research has identified a key role of the corticospinal tract in motor dysfunction and motor recovery post-stroke. Of note, neuroimaging studies have utilized magnetic resonance imaging (MRI) of the brain to describe the timeline of neurodegeneration of the corticospinal tract in tandem with motor function following a stroke. However, research has suggested that alternate motor pathways may also underlie disease progression and the degree of functional recovery post-stroke. …

The Prevalence, Etiology And Treatment Of Gastroduodenal Ulcers And Perforation: A Systematic Review, Rizki Amalia, Amie Vidyani, Reny I'Tishom, Wiwin Is Efendi, Edwin Danardono, Bogi Pratomo Wibowo, Muhammad Lutfi Parewangi, Muhammad Miftahussurur, Hoda M Malaty

Faculty, Staff and Students Publications

(1) Background: Gastroduodenal perforation (GDP) is a life-threatening condition caused by a spontaneous or traumatic event. Treatment should be based on the mechanism of damage, timing, location, extent of the injury, and the patient's clinical condition. We aimed to examine several etiologic factors associated with gastroduodenal perforation and to search for the best method(s) for its prevention and treatment. (2) Methods: We conducted extensive literature reviews by searching numerous studies obtained from PubMed, Science Direct, and Cochrane for the following keywords: gastroduodenal perforation,

Engineering Human Pluripotent Stem Cell Lines To Evade Xenogeneic Transplantation Barriers, Hannah A Pizzato, Paula Alonso-Guallart, James Woods, Jon P Connelly, Todd A Fehniger, John P Atkinson, Shondra M Pruett-Miller, Frederick J Monsma Jr, Deepta Bhattacharya

2020-Current year OA Pubs

Successful allogeneic human pluripotent stem cell (hPSC)-derived therapies must overcome immunological rejection by the recipient. To build reagents to define these barriers, we genetically ablated β2M, TAP1, CIITA, CD74, MICA, and MICB to limit expression of HLA-I, HLA-II, and natural killer (NK) cell activating ligands in hPSCs. Transplantation of these cells that also expressed covalent single chain trimers of Qa1 and H2-K

Dynamic Changes In The Mouse Hepatic Lipidome Following Warm Ischemia Reperfusion Injury, Kim H H Liss, Muhammad Mousa, Shria Bucha, Andrew Lutkewitte, Jeremy Allegood, L Ashley Cowart, Brian N Finck

2020-Current year OA Pubs

Liver failure secondary to metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common cause for liver transplantation in many parts of the world. Moreover, the prevalence of MASLD not only increases the demand for liver transplantation, but also limits the supply of suitable donor organs because steatosis predisposes grafts to ischemia-reperfusion injury (IRI). There are currently no pharmacological interventions to limit hepatic IRI because the mechanisms by which steatosis leads to increased injury are unclear. To identify potential novel mediators of IRI, we used liquid chromatography and mass spectrometry to assess temporal changes in the hepatic lipidome in …

Connexin43 In Mesenchymal Lineage Cells Regulates Body Adiposity And Energy Metabolism In Mice, Seung-Yon Lee, Francesca Fontana, Toshifumi Sugatani, Ignacio Portales Castillo, Giulia Leanza, Ariella Coler-Reilly, Roberto Civitelli

2020-Current year OA Pubs

Connexin43 (Cx43) is the most abundant gap junction protein present in the mesenchymal lineage. In mature adipocytes, Cx43 mediates white adipose tissue (WAT) beiging in response to cold exposure and maintains the mitochondrial integrity of brown adipose tissue (BAT). We found that genetic deletion of Gja1 (Cx43 gene) in cells that give rise to chondro-osteogenic and adipogenic precursors driven by the Dermo1/Twist2 promoter led to lower body adiposity and partial protection against the weight gain and metabolic syndrome induced by a high-fat diet (HFD) in both sexes. These protective effects were related to increased locomotion, fuel utilization, energy expenditure, nonshivering …

Lysosome-Related Organelles Contain An Expansion Compartment That Mediates Delivery Of Zinc Transporters To Promote Homeostasis, Adelita D Mendoza, Nicholas Dietrich, Chieh-Hsiang Tan, Daniel Herrera, Jennysue Kasiah, Zachary Payne, Ciro Cubillas, Daniel L Schneider, Kerry Kornfeld

2020-Current year OA Pubs

Zinc is an essential nutrient-it is stored during periods of excess to promote detoxification and released during periods of deficiency to sustain function. Lysosome-related organelles (LROs) are an evolutionarily conserved site of zinc storage, but mechanisms that control the directional zinc flow necessary for homeostasis are not well understood. In

Dna Hypomethylation Ameliorates Erosive Inflammatory Arthritis By Modulating Interferon Regulatory Factor-8, Gaurav Swarnkar, Nicholas P Semenkovich, Manoj Arra, Dorothy K Mims, Syeda Kanwal Naqvi, Timothy Peterson, Gabriel Mbalaviele, Chia-Lung Wu, Yousef Abu-Amer

2020-Current year OA Pubs

Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and restore immune homeostasis. In the present study, we demonstrate that DAC elicits potent anti-inflammatory effects and attenuates disease symptoms in several animal models of arthritis. Transcriptomic and epigenomic profiling show that DAC-mediated hypomethylation regulates a wide range of cell types in arthritis, altering the differentiation trajectories of anti-inflammatory macrophage populations, regulatory T cells, and tissue-protective synovial fibroblasts (SFs). Mechanistically, DAC-mediated demethylation of intragenic 5'-Cytosine phosphate Guanine-3' (CpG) islands of the …

A General Computational Design Strategy For Stabilizing Viral Class I Fusion Proteins, Karen J Gonzalez, Jiachen Huang, Miria F Criado, Avik Banerjee, Stephen M Tompkins, Jarrod J Mousa, Eva-Maria Strauch

2020-Current year OA Pubs

Many pathogenic viruses rely on class I fusion proteins to fuse their viral membrane with the host cell membrane. To drive the fusion process, class I fusion proteins undergo an irreversible conformational change from a metastable prefusion state to an energetically more stable postfusion state. Mounting evidence underscores that antibodies targeting the prefusion conformation are the most potent, making it a compelling vaccine candidate. Here, we establish a computational design protocol that stabilizes the prefusion state while destabilizing the postfusion conformation. With this protocol, we stabilize the fusion proteins of the RSV, hMPV, and SARS-CoV-2 viruses, testing fewer than a …

Physiological Impact Of Ergot Alkaloid Consumption In Ruminant Livestock, J. L. Klotz, S. K. Duckett, D. L. Harmon

IGC Proceedings (1977-2023)

Ergot alkaloids in feeds and forages are a worldwide concern. Consumption of ergot alkaloids by ruminant livestock can range from extreme cases that threaten the life of the animal to more frequent and chronic outcomes where livestock productivity is decreased. Consumption of ergot alkaloids alters ruminant physiology such that it outwardly manifests in lower animal intake and gain, decreased reproductive efficiency, and a compromised circulatory system. This talk will cover current research that is improving our understanding of how ergot alkaloids alter cell and tissue physiology that results in the compromised growth and reproduction observed at the whole animal level.

Biodiverse Forage Mixtures For Bees And Beef Cattle, J. O. C. Kubesch, S. P. Greiner, G. J. Pent, J. L. Reid, B. F. Tracey

IGC Proceedings (1977-2023)

Introduction: Beef cattle performance in the southeastern US is limited by tall fescue (TF) toxicosis. Native warm season grasses (NWSGs) can provide alternative forage for cattle and reduce TF toxicosis. Pollinator populations, especially bees, also have been declining across North America. Introducing native wildflowers into tall fescue grasslands might improve pollinator populations. An ongoing grazing experiment in central Virginia USA is testing the feasibility of integrating wildflowers and native grasses as a way to generate ecosystem services.

Objectives: This study sought to determine whether including native grasses and wildflowers in tall fescue pasture systems could improve beef heifer performance.

Methods: …

Winter Performance Of North American Bos Grunniens Offered Hay Harvested From Different Forage Species, Jeff Lehmkuhler, G. Dike, M. Mccarty

IGC Proceedings (1977-2023)

Bos grunniens or the domesticated yak was brought to North America in the late 1800’s and early 1900’s. In Asia, yaks have been observed to lose 25% or more of their body weight over the winter in the high mountain altitudes. Little research has been conducted with the domesticated yak and their nutritional needs. Maintaining positive weight change during the winter is expected to improve the profitability and viability of yak production systems in North America. An on-farm study was conducted near Wellington, KY, USA to investigate the winter performance of yaks and hay type. Four outdoor grass lots approximate …

Warm-Season Annual Grasses As Pinpoint Grazing Opportunities, Rocky Lemus, J. A. White

IGC Proceedings (1977-2023)

There is a need to determine the use of annual warm-season grasses (AWSGs) such as forage sorghum (FS), millets (M), sudangrass (SG), and sorghum-sudangrass hybrid (SSH) can be integrated for grazing or hay production when utilized with appropriate grazing management strategies. The objective of the study was to screen new cultivars with the potential for resistance to sugar cane aphid (SCA, Melanaphis sacchar) for biomass production and nutritive value in a one-cut system. Treatments consisted of 30 cultivars that included FS, SG, SSH, and millets (M). Treatments were replicated three times in a randomized complete block design. Cultivars influenced …

Tannins In Perennial Legume And Forb Functional Forages, J. Macadam, Juan Villalba, S. Lagrange, E. Stewart, S. Hunt, J. Legako, R. Christensen, R. L. Pitcher, A. Bolletta

IGC Proceedings (1977-2023)

Feed is the greatest input cost for cattle producers. The studies summarized here employed non-bloating, tannin-containing irrigated perennial legume pastures or hay of legumes or a hydrolysable tannin-containing forb that were grown in the Mountain West USA, with non-tannin legume, grass, or feedlot treatments for comparison. Cattle grazing legume pastures or fed legume or forb hays had greater intake, gain and nitrogen retention, and in some cases, reduced enteric methane emissions compared with grass pastures or hay, and methane emissions were not different from feedlot-fed cattle.

Yearling Beef Cattle Grazing Diverse Summer Annual Swards, K. Mercier, Christopher D. Teutsch, S. R. Smith, K. H. Burdine, E. S. Vanzant, E. L. Ritchey

IGC Proceedings (1977-2023)

Utilizing summer annuals is often regarded as “a breakeven proposition at best” due to high establishment costs. This study investigated using botanical diversity to increase forage yield or animal performance to improve the economic feasibility of grazing summer annual forages in western Kentucky, USA. Sorghum-sudangrass (Sorghum bicolor x S. bicolor spp. drummondii)-based treatments included a monoculture, a three-species mixture (two grasses, one legume), and a 12-species mixture (five grasses, four legumes, two brassicas, and one forb). Angus-cross yearling beef calves (329, 366, and 297 kg in 2017, 2018, and 2019, respectively) grazed summer annuals in 2017-2019 for an …

Opportunities Of Grazing Personality Genetics For Steep And Rugged Rangelands, Moreno Garcia, T. M. R. Maxwell, R. Dynes, H. Zhou, J. Hickford

IGC Proceedings (1977-2023)

Globally, extensive pastoral grazing systems are facing multiple pressures, including to address emerging public concerns about environmental impact and animal well-being. This may require new regulatory constraints to be met, while maintaining the economic viability of the systems. One novel approach to addressing these challenges is to capitalize on naturally occurring differences in livestock behaviors, specifically differences in grazing personalities, to assist the production systems deliver more effective and responsible use of rangelands. Herbivores may exhibit consistent grazing behaviors over time and across spatial contexts, which differ among individuals and between groups leading to distinctive grazing patterns known as grazing …

Intake, Relative Palatability Indices And Blood Parameters Of Vetch Varieties As A Component Of Goat Diet, N. H. Msiza, K. E. Ravhuhali, H. K. Mokoboki, Sydney Mavengahama, G. M. Chelopo

IGC Proceedings (1977-2023)

Therefore, the objective of this study was to assess the feed intake, relative palatability indices and blood parameters of vetch varieties as a component of goat diet. The field and palatability study was carried out at the North West University, Molelwane Farm, North West province, South Africa. Ten weaner goats (16 ±2 kg) were used in this experiment. Four feeds (Vicia sativa – common & volga vetch ), Vicia villosa Roth (haymaker plus vetch) and buffalo hay grass were used in this experiment and each goat was exposed to these treatment diets. A cafeteria feeding method was used, allowing …

Adaptive Multi-Paddock Grazing Of Cover Crops In Integrated Crop-Livestock Systems In Mediterranean Regions: A Review, G. A. Musto, A. Swanepoel, J. A. Strauss

IGC Proceedings (1977-2023)

Small-grain farming systems in Mediterranean climatic regions are characterized by poor quality soils, high climate variability, and resulting heavy agrochemical reliance. The integration of continuously grazed monocrop pasture phases has improved soil fertility, crop productivity, and mitigated financial risk. However, emerging sustainability issues such as herbicide resistance, inputs costs rising disproportionately to product prices, and increasing climate variability and predictability, drive the need for ongoing innovation in crop-livestock integration. The option of growing multi-species cover crops as a dual-forage and service crop is evaluated within Mediterranean climate contexts. Furthermore, the option of subjecting the cover crops to adaptive multi-paddock (AMP) …

Stockpiling Tall Fescue In The Mid-Latitude Region Of The Eastern United States, H. D. Naumann

IGC Proceedings (1977-2023)

Stockpiling grass is a method of growing forage for deferred grazing during winter. Tall fescue is the best adapted cool-season perennial grass available in the mid-latitude of the eastern United States (US) for stockpiling (accumulating growth of) forage for deferred grazing in the fall and winter. Thus it can provide much of the fall and winter feed for livestock. Grazing stockpiled tall fescue reduces winter feeding cost and better distributes nutrients compared to traditional hay feeding methods. This presentation focuses on how to stockpile tall fescue, how to graze stockpiled tall fescue, and benefits of stockpiled tall fescue compared to …

Dry Matter Intake, Milk Performance And Production Efficiency From Spring Calving Dairy Cows Offered Grass-Only, Grass-White Clover And Total Mixed Ration Diets, E. Fitzpatrick, Luc Delaby, Trevor J. Gilliland, D. Hennessy

IGC Proceedings (1977-2023)

In pasture-based dairy production systems, dry matter intake (DMI) is one of the main factors curtailing milk production and production efficiency. The inclusion of white clover (Trifolium repens L.) in swards of perennial ryegrass (PRG; Lolium perenne L.) can increase DMI from increased sward nutritive value over a grass-only sward. Feeding a fully balanced TMR diet can enhance milk production as a result of greater DMI and through greater control of feed quality. Therefore, the objective of this study was to determine the relationship between DMI, milk production, and energy efficiencies for dairy cows consuming different diets. A farm …