Digital Commons Network^™

Influence Of Maternal Supplementation With Vitamins, Minerals, And (Or) Protein/Energy On Placental Development And Angiogenic Factors In Beef Heifers During Pregnancy, Bethania J. Dávila Ruiz, Carl R. Dahlen, Kacie L. Mccathy, Joel S. Caton, Jennifer L. Hurlbert, Friederike Baumgaertner, Ana Clara B. Menezes, Wellison J. S. Diniz, Sarah R. Underdahl, James D. Kirsch, Kevin K. Sedivec, Kerri A. Bochantin, Pawel P. Borowicz, Sebastián Canovas, Lawrence P. Reynolds

Department of Animal Science: Faculty Publications

The effect of vitamins and minerals supplementation (VTM) and/or two rates of body weight gain (GAIN) on bovine placental vascular development and angiogenic factors gene expression were evaluated in two experiments: In Exp. 1, crossbred Angus heifers (n = 34) were assigned to VTM/NoVTM treatments at least 71 days before breeding to allow changes in the mineral status. At breeding, through artificial insemination (AI), heifers were assigned to low-gain (LG) 0.28 kg/d or moderate-gain (MG) 0.79 kg/d treatments, resulting in NoVTM-LG (Control; n = 8), NoVTM-MG (n = 8), VTM-LG (n = 9), and VTM-MG (n = …

Selective Targeting Of Microglia By Quantum Dots And Green Synthesis Of Metal Organic Biohybrids; Applications In Dynamic Cell And Assay Systems, Navya Uppu

Doctoral Dissertations

Neurological disorders are the leading cause of physical and cognitive disability across the globe, currently affecting approximately 15% of the worldwide population. Part of the glioma microenvironment are microglia, resident immune cells of the CNS that were thought to be involved in the pathogenesis of diverse neurodegenerative diseases. Though it remains uncertain what triggers microglial activation in these disorders, targeting and tracking microglial functions using nanotools like Quantum Dots (QDs) could help us elucidate them in such neurological diseases. This research focuses on the comparative study of different QDs formulations and their selective uptake by brain microglia in primary cultures …

Development And Characterization Of Injectable, Cell-Encapsulated Chitosan-Genipin Hydrogels, Tyler R. Priddy-Arrington

Doctoral Dissertations

Over 150,000 patients undergo lower extremity amputation every year in the United States, most commonly caused by complications due to diabetes mellitus, peripheral vascular disease, and trauma. Diseased or damaged tissues that are unable to naturally repair themselves must either be fully removed or replaced, otherwise the injuries can lead to further complications such as infection or death. Tissue resection and amputation, as forms of removing damaged tissue, are not favorable to patients as they can cause pain, reduce mobility, and negatively impact quality of life. However, replacing lost or damaged tissues with donor tissues carries the risks of tissue …

Rebound Intracranial Hypertension, Simy K. Parikh

Department of Jefferson Headache Center Papers and Presentations

PURPOSE OF REVIEW: Rebound intracranial hypertension (RIH) is a post-procedural treatment complication in patients with spontaneous intracranial hypotension (SIH) characterized by transient high-pressure headache symptoms. This article reviews the epidemiology, clinical features, risk factors, and treatment options for RIH.

RECENT FINDINGS: This article discusses how changes in underlying venous pressure and craniospinal elastance can explain symptoms of RIH, idiopathic intracranial hypertension (IIH), and SIH.

SUMMARY: The pathophysiology of RIH provides a clue for how high and low intracranial pressure disorders, such as IIH and SIH, are connected on a shared spectrum.

Like Mother, Unlike Daughter, Joan Harris

Erma Bombeck Writers' Workshop Blog

Everyone tells me I'll inevitably do or say something that makes me realize I have become my mother, but I’m not so sure. You see, my mother and I have next to nothing in common.

Diagnosing Brain Tumors From Mri Images Through A Multi-Fused Cnn With Auxiliary Layers, Ahed J. Alkhatib, Mohamad Alharoun, Areej Alzoubi, Esraa Muqdadi, Aseel Abu Aqoulah, Almo’Men Bellah Alawnah, Razan Abedulhammeed Youn's

Sustainable Machine Intelligence Journal

In this study, we proposed a novel Multi-Fused Residual Convolutional Neural Network (MFR-CNN) with Auxiliary Fusing Layers (AuxFL) to diagnose various types of brain tumor MRI images. The MFR-CNN was designed to handle four specific cases, namely glioma, meningioma, pituitary, and healthy brain images, obtained from reliable Kaggle databases. Our proposed model integrated three state-of-the-art models into a single feature extraction pipeline, incorporating partially frozen and truncated layers. This strategic fusion enabled the propagation of robust features and improved diagnostic performance without incurring significant computing costs, unlike most existing state-of-the-art models. Moreover, the MFR-CNN effectively mitigated overfitting and performance saturation …

Detection Of Depression From Arabic Tweets Using Machine Learning, Areej Alzoubi, Ahmad Alaiad, Khaled Alkhattib, Ahed J. Alkhatib, Aseel Abu Aqoulah, Almo’Men Bellah Alawnah, Ola Hayajnah

Sustainable Machine Intelligence Journal

Depression has become the disease of the times and has caused suffering and disruption in the lives of millions of people around the world of all ages. Method: We obtained 16,581 Arabic tweets, whether they express depression or not, and the symptoms they contain for 1439 Arab Twitter users. We classified whether the user is depressed or not. We used many machine learning algorithms: DT, RF, Mutational Naïve Bayes, and AdaBoost , we also used feature extraction like BOW and TF-IDF. The result: Our experiments showed that Mutational Naïve Bayes with TF-IDF had the highest accuracy of 86% when rating …

A Greb1-Steroid Receptor Feedforward Mechanism Governs Differential Greb1 Action In Endometrial Function And Endometriosis, Sangappa B Chadchan, Pooja Popli, Zian Liao, Eryk Andreas, Michelle Dias, Tianyuan Wang, Stephanie J Gunderson, Patricia T Jimenez, Denise G Lanza, Rainer B Lanz, Charles E Foulds, Diana Monsivais, Francesco J Demayo, Hari Krishna Yalamanchili, Emily S Jungheim, Jason D Heaney, John P Lydon, Kelle H Moley, Bert W O'Malley, Ramakrishna Kommagani

Faculty, Staff and Students Publications

Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums for steroid receptors are unidentified. Herein, we found that a common feed-forward mechanism between GREB1 and steroid receptors regulates the differential effect of GREB1 on steroid hormones in a physiological or pathological context. In physiological (receptive) endometrium, GREB1 controls P4-responses in uterine stroma, affecting endometrial receptivity and decidualization, while not affecting E2-mediated epithelial proliferation. Of mechanism, progesterone-induced GREB1 physically interacts with the progesterone receptor, acting as a cofactor in a positive feedback …

Structure-Based Targeting Of The Nemo:Ikk Interaction For Canonical Nf-Κb Inhibition, Amy Kennedy

Dartmouth College Ph.D Dissertations

The NF-κB pathway is important for cell survival and proliferation, inflammation, and innate immunity, and its dysregulation is a common theme in many cancers, autoimmune disorders, and other disease states. The protein-protein interaction between the scaffolding protein NEMO and the kinase IKK in the NF-κB pathway represents a compelling target for selective NF-κB inhibition because it occurs only in the canonical branch of the NF-κB pathway. Disruption of the NEMO:IKK interaction has been established for decades in the literature as a safe and effective way to selectively inhibit overactivation of the canonical branch of the NF-κB pathway. The benchmark in …

The Proximate Regulation Of Prosocial Behaviour: Towards A Conceptual Framework For Comparative Research, Kathrin S. Kopp, Patricia Kanngiesser, Rahel K. Brügger, Moritz M. Daum, Anja Gampe, Moritz Köster, Carel P. Van Schaik, Katja Liebal, Judith M. Burkart

School of Psychology

Humans and many other animal species act in ways that benefit others. Such prosocial behaviour has been studied extensively across a range of disciplines over the last decades, but findings to date have led to conflicting conclusions about prosociality across and even within species. Here, we present a conceptual framework to study the proximate regulation of prosocial behaviour in humans, non-human primates and potentially other animals. We build on psychological definitions of prosociality and spell out three key features that need to be in place for behaviour to count as prosocial: benefitting others, intentionality, and voluntariness. We then apply this …

A Greb1-Steroid Receptor Feedforward Mechanism Governs Differential Greb1 Action In Endometrial Function And Endometriosis, Sangappa B Chadchan, Eryk Andreas, Stephanie J Gunderson, Patricia T Jimenez, Emily S Jungheim, Kelle H Moley, Et Al.

2020-Current year OA Pubs

Cellular responses to the steroid hormones, estrogen (E2), and progesterone (P4) are governed by their cognate receptor's transcriptional output. However, the feed-forward mechanisms that shape cell-type-specific transcriptional fulcrums for steroid receptors are unidentified. Herein, we found that a common feed-forward mechanism between GREB1 and steroid receptors regulates the differential effect of GREB1 on steroid hormones in a physiological or pathological context. In physiological (receptive) endometrium, GREB1 controls P4-responses in uterine stroma, affecting endometrial receptivity and decidualization, while not affecting E2-mediated epithelial proliferation. Of mechanism, progesterone-induced GREB1 physically interacts with the progesterone receptor, acting as a cofactor in a positive feedback …

A Poetics Of Entanglement: The Enmeshed Creation Of Interrogative Space, Phil Spotswood

Theses and Dissertations

This dissertation theorizes and deploys a poetics of entanglement as a creative practice for questioning relationality and its role in meaning-making. The dissertation includes a critical preface that explores a poetics of entanglement by analyzing poetry by gay cis male US poets whose work is thematically linked by their creative disruptions of the feeling of shame. The dissertation’s creative chapter is a collection of original poems titled It Bears Repeating; the poems deploy a poetics of entanglement to open questions in the shamed body. The dissertation concludes with considerations for how a poetics of entanglement might be taught to undergraduate …

Survival And Vision Restoration Following Severe Metformin-Associated Metabolic Acidosis With Transient Blindness: A Case Report And Review Of The Literature, Elizabeth Mikhail, Matthew Jankowski, Dheeraj Alexander, Dhwani Pandya, Arvind Kunadi

Journal of Community Hospital Internal Medicine Perspectives

Metformin-associated lactic acidosis (MALA) is a life-threatening condition that may occur as a side effect of biguanides. This condition has a mortality rate of approximately 55% depending on the severity. Typical symptoms include abdominal pain, nausea, vomiting, and diarrhea, but may also manifest with severe symptoms such as blindness, distributive shock, and renal failure requiring ICU level care. We present the case of a female in her early 70s who arrived at the emergency department with altered mental status and new-onset blindness, later diagnosed with severe acidosis (pH 6.607). She was intubated for hemodynamic instability and continuous renal replacement therapy …

Streptococcus Canis Native Aortic Valve Endocarditis Linked To Cat Exposure: A Case Report And Review, Michael S. Wang, Maria Huaringa, Lauren Feld, Ken Ochiai, Tiffany Whelan, Nicholas M. Frazier

Journal of Community Hospital Internal Medicine Perspectives

Streptococcus canis is an uncommon human pathogen, but documented infections have been mostly associated with exposure to dogs. There are only five documented cases of endocarditis secondary to streptococcus canis, with all cases except one documenting exposure to a canine. We present a 74-year-old male with a history of Type 2 diabetes mellitus, CKD 3, moderate aortic stenosis and remote exposure to agent orange, who was found to have Streptococcus canis native valve endocarditis without exposure to a dog. To the best of our knowledge this case is the first case of endocarditis linked to feline exposure.

A Tale Of Two Diagnoses; Gout Vs Chronic Osteomyelitis. A Case Report, Mashal Imtiaz Khan, Wajiha , Ali, Ali Javed, Saadia Haleema, Yasir . Ahmed

Journal of Community Hospital Internal Medicine Perspectives

Gout can potentially be diagnosed clinically and treated, if classical symptoms are present. In some cases, gout and osteomyelitis can have similar presenting signs and symptoms and it may be difficult to differentiate just on clinical presentation, routine laboratory workup and imaging like radiography or ultrasound. Arthrocentesis can be crucial in such scenarios to differentiate the two entities as missed opportunity to treat infectious etiology can have detrimental outcomes. We present a case of patient with ankle pain and swelling treated as recurrent gout, as there were no risk factors for osteomyelitis. Arthrocentesis confirmed the diagnosis of osteomyelitis and patient …

Global Perspective On Covid-19 Therapies, Cardiovascular Outcomes, And Implications For Long Covid: A State-Of-The-Art Review, Azza Sarfraz, Zouina Sarfraz, Shehar Bano, Muzna Sarfraz, Ali Jaan, Amna Minhas, Aminah Abdul Razzack, Gaurav Patel, Manish Kc, Sarabjot Singh Makkar, Radhika Garimella, Krunal Pandav, Jose Almonte, Trissa Paul, Tahlianna Almonte, Lissandra Jimenez, Juan C Pantoga, Nada El Mazboudi, George Yatzkan, George Michel, Jack Michel

Journal of Community Hospital Internal Medicine Perspectives

The COVID-19 pandemic has resulted in many therapies, of which many are repurposed and used for other diseases in the last decade such in Influenza and Ebola. We intend to provide a robust foundation for cardiovascular outcomes of the therapies to better understand the rationale for the clinical trials that were conducted during the COVID-19 pandemic, and better understand the steps moving forward should the repurposing provide clinical benefit in pandemic situations. With this state-of-the-art review, we aim to improve the understanding of the cardiovascular involvement of the therapies prior to, during, and after the COVID-19 pandemic to provide meaningful …

Efficacy And Safety Of Bempedoic Acid In Patients With Hyperlipidemia And Non-Alcoholic Fatty Liver Disease, Sibtain Nisar, Sidra Sohail, Saman Fatima, Muhammad Talha Akhtar, Muhammad Ahmad, Muhammad Waqar Hanif, Masood Khan, Amin Mehmoodi, Jahanzeb Malik

Journal of Community Hospital Internal Medicine Perspectives

Hyperlipidemia and its association with cardiovascular diseases have been significant public health concerns for many decades. Statins have long been the primary therapeutic option for lowering cholesterol levels and reducing cardiovascular mortality. However, a substantial number of patients either do not achieve optimal lipid goals with maximally tolerated statin doses or experience statin intolerance. In recent years, there have been remarkable developments in the field of hyperlipidemia management, leading to the approval of novel hypolipidemic drugs in North America and Europe. This article reviews the clinical development of bempedoic acid, a promising new drug, alone and in combination with ezetimibe, …

The Latest Evidence On Bempedoic Acid: Meta-Analysis Of Safety And Efficacy In High Cardiovascular Risk Patients With Hypercholesterolemia, Muhammad Adil Afzal, Noman Khalid, Muhammad Abdullah, Ata Ul Haiy, Mubariz Ahmed Hassan, Hania Sana, Sherif Elkattawy, Ahmad Azam Malik, Patrick Michael, Rahul Vasudev, Fayez Shamoon

Journal of Community Hospital Internal Medicine Perspectives

Background: Bempedoic Acid (BA) is a novel drug that has a potential to serve as an alternative to statins to decrease lipid levels and improve cardiovascular disease (CVD) outcomes, particularly for statin-intolerant individuals. However, insufficient statistical power has limited our understanding of the efficacy and safety of BA. This meta-analysis utilizes the latest data to improve our knowledge of BA's effects on lipids and CVD with increased statistical power.

Methods: MEDLINE, Embase, Cochrane Central, Clinicaltrials.gov, abstracts of national and international conferences, and reference lists of studies were searched for relevant studies. Rayyan was used to screen the search results, and …

Book Reviews, Florida Historical Society

Florida Historical Quarterly

Thulman and Garrison, eds., New Directions in the Search for the First Floridians. by Shawn Joy; Sledge, The Gulf of Mexico: A Maritime History. by Deanne Stephens; Smith, ed., Submerged History: Underwater Archaeology in Florida. by John J. Bertalan; Clavin, The Battle of Negro Fort: The Rise and Fall of a Fugitive Slave Community. by Uzi Baram; Nelson, How The New Deal Built Florida Tourism: The Civilian Conservation Corps and State Parks. by Tara Mitchell Mielnik; Odom and Waling, eds., NASA and the Long Civil Rights Movement. by Amy E. Foster; Delerme, Latino Orlando: Suburban Transformation and Racial Conflict. by …

Amnesia, Anamnesis, And Myth-Making In Florida: A Case Study Of Chipco, Eric Hannel

Florida Historical Quarterly

History often finds ways of retaining information deemed "valuable," while discarding information no longer of interest or importance to its scrivener. During this process, those who recount history intentionally or unintentionally forget some details while retaining others, perhaps even embellishing them for later generations. At the nexus of this amnesia and purposeful anamnesis (the way history is remembered), rests American mythmaking. Each layer of mythmaking connects with place or geography representing forgotten as well as recollected details, a reclamation of past events and altered memories that aggrandize, justify, and construct out of messy, complex, and often brutal reality, a sanitized …

Volusia And Vibilia: Companion Plantations On The St. Johns River In Spanish And Territorial East Florida, Lani Friend

Florida Historical Quarterly

The names Volusia and Vibilia are mellifluous, "soft and pleasing to the ear." These are words used by Horatio Dexter to describe the Seminole language, but they are well suited to the names of these Spanish land grant plantations on the St.Johns River. Volusia and Vibilia seem to belong together because they do-they share a semantic affinity; they originate from a common cultural source; they were likely bestowed by the same person/s; and the lands bearing the names are closely linked in their history and development. Volusia and Vibilia were companion plantations in Spanish and Territorial East Florida.

Florida Historical Quarterly, Vol. 97, Number 4, Florida Historical Society

Florida Historical Quarterly

Volusia and Vibilia: Companion Plantations on the St. Johns River in Spanish and Territorial East Florida, Lani Friend
The Making of Florida's "Criminal Class": Race, Modernity, And the Convict Leasing Program, 1877-1919, Connor Donegan
Covert Cross-Racial Mobilization, Black Activism, and Political Participation Pre-Voting Rights Act, Loren Collingwood and Benjamin Bonzales-O'Brien
Book Reviews
End Notes
Index for Volume 97

War, Fear, And Bread In Tampa, 1917-1918, Andy Huse

Florida Historical Quarterly

In early Febrnary 1917, two months before the U.S. entered World War I, local authorities in Tampa, Florida, required German aliens over age thirteen to register with the federal government. That same month, the city's German-American Club entered an extravagant float in the city's annual Gasparilla Fiesta parade. The float, one of only six that year, depicted a mighty waterfall. The Great War cast a long and dark shadow, unleashing a flood of fierce nationalism and suspicion across the U.S. home front. The conflict gave a new focus and urgency to anti-immigration fears across the nation, and the presence of …

Nanotechnology In Food Science: Opportunities And Challenges, Raksha S Shettigar, Usha Yogendra Nayak

International Conference on ‘NANOSCIENCE AND NANOTECHNOLOGY'

No abstract provided.

A Natural Interaction Paradigm To Facilitate Cardiac And Nerve Anatomy Education Using Augmented Reality And A Surgical Metaphor, Shashikala S V, Amith D, Lekhana H L, Disha T S, Likith R

International Conference on ‘NANOSCIENCE AND NANOTECHNOLOGY'

No abstract provided.

Anatomy And Physiology Of Intraosseous Infusion, Andrew Mizerowski, James Paxton

Medical Student Research Symposium

The introduction of fluids and medications via intraosseous (IO) infusion is highly dependent upon many unique aspects of bone anatomy and physiology. Key considerations include differences in the medullary cross-sectional area between insertion sites, age- and location-dependent variation in the distribution of red and yellow bone marrow, volume and pressure capacity within the venous system, and the influence of hormones and other chemical messengers on vasomotor tone. In addition to an exploration of these concepts, this chapter will also discuss the physiologic basis for pharmacokinetic relationships reported in the prevailing literature and propose methods to optimize the use of IO …

Activating Neuroprotective Effects Of Glial Cells In Vps13d-Associated Ataxia, Abrielle Fretz

Medical Student Research Symposium

Ataxia is a common symptom among many neurological conditions. Due to its high prevalence and quality of life impact, there is significant interest in understanding the underlying cause, as well as potential therapeutic approaches to mitigate its severity. Our lab uses a model of Vps13D-associated ataxia in the fruit fly, Drosophila Melanogaster, which recapitulates aspects of the human disease including age-dependent motor deficits.

The anti-oxidant compounds gastrodin and 4-HBA were found to have neuroprotective effects in Drosophila and mouse models of Parkinson’s disease. Previous work has demonstrated that these compounds can activate the Nrf2-pathway, a master regulator of anti-oxidant defenses. …

Take A Risk: A Review Of Expanding Literacy, Hollie M. Bergeron, Jenny M. Martin

Virginia English Journal

This is a book review of Expanding Literacy: Bringing Digital Storytelling into Your Classroom by Brett Pierce in 2022. Review collaboratively by two teacher educators and a content area literacy course, this thorough review of Pierce's book for educators includes many perspectives.

P2y2 Inhibition Modifies The Anabolic Response To Exercise In Adult Mice, Nickolas Vinokurov, Devin Mendez, Amit Chougule Dr, Chunbin Zhang, Joseph Gardinier Dr

Medical Student Research Symposium

Osteocytes serve as a sensory network that responds to dynamic loading of the skeleton and play a crucial role in regulating bone mass while maintaining bone quality [1]. Osteocytes’ induction of bone formation in response to loading is extremely age dependent, such that clinical studies have shown exercise to be less and less effective as we age [2,3]. As a result, modifying osteocytes’ mechanosensitivity may enable older adults to better capitalize on the anabolic nature of exercise to increase bone mass and reduce fracture risk. Based on our previous work, P2Y2 activation down-regulates the mechanosensitivity of bone cells by increasing …

Role Of Intraflagellar Transport Protein Ift20 In The Formation And Function Of Motile Cilia In Mammals, Mohammad Z. Abdulghani, Wei Li, Tao Li, Michael J. Holtzman, Gregory J. Pazour, Zhibing Zhang

Medical Student Research Symposium

Cilia are microtubular structures present on most mammalian cells, which can be categorized into motile cilia and primary cilia (non-motile cilia). The axoneme of both cilia types possess intraflagellar transport (IFT) machinery, composed of unique protein complexes that travel in opposite directions along the microtubules. Although the role of IFT in primary cilia formation has been well studied, little is known about its role in mammalian motile cilia assembly. IFT20 is a component of IFT-B complex. We generated conditional Ift20 knockout mice by crossing floxed Ift20 mice with the Foxj1-Cre transgenic mouse line to specifically delete Ift20 from motile cilia. …