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Isotherms And Thermodynamic Parameters Of Metoprolol Drug Adsorption On The Prepared Mesoporous Silica, Manar A. Sachit, Sameer H. Kareem

Baghdad Science Journal

In this study, mesoporous silica (MPS) is made using the sol-gel method from a cheap source (Na2SiO3) using the surfactant hydroxycetyl hydroxyethyl dimonium chloride as a template. The task is the adsorption-based removal of the medication metoprolol (MP) at concentrations between 10 and 50 ppm. Variables such as: contact time, dose of adsorbent, starting concentration of adsorbate, and adsorption temperature were studied which show the equilibrium time and adsorbent dose are 40 min and 0.05 g respectively. The Langmuir, Freundlich, Temkin, and Dubinin-Radushkevich isotherm models were fitted to the data obtained from the experiments. Comparing the outcomes showed that, of …

A Genotyping Array For The Globally Invasive Vector Mosquito, Aedes Albopictus, Luciano Veiga Cosme, Margaret Corley, Thomas Johnson, Dave W Severson, Guiyun Yan, Xiaoming Wang, Nigel Beebe, Andrew Maynard, Mariangela Bonizzoni, Ayda Khorramnejad, Ademir Jesus Martins, José Bento Pereira Lima, Leonard E Munstermann, Sinnathamby N Surendran, Chun-Hong Chen, Kevin Maringer, Isra Wahid, Shomen Mukherjee, Jiannon Xu, Michael C Fontaine, Elizabet L Estallo, Marina Stein, Todd Livdahl, Patricia Y Scaraffia, Brendan H Carter, Motoyoshi Mogi, Nobuko Tuno, James W Mains, Kim A Medley, David E Bowles, Richard J Gill, Roger Eritja, Ranulfo González-Obando, Huynh T T Trang, Sébastien Boyer, Ann-Marie Abunyewa, Kayleigh Hackett, Tina Wu, Justin Nguyễn, Jiangnan Shen, Hongyu Zhao, Jacob E Crawford, Peter Armbruster, Adalgisa Caccone

Faculty, Staff and Student Publications

BACKGROUND: Although whole-genome sequencing (WGS) is the preferred genotyping method for most genomic analyses, limitations are often experienced when studying genomes characterized by a high percentage of repetitive elements, high linkage, and recombination deserts. The Asian tiger mosquito (Aedes albopictus), for example, has a genome comprising up to 72% repetitive elements, and therefore we set out to develop a single-nucleotide polymorphism (SNP) chip to be more cost-effective. Aedes albopictus is an invasive species originating from Southeast Asia that has recently spread around the world and is a vector for many human diseases. Developing an accessible genotyping platform is essential in …

Craniofacial Bone Anomalies Related To Cholesterol Synthesis Defects, Chihiro Iwaya, Akiko Suzuki, Junbo Shim, Aemin Kim, Junichi Iwata

Faculty, Staff and Student Publications

DHCR7 and SC5D are enzymes crucial for cholesterol biosynthesis, and mutations in their genes are associated with developmental disorders, which are characterized by craniofacial deformities. We have recently reported that a loss of either Dhcr7 or Sc5d results in a failure in osteoblast differentiation. However, it remains unclear to what extent a loss of function in either DHCR7 or SC5D affects craniofacial skeletal formation. Here, using micro computed tomography (μCT), we found that the bone phenotype differs in Dhcr7

The Identification Of A Distinct Astrocyte Subtype That Diminishes In Alzheimer's Disease, Haichao Wei, Joseph Withrow, Jyotirmoy Rakshit, Faiz Ul Amin, Joshua Nahm, Francesca E Mowry, Zhengmei Mao, Meenakshi B Bhattacharjee, Jay-Jiguang Zhu, Yongjie Yang, Jia Qian Wu

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is characterized by the presence of two hallmark pathologies: the accumulation of Amyloid beta (Aβ) and tau proteins in the brain. There is a growing body of evidence suggesting that astrocytes, a type of glial cell in the brain, play crucial roles in clearing Aβ and binding to tau proteins. However, due to the heterogeneity of astrocytes, the specific roles of different astrocyte subpopulations in response to Aβ and tau remain unclear. To enhance the understanding of astrocyte subpopulations in AD, we investigated astrocyte lineage cells based on single-nuclei transcriptomic data obtained from both human and mouse …

Lilrb3 Supports Immunosuppressive Activity Of Myeloid Cells And Tumor Development, Ryan Huang, Xiaoye Liu, Jaehyup Kim, Hui Deng, Mi Deng, Xun Gui, Heyu Chen, Guojin Wu, Wei Xiong, Jingjing Xie, Cheryl Lewis, Jade Homsi, Xing Yang, Chengcheng Zhang, Yubo He, Qi Lou, Caroline Smith, Samuel John, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

Faculty, Staff and Student Publications

The existing T cell-centered immune checkpoint blockade therapies have been successful in treating some but not all patients with cancer. Immunosuppressive myeloid cells, including myeloid-derived suppressor cells (MDSC), that inhibit antitumor immunity and support multiple steps of tumor development are recognized as one of the major obstacles in cancer treatment. Leukocyte Ig-like receptor subfamily B3 (LILRB3), an immune inhibitory receptor containing tyrosine-based inhibitory motifs (ITIM), is expressed solely on myeloid cells. However, it is unknown whether LILRB3 is a critical checkpoint receptor in regulating the activity of immunosuppressive myeloid cells, and whether LILRB3 signaling can be blocked to activate the …

Neuroinvasive West Nile Virus Infection In Immunosuppressed And Immunocompetent Adults., Amir A Mbonde, David Gritsch, Ehab Y Harahsheh, Sabirah N Kasule, Shemonti Hasan, Angela M Parsons, Nan Zhang, Richard Butterfield, Harn Shiue, Kathryn A Norville, Jenna L Reynolds, Holenarasipur R Vikram, Brian Chong, Marie F Grill

Neuroscience Articles

IMPORTANCE: West Nile virus (WNV) is the leading cause of human arboviral disease in the US, peaking during summer. The incidence of WNV, including its neuroinvasive form (NWNV), is increasing, largely due to the expanding distribution of its vector, the Culex mosquito, and climatic changes causing heavy monsoon rains. However, the distinct characteristics and outcomes of NWNV in individuals who are immunosuppressed (IS) and individuals who are not IS remain underexplored.

OBJECTIVE: To describe and compare clinical and radiographic features, treatment responses, and outcomes of NWNV infection in individuals who are IS and those who are not IS.

DESIGN, SETTING, …

Faculty Senate Agenda March 4, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• 3:05 University Business
• 3:25 Faculty Senate Business .
• 3:35 Information
• 3:40 Reports
• 3:55 Old Business
• 4:05 New Business
• Adjourn: 4:30 pm

Gene Expression Networks Regulated By Human Personality, Coral Del Val, Elisa Díaz De La Guardia-Bolívar, Igor Zwir, Pashupati Mishra, Alberto Mesa, Ramiro Salas, Guillermo F. Poblete, Gabriel A. De Erausquin, Emma Raitoharju, Mika Kähönen

School of Medicine Publications

Genome-wide association studies of human personality have been carried out, but transcription of the whole genome has not been studied in relation to personality in humans. We collected genome-wide expression profiles of adults to characterize the regulation of expression and function in genes related to human personality. We devised an innovative multi-omic approach to network analysis to identify the key control elements and interactions in multi-modular networks. We identified sets of transcribed genes that were co-expressed in specific brain regions with genes known to be associated with personality. Then we identified the minimum networks for the co-localized genes using bioinformatic …

Adipose Triglyceride Lipase Is A Therapeutic Target In Advanced Prostate Cancer That Promotes Metabolic Plasticity, Dominik Awad, Pham Hong Anh Cao, Thomas L Pulliam, Meredith Spradlin, Elavarasan Subramani, Tristen V Tellman, Caroline F Ribeiro, Riccardo Muzzioli, Brittany E Jewell, Hubert Pakula, Jeffrey J Ackroyd, Mollianne M Murray, Jenny J Han, Mei Leng, Antrix Jain, Badrajee Piyarathna, Jingjing Liu, Xingzhi Song, Jianhua Zhang, Albert R Klekers, Justin M Drake, Michael M Ittmann, Cristian Coarfa, David Piwnica-Worms, Mary C Farach-Carson, Massimo Loda, Livia S Eberlin, Daniel E Frigo

Faculty, Staff and Students Publications

UNLABELLED: Lipid metabolism plays a central role in prostate cancer. To date, the major focus has centered on de novo lipogenesis and lipid uptake in prostate cancer, but inhibitors of these processes have not benefited patients. A better understanding of how cancer cells access lipids once they are created or taken up and stored could uncover more effective strategies to perturb lipid metabolism and treat patients. Here, we identified that expression of adipose triglyceride lipase (ATGL), an enzyme that controls lipid droplet homeostasis and a previously suspected tumor suppressor, correlates with worse overall survival in men with advanced, castration-resistant prostate …

Enhancing Pharmaceutical Waste Management: Insights From Pharmacists' Perspectives On The Drug Take-Back Program, Mona Daher

Theses

Pharmaceutical waste management is essential for mitigating environmental risks associated with improper medication disposal, with pharmacists playing a pivotal role in drug take-back programs (DTBPs). However, there is limited understanding of pharmacists' engagement, perceptions, and challenges within these initiatives. This study aimed to address this gap by investigating these aspects among licensed pharmacists in the United States. A mixed-methods survey was distributed to 2200 pharmacists, yielding 81 responses (3.7% response rate). The findings revealed that familiarity with DTBPs did not significantly differ by state or practice setting, but positively correlated with experience and perceived effectiveness. Interestingly, on-the-job learning emerged as …

Mood Disorders In Adults With Epilepsy: A Review Of Unrecognized Facts And Common Misconceptions, Andres M. Kanner, Rohit Shankar, Nils G. Margraf, Bettina Schmitz, Elinor Ben-Menachem, Josemir W. Sander

Peninsula Medical School

Epilepsy is one of the most common neurologic conditions. Its clinical manifestations are not restricted to seizures but often include cognitive disturbances and psychiatric disorders. Prospective population-based studies have shown that people with epilepsy have an increased risk of developing mood disorders, and people with a primary mood disorder have an increased risk of developing epilepsy. The existence of common pathogenic mechanisms in epilepsy and mood disorders may explain the bidirectional relation between these two conditions. Recognition of a personal and family psychiatric history at the time of evaluation of people for a seizure disorder is critical in the selection …

Characteristic Morphology And Biomass Production Of Napier Grass (Pennisetum Purpureum) Cultivar Gama Umami Under Teak Tree (Tectona Grandis) Shade In Blora, Central Java, Muhammad Zayyan Muafi, Nafiatul Umami, Bambang Suhartanto, Bambang Suwignyo, Miftahush Shirotul Haq, Nilo Suseno, Widiyatno Widiyatno, Leisa Armstrong, David Cook, Yogi Sidik Prasojo

Research outputs 2022 to 2026

This study aims to determine the characteristic morphology and biomass production of Napier grass (Pennisetum purpureum) cultivar Gama Umami under teak tree (Tectona grandis) shade in teak tree forest area of Blora, Central Java. The grass was planted using stem cuttings and maintained for four months using the randomized block design (RBD) method with six repetitions in each treatment. This study consisted of two treatments, namely shade under teak tree stands and non-shade or open area as a control. Maintenance was carried out for 14 weeks with the addition of fertilizers, such as NPK (nitrogen, phosphor, and potassium) and urea. …

Adipose Tissue Dysfunction And Energy Balance Paradigms In People Living With Hiv, Claudia E Ramirez Bustamante, Neeti Agarwal, Aaron R Cox, Sean M Hartig, Jordan E Lake, Ashok Balasubramanyam

Faculty, Staff and Students Publications

Over the past 4 decades, the clinical care of people living with HIV (PLWH) evolved from treatment of acute opportunistic infections to the management of chronic, noncommunicable comorbidities. Concurrently, our understanding of adipose tissue function matured to acknowledge its important endocrine contributions to energy balance. PLWH experience changes in the mass and composition of adipose tissue depots before and after initiating antiretroviral therapy, including regional loss (lipoatrophy), gain (lipohypertrophy), or mixed lipodystrophy. These conditions may coexist with generalized obesity in PLWH and reflect disturbances of energy balance regulation caused by HIV persistence and antiretroviral therapy drugs. Adipocyte hypertrophy characterizes visceral …

Mood Disorders In Adults With Epilepsy: A Review Of Unrecognized Facts And Common Misconceptions, Am Kanner, R Shankar, Ng Margraf, Et Al

Peninsula Medical School

Epilepsy is one of the most common neurologic conditions. Its clinical manifestations are not restricted to seizures but often include cognitive disturbances and psychiatric disorders. Prospective population-based studies have shown that people with epilepsy have an increased risk of developing mood disorders, and people with a primary mood disorder have an increased risk of developing epilepsy. The existence of common pathogenic mechanisms in epilepsy and mood disorders may explain the bidirectional relation between these two conditions. Recognition of a personal and family psychiatric history at the time of evaluation of people for a seizure disorder is critical in the selection …

Microglia At Sites Of Atrophy Restrict The Progression Of Retinal Degeneration Via Galectin-3 And Trem2, Chen Yu, Yun Chen, Jinchao Hou, Marco Colonna, Et Al.

2020-Current year OA Pubs

Outer retinal degenerations, including age-related macular degeneration (AMD), are characterized by photoreceptor and retinal pigment epithelium (RPE) atrophy. In these blinding diseases, macrophages accumulate at atrophic sites, but their ontogeny and niche specialization remain poorly understood, especially in humans. We uncovered a unique profile of microglia, marked by galectin-3 upregulation, at atrophic sites in mouse models of retinal degeneration and human AMD. In disease models, conditional deletion of galectin-3 in microglia led to phagocytosis defects and consequent augmented photoreceptor death, RPE damage, and vision loss, indicating protective roles. Mechanistically, Trem2 signaling orchestrated microglial migration to atrophic sites and induced galectin-3 …

Inositol Phosphatase Inpp4b Sustains Ilc1s And Intratumoral Nk Cells Through An Akt-Driven Pathway, Vincent Peng, Tihana Trsan, Raki Sudan, Bishan Bhattarai, Victor S Cortez, Martina Molgora, Jean Vacher, Marco Colonna

2020-Current year OA Pubs

Innate lymphoid cells (ILCs) are a heterogeneous population of lymphocytes that coordinate early immune responses and maintain tissue homeostasis. Type 1 innate immune responses are mediated by natural killer (NK) cells and group 1 ILCs (ILC1s). Despite their shared features, NK cells and ILC1s display profound differences among various tissue microenvironments. Here, we identify the inositol polyphosphatase INPP4B as a hallmark feature of tissue-resident ILC1s and intratumoral NK cells using an scRNA-seq atlas of tissue-associated and circulating NK/ILC1s. Conditional deletion of Inpp4b in ILC1s and NK cells reveals that it is necessary for the homeostasis of tissue-resident ILC1s but not …

Strategies Leaders Of Nonprofits Use To Increase Community Awareness And Capital Funding, Michael Beverly, Jr.

Walden Dissertations and Doctoral Studies

Nonprofit leaders’ ability to establish and sustain effective awareness of their mission-oriented work with organizational stakeholders affects performance and sustainability. The failure to implement community awareness strategies and obtain capital funding through donations and contributions can adversely affect nonprofit leaders’ ability to ensure that their organizations can provide services and support to communities. Grounded in stakeholder theory, the purpose of this qualitative single case study was to explore strategies that nonprofit organization leaders use to increase community awareness to catalyze capital funding. The participants were three senior leaders of a nonprofit organization in the mid-Atlantic region that successfully obtained funding …

Review Of No Guilty Bystander: The Extraordinary Life Of Bishop Thomas Gumbleton, Tom Cordaro

The Journal of Social Encounters

No abstract provided.

Review Of Playing God: American Catholic Bishops And The Far Right, Daniel R. Dileo

The Journal of Social Encounters

No abstract provided.

Review Of Ecomartyrdom In The Americas: Living And Dying For Our Common Home, Caesar A. Montevecchio

The Journal of Social Encounters

No abstract provided.

In Memory Of Bishop Paride Taban, Sara Ketelaar, Fr. Peter Mbaro, John Ashworth, Fr. Joseph G. Healey, Rosanne Fischer, William O’Keefe

The Journal of Social Encounters

The Journal of Social Encounters mourns the loss, and celebrates the life, of the much-loved Bishop Paride Taban. We thank our authors below for sharing their reflections on him. In his memory, we also re-print an essay about him by Alberto Eisman Torres, A Beacon of Hope in a Troubled Context: Sketches of the Life of Mons. Paride Taban, Shepherd and Bridge-builder, an essay in our special collection on Peace Bishops. I was blessed to know Bisop Taban, and would see him in Nairobi and in Minnesota. One of his associates was a student of mine at the Catholic …

Peace Bishop: Bishop Nicolas Djoma Lola -- Bishop Of Tshumbé, Stephen R. Hilbert

The Journal of Social Encounters

Fr. Nicolas Djomo Lola was appointed a bishop in the Democratic Republic of the Congo (DRC) in 1997 and immediately was thrust into a brutal war between Rwanda, Burundi and Zaire that lasted through 2003. That conflict exacerbated deadly ethnic conflicts in the eastern provinces of the Congo that continue to this day. Bishop Djomo, driven by his belief that Jesus Christ calls all people to build peace, and protect people from violence responded to this war and chaos in remarkable ways. He led a delegation of the Central Africa Bishops to advocate with the Presidents of Burundi, Rwanda and …

Pacem In Terris: Historical Context & The Call For Global Governance, Joseph J. Fahey

The Journal of Social Encounters

This essay examines the historical context that led to Pope John XXIII’s proposal for a global “public authority” in his April 11, 1963, encyclical letter, Pacem in Terris (Peace on Earth). The catalyst for this letter was the Cuban Missile Crisis that occurred between October 22 and October 29, 1962. Pope John offered to mediate that crisis, and President Kennedy and Premier Khrushchev agreed and eventually came to an agreement not only to end the crisis but also to negotiate a limited nuclear test ban treaty. In the last year of his life, a time for him …

Eco-Virtue Ethics And Anthropological Commitments Of Laudato Si’ And Laudate Deum: Towards A Renewed Integral Ecology, Ugochukwu Stophynus Anyanwu

The Journal of Social Encounters

The Fourth Chapter of Laudato Si’ (LS) of Pope Francis deals with the theme of ‘Integral Ecology’ from a religious tradition. This chapter can be interpreted as the fulcrum of the encyclical because of the density of its anthropological and ethical considerations. The theme of this chapter has informed a more emphatic presentation in the apostolic exhortation Laudate Deum (LD) on the climatic challenges confronting humanity. Both documents, with incomparable courage and novelty, offer enriching ethical discourses for advancing social, cultural, and human ecology in consonance with social justice, common good, solidarity, and subsidiarity. They contain the magisterial appeal that …

Guns, Bombs, And Pollution: Unraveling The Nexus Between Warfare, Terrorism, And Ecological Devastation In Iraq, Hogr Tarkhani

The Journal of Social Encounters

Iraq's environment has experienced significant pollution and degradation, earning it the dubious distinction of being one of the most polluted and degraded regions globally, according to the Globe Pollution Review. The past three decades of armed conflict have exacted a heavy toll on the country, resulting in widespread human suffering, including countless fatalities, injuries, and a massive displacement of people. Amidst this death and destruction, the ecosystem has also endured severe damage, and its decline carries long-lasting implications.

The environmental crisis in Iraq has been worsened by the presence of extremist groups such as the Islamic State (ISIS) and various …

Sauron: Weirdly Sexy, Robert T. Tally Jr.

Journal of Tolkien Research

A popular meme depict Galadriel and Frodo admitting that Sauron is "weirdly sexy," a humorous allusion to The Rings of Power’s Halbrand. The show's controversial revelation of Halbrand as Sauron highlights the differences between Tolkien’s construction of Second and Third Age Sauron as an attractive or admirable leader compared to Peter Jackson’s portrayal of him as a monster or disembodied fiery eyeball. This, in turn, has implications for the geopolitical order of Middle-earth in which many people legitimately might wish to be on Sauron’s side. Acknowledging Sauron's "sexiness" may allow us to see Tolkien's world system in a new …

Prenatal, Perinatal And Postnatal Risk Factors Associated With Autism Spectrum Disorder In Palestine: A Case-Control Study, Mustafa Ghanim, Mariam Al-Tell, Samaa Staiti, Maha Rabayaa, Johnny Amer, Malik Alqub, Sameeha Atout, Nihad Al-Othman, Marwa Ismail

An-Najah University Journal for Research - B (Humanities)

Background: Autism spectrum disorder (ASD) is a multifactorial neurodevelopment disorder. Several prenatal, perinatal, and postnatal factors are suggested as risk factors for ASD. This study aimed to correlate prenatal, perinatal, and postnatal factors in a limited number of ASD cases in Palestine. Methods: A case-control study involved 120 children (60 typically diagnosed with ASD and 60 healthy matched with the ASD group). The parents of the children in both groups were asked to fill out the questionnaire. Results: The study showed a higher male-to-female ratio in the ASD group. A family history of ASD was reported in 38.3% of the …

Humor And School Culture In Special Education Schools, Saied Hussein Bishara

An-Najah University Journal for Research - B (Humanities)

Recently there have been discussions about the importance of incorporating humor, particularly in subjects such as mathematics, languages and more. The aim of integrating humor into the educational context stems from the need to mitigate the learning atmosphere that is seen as serious and boring, especially in special education schools. Therefore, the aim of the current research is to study the relationship between the integration of humor in teaching and learning and school culture in special education schools. Humor can have a positive impact on the school, as it stimulates students' interest and memory, and leads to interaction based on …

Briefing Note: 45th Meeting Of The Wipo Standing Committee On Copyright And Related Rights, Sean Flynn

Joint PIJIP/TLS Research Paper Series

This analysis provides a historical and legal overview of the principle agenda items to be discussed at the 45th meeting of the Standing Committee on Copyright and Related Rights.

The Art Speaks For Itself: Aura And Corruption In Cuarón’S Children Of Men, Colby Orton

Criterion: A Journal of Literary Criticism

In the world of Alfonso Cuarón’s Children of Men, the audience comes face to face with many scenes and shots that are filled with symbolism that it may become difficult to pick up on all the excellent directional moves made by Cuarón. This essay will closely analyze not only the clever placement of art but the heavy symbolic nature that each of these art pieces possess; furthermore, I will analyze the implications that these symbolic references bring to the film and how these implications complicate the film while furthering the difficult themes proposed by Cuarón. To achieve the highest understanding …