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Articles 58681 - 58710 of 735300
Full-Text Articles in Entire DC Network
Anthropology On Social Media, Danielle Airola M.A.
Anthropology On Social Media, Danielle Airola M.A.
UM Graduate Student Research Conference (GradCon)
In 2018, only about half of Americans (49%) agreed that “human beings, as we know them today, developed from earlier species of animals,” and 38% that “the universe began with a big explosion” (Besley and Hill, 2020). These basic facts may be well understood by the scientific and academic communities, but how do we go about disseminating this sort of knowledge to the general public? What about more nuanced and detailed information that may affect people’s understanding of our human heritage or health? Social media has great potential for increasing the reach and broadening the understanding of individuals. However, it …
Florida History In Publications, 2020, Florida Historical Society
Florida History In Publications, 2020, Florida Historical Society
Florida Historical Quarterly
No abstract provided.
Pathfinders, Progressives, And Boosters: The 1911 "Gulf-To-Great-Lakes-As-The-Crow-Flies" Automobile Adventure, Martin T. Olliff
Pathfinders, Progressives, And Boosters: The 1911 "Gulf-To-Great-Lakes-As-The-Crow-Flies" Automobile Adventure, Martin T. Olliff
Florida Historical Quarterly
At 10 a.m. on September 3, 1911, Dr. S. R. M. Kennedy, Frank L. Mayes, A. M. Avery, Jr., and F. C. Brent, Jr., left Pensacola for Chicago in Kennedy's Speedwell 50 touring car. Calling themselves the "Gulf-to-Great-Lakes-As-The-Crow-Flies" pathfinders, their ostensible mission was to represent Florida at the Fourth International Good Roads Congress. But their real goals were to add a Pensacola-to-Birmingham route description to the American Automobile Association's Blue Book (to complete the trail between the Great Lakes and the Gulf) and to promote Pensacola as a destination for midwestern tourists. At a time when road conditions rattled bones …
Amateur Minstrel Shows And Blackface Amusements At The University Of Florida In The Jim Crow Era, Myles Sullivan
Amateur Minstrel Shows And Blackface Amusements At The University Of Florida In The Jim Crow Era, Myles Sullivan
Florida Historical Quarterly
In the spring of 1914, the University of Florida's (UF) studentrun newspaper, The Florida Alligator, heralded "one of the biggest attractions of the spring season" with the front page headline "Heah Dey Kum! Dat Minstrel Show." As a theatrical performance style that had gained widespread popularity in the United States in the early 1800s, minstrel shows were often delivered with this imagined faux speech of rural African Americans. Its defining feature was culturally deemed white individuals "blacking up" their faces with burnt cork in visually cued racial caricatures acted out in music, song, and dance. Indeed, when subsequently reviewing the …
Invading Eden: Exotic Pets And Invasive Species In South Florida, Andrew Pemberton
Invading Eden: Exotic Pets And Invasive Species In South Florida, Andrew Pemberton
Florida Historical Quarterly
On July 8, 2019, South Floridians woke up to a headline describing the removal of a sixteen-foot-long Burmese python and fifty of its eggs from beneath a suburban home near the Everglades. This is a common spectacle in South Florida. Floridians, long accustomed to their scaly, cold-blooded co-habitants, have seen these types of headlines since the 1980s. With increasing frequency, non-indigenous species are entering the state's public eye. Perhaps more remarkable than these snakes' presence beneath Floridia homes is their welcomed presence in households across the country. However, this trend in pet-keeping poses the most risk to ecosystems in Florida, …
The History Of The Merritt Island National Wildlife Refuge (Minwr): A Partnership Of Rockets And Wildlife, Charles Venuto
The History Of The Merritt Island National Wildlife Refuge (Minwr): A Partnership Of Rockets And Wildlife, Charles Venuto
Florida Historical Quarterly
The Christmas season is associated with the creation of many lists such as gifts, groceries and holiday cards. But there is another list citizen scientists assemble this time of year as well. The National Audubon Society (NAS) Christmas Bird Count (CBC), originally established to counter what had turned into an annual Christmas day bird slaughter, began in 1900 and look place at 25 different sites, primarily in the northeast United States although California and the Midwest were also represented.
Anton Alaminos, Juan Ponce De Leon And A 1513-1514 European Discovery Of Mexico, Sam Turner
Anton Alaminos, Juan Ponce De Leon And A 1513-1514 European Discovery Of Mexico, Sam Turner
Florida Historical Quarterly
On October 12, 1519, during the early days of the Spanish conquest of what is today Mexico, an irate Diego Velazquez, Governor of Cuba, wrote to the young Charles V of Spain from the port of Santiago de Cuba. In his letter he complained that a vessel had arrived August 23rd of that year, secretly and illegally from Mexico, with a substantial cargo of gold and jewels. The vessel carried Captain Francisco de Montejo, who would one day be the Governor of Yucatan and Honduras, and Captain Alonso Hernandez Puerto Carrero. The vessel sailed under the expert guidance of the …
A Movement For The Birds: Pelican Island And The Origins Of The First American Wildlife Refuge, Evan B. Jaynes
A Movement For The Birds: Pelican Island And The Origins Of The First American Wildlife Refuge, Evan B. Jaynes
Florida Historical Quarterly
"Very well then, I So Declare It." This is supposedly what President Theodore Roosevelt said early in 1903 when he was informed that there was not any law that would prevent him from making Pelican Island a federally protected wildlife reserve. Shortly thereafter, on March 14, 1903, Roosevelt issued an executive order that established Pelican Island-a small and seemingly unremarkable piece of land off Florida's Atlantic-facing coast-as the nation's first wildlife sanctuary. Proclaiming that the island be "reserved and set apart for the use of the Department of Agriculture as a preserve and breeding ground for native birds," the action …
Florida Historical Quarterly, Vol 99, No. 1/2, Florida Historical Society
Florida Historical Quarterly, Vol 99, No. 1/2, Florida Historical Society
Florida Historical Quarterly
No abstract provided.
John Grattan Gamble's Mother And Sisters: Antebellum Aristrocrats And Their Flight From Successful Women, John T. Foster
John Grattan Gamble's Mother And Sisters: Antebellum Aristrocrats And Their Flight From Successful Women, John T. Foster
Florida Historical Quarterly
There were prominent women in Antebellum Richmond whose lives resemble women of today. Catherine Grattan Gamble and her daughter, Elizabeth Gamble Wirt, participated in their husbands' careers and sought places of equality with their spouses long before such behavior became common. Their lives are a dramatic departure from images of the Old South and the heritage claimed by relatives who became prominent in Middle Florida.
Paradise Is Dynamic: Florida's Changing Landscape, Thomas Chesnes
Paradise Is Dynamic: Florida's Changing Landscape, Thomas Chesnes
Florida Historical Quarterly
The following interview was conducted in the summer of 2020. Thomas Chesnes, the interviewee, is long-time professor of biology at Palm Beach Atlantic University in West Palm Beach, Florida. A native Floridian, Chesnes completed all of his degrees at the University of Florida in Gainesville (Ph.D., environmental engineering sciences/systems ecology/wetlands; M.S., environmental engineering sciences/estuarine systems; B.S., zoology). His research has focused on seagrasses, soil salinity, the Gulf killifish, the mangrove saltmarsh snake, the Atlantic red snapper, and all matters pertaining to wetlands, coastal habitats, and aquatic environments. For over a quarter of century, with numerous grants awarded (including a $50,000 …
The Hidden History Of The Florida-Born, Early Progressive Nurse Leader: Mary E. Macdonald Carter, Christine Ardalan
The Hidden History Of The Florida-Born, Early Progressive Nurse Leader: Mary E. Macdonald Carter, Christine Ardalan
Florida Historical Quarterly
The young women of Miami High School gathered in the auditorium on April 4, 1919, for a vocational hour to bear "a number of Miami's most brilliant and successful women [impart] a taste of what is to be accomplished by choosing the fitting vocation and getting a right start." The Rev. Mrs. Mecca Marie Varney (1873-1959), the organizer of the event, was well known in Miami with clout to draw the adept speakers together. Hailing from Iowa, the evangelical minister was a national leader in the Women's Christian Temperance Union (WCTU) and a lecturer on the Chautauqua Circuit. Earning widespread …
Florida Historical Quarterly, Vol 98, No. 3/4, Florida Historical Society
Florida Historical Quarterly, Vol 98, No. 3/4, Florida Historical Society
Florida Historical Quarterly
No abstract provided.
Tier 2 Monitoring In The Great Bay Estuary, Nh/Me Field Season 2022, Trevor Mattera, Lara Martin, Amanda Giacchetti, Kalle Matso, Tom Gregory, David M. Burdick
Tier 2 Monitoring In The Great Bay Estuary, Nh/Me Field Season 2022, Trevor Mattera, Lara Martin, Amanda Giacchetti, Kalle Matso, Tom Gregory, David M. Burdick
PREP Reports & Publications
No abstract provided.
The Student Movement Volume 108 Issue 18: Empow-Her-Ment: Celebrating Women At Andrews, Nate Miller, Andrew Francis, Grace No, Katie Davis, Corinna Bevier, Abby Shim, Alyssa Caruthers, Lexie Dunham, Anna Rybachek
The Student Movement Volume 108 Issue 18: Empow-Her-Ment: Celebrating Women At Andrews, Nate Miller, Andrew Francis, Grace No, Katie Davis, Corinna Bevier, Abby Shim, Alyssa Caruthers, Lexie Dunham, Anna Rybachek
The Student Movement v. 108 (2023-2024)
HUMANS
Women in Adventist Ministry with Kayla Goodman, Interviewed by Nate Miller
A Conversation with Lexie Dunham of WEAAU, Interviewed by Nate Miller
Who are the New AUSA Cabinet Members?, Andrew Francis
Talking Teaching with Professor Anneris Coria-Navia, Interviewed by Grace No
ARTS & ENTERTAINMENT
Fallen Leaves, Grace No
I wish upon a dandelion, Katie Davis
The Secret Identities of The Brontë Sisters, Corinna Bevier
We Watched Every 2023 Best Picture Nominee (so you don't have to), Corinna Bevier and Nate Miller
NEWS
'24-'25 AUSA Cabinet Prepares for Leadership, Andrew Francis
International Women's Day, Katie Davis
IDEAS
Here for a …
Ucc Minutes Mar 8, 2024, Undergraduate Curriculum Committee
Ucc Minutes Mar 8, 2024, Undergraduate Curriculum Committee
Undergraduate Currirculum Committee Minutes
No abstract provided.
It Ain’T Necessarily So: Ludwig Boltzmann’S Darwinian Notion Of Entropy, Steven Gimbel
It Ain’T Necessarily So: Ludwig Boltzmann’S Darwinian Notion Of Entropy, Steven Gimbel
Philosophy Faculty Publications
Ludwig Boltzmann's move in his seminal paper of 1877, introducing a statistical understanding of entropy, was a watershed moment in the history of physics. The work not only introduced quantization and provided a new understanding of entropy, it challenged the understanding of what a law of nature could be. Traditionally, nomological necessity, that is, specifying the way in which a system must develop, was considered an essential element of proposed physical laws. Yet, here was a new understanding of the Second Law of Thermodynamics that no longer possessed this property. While it was a new direction in physics, in other …
Late-Ming Book Culture And The Fujian Christian Community: A Case Study Of Lixiu Yijian 勵修一鑑 (A Mirror To Encourage Self-Cultivation), Yunjing Xu
Faculty Journal Articles
This study demonstrates the importance of book culture in the building of a religious community and in the preservation and interpretation of local experiences, through the making of a book titled Lixiu yijian 勵修一鑑 (A mirror to encourage self-cultivation) around 1645. The main author, Li Jiugong 李久功, mobilized members of the Fujian Christian community to collaborate on this communal book project outside the Christian church. Both xylographic print culture and manuscript culture were involved in the process and in the final product of this project. Through genre affiliation, content categorization, and the addition of commentaries, Li and his associates transformed …
Now It’S Your Turn!: Eye Blink Rate In A Jenga Task Modulated By Interaction Of Task Wait Times, Effortful Control, And Internalizing Behaviors, Kelley E. Gunther, Xiaoxue Fu Ph.D., Leigha A. Macneill, Morgan Jones, Briana Ermanni, Koraly Pérez-Edgar
Now It’S Your Turn!: Eye Blink Rate In A Jenga Task Modulated By Interaction Of Task Wait Times, Effortful Control, And Internalizing Behaviors, Kelley E. Gunther, Xiaoxue Fu Ph.D., Leigha A. Macneill, Morgan Jones, Briana Ermanni, Koraly Pérez-Edgar
Faculty Publications
Dopamine is a versatile neurotransmitter with implications in many domains, including anxiety and effortful control. Where high levels of effortful control are often regarded as adaptive, other work suggests that high levels of effortful control may be a risk factor for anxiety. Dopamine signaling may be key in understanding these relations. Eye blink rate is a non-invasive proxy metric of midbrain dopamine activity. However, much work with eye blink rate has been constrained to screen-based tasks which lack in ecological validity. We tested whether changes in eye blink rate during a naturalistic effortful control task differ as a function of …
Activity-Dependent Compartmentalization Of Dendritic Mitochondria Morphology Through Local Regulation Of Fusion-Fission Balance In Neurons In Vivo., Daniel M Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J Park, Victoria L Hewitt, David Zhang, Kevin C Gonzalez, Fiona M Russell, D Grahame Hardie, Julien Prudent, Erik B Bloss, Attila Losonczy, Franck Polleux, Tommy L Lewis
Activity-Dependent Compartmentalization Of Dendritic Mitochondria Morphology Through Local Regulation Of Fusion-Fission Balance In Neurons In Vivo., Daniel M Virga, Stevie Hamilton, Bertha Osei, Abigail Morgan, Parker Kneis, Emiliano Zamponi, Natalie J Park, Victoria L Hewitt, David Zhang, Kevin C Gonzalez, Fiona M Russell, D Grahame Hardie, Julien Prudent, Erik B Bloss, Attila Losonczy, Franck Polleux, Tommy L Lewis
Faculty Research 2024
Neuronal mitochondria play important roles beyond ATP generation, includ- ing Ca2+ uptake, and therefore have instructive roles in synaptic function and neuronal response properties. Mitochondrial morphology differs significantly between the axon and dendrites of a given neuronal subtype, but in CA1 pyr- amidal neurons (PNs) of the hippocampus, mitochondria within the dendritic arbor also display a remarkable degree of subcellular, layer-specific compart- mentalization. In the dendrites of these neurons, mitochondria morphology ranges from highly fused and elongated in the apical tuft, to more fragmented in the apical oblique and basal dendritic compartments, and thus occupy a smaller fraction of dendritic …
Identification Of Novel Small Molecule Inhibitors Of Twin Arginine Translocation (Tat) Pathway And Their Effect On The Control Of Campylobacter Jejuni In Chickens, Loïc Deblais, Mary Drozd, Anand Kumar, Janet Antwi, James Fuchs, Rahul Khupse, Yosra A. Helmy, Gireesh Rajashekara
Identification Of Novel Small Molecule Inhibitors Of Twin Arginine Translocation (Tat) Pathway And Their Effect On The Control Of Campylobacter Jejuni In Chickens, Loïc Deblais, Mary Drozd, Anand Kumar, Janet Antwi, James Fuchs, Rahul Khupse, Yosra A. Helmy, Gireesh Rajashekara
School of Veterinary and Biomedical Sciences: Faculty Publications
Introduction: Control of Campylobacter from farm to fork is challenging due to the frequent emergence of antimicrobial-resistant isolates. Furthermore, poultry production systems are known reservoirs of Campylobacter. The twinarginine translocation (Tat) pathway is a crucial bacterial secretion system that allows Campylobacter to colonize the host intestinal tract by using formate as the main source of energy. However, Tat pathway is also a major contributing factor for resistance to copper sulfate (CuSO4).
Methods: Since mammals and chickens do not have proteins or receptors that are homologous to bacterial Tat proteins, identification of small molecule (SM) inhibitors …
“It Is Luring You To Click On The Link With False Advertising” - Mental Models Of Clickbait And Its Impact On User’S Perceptions And Behavior Towards Clickbait Warnings, Ankit Shrestha, Arezou Behfar, Mahdi Nasrullah Al-Ameen
“It Is Luring You To Click On The Link With False Advertising” - Mental Models Of Clickbait And Its Impact On User’S Perceptions And Behavior Towards Clickbait Warnings, Ankit Shrestha, Arezou Behfar, Mahdi Nasrullah Al-Ameen
Computer Science Student Research
Clickbait, a social engineering attack performed through social media, tricks users through sensationalized or misleading posts into clicking on links that direct them to malicious websites. With the recent boom in social media, clickbait has become a substantial security concern, necessitating efforts from platforms and academia to control it. Despite these attempts, clickbait is effective due to the lack of users’ knowledge. Therefore, we explore user mental models (thought processes about how something works) about clickbait to analyze their deficiencies and their influences on users’ behavior towards clickbait warnings. To this end, we conducted an online study with 770 participants …
Grb2 Stabilizes Rad51 At Reversed Replication Forks Suppressing Genomic Instability And Innate Immunity Against Cancer, Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed
Grb2 Stabilizes Rad51 At Reversed Replication Forks Suppressing Genomic Instability And Innate Immunity Against Cancer, Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed
Faculty, Staff and Student Publications
Growth factor receptor-bound protein 2 (GRB2) is a cytoplasmic adapter for tyrosine kinase signaling and a nuclear adapter for homology-directed-DNA repair. Here we find nuclear GRB2 protects DNA at stalled replication forks from MRE11-mediated degradation in the BRCA2 replication fork protection axis. Mechanistically, GRB2 binds and inhibits RAD51 ATPase activity to stabilize RAD51 on stalled replication forks. In GRB2-depleted cells, PARP inhibitor (PARPi) treatment releases DNA fragments from stalled forks into the cytoplasm that activate the cGAS-STING pathway to trigger pro-inflammatory cytokine production. Moreover in a syngeneic mouse metastatic ovarian cancer model, GRB2 depletion in the context of PARPi treatment …
Protecting Our Pups At All Costs: Why Dogfighting Cases Require A Mandatory Restitution Assessment, Ayah Ighneim
Protecting Our Pups At All Costs: Why Dogfighting Cases Require A Mandatory Restitution Assessment, Ayah Ighneim
Cleveland State Law Review
This Note recommends that Congress acknowledge the dangers behind dogfighting by updating the federal mandatory restitution statute to include “animals” within the definition of a “victim” eligible to receive restitution and by updating federal animal-cruelty laws. This recommendation stems from the popularization of dogfighting in the twenty-first century. Specifically, this Note articulates the link between the prevalence of dogfighting in America and the lack of deterrence targeted toward dogfighting in America. This Note then argues that this lack of deterrence is a result of the lack of Congressional guidance within both the federal restitution statute and within federal animal-cruelty laws. …
Observation On Efficacy And Underlying Mechanism Of Cheek Acupuncture On Ovulation Induction For Infertile Women With Pcos: Case Series, Yi Yang, Lihua Jin, Shasha Xu, Huijun Ye, Xi Luo, Ruilan Li, Yuebing Yue
Observation On Efficacy And Underlying Mechanism Of Cheek Acupuncture On Ovulation Induction For Infertile Women With Pcos: Case Series, Yi Yang, Lihua Jin, Shasha Xu, Huijun Ye, Xi Luo, Ruilan Li, Yuebing Yue
Faculty, Staff and Student Publications
RATIONALE: Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder among women of childbearing age and is the primary cause of anovulatory infertility, accounting for 70% to 80% of cases. Ovulation induction is the main treatment approach for infertile patients with PCOS. Commonly utilized medications for this purpose are clomiphene citrate (CC) and letrozole (LE). Clomiphene citrate administration results in an ovulation rate ranging from 60% to 85%, while the pregnancy rate is limited to 35% to 40%, and a further reduction is observed in live birth rates. Letrozole demonstrates a slightly higher pregnancy rate and live birth …
Worldwide Accumulation Of Atmospheric Mercury In Glacier Cryoconite, Agnieszka Pasieka, Kamil Brudecki, Przemysław Niedzielski, Alexandra Proch, Nozomu Takeuchi, Roberto Ambrosini, Philip N. Owens, K Zawierucha, Giovanni Baccolo, Caroline Clason, Dylan Beard, Jacob Clement Yde, Edyta Łokas
Worldwide Accumulation Of Atmospheric Mercury In Glacier Cryoconite, Agnieszka Pasieka, Kamil Brudecki, Przemysław Niedzielski, Alexandra Proch, Nozomu Takeuchi, Roberto Ambrosini, Philip N. Owens, K Zawierucha, Giovanni Baccolo, Caroline Clason, Dylan Beard, Jacob Clement Yde, Edyta Łokas
School of Geography, Earth and Environmental Sciences
Mercury (Hg) is a chemical element recognized as one of the most toxic among all naturally occurring elements, with health risks depending on its form, concentration, route and time of exposure. Mercury appears in the environment as a result of human activities, which include burning coal or lignite, improper waste disposal, oil refining, use of mercury-containing pesticides and fertilizers, and industrial development such as mining, chemical, pharmaceutical and paper industries. The element also appears in the environment as a consequence of natural phenomena, among which are volcanic emissions, rock erosion, biomass burning and geothermal processes, but also as a result …
Activator Protein Transcription Factors Coordinate Human Il-33 Expression From Noncanonical Promoters In Chronic Airway Disease, Heather E. Raphael, Ghandi F. Hassan, Omar A. Osorio, Lucy S. Cohen, Morgan D. Payne, Ella Katz-Kiriakos, Ishana Tata, Jamie Hicks, Derek E. Byers, Bo Zhang, Jen Alexander-Brett
Activator Protein Transcription Factors Coordinate Human Il-33 Expression From Noncanonical Promoters In Chronic Airway Disease, Heather E. Raphael, Ghandi F. Hassan, Omar A. Osorio, Lucy S. Cohen, Morgan D. Payne, Ella Katz-Kiriakos, Ishana Tata, Jamie Hicks, Derek E. Byers, Bo Zhang, Jen Alexander-Brett
2020-Current year OA Pubs
IL-33 is a cytokine central to type 2 immune pathology in chronic airway disease. This cytokine is abundantly expressed in the respiratory epithelium and increased in disease, but how expression is regulated is undefined. Here we show that increased IL33 expression occurs from multiple noncanonical promoters in human chronic obstructive pulmonary disease (COPD), and it facilitates production of alternatively spliced isoforms in airway cells. We found that phorbol 12-myristate 13-acetate (PMA) can activate IL33 promoters through protein kinase C in primary airway cells and lines. Transcription factor (TF) binding arrays combined with RNA interference identified activator protein (AP) TFs as …
Observing Change In Pelagic Animals As Sampling Methods Shift: The Case Of Antarctic Krill, Simeon L. Hill, Angus Atkinson, Javier A. Arata, Anna Belcher, Susan Bengtson Nash, Kim S. Bernard, Alison Cleary, John A. Conroy, Ryan Driscoll, Sophie Fielding, Hauke Flores, Jaume Forcada, Svenja Halfter, Jefferson T. Hinke, Luis Hückstädt, Nadine M. Johnston, Mary Kane, So Kawaguchi, Bjørn A. Krafft, Lucas Krüger, Hyoung Sul La, Cecilia M. Liszka, Bettina Meyer, Eugene J. Murphy, Evgeny A. Pakhomov, Frances Perry, Andrea Piñones, Michael J. Polito, Keith Reid, Christian Reiss
Observing Change In Pelagic Animals As Sampling Methods Shift: The Case Of Antarctic Krill, Simeon L. Hill, Angus Atkinson, Javier A. Arata, Anna Belcher, Susan Bengtson Nash, Kim S. Bernard, Alison Cleary, John A. Conroy, Ryan Driscoll, Sophie Fielding, Hauke Flores, Jaume Forcada, Svenja Halfter, Jefferson T. Hinke, Luis Hückstädt, Nadine M. Johnston, Mary Kane, So Kawaguchi, Bjørn A. Krafft, Lucas Krüger, Hyoung Sul La, Cecilia M. Liszka, Bettina Meyer, Eugene J. Murphy, Evgeny A. Pakhomov, Frances Perry, Andrea Piñones, Michael J. Polito, Keith Reid, Christian Reiss
School of Geography, Earth and Environmental Sciences
Understanding and managing the response of marine ecosystems to human pressures including climate change requires reliable large-scale and multi-decadal information on the state of key populations. These populations include the pelagic animals that support ecosystem services including carbon export and fisheries. The use of research vessels to collect information using scientific nets and acoustics is being replaced with technologies such as autonomous moorings, gliders, and meta-genetics. Paradoxically, these newer methods sample pelagic populations at ever-smaller spatial scales, and ecological change might go undetected in the time needed to build up large-scale, long time series. These global-scale issues are epitomised by …
Transmembrane Domain-Driven Pd-1 Dimers Mediate T Cell Inhibition, Elliot A Philips, Jia Liu, Audun Kvalvaag, Alexander M Mørch, Anna S Tocheva, Charles Ng, Hong Liang, Ian M Ahearn, Ruimin Pan, Christina C Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R Littman, Michael L Dustin, Jun Wang, Xiang-Peng Kong
Transmembrane Domain-Driven Pd-1 Dimers Mediate T Cell Inhibition, Elliot A Philips, Jia Liu, Audun Kvalvaag, Alexander M Mørch, Anna S Tocheva, Charles Ng, Hong Liang, Ian M Ahearn, Ruimin Pan, Christina C Luo, Alexander Leithner, Zhihua Qin, Yong Zhou, Antonio Garcia-España, Adam Mor, Dan R Littman, Michael L Dustin, Jun Wang, Xiang-Peng Kong
Faculty, Staff and Student Publications
Programmed cell death-1 (PD-1) is a potent immune checkpoint receptor on T lymphocytes. Upon engagement by its ligands, PD-L1 or PD-L2, PD-1 inhibits T cell activation and can promote immune tolerance. Antagonism of PD-1 signaling has proven effective in cancer immunotherapy, and conversely, agonists of the receptor may have a role in treating autoimmune disease. Some immune receptors function as dimers, but PD-1 has been considered monomeric. Here, we show that PD-1 and its ligands form dimers as a consequence of transmembrane domain interactions and that propensity for dimerization correlates with the ability of PD-1 to inhibit immune responses, antitumor …
Antioxidant Responses And Phytochemical Accumulation In Raphanus Species Sprouts Through Elicitors And Predictive Models Under High Temperature Stress, María-Trinidad Toro, Roberto Fustos-Toribio, Jaime Ortiz, José Becerra, Nelson Zapata, María Dolores López-Belchí
Antioxidant Responses And Phytochemical Accumulation In Raphanus Species Sprouts Through Elicitors And Predictive Models Under High Temperature Stress, María-Trinidad Toro, Roberto Fustos-Toribio, Jaime Ortiz, José Becerra, Nelson Zapata, María Dolores López-Belchí
Faculty, Staff and Students Publications
Crop production is being impacted by higher temperatures, which can decrease food yield and pose a threat to human nutrition. In the current study, edible and wild radish sprouts were exposed to elevated growth temperatures along with the exogenous application of various elicitors to activate defense mechanisms. Developmental traits, oxidative damage, glucosinolate and anthocyanin content, and antioxidant capacity were evaluated alongside the development of a predictive model. A combination of four elicitors (citric acid, methyl jasmonate—MeJa, chitosan, and K2SO4) and high temperatures were applied. The accumulation of bioactives was significantly enhanced through the application of two elicitors, K2SO4 and methyl …