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Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-Omics Approach Using Patient-Derived Xenografts, Vinay K Pattalachinti, Ichiaki Ito, Saikat Chowdhury, Abdelrahman Yousef, Yue Gu, Betul Beyza Gunes, Emma R Salle, Melissa W Taggart, Keith Fournier, Natalie W Fowlkes, John Paul Shen Apr 2024

Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-Omics Approach Using Patient-Derived Xenografts, Vinay K Pattalachinti, Ichiaki Ito, Saikat Chowdhury, Abdelrahman Yousef, Yue Gu, Betul Beyza Gunes, Emma R Salle, Melissa W Taggart, Keith Fournier, Natalie W Fowlkes, John Paul Shen

Faculty, Staff and Student Publications

Appendiceal adenocarcinoma (AA) is unique from other gastrointestinal malignancies in that it almost exclusively metastasizes to the peritoneal cavity. However, few studies have investigated the molecular interaction of the peritoneal microenvironment and AA. Here, we use a multi-omics approach with orthotopic and flank-implanted patient-derived xenografts (PDX) to study the effect of the peritoneal microenvironment on AA. AA tumors implanted in the peritoneal microenvironment tended to grow faster and displayed greater nuclear expression of Ki-67 relative to the same tumors implanted in the flank. Comparing the tumor-specific transcriptome (excluding stromal transcription), the peritoneal microenvironment relatively upregulated genes related to proliferation, including …

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Neutrophil Elastase Remodels Mammary Tumors To Facilitate Lung Metastasis, Amriti R Lulla, Said Akli, Cansu Karakas, Joseph A Caruso, Lucas D Warma, Natalie W Fowlkes, Xiayu Rao, Jing Wang, Kelly K Hunt, Stephanie S Watowich, Khandan Keyomarsi Apr 2024

Neutrophil Elastase Remodels Mammary Tumors To Facilitate Lung Metastasis, Amriti R Lulla, Said Akli, Cansu Karakas, Joseph A Caruso, Lucas D Warma, Natalie W Fowlkes, Xiayu Rao, Jing Wang, Kelly K Hunt, Stephanie S Watowich, Khandan Keyomarsi

Faculty, Staff and Student Publications

Metastatic disease remains the leading cause of death due to cancer, yet the mechanism(s) of metastasis and its timely detection remain to be elucidated. Neutrophil elastase (NE), a serine protease secreted by neutrophils, is a crucial mediator of chronic inflammation and tumor progression. In this study, we used the PyMT model (NE+/+ and NE-/-) of breast cancer to interrogate the tumor-intrinsic and -extrinsic mechanisms by which NE can promote metastasis. Our results showed that genetic ablation of NE significantly reduced lung metastasis and improved metastasis-free survival. RNA-sequencing analysis of primary tumors indicated differential regulation of tumor-intrinsic actin cytoskeleton signaling pathways …

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Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission By Promoting B/Cd 4 T Cell Crosstalk, Chengyi Li, Ryan Clauson, Luke F Bugada, Fang Ke, Bing He, Zhixin Yu, Hongwei Chen, Binyamin Jacobovitz, Hongxiang Hu, Polina Chuikov, Brett Dallas Hill, Syed M Rizvi, Yudong Song, Kai Sun, Pasieka Axenov, Daniel Huynh, Xinyi Wang, Lana Garmire, Yu Leo Lei, Irina Grigorova, Fei Wen, Marilia Cascalho, Wei Gao, Duxin Sun Apr 2024

Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission By Promoting B/Cd 4 T Cell Crosstalk, Chengyi Li, Ryan Clauson, Luke F Bugada, Fang Ke, Bing He, Zhixin Yu, Hongwei Chen, Binyamin Jacobovitz, Hongxiang Hu, Polina Chuikov, Brett Dallas Hill, Syed M Rizvi, Yudong Song, Kai Sun, Pasieka Axenov, Daniel Huynh, Xinyi Wang, Lana Garmire, Yu Leo Lei, Irina Grigorova, Fei Wen, Marilia Cascalho, Wei Gao, Duxin Sun

Faculty, Staff and Student Publications

Current cancer vaccines using T cell epitopes activate antitumor T cell immunity through dendritic cell/macrophage-mediated antigen presentation, but they lack the ability to promote B/CD4 T cell crosstalk, limiting their anticancer efficacy. We developed antigen-clustered nanovaccine (ACNVax) to achieve long-term tumor remission by promoting B/CD4 T cell crosstalk. The topographic features of ACNVax were achieved using an iron nanoparticle core attached with an optimal number of gold nanoparticles, where the clusters of HER2 B/CD4 T cell epitopes were conjugated on the gold surface with an optimal intercluster distance of 5-10 nm. ACNVax effectively trafficked to lymph nodes and cross-linked with …

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What The Trust? Overcoming Barriers To Renewable Energy Development In Indian Country, Malcolm M. Gilbert, Aspen B. Ward Apr 2024

What The Trust? Overcoming Barriers To Renewable Energy Development In Indian Country, Malcolm M. Gilbert, Aspen B. Ward

Public Land & Resources Law Review

No abstract provided.

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Avoiding The Pitfalls In Administrative Record Review Cases, Kim Wilson, Brian Brammer Apr 2024

Avoiding The Pitfalls In Administrative Record Review Cases, Kim Wilson, Brian Brammer

Public Land & Resources Law Review

No abstract provided.

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Corner Crossing: Unlocking Public Lands Or Invading The Airspace Of Landowners?, Kevin Frazier Apr 2024

Corner Crossing: Unlocking Public Lands Or Invading The Airspace Of Landowners?, Kevin Frazier

Public Land & Resources Law Review

No abstract provided.

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States Of Mind Or State Of Crime: Exploring The Prosecution Of Environmental Crimes In The Western United States, Joshua Ozymy, Melissa Ozymy Apr 2024

States Of Mind Or State Of Crime: Exploring The Prosecution Of Environmental Crimes In The Western United States, Joshua Ozymy, Melissa Ozymy

Public Land & Resources Law Review

No abstract provided.

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Cutting The Mussel's Threads: A Legal Perspective On Invasive Species, Hallee C. Frandsen Apr 2024

Cutting The Mussel's Threads: A Legal Perspective On Invasive Species, Hallee C. Frandsen

Public Land & Resources Law Review

No abstract provided.

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Editors And Staff Members Apr 2024

Editors And Staff Members

Public Land & Resources Law Review

No abstract provided.

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The Outer Wilds And Manufactured Wilderness, Seth Thoelke Apr 2024

The Outer Wilds And Manufactured Wilderness, Seth Thoelke

Floodwall Magazine

No abstract provided.

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Animated Parables: A Pedagogy Of Seven Deadly Sins And A Few Virtues, Joel Mayward Apr 2024

Animated Parables: A Pedagogy Of Seven Deadly Sins And A Few Virtues, Joel Mayward

Journal of Religion & Film

This is a book review of Terry Lindvall, Animated Parables: A Pedagogy of Seven Deadly Sins and a Few Virtues (Lexington Books/Fortress Academic, 2023).

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Radically Feminist Or Monstrously Feminine?: Witches And Goddesses In Guadagnino's Suspiria (2018), Lindsay Macumber Apr 2024

Radically Feminist Or Monstrously Feminine?: Witches And Goddesses In Guadagnino's Suspiria (2018), Lindsay Macumber

Journal of Religion & Film

Guadagnino’s 2018 remake of Suspiria explicitly and implicitly incorporates two connected myths, witchcraft and goddess centered matriarchal prehistory. The fact that each of these myths have been claimed by feminists in myriad ways may explain Guadagnino’s claim that Suspiria is a great feminist film that escapes the male gaze. In this article, I argue that Guadagnino’s representation of these myths lays bare their misogynistic origins and perpetuates, rather than subverts, patriarchal power structures.

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Spiritual Cinema: Agel, Merleau-Ponty And The Cinematic Real, Patrick O'Connor Dr Apr 2024

Spiritual Cinema: Agel, Merleau-Ponty And The Cinematic Real, Patrick O'Connor Dr

Journal of Religion & Film

This article seeks to retrieve the work of Henri Agel, and his collaborator Amédée Ayfre, for our theoretical understanding of film-philosophy. I explore their distinctive contribution to thinking philosophically about film and assess the relative merits of their work for the phenomenology of film. While exceptionally valuable for religious and theological interpretations of film I proceed to argue that Agel and Ayfre’s work needs to be supplemented with the work of Maurice Merleau-Ponty’s film-phenomenology to adequately express the temporal and motional nature of film. Merleau-Ponty’s work I contend while exceptionally valuable is brief and underdeveloped, and therefore does not fully …

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The Lantern, 2023-2024, Grace Wurzer, Naila Twyman, Owen Fazzini, Catherine Stump, Aiden Jones, Keegan Mcgowan, Nanditha Vinod, Olivia Cross, Tatiana Kent, Sidney Belleroche, Zach Devita-Paulson, Christopher Gerrow, Morgan Grabowski, Leyna Maio, Derek Matarazzo, Madeline O'Connor, Luke Peloquin, Ze'ev Shaheen, Hana Yolacan, Mary Mcnabb, Mary Lobo, Hannah Conley, Matilda Dumaine, Mairead Mcdermott, Abigail Prince, Livia M. Nocito, Heather Reitnauer, Ashley Adam, Ryan Bernier, Erin Corcoran, Leo Cox, Julia Decamp, Izabella Entrekin, Georgia Gardner, Emily Gurganus, Amber Leech, Kelsey Lyons, Aurora Mckee, Amy Smith, Miara Truog Sebouhian Apr 2024

The Lantern, 2023-2024, Grace Wurzer, Naila Twyman, Owen Fazzini, Catherine Stump, Aiden Jones, Keegan Mcgowan, Nanditha Vinod, Olivia Cross, Tatiana Kent, Sidney Belleroche, Zach Devita-Paulson, Christopher Gerrow, Morgan Grabowski, Leyna Maio, Derek Matarazzo, Madeline O'Connor, Luke Peloquin, Ze'ev Shaheen, Hana Yolacan, Mary Mcnabb, Mary Lobo, Hannah Conley, Matilda Dumaine, Mairead Mcdermott, Abigail Prince, Livia M. Nocito, Heather Reitnauer, Ashley Adam, Ryan Bernier, Erin Corcoran, Leo Cox, Julia Decamp, Izabella Entrekin, Georgia Gardner, Emily Gurganus, Amber Leech, Kelsey Lyons, Aurora Mckee, Amy Smith, Miara Truog Sebouhian

The Lantern Literary Magazines, 1933 to Present

"God," worship, and damnation in the font of my body • The Men in My Life • Vagabond Fishermen • Unfinished Elegy • Big Game • Bitters • On the Ferris Wheel • Ruffling Feathers • Haunted House • Dragon in the Pond • Saint Sebastian • The Last Supper • The Perfect Babka • Session • Sunrise • Dish Dog • A Love Letter to Hands • In Memoriam: Mary Lobo '15 • Champagne • Resting Place • Balance • An Arboreal Requiem • Moving Forward • Bye-Bye Beach Days • Portofino • The Moth on My Dashboard • …

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Effects Of Sex, Cadmium, And High-Fat-Diet On Accumulation Of Essential Metals In Mouse Kidneys., Justin Y. Xu, Adam Gaweda, Michelle Barati, Michael Merchant, Jun Cai, Lu Cai, Madhavi Rane Apr 2024

Effects Of Sex, Cadmium, And High-Fat-Diet On Accumulation Of Essential Metals In Mouse Kidneys., Justin Y. Xu, Adam Gaweda, Michelle Barati, Michael Merchant, Jun Cai, Lu Cai, Madhavi Rane

Undergraduate Research Events

Effects of cadmium and obesity on accumulation of essential metals in mouse kidney were evaluated. Starting in utero and continuing until 24 weeks postweaning, male/female mice were exposed to cadmium (0, 0.5, or 5 ppm) and were fed on Normal Diet (ND)/High-Fat Diet (HFD) post weaning. ICP-MS analysis was performed to evaluate cadmium and essential metals absorbed in the kidneys of aforementioned mice. Metals data obtained was analyzed using MANOVA with multiple comparisons (Bonferroni correction with p

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A Communication-Efficient Federated Learning Framework For Sustainable Development Using Lemurs Optimizer, Mohammed Azmi Al-Betar, Ammar Kamal Abasi, Zaid Abdi Alkareem Alyasseri, Salam Fraihat, Raghad Falih Mohammed Apr 2024

A Communication-Efficient Federated Learning Framework For Sustainable Development Using Lemurs Optimizer, Mohammed Azmi Al-Betar, Ammar Kamal Abasi, Zaid Abdi Alkareem Alyasseri, Salam Fraihat, Raghad Falih Mohammed

Machine Learning Faculty Publications

The pressing need for sustainable development solutions necessitates innovative data-driven tools. Machine learning (ML) offers significant potential, but faces challenges in centralized approaches, particularly concerning data privacy and resource constraints in geographically dispersed settings. Federated learning (FL) emerges as a transformative paradigm for sustainable development by decentralizing ML training to edge devices. However, communication bottlenecks hinder its scalability and sustainability. This paper introduces an innovative FL framework that enhances communication efficiency. The proposed framework addresses the communication bottleneck by harnessing the power of the Lemurs optimizer (LO), a nature-inspired metaheuristic algorithm. Inspired by the cooperative foraging behavior of lemurs, the …

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Wcsa Alumnews: Spring 2024, Communications And Marketing Apr 2024

Wcsa Alumnews: Spring 2024, Communications And Marketing

WCSA AlumNEWS

Contents include: Harley Hanke Honored at Minnesota State Capitol; WCSA Alumni Association Scholarship Recipients; Remembering Carol Pederson Meyer; Fondly Remembered...; ALUMNEWS Online;

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Augustine On The Religious Foundation Of Citizenship, Jesús E. Muñoz Apr 2024

Augustine On The Religious Foundation Of Citizenship, Jesús E. Muñoz

Jesuit School of Theology Dissertations

In Gaudium et spes, the Second Vatican Council declared, “Let the citizens cultivate with magnanimity and loyalty the love of the country, but without a narrow mind, so that they always look also for the good of the whole human family, united by all kinds of links between the races, and the nations.”1 This declaration responded to one of the most pressing issues of the time, the problem of defining the limits of the state’s social agency. Twenty years prior to Vatican II, the Church witnessed one of the most explosive wars in recorded history, a conflict that had …

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Non-Profit Grant Writing: Supporting A Local Breed Specific Dog Rescue, Kamy Godoy Apr 2024

Non-Profit Grant Writing: Supporting A Local Breed Specific Dog Rescue, Kamy Godoy

IPS/BAS 495 Undergraduate Capstone Projects

For this action project, I chose to pursue a project that would help support the needs, specifically medical, of a local non-profit, no kill dog rescue called Boise Bully Breed Rescue (BBBR). I chose this rescue because it is breed specific and because it is bully specific, this rescue must work a little harder to acquire sources of funding to aid them. After receiving guidance from the rescue’s founder, I decided that the most optimal way to help this rescue was through finding and applying for grants that could offer funding to support their growing medical costs. Funding through grants …

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Development Of A Novel Humanized Anti-Tslp Monoclonal Antibody Hz-1127 With Anti-Allergic Diseases And Cancer Potential., Xiaolei Liu, Jianzhong Han, Qian Wang, Peng Wang, Li Li, Kehe Du, Fengchao Jiang, Pei Zhang, Hongjun Liu, Jian Huang Apr 2024

Development Of A Novel Humanized Anti-Tslp Monoclonal Antibody Hz-1127 With Anti-Allergic Diseases And Cancer Potential., Xiaolei Liu, Jianzhong Han, Qian Wang, Peng Wang, Li Li, Kehe Du, Fengchao Jiang, Pei Zhang, Hongjun Liu, Jian Huang

Cooper Medical School of Rowan University Departmental Research

Thymic stromal lymphopoietin (TSLP) is a member of the IL-2 cytokine family and has been widely recognized as a master regulator of type 2 inflammatory responses at barrier surfaces. Recent studies found dysregulation of the TSLP-TSLP receptor (TSLPR) pathway is associated with the pathogenesis of not only allergic diseases but also a wide variety of cancers including both solid tumors and hematological tumors. Thus, the blockade of TSLP represents an attractive therapeutic strategy for allergic diseases and cancer. In this study, we report the development of a novel humanized anti-TSLP monoclonal antibody (mAb) HZ-1127. Binding affinity, specificity, and ability of …

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Research Trends In Group Investigation Learning Model For Critical Thinking Skills In Science Learning, Anisa Ayu Solikah, Sulistyo Saputro, Sri Yamtinah, Mohammad Masykuri Apr 2024

Research Trends In Group Investigation Learning Model For Critical Thinking Skills In Science Learning, Anisa Ayu Solikah, Sulistyo Saputro, Sri Yamtinah, Mohammad Masykuri

Jurnal Inovasi Pendidikan IPA

The 21st-century learning needs to be applied in science learning amidst the rapid development of this era to equip students with important skills, such as critical thinking skills. One of the factors that affect the success of learning is a learning model that has unique characteristics. The Group Investigation Learning Model is a learning model that allows students to play an active role in determining their learning goals and processes, including critical thinking skills. To see the application of the Group Investigation Learning Model in improving critical thinking skills, it is necessary to carry out a literature review study using …

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Students’ Alternative Concept On The Topic Of Energy In Life, Safira Permata Dewi, Saparini Saparini, Elvira Destiansari, Ersa Lois Anjelina, Liska Setiani Apr 2024

Students’ Alternative Concept On The Topic Of Energy In Life, Safira Permata Dewi, Saparini Saparini, Elvira Destiansari, Ersa Lois Anjelina, Liska Setiani

Jurnal Inovasi Pendidikan IPA

This research aims to get the alternative concepts of students regarding the concept of energy in life using integrative instruments. The concept of energy in life consists of two topics, photosynthesis and cellular respiration. A sample of 375 students was established using the random sampling technique. They were from 14 junior high schools in Palembang City using the stratified cluster sampling. The instrument used consists of 30 free-response. The results of this research show that students understand the concept that photosynthesis can only occur in leaves (23.70%) and takes place during the day (33%) by utilizing oxygen (25.80%) while existing …

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Assessing The Creative Thinking Level Of In-Service Chemistry Teachers Using A Case Study Test, Das Salirawati, Metridewi Primastuti, Erfan Priyambodo Apr 2024

Assessing The Creative Thinking Level Of In-Service Chemistry Teachers Using A Case Study Test, Das Salirawati, Metridewi Primastuti, Erfan Priyambodo

Jurnal Inovasi Pendidikan IPA

In the 21st century is an urge that teachers are not only required to change teaching methods but also have a role and responsibility to be able to motivate students' reasoning and logic to think critically, creatively, and innovatively. This study was conducted to assess the level of creative thinking skills of high school chemistry teachers in one of the districts/cities in Yogyakarta Province. As a survey with a quantitative approach, this study involved 24 in-service chemistry teachers as respondents. All of the population became the respondents in this study so that saturated sampling technique was applied. Creative thinking skills …

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Saga Vol.87 / 2023-24, Lainey Terfruchte, Megan Yarusso Apr 2024

Saga Vol.87 / 2023-24, Lainey Terfruchte, Megan Yarusso

SAGA Art & Literary Magazine

No abstract provided.

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The Effects Of Racial Prejudice And Humanization On Private Aid Donations, Mary Harris, Ashlynn Hokanson, Zeke Peters, Phoebe Roberts, Daniel Nielson Apr 2024

The Effects Of Racial Prejudice And Humanization On Private Aid Donations, Mary Harris, Ashlynn Hokanson, Zeke Peters, Phoebe Roberts, Daniel Nielson

Sigma: Journal of Political and International Studies

World Vision predicts that there are more than 719 million people living in poverty (Peer 2023). Charitable organizations often strive to fill gaps of government programs and alleviate poverty by offering food, clothing, and support to these millions of individuals in need. To be successful in realizing the goals of these charitable organizations, the quantity of charitable donations must be large to create change. Charitable organizations regularly attempt to obtain donations through means of advertising; however, are these methods of advertising effective in soliciting donations to help underprivileged populations across the globe? By improving the understanding of effective donation solicitation …

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Chapter 06. Instructional Message Design For Adult Learners, Pamela J. Smith-Downing Apr 2024

Chapter 06. Instructional Message Design For Adult Learners, Pamela J. Smith-Downing

Instructional Message Design, Volume 3

As stated in Chapter 1, message design is all around us, from the presentations we see in meetings and classes, to the instructions that come with our latest tech gadgets, to multi-million-dollar training simulations. The instructional message design field of study pulls from many applied sciences, including cognitive psychology, industrial design, graphic design, instructional design, information technology, and human performance technology, to name just a few. In this chapter, we will visit several adult learning theories and examples that guide our research into adult learning, look at different real-world instructional message designs for adult learners, and discuss directions for future …

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Chapter 02: Multimedia Learning Theory And Instructional Message Design, Miguel Ramlatchan Apr 2024

Chapter 02: Multimedia Learning Theory And Instructional Message Design, Miguel Ramlatchan

Instructional Message Design, Volume 3

Multimedia learning theory describes how the designers of instructional messages, systems and learning environments can optimize learning. The principles and heuristics of multimedia learning theory have application in traditional and online environments, with young and adult learners, in K-12, higher education, military, corporate, government, and informal learning environments. This diversity of application is based on the foundational premise that all learners can independently process auditory and visual information, have limited working memory resources, and require cognitive resources to process new information and to learn. This chapter describes the basic tenets of multimedia learning theory, best practices that can improve our …

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Acer Reconciliation Action Plan: 31 March 2024–31 December 2025: Reflect, Australian Council For Educational Research (Acer) Apr 2024

Acer Reconciliation Action Plan: 31 March 2024–31 December 2025: Reflect, Australian Council For Educational Research (Acer)

Indigenous Education Research

ACER’s Reconciliation Action Plan (RAP) was developed in a collaborative partnership with Reconciliation Australia. This RAP covers March 2024 to December 2025. It is a statement of ACER's commitment to build deeper mutual understanding and more effective relationships with First Nations peoples, and to promote the integration of First Nations’ cultures, histories and knowledges into Australian educational processes. The four RAP types — Reflect, Innovate, Stretch and Elevate — allow continuous development and strengthening of reconciliation commitments. This Reflect RAP will lay the foundations, priming the workplace for future RAPs and reconciliation initiatives.

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Honors Oracle, April 2024, Marshall University Honors College Apr 2024

Honors Oracle, April 2024, Marshall University Honors College

Honors Oracle

Marshall University’s Honors College newsletter.

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I Am Willow, Ella Burch Apr 2024

I Am Willow, Ella Burch

English Student Projects

A creative writing piece used to personify a willow tree's view of our ever changing and expanding world. A subtle warning against humanity's destruction of nature, and a reminder of the small joys and natural beauty of our world.

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