Digital Commons Network^™

Administrative Appeal Decision - Thomas, Floyd (2022-08-25)

Parole Administrative Appeal Decisions

No abstract provided.

Video Game Creation Class, Darec Wagner, Dylan Wagner, Joshua Gage

SACAD: Scholarly Activities

Developing games is not a straight line and you often encounter problems and inconsistencies within your game. There are many more parts to making a game than you would initially think. Animation and character interactions have been particularly difficult for our group to perfect.

The Utah Statesman, April 8, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Uncomplicating The Complicated: The Definition Of Life, Jennifer S. Primatic

Honors College Theses

The issue of defining life has long been debated by biologists and philosophers alike, but the issue surrounding it has been that the definition is overcomplicated and attempts to include so many definitions from previous scientific discussions. The proposed definition is– a living thing consists of an organic entity which, taken out of the ideal condition, will work toward sustaining itself without outside influence. This definition addresses many issues present in the previous definition, while also including organic entities which should be considered alive.

Historical Alabamiana: Finding Aid, Bethany Latham

Finding Aids

This collection is comprised of items related to the State of Alabama. The items are in a variety of formats, including pamphlets, brochures, clippings, postcards, correspondence, magazines, and more. These items run the gamut as far as their content and have been organized roughly by category. The items originated with the Library’s vertical file, which was culled and the majority of items discarded in 2020. Items related to Alabama and items deemed of significant historical interest were retained and added to the Library’s Special Collections. The vertical file’s original contents date back to JSU’s time as a Normal School; it …

Faculty Senate Executive Committee Agenda April 15, 2024, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:30 Call to Order
• Approval of Minutes – March 18, 2024
• 3:35 University Business
• 3:55 Faculty Senate Business
• 4:00 Information
• Educational Policies Committee – April 4, 2024
• Student Nutrition Access Center
• 4:10 Reports
• Budget and Faculty Welfare Annual Report
• Calendar Committee Annual Report
• Committee on Committees Annual Report
• Recruitment & Retention Annual Report
• 4:30 Old Business
• 4:35 New Business
• Adjourn: 5:00 pm

The Effects Of Acute And Chronic Ethanol Exposure On Mouse Spontaneous Spatial Behaviors, Tia Donaldson

Psychology ETDs

Within the open field, rodents spontaneously explore their surroundings by alternating between stops (absence of movement) and progressions (locomotion between locations). Few studies have examined how alcohol influences the organization of these spatial behaviors; therefore, we evaluated the effects of acute single-dose and binge-like alcohol exposure on spontaneous open-field behaviors. In Experiment 1, adults received a single injection of ethanol and explored a dark environment for 30 minutes. We found that mice assessed immediately after the injection exhibited reductions in locomotion and spontaneous behavior, while those tested 30 minutes later only exhibited suppressed locomotion. In Experiment 2, adolescent/adult mice received …

Constitutional Rights Of Artificial Intelligence, Mizuki Hashiguchi

Washington Journal of Law, Technology & Arts

On February 8, 2022, the Italian Parliament approved constitutional amendments to protect the environment. A member of Parliament stated that the environment is an element of Italy, and that safeguarding the environment means safeguarding humans. The need to protect the environment seems to have become a critical component of public conscience. Likewise, if society perceives that artificial intelligence is vitally important for humanity, does constitutional law allow constitutional rights for artificial intelligence to be created?

Extending constitutional rights to artificial intelligence may be consistent with the jurisprudential history of rights. Constitutional rights have undergone metamorphosis over time to protect new …

Rembrandt’S Missing Piece: Ai Art And The Fallacies Of Copyright Law, Eleni Polymenopoulou

Washington Journal of Law, Technology & Arts

This article discusses contemporary problems related to Artificial Intelligence (AI), law and the visual arts. It suggests that the fallacies of copyright law are already visible in legal conundrums raised by AI in the creative sector. These include, for instance, the lack of uniformity in relation to creations’ copyrightability, the massive scale of copyright infringement affecting visual artists and the creative industry, and the difficulties in implementing media regulation and cyber-regulation. The deeply cherished ‘human authorship’ criterion that was sustained recently by a US Federal Appeals Court in Thaler, in particular, is a short-term solution to the legal challenges …

All Eyez On Rap & Hip-Hop: Analyzing How Black Expression Is Criminalized And The Language Of The Rap Act Of 2022, Maia Young

Washington Journal of Law, Technology & Arts

The Black existence, in the United States of America, has always been regarded as a conditional right. Conventionally, Blackness must always be nonviolent and non-disruptive to safely exist. Because of this, Blackness cannot be confined to restraints and disrupts these conventions with acts of joy and creative expression. Black creativity is both unconventional and sacred. Black creative expression documents, preserves, and unifies cultural lived experiences, from a first-hand lens of those oppressed. Creative and artistic expression celebrates the myriad of stories that are a part of the collective Black experience. Yet, Black creative expression is now being weaponized by prosecutors …

Ypfs Lessons Learned Oral History Project: An Interview With Jason Cave, Greg Feldberg, Vincient Arnold

Documents

No abstract provided.

The Echo: April 8, 2024, Taylor University

2023-2024 (Volume 111)

No abstract provided.

The Role Of Spreading Depolarizations In Mild Traumatic Brain Injuries, Natalie J. Pinkowski

Biomedical Sciences ETDs

Mild traumatic brain injuries (mTBIs) often lead to acute symptoms like disorientation and discoordination, but the underlying mechanisms are unknown. Although most patients recover quickly from a single mTBI, repeated injuries can be debilitating. After an mTBI, a neurometabolic cascade produces metabolic burden and vulnerability. Spreading depolarizations (SDs) have been observed after mTBIs. Here we investigated SDs’ role in short-term motor behavioral deficits post-mTBI. We hypothesized that SDs contribute to the deficits, and exacerbated symptoms after repeated mTBIs. To test this, we used acute motor behavioral tests and long-term behavioral and cognitive tests after initiating SDs by mTBI, chemical, or …

Mir-574-5p Activates Human Tlr8 To Promote Autoimmune Signaling And Lupus, Tao Wang, Dan Song, Xuejuan Li, Yu Luo, Dianqiang Yang, Xiaoyan Liu, Xiaodan Kong, Yida Xing, Shulin Bi, Yan Zhang, Tao Hu, Yunyun Zhang, Shuang Dai, Zhiqiang Shao, Dahan Chen, Jinpao Hou, Esteban Ballestar, Jianchun Cai, Feng Zheng, James Y Yang

Faculty, Staff and Student Publications

Endosomal single-stranded RNA-sensing Toll-like receptor-7/8 (TLR7/8) plays a pivotal role in inflammation and immune responses and autoimmune diseases. However, the mechanisms underlying the initiation of the TLR7/8-mediated autoimmune signaling remain to be fully elucidated. Here, we demonstrate that miR-574-5p is aberrantly upregulated in tissues of lupus prone mice and in the plasma of lupus patients, with its expression levels correlating with the disease activity. miR-574-5p binds to and activates human hTLR8 or its murine ortholog mTlr7 to elicit a series of MyD88-dependent immune and inflammatory responses. These responses include the overproduction of cytokines and interferons, the activation of STAT1 signaling …

The Rider (2024-04-08), Natalie Lapsley

The Rider Archives

Vol.9 No.26

Arid1a Orchestrates Swi/Snf-Mediated Sequential Binding Of Transcription Factors With Arid1a Loss Driving Pre-Memory B Cell Fate And Lymphomagenesis, Darko Barisic, Christopher R Chin, Cem Meydan, Matt Teater, Ioanna Tsialta, Coraline Mlynarczyk, Amy Chadburn, Xuehai Wang, Margot Sarkozy, Min Xia, Sandra E Carson, Santo Raggiri, Sonia Debek, Benedikt Pelzer, Ceyda Durmaz, Qing Deng, Priya Lakra, Martin Rivas, Christian Steidl, David W Scott, Andrew P Weng, Christopher E Mason, Michael R Green, Ari Melnick

Faculty, Staff and Student Publications

ARID1A, a subunit of the canonical BAF nucleosome remodeling complex, is commonly mutated in lymphomas. We show that ARID1A orchestrates B cell fate during the germinal center (GC) response, facilitating cooperative and sequential binding of PU.1 and NF-kB at crucial genes for cytokine and CD40 signaling. The absence of ARID1A tilts GC cell fate toward immature IgM+CD80-PD-L2- memory B cells, known for their potential to re-enter new GCs. When combined with BCL2 oncogene, ARID1A haploinsufficiency hastens the progression of aggressive follicular lymphomas (FLs) in mice. Patients with FL with ARID1A-inactivating mutations preferentially display an immature memory B cell-like state with …

Smarca4 Is A Haploinsufficient B Cell Lymphoma Tumor Suppressor That Fine-Tunes Centrocyte Cell Fate Decisions, Qing Deng, Priya Lakra, Panhong Gou, Haopeng Yang, Cem Meydan, Matthew Teater, Christopher Chin, Wenchao Zhang, Tommy Dinh, Usama Hussein, Xubin Li, Estela Rojas, Weiguang Liu, Patrick K Reville, Atish Kizhakeyil, Darko Barisic, Sydney Parsons, Ashley Wilson, Jared Henderson, Brooks Scull, Channabasavaiah Gurumurthy, Francisco Vega, Amy Chadburn, Branko Cuglievan, Nader Kim El-Mallawany, Carl Allen, Christopher Mason, Ari Melnick, Michael R Green

Faculty, Staff and Student Publications

SMARCA4 encodes one of two mutually exclusive ATPase subunits in the BRG/BRM associated factor (BAF) complex that is recruited by transcription factors (TFs) to drive chromatin accessibility and transcriptional activation. SMARCA4 is among the most recurrently mutated genes in human cancer, including ∼30% of germinal center (GC)-derived Burkitt lymphomas. In mice, GC-specific Smarca4 haploinsufficiency cooperated with MYC over-expression to drive lymphomagenesis. Furthermore, monoallelic Smarca4 deletion drove GC hyperplasia with centroblast polarization via significantly increased rates of centrocyte recycling to the dark zone. Mechanistically, Smarca4 loss reduced the activity of TFs that are activated in centrocytes to drive GC-exit, including SPI1 …

Single-Cell Systems Pharmacology Identifies Development-Driven Drug Response And Combination Therapy In B Cell Acute Lymphoblastic Leukemia, Xin Huang, Yizhen Li, Jingliao Zhang, Lei Yan, Huanbin Zhao, Liang Ding, Sheetal Bhatara, Xu Yang, Satoshi Yoshimura, Wenjian Yang, Seth E Karol, Hiroto Inaba, Charles Mullighan, Mark Litzow, Xiaofan Zhu, Yingchi Zhang, Wendy Stock, Nitin Jain, Elias Jabbour, Steven M Kornblau, Marina Konopleva, Ching-Hon Pui, Elisabeth Paietta, William Evans, Jiyang Yu, Jun J Yang

Faculty, Staff and Student Publications

Leukemia can arise at various stages of the hematopoietic differentiation hierarchy, but the impact of developmental arrest on drug sensitivity is unclear. Applying network-based analyses to single-cell transcriptomes of human B cells, we define genome-wide signaling circuitry for each B cell differentiation stage. Using this reference, we comprehensively map the developmental states of B cell acute lymphoblastic leukemia (B-ALL), revealing its strong correlation with sensitivity to asparaginase, a commonly used chemotherapeutic agent. Single-cell multi-omics analyses of primary B-ALL blasts reveal marked intra-leukemia heterogeneity in asparaginase response: resistance is linked to pre-pro-B-like cells, with sensitivity associated with the pro-B-like population. By …

Making Way: A Methods Experiment With Arts-Based Embodied Postformal Autoethnography To Prepare For Research-As-Community Building With A Diverse Urban Elementary School, Kelly Elizabeth Bare

Theses & Dissertations

Using autoethnographic, arts-based, and embodied methods, this postformal dissertation study establishes the first of a two-part research-as-community-building template designed with racially and socioeconomically diverse school communities in mind. Imagined as a double helix in an echo of human DNA, it describes an arts-based, embodied self-study (Helix 1) as a prerequisite for later study of community (Helix 2, not yet complete) typified by mindful engagement across socially constructed lines of difference and attention to the potential building blocks of collaborative leadership across those same lines. As a prerequisite to community work, I explored my lifetime encounters with others of difference (Chang, …

Sickle Cell Disease In The State Of Tennessee, Ayesha Mukhopadhyay

Electronic Theses and Dissertations Archive

Sickle cell disease (SCD) is an inherited blood disorder. Normal red blood cells are round. In those with SCD, the red blood cells are crescent shaped. In the Unites States (US), more than 90% of those living with SCD are Black. We conducted three epidemiological studies related to the burden of common comorbidities in individuals with SCD, the relationship between SCD and chronic kidney disease, and the effects of historical racial housing policies on births with SCD. First, we evaluated the annual incidence and demographic associations of stroke, seizures, congestive heart failure, asthma, systemic hypertension, and diabetes mellitus in individuals …

Arsenic Contamination Needs Serious Attention: An Opinion And Global Scenario, Abhijnan Bhat School Of Food Science And Environmental Health, Kamna Ravi Health, Engineering & Materials Sciences (Hems) Hub, Furong Tian Nanolab Research Centre, Baljit Singh Micra Biodiagnostics Technology Gateway

Articles

Arsenic (As) contamination is a serious global concern, polluting our natural resources, including water and soil, and posing a danger to the environment and public health. Arsenic is present in the groundwater of several countries and this contaminated water is used for irrigation, drinking, and food preparation, which poses the greatest threat to public health. Nearly 106 countries are affected by groundwater arsenic contamination and an estimated 230 million individuals worldwide are exposed to its adverse health effects, including increased cancer risks, associated cardiovascular disease and diabetes, skin lesions, neurological effects, kidney damage, and foetal or cognitive development-related complications. Arsenic …

First-Time Market Goat, Ashley Longmore, Cheyenne Reid

All Current Publications

This fact sheet is 4-H youth who are thinking about or have recently purchased their first 4-H goat. This fact sheet is a simple outline that provides information on selection, feeding, housing, basic care, and grooming.

First-Time Market Lamb, Ashley Longmore, Cheyenne Reid

All Current Publications

This fact sheet is 4-H youth who are thinking about or have recently purchased their first 4-H lamb. This fact sheet is a simple outline providing more information on selection, feeding, housing, basic care, and grooming.

The Aggregation Effect Of Offshore Mussel Farming On Pelagic Fishes, D Bridger, Mj Attrill, Se Rees, Ev Sheehan

School of Biological and Marine Sciences

The increase in hard artificial structures in the marine environment is contributing to ocean sprawl. As well as adding hard structure to the seabed, mussel aquaculture adds rope droppers and anchor lines to the water column, where such structure would otherwise be absent. This paper aims to monitor the effects of mussel headlines on the pelagic fish community over time, as well as to investigate whether there is an interaction between the age of cultivated mussels with the number of epibiota species and the abundance of pelagic fishes. Two surveys were carried out: a time series monitoring survey to assess …

Indigenizing The Right To A Healthy Environment, Elisabeth Parker, Heather Tanana

Pace Environmental Law Review

The most severe impacts resulting from environmental degradation are experienced by already-vulnerable populations, including Indigenous peoples. A growing number of countries are formally recognizing the basic human right to a healthy environment, which can help realize environmental and climate justice for these communities. On July 28, 2022, the United Nations General Assembly passed a landmark resolution formally recognizing the human right to a clean, healthy, and sustainable environment. The adoption of this resolution represents a pivotal moment in the understanding and implementation of a human rights-based approach to protecting the environment. However, it is important to recognize that historically, Indigenous …

130 Years And Counting Into Forever — New York's Forever Wild Constitutional Amendment And Lessons For Modern Green Amendments, Timothy E. Cox

Pace Environmental Law Review

In the 135 years of New York’s Forever Wild Amendment’s existence, it has been challenged by a range of court cases and thereby interpreted by courts throughout New York. The results of these cases frequently have upheld the heart of Forever Wild: to protect New York’s Forest Preserve land. This Article provides a history of the Forever Wild Amendment, an analysis of the courts’ and New York Attorney General’s interpretations of the Amendment, and a discussion of how this information can guide the future of New York’s Green Amendment.

Human Rights In The News, Joseph Thorpe

Honors Program Theses and Projects

This honors thesis contains thirteen hard news stories that focus on human rights issues in the United States. The United Nations defines Human rights as including, but not limited to, “the right to life and liberty, freedom from slavery and torture, freedom of opinion and expression, the right to work and education, and many more.” Human rights, the U.N. continues, “are essential for making life worth living and are the basis for a just and fair society.”

Meso-Scale Seabed Quantification With Geoacoustic Inversion, Tim Sonnemann, Jan Dettmer, Charles W. Holland, Stan E. Dosso

Electrical and Computer Engineering Faculty Publications and Presentations

Abstract Knowledge of sub-seabed geoacoustic properties, for example depth dependent sound speed and porosity, is of importance for a variety of applications. Here, we present a semi-automated geoacoustic inversion method for autonomous underwater vehicle data that objectively adapts model inference to seabed structure. Through parallelized trans-dimensional Bayesian inference, we infer seabed properties along a 12 km survey track on the scale of about 10 cm and 50 m in the vertical and horizontal, respectively. The inferred seabed properties include sound speed, attenuation, density, and porosity as a function of depth from acoustic reflection coefficient data. Parameter uncertainties are quantified, and …

Improving Pharmacokinetics Of Peptides Using Phage Display, Mallika Asar, Jessica Newton-Northup, Mette Soendergaard

Student Publications

Phage display is a versatile method often used in the discovery of peptides that targets disease-related biomarkers. A major advantage of this technology is the ease and cost efficiency of affinity selection, also known as biopanning, to identify novel peptides. While it is relatively straightforward to identify peptides with optimal binding affinity, the pharmacokinetics of the selected peptides often prove to be suboptimal. Therefore, careful consideration of the experimental conditions, including the choice of using in vitro, in situ, or in vivo affinity selections, is essential in generating peptides with high affinity and specificity that also demonstrate desirable pharmacokinetics. Specifically, …

Molecular Nano-Motors (Mnms): A Novel Delivery Modality For Oligonucleotides, Hamutal Ben Dov, Hagit Grimberg

Delivery Of Nucleic Acid Therapeutics II: Biology, Engineering And Development

Please click Additional Files below to see the full abstract.