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Executive Committee - Agenda 4/2/2024, Academic Senate

Academic Senate Agendas

No abstract provided.

Deep-Learning-Based Group Pointwise Spatial Mapping Of Structure To Function In Glaucoma, Zhiqi Chen, Hiroshi Ishikawa, Yao Wang, Gadi Wollstein, Joel Schuman

Wills Eye Hospital Papers

PURPOSE: To establish generalizable pointwise spatial relationship between structure and function through occlusion analysis of a deep-learning (DL) model for predicting the visual field (VF) sensitivities from 3-dimensional (3D) OCT scan.

DESIGN: Retrospective cross-sectional study.

PARTICIPANTS: A total of 2151 eyes from 1129 patients.

METHODS: A DL model was trained to predict 52 VF sensitivities of 24-2 standard automated perimetry from 3D spectral-domain OCT images of the optic nerve head (ONH) with 12 915 OCT-VF pairs. Using occlusion analysis, the contribution of each individual cube covering a 240 × 240 × 31.25 μm region of the ONH to the model's …

Peritoneal Microenvironment Promotes Appendiceal Adenocarcinoma Growth: A Multi-Omics Approach Using Patient-Derived Xenografts, Vinay K Pattalachinti, Ichiaki Ito, Saikat Chowdhury, Abdelrahman Yousef, Yue Gu, Betul Beyza Gunes, Emma R Salle, Melissa W Taggart, Keith Fournier, Natalie W Fowlkes, John Paul Shen

Faculty, Staff and Student Publications

Appendiceal adenocarcinoma (AA) is unique from other gastrointestinal malignancies in that it almost exclusively metastasizes to the peritoneal cavity. However, few studies have investigated the molecular interaction of the peritoneal microenvironment and AA. Here, we use a multi-omics approach with orthotopic and flank-implanted patient-derived xenografts (PDX) to study the effect of the peritoneal microenvironment on AA. AA tumors implanted in the peritoneal microenvironment tended to grow faster and displayed greater nuclear expression of Ki-67 relative to the same tumors implanted in the flank. Comparing the tumor-specific transcriptome (excluding stromal transcription), the peritoneal microenvironment relatively upregulated genes related to proliferation, including …

Neutrophil Elastase Remodels Mammary Tumors To Facilitate Lung Metastasis, Amriti R Lulla, Said Akli, Cansu Karakas, Joseph A Caruso, Lucas D Warma, Natalie W Fowlkes, Xiayu Rao, Jing Wang, Kelly K Hunt, Stephanie S Watowich, Khandan Keyomarsi

Faculty, Staff and Student Publications

Metastatic disease remains the leading cause of death due to cancer, yet the mechanism(s) of metastasis and its timely detection remain to be elucidated. Neutrophil elastase (NE), a serine protease secreted by neutrophils, is a crucial mediator of chronic inflammation and tumor progression. In this study, we used the PyMT model (NE+/+ and NE-/-) of breast cancer to interrogate the tumor-intrinsic and -extrinsic mechanisms by which NE can promote metastasis. Our results showed that genetic ablation of NE significantly reduced lung metastasis and improved metastasis-free survival. RNA-sequencing analysis of primary tumors indicated differential regulation of tumor-intrinsic actin cytoskeleton signaling pathways …

Section 112(A) Strife At The Federal Circuit: A Call For Congressional Amendment To Save The Genus Claim And Preserve Patent Protection In The Biological Arts, James R. Vancamp Jr.

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission By Promoting B/Cd 4 T Cell Crosstalk, Chengyi Li, Ryan Clauson, Luke F Bugada, Fang Ke, Bing He, Zhixin Yu, Hongwei Chen, Binyamin Jacobovitz, Hongxiang Hu, Polina Chuikov, Brett Dallas Hill, Syed M Rizvi, Yudong Song, Kai Sun, Pasieka Axenov, Daniel Huynh, Xinyi Wang, Lana Garmire, Yu Leo Lei, Irina Grigorova, Fei Wen, Marilia Cascalho, Wei Gao, Duxin Sun

Faculty, Staff and Student Publications

Current cancer vaccines using T cell epitopes activate antitumor T cell immunity through dendritic cell/macrophage-mediated antigen presentation, but they lack the ability to promote B/CD4 T cell crosstalk, limiting their anticancer efficacy. We developed antigen-clustered nanovaccine (ACNVax) to achieve long-term tumor remission by promoting B/CD4 T cell crosstalk. The topographic features of ACNVax were achieved using an iron nanoparticle core attached with an optimal number of gold nanoparticles, where the clusters of HER2 B/CD4 T cell epitopes were conjugated on the gold surface with an optimal intercluster distance of 5-10 nm. ACNVax effectively trafficked to lymph nodes and cross-linked with …

Targeting Branched N-Glycans And Fucosylation Sensitizes Ovarian Tumors To Immune Checkpoint Blockade, Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang

Faculty, Staff and Student Publications

Aberrant glycosylation is a crucial strategy employed by cancer cells to evade cellular immunity. However, it's unclear whether homologous recombination (HR) status-dependent glycosylation can be therapeutically explored. Here, we show that the inhibition of branched N-glycans sensitizes HR-proficient, but not HR-deficient, epithelial ovarian cancers (EOCs) to immune checkpoint blockade (ICB). In contrast to fucosylation whose inhibition sensitizes EOCs to anti-PD-L1 immunotherapy regardless of HR-status, we observe an enrichment of branched N-glycans on HR-proficient compared to HR-deficient EOCs. Mechanistically, BRCA1/2 transcriptionally promotes the expression of MGAT5, the enzyme responsible for catalyzing branched N-glycans. The branched N-glycans on HR-proficient tumors augment their …

Alterations In Serum Thiol-Disulfide Homeostasis And Ischemia-Modified Albumin Concentrations In Clinical Canine Parvoviral Enteritis, Yasi̇n Şenel, Osman Safa Terzi̇, Erdal Kara, Özcan Erel, Sali̇m Neşeli̇oğlu, Ebubeki̇r Ceylan

Turkish Journal of Veterinary & Animal Sciences

Monitoring biomarkers related to inflammation and oxidative stress is critical in dogs because parvovirus causes both inflammatory and antioxidant alterations. The aim of this study was to investigate inflammatory and antioxidant changes caused by canine parvoviral enteritis to better understand the oxidative stress process related to this disease. Thus, the total thiol, native thiol, disulfide, and ischemia-modified albumin levels of Canine parvovirus infected symptomatic puppies and healthy puppies were examined. Using the results of complete blood counts, the blood serum thiol-disulfide homeostasis and ischemia modified albumin levels of the puppies with Canine parvoviral enteritis (n = 65) and the healthy …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Dying Of Natural Silk Deglued By Various Methods, Venera Djavdatovna Khamidova

Technical science and innovation

Products made of natural silk are indispensable for their hygienic properties and will always be in great demand. To obtain an even and intense coloration on a textile material, it is necessary to ensure its effective preparation with the most complete removal of hydrophobic contaminants (both natural and silicone oils applied during the weaving process, lubricants, etc.), which hinder the dyeing of the substrate and reduce the color characteristics of the obtained colors. Therefore, the issue of preparing natural silk for dyeing is relevant. In view of the sensitivity of the main fiber-forming component of natural silk - fibroin to …

Nfĸb Signaling Drives Myocardial Injury Via Ccr2+ Macrophages In A Preclinical Model Of Arrhythmogenic Cardiomyopathy, Stephen P. Chelko, Vinay R. Penna, Morgan Engel, Emily A. Shiel, Ann M. Centner, Waleed Farra, Elisa N. Cannon, Maicon Landim-Vieira, Niccole Schaible, Kory Lavine, Jeffrey E. Saffitz

2020-Current year OA Pubs

Nuclear factor κ-B (NFκB) is activated in iPSC-cardiac myocytes from patients with arrhythmogenic cardiomyopathy (ACM) under basal conditions, and inhibition of NFκB signaling prevents disease in Dsg2mut/mut mice, a robust mouse model of ACM. Here, we used genetic approaches and single-cell RNA-Seq to define the contributions of immune signaling in cardiac myocytes and macrophages in the natural progression of ACM using Dsg2mut/mut mice. We found that NFκB signaling in cardiac myocytes drives myocardial injury, contractile dysfunction, and arrhythmias in Dsg2mut/mut mice. NFκB signaling in cardiac myocytes mobilizes macrophages expressing C-C motif chemokine receptor-2 (CCR2+ cells) to affected areas within the …

Bull Production: Breeding Soundness Exam And Expected Progeny Differences, Ethan Gilliam

All Current Publications

This fact sheet defines a breeding soundness exam (BSE) for a breeding bull and reviews the meaning of expected progeny differences (EPDs). Acronyms used and depended on by livestock producers are reviewed. Understanding the meaning of livestock acronyms is commonly overlooked. Highlights include how a producer makes financial decisions throughout the year in relation to their livestock.

The Fibromyalgia Pain Experience: A Scoping Review Of The Preclinical Evidence For Replication And Treatment Of The Affective And Cognitive Pain Dimensions, Cassie M. Argenbright, Alysia M. Bertlesman, Izabella M. Russell, Tracy L. Greer, Yuan B. Peng, Perry N. Fuchs

Psychological Science Faculty Publications

Fibromyalgia is a chronic, widespread pain disorder that is strongly represented across the affective and cognitive dimensions of pain, given that the underlying pathophysiology of the disorder is yet to be identified. These affective and cognitive deficits are crucial to understanding and treating the fibromyalgia pain experience as a whole but replicating this multidimensionality on a preclinical level is challenging. To understand the underlying mechanisms, animal models are used. In this scoping review, we evaluate the current primary animal models of fibromyalgia regarding their translational relevance within the affective and cognitive pain realms, as well as summarize treatments that have …

Advancing Text Summarization And Classification: Deep Insights From Transformer-Based Statistical Learning, Kun Bu

USF Tampa Graduate Theses and Dissertations

Artificial Intelligence (AI) is a part of human's daily life nowadays. Machine Learning (ML) as one aspect from AI has been rapidly developing during the past two decades, especially from the statistical learning approaches, which emphasized the use of probability and statistics to model data, such as Support Vector Machines (SVMs) for classification and regression tasks to the ensemble learning techniques, such as Random Forest, Gradient Boosting Machine (GBM), and stacking. Ensemble learning has evolved into a pivotal concept in contemporary machine learning, empowering practitioners to amalgamate multiple models to enhance generalization, accuracy, and robustness. As the field of machine …

A Compendium Of Multi-Omics Data Illuminating Host Responses To Lethal Human Virus Infections, Amie J Eisfeld, Larissa B Thackray, Qing Tan, Michael S Diamond, Et Al.

2020-Current year OA Pubs

Human infections caused by viral pathogens trigger a complex gamut of host responses that limit disease, resolve infection, generate immunity, and contribute to severe disease or death. Here, we present experimental methods and multi-omics data capture approaches representing the global host response to infection generated from 45 individual experiments involving human viruses from the Orthomyxoviridae, Filoviridae, Flaviviridae, and Coronaviridae families. Analogous experimental designs were implemented across human or mouse host model systems, longitudinal samples were collected over defined time courses, and global multi-omics data (transcriptomics, proteomics, metabolomics, and lipidomics) were acquired by microarray, RNA sequencing, or mass spectrometry analyses. For …

What The Trust? Overcoming Barriers To Renewable Energy Development In Indian Country, Malcolm M. Gilbert, Aspen B. Ward

Public Land & Resources Law Review

No abstract provided.

Avoiding The Pitfalls In Administrative Record Review Cases, Kim Wilson, Brian Brammer

Public Land & Resources Law Review

No abstract provided.

Corner Crossing: Unlocking Public Lands Or Invading The Airspace Of Landowners?, Kevin Frazier

Public Land & Resources Law Review

No abstract provided.

States Of Mind Or State Of Crime: Exploring The Prosecution Of Environmental Crimes In The Western United States, Joshua Ozymy, Melissa Ozymy

Public Land & Resources Law Review

No abstract provided.

Cutting The Mussel's Threads: A Legal Perspective On Invasive Species, Hallee C. Frandsen

Public Land & Resources Law Review

No abstract provided.

Editors And Staff Members

Public Land & Resources Law Review

No abstract provided.

The Outer Wilds And Manufactured Wilderness, Seth Thoelke

Floodwall Magazine

No abstract provided.

Animated Parables: A Pedagogy Of Seven Deadly Sins And A Few Virtues, Joel Mayward

Journal of Religion & Film

This is a book review of Terry Lindvall, Animated Parables: A Pedagogy of Seven Deadly Sins and a Few Virtues (Lexington Books/Fortress Academic, 2023).

Radically Feminist Or Monstrously Feminine?: Witches And Goddesses In Guadagnino's Suspiria (2018), Lindsay Macumber

Journal of Religion & Film

Guadagnino’s 2018 remake of Suspiria explicitly and implicitly incorporates two connected myths, witchcraft and goddess centered matriarchal prehistory. The fact that each of these myths have been claimed by feminists in myriad ways may explain Guadagnino’s claim that Suspiria is a great feminist film that escapes the male gaze. In this article, I argue that Guadagnino’s representation of these myths lays bare their misogynistic origins and perpetuates, rather than subverts, patriarchal power structures.

Spiritual Cinema: Agel, Merleau-Ponty And The Cinematic Real, Patrick O'Connor Dr

Journal of Religion & Film

This article seeks to retrieve the work of Henri Agel, and his collaborator Amédée Ayfre, for our theoretical understanding of film-philosophy. I explore their distinctive contribution to thinking philosophically about film and assess the relative merits of their work for the phenomenology of film. While exceptionally valuable for religious and theological interpretations of film I proceed to argue that Agel and Ayfre’s work needs to be supplemented with the work of Maurice Merleau-Ponty’s film-phenomenology to adequately express the temporal and motional nature of film. Merleau-Ponty’s work I contend while exceptionally valuable is brief and underdeveloped, and therefore does not fully …

The Lantern, 2023-2024, Grace Wurzer, Naila Twyman, Owen Fazzini, Catherine Stump, Aiden Jones, Keegan Mcgowan, Nanditha Vinod, Olivia Cross, Tatiana Kent, Sidney Belleroche, Zach Devita-Paulson, Christopher Gerrow, Morgan Grabowski, Leyna Maio, Derek Matarazzo, Madeline O'Connor, Luke Peloquin, Ze'ev Shaheen, Hana Yolacan, Mary Mcnabb, Mary Lobo, Hannah Conley, Matilda Dumaine, Mairead Mcdermott, Abigail Prince, Livia M. Nocito, Heather Reitnauer, Ashley Adam, Ryan Bernier, Erin Corcoran, Leo Cox, Julia Decamp, Izabella Entrekin, Georgia Gardner, Emily Gurganus, Amber Leech, Kelsey Lyons, Aurora Mckee, Amy Smith, Miara Truog Sebouhian

The Lantern Literary Magazines, 1933 to Present

"God," worship, and damnation in the font of my body • The Men in My Life • Vagabond Fishermen • Unfinished Elegy • Big Game • Bitters • On the Ferris Wheel • Ruffling Feathers • Haunted House • Dragon in the Pond • Saint Sebastian • The Last Supper • The Perfect Babka • Session • Sunrise • Dish Dog • A Love Letter to Hands • In Memoriam: Mary Lobo '15 • Champagne • Resting Place • Balance • An Arboreal Requiem • Moving Forward • Bye-Bye Beach Days • Portofino • The Moth on My Dashboard • …

Effects Of Sex, Cadmium, And High-Fat-Diet On Accumulation Of Essential Metals In Mouse Kidneys., Justin Y. Xu, Adam Gaweda, Michelle Barati, Michael Merchant, Jun Cai, Lu Cai, Madhavi Rane

Undergraduate Research Events

Effects of cadmium and obesity on accumulation of essential metals in mouse kidney were evaluated. Starting in utero and continuing until 24 weeks postweaning, male/female mice were exposed to cadmium (0, 0.5, or 5 ppm) and were fed on Normal Diet (ND)/High-Fat Diet (HFD) post weaning. ICP-MS analysis was performed to evaluate cadmium and essential metals absorbed in the kidneys of aforementioned mice. Metals data obtained was analyzed using MANOVA with multiple comparisons (Bonferroni correction with p

A Communication-Efficient Federated Learning Framework For Sustainable Development Using Lemurs Optimizer, Mohammed Azmi Al-Betar, Ammar Kamal Abasi, Zaid Abdi Alkareem Alyasseri, Salam Fraihat, Raghad Falih Mohammed

Machine Learning Faculty Publications

The pressing need for sustainable development solutions necessitates innovative data-driven tools. Machine learning (ML) offers significant potential, but faces challenges in centralized approaches, particularly concerning data privacy and resource constraints in geographically dispersed settings. Federated learning (FL) emerges as a transformative paradigm for sustainable development by decentralizing ML training to edge devices. However, communication bottlenecks hinder its scalability and sustainability. This paper introduces an innovative FL framework that enhances communication efficiency. The proposed framework addresses the communication bottleneck by harnessing the power of the Lemurs optimizer (LO), a nature-inspired metaheuristic algorithm. Inspired by the cooperative foraging behavior of lemurs, the …

Wcsa Alumnews: Spring 2024, Communications And Marketing

WCSA AlumNEWS

Contents include: Harley Hanke Honored at Minnesota State Capitol; WCSA Alumni Association Scholarship Recipients; Remembering Carol Pederson Meyer; Fondly Remembered...; ALUMNEWS Online;

Augustine On The Religious Foundation Of Citizenship, Jesús E. Muñoz

Jesuit School of Theology Dissertations

In Gaudium et spes, the Second Vatican Council declared, “Let the citizens cultivate with magnanimity and loyalty the love of the country, but without a narrow mind, so that they always look also for the good of the whole human family, united by all kinds of links between the races, and the nations.”¹ This declaration responded to one of the most pressing issues of the time, the problem of defining the limits of the state’s social agency. Twenty years prior to Vatican II, the Church witnessed one of the most explosive wars in recorded history, a conflict that had …