Digital Commons Network^™

The Importance Of Urban Eco-Gardens For Biodiversity And Human Sustainability: A Case Study From Palestine, Mazin B. Qumsiyeh, Mohammad H. Najajrah, Elias N. Handal, Johanna Gideon, Mohammed A. Abusarhan, Ruediger Prasse

Cities and the Environment (CATE)

The situation in Palestine is of concern where global threats of climate change, overexploitation, habitat destruction, invasive species, and pollution are compounded by occupation and conflict. Thus, almost 1/3^rd of vascular plant species are rare and over 50 are listed as endangered or rare based on their abundance and presence in grids studied earlier. Here, we describe the development of a conservation botanic garden that works via research, education, and direct in situ and ex situ conservation of plant species. The garden now boasts 381 species of vascular plants (63 are rare). The team scientifically and selectively introduced some …

Yukon Harmony Veterinary Clinic Business Proposal, Shaina Atcherian, Aiyana Erhart, Marcelo Ketzler-Lopez, Elise Wood, Jillian Bjornstad

2024 Research and Creative Activity Day Posters

A hub and spoke veterinary clinic based in Fort Yukon, Alaska, that would provide preventative Veterinary services to communities in Interior Rural Alaska at no cost.

Effects Of Hypoxia On Blood Osmolarity In Antarctic Fish Species, Christian Bolton, Kristin O'Brien

2024 Research and Creative Activity Day Posters

Temperature is increasing in the Southern Ocean surrounding Antarctica and as a result, oxygen levels are also decreasing, potentially affecting native fish species. I am measuring blood osmolarity to determine if hypoxia affects the ability of Antarctic fish to regulate blood osmolarity.

The Influence Of Ground Cover And Soil Conditions On Blueberry Productivity, Jedidiah Fincher, Kendall Martinez, Katie Spellman

2024 Research and Creative Activity Day Posters

A study of the effects of ground cover and soil conditions on Blueberry productivity at Bonanza Creek Long Term Ecological Research Station.

The Food Waste Challenge, Andrew N. Rowan, Kathleen Rowan

WellBeing News

The world wastes an extraordinary quantity of food, but the issue has begun to be addressed.

The Latest Australian 'Threat Abatement Plan' For Cats, Andrew N. Rowan

WellBeing News

Australia continues to explore ways to save its unique fauna from predation by domestic cats.

Roadkill: Citizen Science At Work, Andrew N. Rowan

WellBeing News

Wildlife roadkill data began to be collected in the 1990s by citizen scientists and is now a global enterprise.

The Use Of Duddingtonia Flagrans Aged In Mineral For Gastrointestinal Parasitic Nematode Control In Small Ruminants, Elisa M. Preston

LSU Master's Theses

Gastrointestinal nematodes (GIN) are a major constraint to small ruminant health and production throughout the world. Haemonchus contortus commonly known as the “barber pole worm” is a major concern for producers and veterinarians because of the severe anemia, and other clinical symptoms these worms cause. For decades, anthelmintics have been used to control the GIN burden small ruminants face. Katahdin (n=36) and Hampshire sheep (n=12) were used in a randomized block design experiment over a 30-day period. The objective of this study was to evaluate the effectiveness of Duddingtonia flagrans spores, the active ingredient in a commercial product, Bioworma® (International …

Idiopathic Intracranial Hypertension After Abrupt Cessation Of Medication: A Case Report Of Abrupt Glucagon-Like Peptide-1 (Glp-1) Receptor Agonist Cessation And Review Of The Literature, Brittany Heckel

Department of Jefferson Headache Center Papers and Presentations

PURPOSE OF REVIEW: The purpose of this review is two-fold: (1) to discuss a case report of idiopathic intracranial hypertension (IIH) after abrupt cessation of a glucagon-like peptide-1 (GLP-1) receptor agonist with resultant rapid weight gain and (2) to review the literature regarding the potential role of GLP-1 receptor agonists in the treatment of IIH as well as potential pitfalls.

RECENT FINDINGS: GLP-1 receptor agonists have become widely used to treat obesity. Obesity is a known risk factor for the development of IIH, though the precise pathophysiology is unclear. GLP-1 receptor agonists may help treat IIH by promoting weight loss, …

Soil Health Cycle, Bijesh Maharjan, Saurav Das, Vesh R. Thapa, Bharat Sharma Acharya

Department of Agronomy and Horticulture: Faculty Publications

Soil health is pivotal to agricultural sustainability. Promoting and sustaining soil health management is challenging since it involves many interdependent components and steps and is an iterative process. Herein, the soil health cycle (SHC) is proposed as a soil health management cycle encompassing human dimensions, management practices, and their effects on soil health indicators (SHIs), leading to subsequent impacts on soil functions. The SHC provides a structure for an iterative testing of changes to improve soil health. A systematic review of research publications was also conducted using the Web of Science database supplemented by Elicit AI and Scopus API searches …

Formulation, Characterization, And In Vivo Immunogenicity Evaluation Of Heat-Stabilized Dissolvable Polymeric Microneedles, Aidan Lane Leyba

Biomedical Engineering ETDs

Since its introduction, vaccination has improved health outcomes tremendously. However, modern vaccination efforts are still difficult to implement, particularly in developing countries with warm climates. This includes complex and expensive cold-chain management of vaccines to maintain stability, a lack of medical personnel to administer parental vaccines, and needle phobia. As an alternative, dissolvable microneedles have recently been studied for their simple and painless application. In this thesis, I present a novel manufacturing process for polymer-based dissolvable microneedles, loaded with virus-like particles vaccines conjugated to TRIO or Sialokinin peptides to target malaria and arboviruses, respectively. We have performed multiple characterization studies …

First-In-Human Phase I Study Of Tinengotinib (Tt-00420), A Multiple Kinase Inhibitor, As A Single Agent In Patients With Advanced Solid Tumors, Sarina A Piha-Paul, Binghe Xu, Ecaterina E Dumbrava, Siqing Fu, Daniel D Karp, Funda Meric-Bernstam, David S Hong, Jordi A Rodon, Apostolia M Tsimberidou, Kanwal Raghav, Jaffer A Ajani, Anthony P Conley, Frank Mott, Ying Fan, Jean Fan, Peng Peng, Hui Wang, Shumao Ni, Caixia Sun, Xiaoyan Qiang, Wendy J Levin, Brenda Ngo, Qinhua Cindy Ru, Frank Wu, Milind M Javle

Faculty, Staff and Student Publications

PURPOSE: This first-in-human phase I dose-escalation study evaluated the safety, pharmacokinetics, and efficacy of tinengotinib (TT-00420), a multi-kinase inhibitor targeting fibroblast growth factor receptors 1-3 (FGFRs 1-3), Janus kinase 1/2, vascular endothelial growth factor receptors, and Aurora A/B, in patients with advanced solid tumors.

PATIENTS AND METHODS: Patients received tinengotinib orally daily in 28-day cycles. Dose escalation was guided by Bayesian modeling using escalation with overdose control. The primary objective was to assess dose-limiting toxicities (DLTs), maximum tolerated dose (MTD), and dose recommended for dose expansion (DRDE). Secondary objectives included pharmacokinetics and efficacy.

RESULTS: Forty-eight patients were enrolled (dose escalation, …

The Social And Economic Dimensions Of One Of The World’S Longest-Operating Shark Fisheries, Matias Braccini, Maddison Watt, Clinton Syers, Nick Blay, Matthew Navarro, Michael Burton

Fisheries Research Articles

Context

Social and economic information is limited for coastal commercial and recreational fisheries, particularly shark fisheries, which are perceived as unsustainable and as targeting sharks for fins.

Aims

To characterise the social and economic dimensions of one of the world’s few long-standing sustainable shark fisheries.

Methods

We reviewed historic data and surveyed stakeholders to understand the economic and social dimensions of the shark fishery currently operating in Western Australia.

Key results

Since the fishery’s historic peak, there has been a substantial reduction in the number of operating vessels and ports due to management intervention. For the vessels that have remained, …

The Scowl - V. 88 N. 6 - April 4, 2024

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 6 - April 4, 2024. 20 pages.

Maine Farmers Receptive To Seaweed Feed, Nicholas Gosling

UNH Today Archive

No abstract provided.

The Effect Of Covid-19 Pandemic On U.S. Beef Exports To Its Major Trading Partners, Richard Bien

Research Papers

This study analyzed the effect of COVID-19 on U.S. beef exports to South Korea, Japan, China, Mexico, and Canada between June 2017 and July 2023. After accounting for potential factors influencing exports, the study finds that the pandemic’s impact was different in both magnitude and persistence among major trading partners. The drop in exports to Japan and Mexico were notable during the pandemic. The decline in exports began early in the year for Mexico and in March for South Korea. Exports to Canada on the other hand both increased and decreased during this period. Exports to China followed a different …

The Sacred And The Supernatural: Christianity And Teutonic Folklore In The Grimms’ Briar Rose, Amelia Stefanescu

Honors Theses

During the nineteenth century, the Brothers Grimm undertook the task of preserving German folklore during a time of cultural upheaval and struggle for national identity. One such tale, Briar Rose, emerges as a site of ideological interplay between Christian themes and Teutonic traditions. By analyzing the Grimms’ 1812 (first) and 1857 (last) editions, this thesis investigates how the text reflects and synthesizes these distinct belief systems into a coherent narrative.

The research explores how Christian and pagan elements co-exist within Briar Rose and what these interactions reveal about the cultural and religious dynamics within the folktale. The study argues that …

April 4, 2024, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

The Clinical Implications Of Kras Mutations And Variant Allele Frequencies In Pancreatic Ductal Adenocarcinoma, Faria Nusrat, Akshay Khanna, Aditi Jain, Wei Jiang, Harish Lavu, Charles Yeo, Wilbur Bowne, Avinoam Nevler

Department of Surgery Faculty Papers

The KRAS proto-oncogene is a major driver of pancreatic tumorigenesis and is nearly ubiquitously mutated in pancreatic ductal adenocarcinoma (PDAC). KRAS point mutations are detected in over 90% of PDAC cases, and these mutations have been shown to be associated with worse therapy response and overall survival. Pathogenic KRAS mutations are mostly limited to codons 12, 13 and 61, with G12D, G12V, G12R, Q61H, and G13D accounting for approximately 95% of the mutant cases. Emerging data have shown the importance of specific mutant subtypes, as well as KRAS variant allele frequency on clinical prognosis. Furthermore, novel technologies and therapies are …

The Scarlet - Volume Cii, No. 10 (April 24, 2024), Scarlet Staff

The Scarlet (Student Newspaper) (2011-present)

The April 24, 2024 edition of The Scarlet (est. 1939), Clark University's student-run newspaper. The Scarlet is intellectually and editorially independent of the University.

Kenyon Collegian - April 4, 2024

The Kenyon Collegian

No abstract provided.

First-Time Market Steer, Ashley T. Longmore, Cheyenne A. Reid

All Current Publications

The target audience for this fact sheet is 4-H youth who are thinking about or have recently purchased their first 4-H steer. This fact sheet is a simple outline that will give them more information on selection, feeding, housing, basic care, and grooming.

First-Time Market Hog, Ashley T. Longmore, Cheyenne A. Reid

All Current Publications

This fact sheet is for 4-H youth who are thinking about or have recently purchased their first 4-H hog. This fact sheet is a simple outline that will give them more information on selection, feeding, housing, basic care, and grooming.

Genetic Identification Of Three Cites-Listed Sharks Using A Paper-Based Lab-On-A-Chip (Loc), Guuske P. Tiktak, Alexandria Gabb, Margarita Brandt, Fernando R. Diz, Karla Bravo-Vasquez, Cesar Peñaherrera-Palma, Jonathan Valdiviezo-Rivera, Aaron Carlisle, Louise M. Melling, Bradley Cain, David Megson, Richard Preziosi, Kirsty J. Shaw

School of Biological and Marine Sciences

Threatened shark species are caught in large numbers by artisanal and commercial fisheries and traded globally. Monitoring both which shark species are caught and sold in fisheries, and the export of CITES-restricted products, are essential in reducing illegal fishing. Current methods for species identification rely on visual examination by experts or DNA barcoding techniques requiring specialist laboratory facilities and trained personnel. The need for specialist equipment and/or input from experts means many markets are currently not monitored. We have developed a paper-based Lab-on-A-Chip (LOC) to facilitate identification of three threatened and CITES-listed sharks, bigeye thresher (Alopias superciliosus), pelagic thresher (A. …

Copper Toxicity And Calcium Supplementation On Nkx2.5 And Mt2 Gene Expression In Zebrafish Embryos, Sahib Mohammad Bakir, Theodore B. Henry, Richard D. Handy

School of Biological and Marine Sciences

Background: Heavy metals are pervasive pollutants in aquatic ecosystems, posing significant threats to the survival and development of aquatic organisms, particularly during their early life stages. While copper is necessary for fish growth and maturation, elevated levels of dissolved copper in water can lead to adverse effects on early developmental stages. The aim of this study was to evaluate the expression pattern of the nkx2.5 gene and the potential of Mt2 expression as a biomarker for metal toxicity. Methods: The study assessed the expression levels of the nkx2.5 gene at different time points during embryonic development, focusing particularly on its …

Promoting Popular Culture (And) Tourism As National Policies: Comparing "Cool Japan" And "Korean Wave", Kyungjae Jang, Sean Kim

Research outputs 2022 to 2026

This chapter discusses how popular culture and tourism promotion have been pursued and implemented in national policies and how these policies have been perceived through a comparative study of Japan and South Korea, two leading exporters of popular culture and major tourism destinations in Asia. Through the analysis of secondary data such as policy documents and white papers as well as newspaper articles, the characteristics of popular culture and tourism in the two countries from a policy perspective are systemically compared to ascertain what commonalities and/or differences are created and observed and how they affect each other. These queries are …

Vista Checkpoint Inhibition By Ph-Selective Antibody Sns-101 With Optimized Safety And Pharmacokinetic Profiles Enhances Pd-1 Response, Thomas Thisted, Yoshiko Takeuchi, Robert D Schreiber, Et Al.

2020-Current year OA Pubs

VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VISTA antibodies. Here we demonstrate that SNS-101, a newly developed pH-selective VISTA antibody, addresses these challenges. Structural and biochemical analyses confirmed the pH-selectivity and unique epitope targeted by SNS-101. These properties confer favorable pharmacokinetic and safety profiles on SNS-101. In syngeneic tumor models utilizing human VISTA knock-in mice, SNS-101 shows in vivo efficacy when combined with a PD-1 inhibitor, modulates cytokine and chemokine signaling, and alters the …

Beach Processes Controlling Erosional Hotspots And Their Influences On Beach Nourishment Performances: A Case Study Along West-Central Florida Barrier Island Beaches, Sophia Gutierrez

USF Tampa Graduate Theses and Dissertations

This study examines the long-term performance of repeated beach nourishment over an approximately 35-year period at two barrier islands, Sand Key and Treasure Island along the west-central Florida coast, USA. Five cycles of beach nourishment on Sand Key and six on Treasure Island were conducted during the study period. Three erosional hotspots were identified along a combined 14-km stretch of the nourished beach. The processes that cause the erosional hotspot were examined through numerical modeling of nearshore wave and current fields.

The most recent three nourishments since 2006 were monitored systematically by this study. Beach profiles were surveyed bimonthly to …

Characterizing The Roles Of Bacterial And Viral Agents In House Crickets (Acheta Domesticus) At Commercial Rearing Facilities In The United States, Kimberly L. Boykin

LSU Doctoral Dissertations

Feeder insects, and in particular crickets, are becoming more popular as food for humans and domesticated animals. However, disease outbreaks continue to decimate commercial populations. The goals of this dissertation were to characterize the epidemiology of different viral and bacterial pathogens affecting the survival of European house crickets (Acheta domesticus) being raised under mass rearing conditions and identify methods to reduce the impact of these pathogens.

Crickets from nine different producers across the United States were sampled during different seasons to better estimate the prevalence of three pathogenic viruses: Acheta domesticus densovirus (AdDV), Acheta domesticus volvovirus (AdVVV), and …

Addition And Subtraction: Coral Reproduction And Disease In A Changing Ocean, Ashley Rossin

LSU Doctoral Dissertations

Marine diseases are changing the landscapes of coral reefs particularly throughout the Western Atlantic. Stony coral tissue loss disease (SCTLD) swept through this region impacting at least 22 stony coral species. White plague (WP) is a more ephemeral disease, but still has a significant impact on coral reef health and perseverance, especially under a changing ocean. While these impacts are seen on the reef-scale, we can zoom into the tissue-level to identify disease markers for both diseases and identify their differences. This has ramifications for disease intervention, as well as mitigation strategies. Despite continuous disease outbreaks, healthy corals persist and …