Digital Commons Network^™

Multisensory Flicker Modulates Widespread Brain Networks And Reduces Interictal Epileptiform Discharges, Lou T Blanpain, Eric R Cole, Emily Chen, James K Park, Michael Y Walelign, Robert E Gross, Brian T Cabaniss, Jon T Willie, Annabelle C Singer

2020-Current year OA Pubs

Modulating brain oscillations has strong therapeutic potential. Interventions that both non-invasively modulate deep brain structures and are practical for chronic daily home use are desirable for a variety of therapeutic applications. Repetitive audio-visual stimulation, or sensory flicker, is an accessible approach that modulates hippocampus in mice, but its effects in humans are poorly defined. We therefore quantified the neurophysiological effects of flicker with high spatiotemporal resolution in patients with focal epilepsy who underwent intracranial seizure monitoring. In this interventional trial (NCT04188834) with a cross-over design, subjects underwent different frequencies of flicker stimulation in the same recording session with the effect …

Enhancement Of Applied Rice Breeding Programs: Exploring Factors Impacting Genomic Selection Accuracy And Discovery Of A Novel Gene For Grain Shape, Maria G. Montiel

LSU Doctoral Dissertations

Plant breeding is a crucial tool in addressing global challenges such as climate change, population growth, and the need for more resilient crops. Rice serves as a staple food for a significant portion of the global population and has served as a model crop for genetic and genomic studies. Genomic selection (GS) has become valuable tool in plant breeding, allowing breeders to predict breeding lines’ performance based on their genotypes. The training (TS) set is a central component of genomic selection and the optimization of the training set is crucial for efficient implementation of genomic selection. The first two objectives …

Targeted Deletion Of Nr2f2 And Vcam1 In Theca Cells Impacts Ovarian Follicular Development: Insights Into Polycystic Ovary Syndrome?†, Nicholes R Candelaria, Joanne S Richards

Faculty, Staff and Students Publications

Defining features of polycystic ovary syndrome (PCOS) include elevated expression of steroidogenic genes, theca cell androgen biosynthesis, and peripheral levels of androgens. In previous studies, we identified vascular cell adhesion molecule 1 (VCAM1) as a selective androgen target gene in specific NR2F2/SF1 (+/+) theca cells. By deleting NR2F2 and VCAM1 selectively in CYP17A1 theca cells in mice, we documented that NR2F2 and VCAM1 impact distinct and sometimes opposing theca cell functions that alter ovarian follicular development in vivo: including major changes in ovarian morphology, steroidogenesis, gene expression profiles, immunolocalization images (NR5A1, CYP11A1, NOTCH1, CYP17A1, INSL3, VCAM1, NR2F2) as well as …

Patterns, Drivers, And Implications Of Postfire Delayed Tree Mortality In Temperate Conifer Forests Of The Western United States, Sebastian Busby, Cody Evers, Andrés Holz

Geography Faculty Publications and Presentations

Conifer forest resilience may be threatened by increasing wildfire activity and compound disturbances in western North America. Fire refugia enhance forest resilience, yet may decline over time due to delayed mortality—a process that remains poorly understood at landscape and regional scales. To address this uncertainty, we used high-resolution satellite imagery (5-m pixel) to map and quantify delayed mortality of conifer tree cover between 1 and 5 years postfire, across 30 large wildfires that burned within three montane ecoregions in the western United States. We used statistical models to explore the influence of burn severity, topography, soils, and climate moisture deficit …

Lead Compound Development Of Src-3 Inhibitors With Improved Pharmacokinetic Properties And Anticancer Efficacy, Dong Lu, Jianwei Chen, Li Qin, Imani Bijou, Ping Yi, Feng Li, Xianzhou Song, Kevin R Mackenzie, Xin Yu, Bin Yang, Sandipan Roy Chowdhury, James D Korp, Bert W O'Malley, David M Lonard, Jin Wang

Faculty, Staff and Students Publications

Steroid receptor coactivator 3 (SRC-3) is a critical mediator of many intracellular signaling pathways that are crucial for cancer proliferation and metastasis. In this study, we performed structure-activity relationship (SAR) exploration and drug-like optimization of the hit compound SI-2, guided by in vitro/in vivo metabolism studies and cytotoxicity assays. Our efforts led to the discovery of two lead compounds, SI-10 and SI-12. Both compounds exhibit potent cytotoxicity against a panel of human cancer cell lines and demonstrate acceptable pharmacokinetic properties. A biotinylated estrogen response element (ERE) pull-down assay demonstrated that SI-12 could disrupt the recruitment of SRC-3 and p300 in …

An Instrument To Evaluate 4-H Cloverbud Stem Programming, Alisha M. Hardman, Donna J. Peterson, Mariah S. Morgan, H. Elizabeth Solace

Journal of Extension

Evaluation data is needed to demonstrate the impact of 4-H science, technology, engineering, and mathematics (STEM) programming on children and youth. However, collecting evaluation data from cloverbuds (ages 5-7) is particularly challenging given their developmental age. We adapted an observational Cloverbud evaluation tool to measure basic life skills, essential elements of positive youth development experiences, and, unique to this tool, STEM specific experiences. We developed the STEM items using educational science standards allowing Extension to document STEM in addition to youth development outcomes. Doing so, may increase the adoption of 4-H STEM programming by teachers in the school setting.

Prevalence And Severity Of Adhd Among Children With Second-Hand Smoke Exposure – A Us Population-Based Study, Saral R. Desai, Edward Lin

Tower Health Research Day

No abstract provided.

Predictors Of Treatment Admissions For Hallucinogen Use In The United States, Saral R. Desai, Hayden Sando, Edward Lin

Tower Health Research Day

No abstract provided.

Cocoa Polyphenols Modulate The Gut Microbiome In A Site-Specific Manner In Mice, Marcus Hayden

Student Research Symposium

Gut Health and the Microbiome

• Colorectal cancer (CRC) is one of the most prevalent cancers in the United States; early-onset CRC is also on the rise [1].
• Colitis-associated CRC is defined as CRC that arises from inflammation of the colon.
• A Western-type diet has been shown to exacerbate colitis.
• Metabolites of the gut microbiome contain anti-cancer and anti-inflammatory properties [2].
• Diet is a key factor in the gut microbiome composition.
• Polyphenols in cocoa may restore the gut microbiome composition from pre-existing dysbiosis.
• More research is needed to study how dietary cocoa supplementation modulates the microbiome across several sites of the …

The Effects Of Including Sprouted Barley In The Diets Of Feeder Lambs, Zachary Crump

Student Research Symposium

Introduction

• Why do we care about sustainable agriculture?
• Increased population, and decreased available resources make production difficult to keep up with demand (Alexandratos and Bruinsma 2012).
• Lamb demand has increased 38% from 2012-2022 in the United States (Agriculture 2024)
• New technology can increase crop intensification to help production meet demand.

The Effect Of The Glucocorticoid Receptor Modulator, Safit, On Acute Stress Reactivity In A Rat Model Of Abusive Head Trauma, Brielle Coe

Tower Health Research Day

No abstract provided.

The Application Of Poly-Ε-Caprolactone Nanoparticles For Endotoxin Removal, Mikaela Ritchie

Undergraduate Research Conference at Missouri S&T

Lipopolysaccharides (LPS), also known as endotoxins, are toxins released from the cell walls of gram-negative bacteria upon their death. Ingestion of LPS by humans or animals can initiate inflammatory immune responses, resulting in blood vessels dilation, organ dysfunction and potential death. These toxins contaminate a variety of manufacturing processes from the pharmaceutical industry to animal feed production, posing a risk to humans and animals alike. This study details the production of PCL nanoparticle capable of removing LPS from water and a preliminary analysis of the removal efficiency. The outcomes of this research hold significant implications for industries reliant on bacterial …

The Influence Of Sensory Modality On Aesthetic Judgments Of Poetry, Jessica Frame, Kendra Mehl

Undergraduate Research Conference at Missouri S&T

Previous research has shown that vividness of evoked imagery is the strongest contributor to aesthetic pleasure for poetry. However, it is 19 unknown whether modality of the poem has an effect on the relationship between vividness and aesthetic appeal, as past work has only used written poems. In this study we want to evaluate rating of vividness, valence, arousal, and aesthetic appeal based on the modality in which poems are presented (listening only, reading only, or combined). Participants were randomly assigned to one of the three modalities: text-only (N=81 ), audio-only (N=74), or combined audio/text (N=78). Our results showed that …

Medical-Dental Staff Topics, 1987, V21 N5, May, Advocate Health - Midwest

Historical Documents - Combined

St. Luke's Hospital, Milwaukee, WI: An issue of "Medical-Dental Staff Topics". This was an internal publication for ASLMC staff members reporting on news, research, events, and staffing updates. Includes a staff calendar and information on continuing education opportunities.

An Indigenous Kitchen: Using Design To Preserve Indigenous North American Food Cultures And Edible Plants, Alida Cummings

Student Research Symposium

Examine the causes and the detriment of reduced rood access, loss of knowledge, nutritional deficit, and reliance on imported foods on Indigenous American populations, with emphasis on the Pueblo, Diné, Apache, Hopi, and Zuni peoples of the American Southwest. Examine attempts to restore cultural food knowledge and Indigenous plant cultivation. Examine traditional foodways of the American Southwest. Propose and demonstrate possible solutions brought about by use of architecture and interior design.

Effect Of Medium On Epigenetics In Fertilized And Cloned Embryos, Ethan Loertscher

Student Research Symposium

• The metabolic pathways that oocytes and embryos take during early development have an important effect on epigenetic events. This leads to the question of whether different cultures affect epigenetics.
• There are some concerns that serum-containing mediums may be correlated with poor health outcomes.
• Acetylation of lysine 9 on histone 3 is associated with chromatin configurations. The intensity of H₃K₉ac is much lower in cloned embryos (somatic cell nuclear transfer (SCNT)) than what is seen in normal embryos
• This study was aiming to compare IVF and SCNT embryos cultured in a medium containing serum and a medium …

E-Cigarette Impacts On Aspects Of Dementia: Basic Research, Daniel S. Da Silva, Lucy N. Scribner

Student Research Symposium

E-cigarettes and Dementia

• Although smoking has declined in recent years, e-cigarette (vaping) use has drastically increased, particularly in youth.
• Smoking escalates risk for vascular dementia, with women more impacted than men.
• Dementia - Impaired capacity to remember, which interferes with the ability to perform daily functions.

A Comparison Of Gray Wolf Home Range Estimates, James Dye

Student Research Symposium

For this study we use GPS collar data from two wolf populations in Turkey and Croatia to compare their home ranges in order to determine which populations home ranges are larger. These two populations live in similar climates but have different impacts from human activity. The wolf population in Turkey experiences larger human presence and almost no natural prey availability, while in Croatia the wolf population exists in a more natural habitat with a substantial natural prey base. This creates an interesting comparison between the two populations and raises the question which average home range would be larger.

Effects On Cytokine Supplementation On Bovine Embryo Development, Pratt Griffeth

Student Research Symposium

• Artificial reproductive techniques (ARTs), such as in-vitro fertilization (IVF), allow for embryo production beyond what is naturally possible.
• To conduct IVF oocytes must reach maturity via in-vitro maturation (IVM), be fertilized by IVF, and the resulting embryos cultured via in-vitro culture (IVC).
• Modifications in maturation media and culture media are often tested experimentally to increase effectiveness of ARTs.
• Researchers have found that supplementing a group of three cytokines (fibroblast growth factor 2 (FGF2), leukemia inhibiting factor (LIF), insulin-like growth factor 1 (IGF1), together known as FLI) in maturation media improved oocyte maturation in pigs and bovine cloning success.^1-2
• Our …

Statistical Modeling Of Fruit Fly Based On Sleep Characteristics, Landon Oelschlaeger, Gayla R. Olbricht, V. A. Samaranayake, Matthew S. Thimgan

Undergraduate Research Conference at Missouri S&T

In this research, a statistical model was developed to predict the lifespan of the fruit fly, Drosophila melanogaster, based on the sleep characteristics. Previously, a model was developed using variables based on the transition probabilities of a fly staying awake or asleep from minute-to-minute. This research builds on the previous work by incorporating additional variables based on traditional sleep metrics along with the transition probability variables into the modeling process. A method was first developed to automate the generation of the traditional sleep metrics, enabling them to be included in the model. Forward stepwise selection was used to determine an …

Xenobiotic-Lnduced Developmental Neuropathology, Lindsay Schneider

Undergraduate Research Conference at Missouri S&T

As new drugs and pollutants are introduced, a larger subset of people are exposed. The question that arises is whether exposure of a pregnant woman to drugs/pollutants will have negative effects on the neurobiology of her unborn child. We are establishing a screen to test the effects of drugs and pollutants on the developmental neuropathology of the model organism, Caenorhabditis elegans. The roundworm has 302 neurons that are structurally similar to human neurons, and defects in single neurons can be detected by impairment in their neural behaviors such as chemotaxis towards an attractant. Using a chemotaxis assay, we can investigate …

Evaluation Of Phosphorus Uptake Within Aquatic Plants For The Use Of Nutrient Removal, Grace Willbanks

Undergraduate Research Conference at Missouri S&T

Stormwater runoff from urban areas can lead to excess nutrients, such as phosphorus or nitrogen, in our waterways. These waste nutrients can lead to overgrowth of algae and plants, deoxygenation of ponds and streams, and death of the aquatic life in these important ecosystems. Currently, floating treatment wetlands are being used to combat these excess nutrients, combining a floating element with an absorptive media, either man-made or natural aquatic plants, into a model to float on an impacted lake. In this research project, multiple small-scale microcosm level experiments were run with different native aquatic plants to test their uptake ability …

Are Pheromones Necessary To Survive?, Galayna Baur

Undergraduate Research Conference at Missouri S&T

Caenorhabditis elegans (C.elegans) is a species of nematodes widely found on rotting plant material due to the presence of their primary food source, bacteria. These animals utilize pheromones for communication to signal larval stages to enter the dauer phase-a survival strategy enabling them to withstand periods of minimal to no food availability, thereby regulating their population size. This study investigates the role of pheromone signaling in population dynamics and survival strategies of C. elegans using a population dynamics experiment. We employ two strains: N2, a laboratory strain with intact pheromone signaling, and a mutant strain lacking the ability to signal …

19th Annual Undergraduate Research Conference (Ugrc) - 2024, Missouri University Of Science And Technology

Undergraduate Research Conference at Missouri S&T

No abstract provided.

Generative Video Ads Tailored To Market Segments, Manoj Muthamizh Selvan

Defensive Publications Series

With user permission, advertisements that are delivered to a user can be selected based on user data in a manner that the advertisements are likely to be useful to the user. However, the content of the advertisement itself is not personalized to the viewer or viewer group/ market segment. This disclosure describes techniques that utilize generative artificial intelligence (gen AI) to automatically create video ad content customized to particular market segments. Inputs from the advertiser such as brand images, logos, props, etc., together with market segment descriptions are provided to a large language model (LLM) that generates text prompts. The …

April 10, 2024 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

Resource Allocation Of Ecosystem Services Of Cross Timbers Forests, Iryna Mcdonald

SACAD: Scholarly Activities

Abstract

Forested ecosystems offer numerous goods and services, many of which are challenging to quantify directly. The productive potential of the Cross-Timber Forest region requires significant policy attention resulting from the economic contributions these services offer the locality – extending from southern Kansas to central Oklahoma and into Texas, including the metropolitan areas like Tulsa (Oklahoma), Oklahoma City (Oklahoma), and Dallas (Texas), providing ecosystem services to millions of residents along the Midwest-South continuum. Stand variety, in this transitional ecoregion, is largely comprised of post oak (Quercus stellata) and blackjack oak (Quercus marilandica) woodlands with varying tree densities interspersed with patches …

Revolutionizing Ecosystems: Innovative Planting Machines Combating Desertification, Sunghun Park, Jeanne Sumrall

SACAD: Scholarly Activities

An important environmental issue that has a profound effect on human welfare, socioeconomic stability, and global ecosystems is desertification. A little over 12 million hectares of land perish year due to the damaging impacts of desertification, which is made worse by overgrazing, deforestation, and inadequate water management. This not only results in a significant loss of arable land, capable of producing 20 million tons of grain, but also in substantial economic repercussions, with estimated annual losses reaching USD 42 billion (UNCCD, 2020). The enormity of the problem emphasizes how urgently we need practical, long-term solutions to stop and reverse the …

The Art Of Motion, Audrey Caleb, Selina Shang

SACAD: Scholarly Activities

Animation is an integral part of our daily lives. From entertainment, to advertisements, to medical visualizations and everything in between, it permeates our world. But what makes animation so compelling? Why do we connect with it so well? And what makes it visually appealing?

Humans are story driven creatures, and so we gravitate towards time-based media—it’s the perfect vehicle for telling stories. Our goal was to explore the variety of styles and tools used in animation, research the 12 principles, understand the process of creating a work from start to finish, and successfully demonstrate the science and art of animation.

My Story Is In The Structure: An Autoethnographic Study By An Instructional Designer Working In A Centralized Academic Reporting Line, Pamela Williams

Dissertations

Although not officially named in the shared governance of an institution, instructional designers play an important role as they collaborate with administrators and faculty to create high quality, regulatory-compliant courses for enrolled students. Instructional designers working in centralized, academic reporting units may be well-positioned to advance the work of institutions to maintain good standing with the industry and regulatory bodies. To illustrate the challenges, opportunities, and strategies employed by an instructional designer working in such a position, an autoethnographic study was conducted to elucidate how shared governance influences, empowers, and disempowers an instructional designer’s ability to lead and collaborate on …