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Articles 56101 - 56130 of 733420
Full-Text Articles in Entire DC Network
2024-04-17 The New College Of Arts And Sciences Dean Monica J. Casper, Caleb Stipkovits
2024-04-17 The New College Of Arts And Sciences Dean Monica J. Casper, Caleb Stipkovits
The Spectator Online
No abstract provided.
2023 Rising Stars In Measurement Science, Shelley Minteer
2023 Rising Stars In Measurement Science, Shelley Minteer
Chemistry Faculty Research & Creative Works
No abstract provided.
Linear And Nonlinear Behaviors Of The Photoreceptor Coupled Network, Ji-Jie Pang, Xiaolong Jiang, Samuel M Wu
Linear And Nonlinear Behaviors Of The Photoreceptor Coupled Network, Ji-Jie Pang, Xiaolong Jiang, Samuel M Wu
Faculty, Staff and Students Publications
Photoreceptors are electrically coupled to one another, and the spatiotemporal properties of electrical synapses in a two-dimensional retinal network are still not well studied, because of the limitation of the single electrode or pair recording techniques which do not allow simultaneously measuring responses of multiple photoreceptors at various locations in the retina. A multiple electrode recording system is needed. In this study, we investigate the network properties of the two-dimensional rod coupled array of the salamander retina (both sexes were used) by using the newly available multiple patch electrode system that allows simultaneous recordings from up to eight cells and …
Encoding Of Visual Objects In The Human Medial Temporal Lobe, Yue Wang, Runnan Cao, Shuo Wang
Encoding Of Visual Objects In The Human Medial Temporal Lobe, Yue Wang, Runnan Cao, Shuo Wang
2020-Current year OA Pubs
The human medial temporal lobe (MTL) plays a crucial role in recognizing visual objects, a key cognitive function that relies on the formation of semantic representations. Nonetheless, it remains unknown how visual information of general objects is translated into semantic representations in the MTL. Furthermore, the debate about whether the human MTL is involved in perception has endured for a long time. To address these questions, we investigated three distinct models of neural object coding-semantic coding, axis-based feature coding, and region-based feature coding-in each subregion of the human MTL, using high-resolution fMRI in two male and six female participants. Our …
Tabletized Nanomedicine: From The Current Scenario To Developing Future Medicine, Rahul Tiwari, Meghana Kolli, Sumeet S. Chauhan, Murali Yallapu
Tabletized Nanomedicine: From The Current Scenario To Developing Future Medicine, Rahul Tiwari, Meghana Kolli, Sumeet S. Chauhan, Murali Yallapu
School of Medicine Publications
The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of …
Characterization Of Early Markers Of Disease In The Mouse Model Of Mucopolysaccharidosis Iiib, Katherine B Mccullough, Amanda Titus, Kate Reardon, Sara Conyers, Joseph D Dougherty, Xia Ge, Joel R Garbow, Patricia Dickson, Carla M Yuede, Susan E Maloney
Characterization Of Early Markers Of Disease In The Mouse Model Of Mucopolysaccharidosis Iiib, Katherine B Mccullough, Amanda Titus, Kate Reardon, Sara Conyers, Joseph D Dougherty, Xia Ge, Joel R Garbow, Patricia Dickson, Carla M Yuede, Susan E Maloney
2020-Current year OA Pubs
BACKGROUND: Mucopolysaccharidosis (MPS) IIIB, also known as Sanfilippo Syndrome B, is a devastating childhood disease. Unfortunately, there are currently no available treatments for MPS IIIB patients. Yet, animal models of lysosomal storage diseases have been valuable tools in identifying promising avenues of treatment. Enzyme replacement therapy, gene therapy, and bone marrow transplant have all shown efficacy in the MPS IIIB model systems. A ubiquitous finding across rodent models of lysosomal storage diseases is that the best treatment outcomes resulted from intervention prior to symptom onset. Therefore, the aim of the current study was to identify early markers of disease in …
Historical Dictionary Of Fantasy Literature, 2nd Ed., Edited By Allen Stroud, Douglas A. Anderson
Historical Dictionary Of Fantasy Literature, 2nd Ed., Edited By Allen Stroud, Douglas A. Anderson
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
No abstract provided.
A Joyful Outpost: Exploring The Household Economy Of The Beavers From The Lion, The Witch, And The Wardrobe By Aaron Bair, Josiah Peterson
A Joyful Outpost: Exploring The Household Economy Of The Beavers From The Lion, The Witch, And The Wardrobe By Aaron Bair, Josiah Peterson
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
Aaron Bair’s new book on Mr. and Mrs. Beaver from The Lion, the Witch, and the Wardrobe combines scholarship with promotion of traditional values he believes are in keeping with C.S. Lewis’s view of the world.
Mystical Perelandra: My Lifelong Reading Of C.S. Lewis & His Favorite Book By James Como, Eleanor Knobil
Mystical Perelandra: My Lifelong Reading Of C.S. Lewis & His Favorite Book By James Como, Eleanor Knobil
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
This article discusses the strengths and weaknesses of James Como's reflective analysis of C.S. Lewis's Perelandra.
Tolkien In The Twenty-First Century: The Meaning Of Middle-Earth Today By Nick Groom, Laura N. Van Dyke
Tolkien In The Twenty-First Century: The Meaning Of Middle-Earth Today By Nick Groom, Laura N. Van Dyke
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
No abstract provided.
J.R.R. Tolkien In Central Europe: Context, Directions, And The Legacy Edited By Janka Kascakova And David Levente Palatinus, Nancy Martsch
J.R.R. Tolkien In Central Europe: Context, Directions, And The Legacy Edited By Janka Kascakova And David Levente Palatinus, Nancy Martsch
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
No abstract provided.
Pursuing An Earthly Spirituality: C.S. Lewis And Incarnational Faith By Gary S. Selby, Sarah O'Dell
Pursuing An Earthly Spirituality: C.S. Lewis And Incarnational Faith By Gary S. Selby, Sarah O'Dell
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
Review of Pursuing an Earthy Spirituality: C.S. Lewis and Incarnational Faith, by Gary S. Selby.
“Hell Is Only A Word. The Reality Is Much, Much Worse”: Black Holes As Fantasy Gateways To Hell, Kristine Larsen
“Hell Is Only A Word. The Reality Is Much, Much Worse”: Black Holes As Fantasy Gateways To Hell, Kristine Larsen
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
While the genre of space horror is generically defined as simply space-based horror, there exist specific tropes that can be used to identify representative works. Among these are: (i) a relatively small ensemble cast, (ii) many of whom die over the course of the story; (iii) a secret corporate/political/military agenda and (iv) physical and psychological stresses due to the arduous process of space travel and related isolation. A subset of space horror adds metaphysical elements, drawing connections to Hell, more specifically a liminal space that Victor Turner terms the “betwixt and between.” As the region around and within the event …
Hell On His Mind: Dean Winchester’S Journey To Hell And Back, Anna Caterino
Hell On His Mind: Dean Winchester’S Journey To Hell And Back, Anna Caterino
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
Season three of Supernatural (2005-2020) closes with a shot of Dean Winchester (Jensen Ackles) in Hell. The place has no discernible features and resembles neither the long waiting line nor the gothic castle of later seasons. What is does resemble is a brain, with a labyrinth of ropes reminiscent of neurons, suggesting Hell is a place that exists first and foremost in Dean’s head. The lack of establishing shots and the abstract terms used to discuss Hell, damnation, and Dean’s experience present the viewer with a physical place into which all of Dean’s fears and trauma converge. This essay analyzes …
Denial And Acceptance: A Core Myth Of Orpheus And Eurydice In The Modern Lyric, Brian O. Murdoch
Denial And Acceptance: A Core Myth Of Orpheus And Eurydice In The Modern Lyric, Brian O. Murdoch
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
The story of Orpheus’s failed attempt to bring Eurydice back from the dead is a frequently used theme in literature and in the modern lyric in particular, and it has been the subject of sometimes excessively complex critical attention. One core of the myth, however, is the need for the living to face and to accept the fact of the death of someone close to them. Modern lyrics in different European languages—the heirs to the classical myth—make clear how Orpheus’s attempt to bring his wife back from Hades was always impossible, and that his reaction was thus a form of …
Substance Abuse: The Symbolic Geography Of Hell In The Great Divorce, Richard A. Bergen
Substance Abuse: The Symbolic Geography Of Hell In The Great Divorce, Richard A. Bergen
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
Blake’s The Marriage of Heaven and Hell is a Romantic vision of evil energy that reaches to the heavens, a geographical representation of capacity and scope and perpetual cosmic change. On the other hand, Lewis’s vision of hell in The Great Divorce is that of a land without substance: a conurbation of addiction to mental maladies, an endless mental substance abuse, an emptying of presence, and a banal stasis to the journey of the soul. Many of Lewis’s sources and inspirations for The Great Divorce, similarly, portray hell as a land of paradoxical “seeming-largeness”, while having ontological smallness. Throughout …
Introduction To Special Issue: Fantasy Goes To Hell, Janet Brennan Croft, Erin Giannini
Introduction To Special Issue: Fantasy Goes To Hell, Janet Brennan Croft, Erin Giannini
Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature
No abstract provided.
Communicating Increased Salinity In The St. Johns River, Kailan Sindelar Ph.D.
Communicating Increased Salinity In The St. Johns River, Kailan Sindelar Ph.D.
DHI Digital Projects Showcase
Poster presented at the 2024 DHI showcase.
Who Is Florida Man?: Perceptions Of Identity Through Language And Media In Florida, Jessica Chandras Ph.D., Sarah Shiell, Bailey Gressett, Ann Bordin
Who Is Florida Man?: Perceptions Of Identity Through Language And Media In Florida, Jessica Chandras Ph.D., Sarah Shiell, Bailey Gressett, Ann Bordin
DHI Digital Projects Showcase
Poster presented at the 2024 DHI Showcase
Investigating The Binding Mechanism Of Draq5, Katelyn Finnerty
Investigating The Binding Mechanism Of Draq5, Katelyn Finnerty
Liberty University Research Week
DRAQ5 is a synthetic fluorescent dye. Most commonly it is used to tag double stranded DNA. Since the dye is able to permeate the cell membrane, it often binds to the nucleus of the cell. This makes the dye useful in analyzing cell cycles. DRAQ5 can be used in many medical fields like immunocytochemistry and immunohistochemistry, and applications like flow cytometry and high content screening. Upon a brief inspection of the literature surrounding DRAQ5, there seemed to be some inconsistencies when talking about the binding mechanism in particular. DRAQ5 can be seen to be described as having both an intercalant …
Investigating Antimicrobial Properties Released From Developing Amphibian Eggs, Olivia Grimsley
Investigating Antimicrobial Properties Released From Developing Amphibian Eggs, Olivia Grimsley
Liberty University Research Week
Early amphibian development often occurs in a hostile environment, abundant with potential predators and pathogens. While it is known that amphibian eggs are protected physically by 5-8 layers of glycoprotein jelly, additional protection mechanisms used against water pathogens are largely unknown. Previous research in our lab has indicated that amphibian eggs exhibit a unique microbiome on the egg surface which is distinct from the surrounding environment. This uniqueness may indicate defensive, rather than offensive, resistance by developing eggs to microbes. A recent series of experiments in our lab to observe a defensive/offensive response have not provided clarity. This project is …
Is The Perfect Soccer Ball Still Out There? A Review And Optimization Of The Beautiful Game., Joshua Walker
Is The Perfect Soccer Ball Still Out There? A Review And Optimization Of The Beautiful Game., Joshua Walker
Liberty University Research Week
Soccer, or football as known in the majority of the world, is the largest sport by fanbase in the world. One of the most critical components of the sport is the ball that is used in the game. The ball has seen many improvements made to every component of the ball and every step of the manufacturing process. Most notable of these improvements made is to the outside of the soccer ball. Old soccer balls were made using a leather cover. This covering would quickly affect the performance of the ball as excess moisture would be absorbed by the leather. …
Fda Investigational New Drug (Ind) Applications, Cassandra Taylor
Fda Investigational New Drug (Ind) Applications, Cassandra Taylor
Oxford ICSB
Current Federal law requires that a drug be the subject of an approved marketing application before it is transported or distributed across state lines. Because a sponsor will probably want to ship the investigational drug to clinical investigators in many states, it must seek an exemption from that legal requirement. The IND is the means through which the sponsor technically obtains this exemption from the FDA. During a new drug's early preclinical development, the sponsor's primary goal is to determine if the product is reasonably safe for initial use in humans, and if the compound exhibits pharmacological activity that justifies …
Volume 10 Full Text, Bjur Staff
Volume 10 Full Text, Bjur Staff
Butler Journal of Undergraduate Research
No abstract provided.
Yayoi Kusama’S Depictions Of Mental Health, Anna Isabel Davis
Yayoi Kusama’S Depictions Of Mental Health, Anna Isabel Davis
Butler Journal of Undergraduate Research
This paper examines Yayoi Kusama’s usage of art as a coping mechanism for her mental illness, particularly through her pumpkins and “nets” motifs. It involves a close analysis of three artworks to emphasize this motif: her first depiction of pumpkins; “nets”; and, finally, her combination of both pumpkins and “nets” into one artwork. Her theme of repetitions as meditative force is evident in each of these works. As such, this paper posits that the goal of her art is not to heal from her mental illness but to better cope and adapt. This research draws on various primary sources, including …
Effects Of Dissolved Oxygen On Northern Leopard Frog (Lithobates Pipiens) Gastrocnemius Muscle Recruitment And Fatigue, Eva L. Gates, Joseph P. Levri
Effects Of Dissolved Oxygen On Northern Leopard Frog (Lithobates Pipiens) Gastrocnemius Muscle Recruitment And Fatigue, Eva L. Gates, Joseph P. Levri
Butler Journal of Undergraduate Research
Dissolved oxygen levels in aquatic systems have decreased because of temperature increases caused by climate change, which in turn has affected ecosystems and wildlife. Many physiological processes in aquatic organisms require a certain dissolved-oxygen range, and decreasing levels can compromise proper functioning. Previous studies have linked muscle performance to dissolved oxygen levels in a variety of aquatic species, but less research has been dedicated to amphibians. Because many amphibians engage in cutaneous respiration, especially when dwelling in aquatic habitats, dissolved oxygen levels may have a significant impact on muscle performance in this taxon. This experiment investigated the effects of dissolved …
Stream Gauging: Investigating The Flow Rate And Residence Time In Laguna Bacalar, Mexico, Elizabeth J. Kowalczyk
Stream Gauging: Investigating The Flow Rate And Residence Time In Laguna Bacalar, Mexico, Elizabeth J. Kowalczyk
Butler Journal of Undergraduate Research
Stream gauging is a standard tool used to measure the flow rate of various bodies of water. Knowing the flow rate of a body of water allows for the residence time of a body of water to be calculated. Currently, there is very little information regarding the flow rate and residence times of Laguna Bacalar. This system has been observed hydrologically consistently only in the past 6 years. In this study, 13 stream-gauging locations of interest were identified and gauged for their respective flow rates using the midsection method. Once the flow rates were acquired, maps depicting the Laguna Bacalar …
Psychosocial Student Adaptations To Covid-19 In Higher Education: A Mixed-Methods Approach To Covid-19 Through The Theoretical Framework Of Anomie, Grace Johnson
Butler Journal of Undergraduate Research
The COVID-19 pandemic affected individuals and social institutions because of an abrupt and expansive change to norms and values, which are key characteristics of an anomic state. The purpose of this exploratory and descriptive study was to understand how students enrolled at a residential university perceived educational and societal pressures associated with COVID-19. This research applied a mixed-methods approach and relied upon three phrases of research: (1) pilot questionnaire (n = 54), (2) qualitative interviews (n = 14), and (3) quantitative questionnaire (n = 253). Findings suggested similarities in how university students responded to COVID-19 and how communities had responded …
Introduction To The Premarket Review Of Human Food Ingredients In The United States And Concepts In The Safety Assessment Of Novel Plant-Derived Ingredients, Troy Hubbard
Oxford ICSB
Premarket regulation of ingredients added to food is a key pillar ensuring the safety of food as it allows the opportunity to address potential safety concerns prior to consumer exposure. In the United States, food and color additives are substances that are intentionally added to food and are subject to pre-market approval by the Food and Drug Administration (FDA) and require a listing in the Code of Federal Regulations, unless the intended use of the substance is generally recognized as safe (GRAS), among qualified experts. GRAS is not an inherent property of a substance, as is often misunderstood; rather, it …
Enterolactone As A Potential Therapeutic Agent For Treatment Of Type-Two Diabetes, Abigail Frommack
Enterolactone As A Potential Therapeutic Agent For Treatment Of Type-Two Diabetes, Abigail Frommack
Liberty University Research Week
Type-two diabetes (T2D) results from insulin resistance causing persistent high blood glucose levels, despite a normal production of insulin. While studying the impact of various coffee polyphenol derivatives, we discovered that enterolactone (ENL) induces glucose uptake in differentiated adipocytes. Insulin-dependent glucose uptake occurs in various cell types, but primarily in adipose and muscle cells. This study focuses on adipose cells, specifically characterizing the mechanism of ENL induced glucose uptake. The goal of our study is to characterize the molecular mechanism of ENL to promote glucose uptake in 3T3-L1 differentiated adipocytes. 3T3-L1 differentiated adipocytes were treated with Enterolactone in a concentration-dependent …