Digital Commons Network^™

Prelimbic Cortex Neuronal Assemblies In Behaviors Predictive Of Drug-Seeking Before And After Cocaine Self-Administration, Karla J. Galvan

Open Access Theses & Dissertations

Literature has established that there are certain behaviors that are predictive of drug seeking and relapse such as impulsivity, distress tolerance (DT), Pavlovian conditioned approach (PCA), anxiety, and sensation-seeking. However, few studies have examined the behavioral interactions among these tasks and drug-seeking, and none have examined the neural interactions in the prelimbic cortex, which has an essential role in drug-seeking and is implicated in each of the aforementioned behaviors of interest.We therefore hypothesized that certain behaviors including high impulsivity, low distress tolerance, high anxiety, and high locomotor activity would predict high cocaine-seeking. We further hypothesized that the neuronal activity in …

Assessing Nordihydroguaiaretic Acid Properties And Its Potential Therapeutic Effect For Glioblastoma, Jose Arturo Guerrero

Open Access Theses & Dissertations

This study employs a combination of theoretical and experimental analysis to spectroscopically investigate the biomechanistic structure relationship and therapeutic effects of the Nordihydroguaiaretic Acid (NDGA) chemical derived from the Larrea Tridentata plant. These relationships are crucial for understanding NDGA's efficacy in disease prevention, treatment, and potential toxicological effects. While the medicinal and antiviral properties of the NDGA have been studied extensively, there remains a gap in optically identifying and reporting its structural changes. The current research successfully reveals evident trends in NDGA's vibrational signatures, particularly highlighting the absence of the Raman feature at 780 〖cm〗^(-1) as indicative of a fully …

"Inwombed" Expressions Of Anxiety: Myhth, Humor, And The Absurd, Jonathan Taylor

Open Access Theses & Dissertations

Abstract poetry collection.

Vidas Perdidas, German Barrera Toro

Open Access Theses & Dissertations

Vidas perdidas es una novela coral que, como muchas otras novelas del género, puede ser leída como un libro de cuentos. La idea central de este proyecto no es otra que desarrollar una tesis muy sencilla pero que, en sí misma, constituye una gran alegoría sobre la existencia humana: La mayoría de nosotros pasaremos por el mundo sin la menor trascendencia histórica —artística, científica, política, espiritual… entre muchos otros campos— y, sin embargo, dichas experiencias vitales no serán vidas perdidas si en esas ventanas de posibilidades que vivimos —Heidegger definía la vida por oposición a la muerte como la posibilidad …

A Muzzle For The Lamb: A Novel, Scott Beggs

Open Access Theses & Dissertations

No abstract provided.

In-Between Frame Generation For 2d Animation Using Generative Adversarial Networks, Francisco Arriaga Pazos

Open Access Theses & Dissertations

Traditional 2D animation remains a largely manual process where each frame in a video is hand-drawn, as no robust algorithmic solutions exist to assist in this process. This project introduces a system that generates intermediate frames in an uncolored 2D animated video sequence using Generative Adversarial Networks (GAN), a deep learning approach widely used for tasks within the creative realm. We treat the task as a frame interpolation problem, and show that adding a GAN dynamic to a system significantly improves the perceptual fidelity of the generated images, as measured by perceptual oriented metrics that aim to capture human judgment …

Iron Curtains: A Novel Of Germany, 1989, John G. Dodson

Open Access Theses & Dissertations

A work of fiction. A story of Love, Treachery, and Freedom on the East German border in 1989. Iron Curtains is a story of four individuals in East and West Germany brought together by an espionage investigation and the revolution in East Germany which led to the fall of the Berlin Wall and Iron Curtain on November 9, 1989. Their stories ultimately intersect as the year passes and culminate in an escape through a tunnel underneath the East German border. There are four main characters and several secondary characters who help drive the story forward by their interaction with the …

Gut Development Following Insulin-Like Growth Factor-1 Supplementation To Preterm Pigs, Martin Bo Rasmussen, Kristine Holgersen, Stanislava Pankratova, Ole Bæk, Douglas G Burrin, Thomas Thymann, Per Torp Sangild

Faculty, Staff and Students Publications

BACKGROUND: Reduced insulin-like growth factor-1 (IGF-1) levels may contribute to impaired organ development in preterm infants. Using preterm pigs as a model, we hypothesized that IGF-1 supplementation improves health and gut development during the first three weeks of life.

METHODS: First, clinical and organ endpoints were compared between artificially-reared, cesarean-delivered preterm pigs and vaginally-delivered, sow-reared term pigs at 5, 9 and 19 days. Next, preterm pigs were treated with recombinant human IGF-1 for 19 days (2.25 mg/kg/day, systemically).

RESULTS: Relative to term pigs, preterm pigs had lower body weight, fat, bone contents, relative weights of liver and spleen and a …

Examining The Relationships Between Social Media Use Constructs And Mental And Sleep Health In Hispanic University Emerging Adults, Miguel Andres Garcia

Open Access Theses & Dissertations

The number of social media users and platforms have increased dramatically in recent years. Several different social media use constructs have developed from past research to assess social media engagement, including overall social media use, nighttime in-bed social media use, social media addiction, social media self-control failure, and emotional investment in social media. Such constructs are distinct from each other and may adversely impact mental and sleep health, especially during emerging adulthood. This study investigated the relationships between such social media use constructs and mental and sleep health in Hispanic university emerging adults through a framework of Uses and Gratifications …

Conserving One Of Hawai'i'S Last Endemic Ducks: Genetics And Habitat Associations Of Koloa, Feral Mallards, And Their Hybrids, Kristi Fukunaga

Open Access Theses & Dissertations

Increases in anthropogenic hybridization through introduced species have accelerated the loss of genetic diversity and reductions in population size of native species that are already threatened by population and genetic diversity decline. Fertile hybrids that are common among waterfowl (order Anseriformes) are especially worrisome. A prime example is the endangered Hawaiian duck (Anas wyvilliana; “koloa maoli”), which is the remaining endemic duck species on the main Hawaiian Islands and is threatened by genetic extinction through ongoing hybridization with feral mallards (Anas platyrhynchos). Of note, koloa populations are known to be strongly male-biased (3:1), and this sex bias is known to …

Bilingual Comprehension Of Accented Speech And Spoken Code Switches, Liam John Gleason

Open Access Theses & Dissertations

Across three experiments, the current study explored how accented speech and coarticulation impact how bilingual listeners comprehend code-switches in speech. Eye-tracking methodology was used to compare responses to single-language and code-switched sentences. Experiment 1 observed how accented speech influenced the costs involved in comprehending code-switches by comparing responses to speakers that had North American English accents to speakers with Juarez/El Paso Spanish accents when speaking English. Experiment 2 compared responses to English speech produced by speakers with North American English, Flemish, and Bulgarian accented speakers. To examine coarticulation as a cue to an upcoming code-switch, Experiment 3 compared naturally produced …

Our Author Is Crazy, Zani A. Meaders

Open Access Theses & Dissertations

This thesis delves into the realm of young adult (YA) fantasy literature, exploring how its meta-narrative elements, fast-paced story beats, and relatable characters can facilitate the acquisition of healthy coping mechanisms among its readers. In the preface, I discuss the importance of providing YA audiences with narratives that not only entertain but also serve as tools for navigating the complexities of adolescence. Drawing upon psychological theories and literary analysis, I argue that meta-awareness in YA fantasy can offer readers a unique perspective on their own struggles and encourage them to develop resilience and coping skills.

The accompanying YA Fantasy story …

Analysis Of Drying Behavior Of Robocasted Barium Titanate, Abigail Ortega

Open Access Theses & Dissertations

Finding an adequate ceramic formulation for material extrusion is a time-consuming process. The necessary equipment may be unavailable to perform the desired test. This study demonstrated an alternative to observe a material after extrusion to understand its drying process. This study focused on 55 solid loading volume percent and a 39 solid loading volume percent, each with two different binder treatments focusing on fresh same day made binder, a 30 day old, aged binder and lastly an artificial binder obtained by a fuming process. Firstly, a formulation was created and loaded onto a pressure-based syringe to be extruded with a …

Deal With A Dead Man, Afton Reed

Open Access Theses & Dissertations

The Value of Fantasy in Exploring Intangibles

Often, a story is sparked because of asking the question, “what if?” which is what happened to create the hydra that is Deal with a Dead Man. Two percolating ideas happened to coincide, and eventually crashed together. Early on, it began when I was introduced to the Russian fairytale of Koschei the Deathless and his fear of death, but inability to enjoy life. Over the past year, my family experienced several deaths, one tragically early, and another of ripe old age. My fascination with the fairytale grew as I watched myself and family …

Synthesis Of Neoglycoproteins As Potential Biomarkers For Chagas Disease And Cutaneous Leishmaniasis Caused By Leishmania (Viannia) Braziliensis, Eileni Rodriguez Gil

Open Access Theses & Dissertations

Protozoan parasites are responsible for causing numerous diseases in humans and mammals worldwide. Among them are Chagas disease (CD), caused by the parasite Trypanosoma cruzi (T. cruzi), and tegumentary leishmaniasis (TL), caused by the parasite Leishmania (Viannia). Both diseases coexist in many regions of Latin America, and current hurdles to differentially diagnose them and determine chemotherapy success need to be overcome. CD can be diagnosed by traditional serological tests and polymerase chain reaction (PCR), but disadvantages of these methods are that they may produce false negatives because the antigens used in commercial CD kits are not conserved across all T.cruzi …

Atlas-Based Analysis Of The Neural Projections From The Lateral Hypothalamic Area To The Lower Brainstem In The Adult Male Rat, Jessica Valeria Salcido Padilla

Open Access Theses & Dissertations

Within the last decade, the number of diseases associated with dysregulation of the neural circuits responsible for energy balance, glucosensing, and feeding control has increased. One brain region containing these circuits is the lateral hypothalamic area (LHA), which plays an important role in the sleep/wake cycle, energy balance, and motivated behavior. Although the LHA has been termed a â??feeding centerâ??, other regions within the hindbrain are known for the regulation of similar functions including energy balance, glucosensing, and feeding control. While many studies have explored and reported projections from the LHA to the hindbrain, few have further investigated the interconnections …

The Daughters Of La Malinche: A Heideggerian Analysis Of The Pazian Archetypal Masks Portrayed In Art, At-Ziry Aileen Torres

Open Access Theses & Dissertations

In this thesis, I present a Heideggerian phenomenological analysis of the Pazian archetypal masks present in The Labyrinth of Solitude, such as El Macho, La Llorona, La Mala Mujer, La Chingada, and La Malinche, and how these masks are represented and depicted by women in art. I analyze the authentic or inauthentic identity and conditions expressed by Mexican women in art through a mimetic lens and extend that analysis to gendered concerns that have emerged in the past fifty or so years in Mexico and the U.S. Mexico border. Such issues include the pervasive machismo culture and the alarming increase …

Bcl2 Mediated Targeted Drug Delivery For The Treatment Of Kidney Fibrosis And Stomach Cancer, Humayra Afrin

Open Access Theses & Dissertations

Apoptosis, the programmed death of cells, is primarily regulated by a delicate balance between pro-apoptotic and anti-apoptotic signals. The Bcl-2 (B-cell lymphoma 2) family of proteins acts as anti-apoptotic agents, promoting cell survival. Dysregulation of these proteins is a common occurrence in conditions such as cancer and fibrosis, where overexpression of anti-apoptotic members can foster tumor cell survival and fibroblast activation. In this study, our aim was to explore the therapeutic potential of Bcl-2 inhibitors, both as a small molecule (specifically Navitoclax (Navi)), inhibitor and as Bcl-2 siRNA, for targeted treatment. Intravenous administration of Navi often leads to thrombocytopenia, necessitating …

Nationwide Practices And Perspectives On Early Literacy Activities In Daycare, Analaura Amador

Open Access Theses & Dissertations

No abstract provided.

Exploring The Effects Of Mindful Nature Walks On College Student Anxiety, Grace Young

Graduate Theses and Dissertations

Individuals pursuing a degree in higher education face challenges that lead to greater levels of anxiety than that of the general U.S. adult population. This disparity, further heightened by the COVID-19 pandemic, presents a need for higher education institutions to search for ways to address this spike in student anxiety and other mental health concerns. This mixed-methods study explored mindful nature walks as a low-cost and easily accessible way for college students to reduce levels of experienced anxiety. Using validated quantitative measures, this study examined the impact of three weekly, consecutive 30-minute mindful nature walks on state and general anxiety …

The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects Of Bile Acids, Sung Ho Lee, Ji Ho Suh, Mi Jeong Heo, Jong Min Choi, Yang Yang, Hyun-Jung Jung, Zhanguo Gao, Yongmei Yu, Sung Yun Jung, Mikhail G Kolonin, Aaron R Cox, Sean M Hartig, Holger K Eltzschig, Cynthia Ju, David D Moore, Kang Ho Kim

Faculty, Staff and Student Publications

Bile acids (BAs) are pleiotropic regulators of metabolism. Elevated levels of hepatic and circulating BAs improve energy metabolism in peripheral organs, but the precise mechanisms underlying the metabolic benefits and harm still need to be fully understood. In the current study, we identified orosomucoid 2 (ORM2) as a liver-secreted hormone (i.e., hepatokine) induced by BAs and investigated its role in BA-induced metabolic improvements in mouse models of diet-induced obesity. Contrary to our expectation, under a high-fat diet (HFD), our Orm2 knockout (Orm2-KO) exhibited a lean phenotype compared with C57BL/6J control, partly due to the increased energy expenditure. However, when challenged …

Multimodal Neurologic Monitoring In Patients Undergoing Extracorporeal Membrane Oxygenation, Khwaja Siddiqui, Muhammad U Hafeez, Ali Ahmad, Syed O Kazmi, Subhasis Chatterjee, Eric Bershad, Mohammad Hirzallah, Chethan Rao, Rahul Damani

Faculty, Staff and Students Publications

Introduction Extracorporeal membrane oxygenation (ECMO) is associated with a high rate of neurologic complications. Multimodal neurologic monitoring (MNM) has the potential for early detection and intervention. We examined the safety and feasibility of noninvasive MNM during ECMO. We hypothesized that survivors and non-survivors would have meaningful differences in transcranial Doppler (TCD) sonography and electroencephalographic (EEG) characteristics, which we aimed to identify. We also investigated adverse neurologic events and attempted to identify differences in EEG and TCD characteristics among patients based on the type of ECMO and the occurrence of these events. Material and methods We performed an observational study on …

Application Of Digital Holographic Imaging To Monitor Real-Time Cardiomyocyte Hypertrophy Dynamics In Response To Norepinephrine Stimulation, Wahida Akter, Herman Huang, Jacquelyn Simmons, Alexander Y. Payumo

Faculty Research, Scholarly, and Creative Activity

Cardiomyocyte hypertrophy, characterized by an increase in cell size, is associated with various cardiovascular diseases driven by factors including hypertension, myocardial infarction, and valve dysfunction. In vitro primary cardiomyocyte culture models have yielded numerous insights into the intrinsic and extrinsic mechanisms driving hypertrophic growth. However, due to limitations in current approaches, the dynamics of cardiomyocyte hypertrophic responses remain poorly characterized. In this study, we evaluate the application of the Holomonitor M4 digital holographic imaging microscope to track dynamic changes in cardiomyocyte surface area and volume in response to norepinephrine treatment, a model hypertrophic stimulus. The Holomonitor M4 permits non-invasive, label-free …

Unraveling The Clcc1 Interactome: Impact Of The Asp25glu Variant And Its Interaction With Sigmar1 At The Mitochondrial-Associated Er Membrane (Mam), Ilaria D'Atri, Emily Rose Martin, Liming Yang, Elizabeth Sears, Emma Baple, Andrew H. Crosby, John K. Chilton, Asami Oguro-Ando

Peninsula Medical School

The endoplasmic reticulum (ER) plays an indispensable role in cellular processes, including maintenance of calcium homeostasis, and protein folding, synthesized and processing. Disruptions in these processes leading to ER stress and the accumulation of misfolded proteins can instigate the unfolded protein response (UPR), culminating in either restoration of balanced proteostasis or apoptosis. A key player in this intricate balance is CLCC1, an ER-resident chloride channel, whose essential role extends to retinal development, regulation of ER stress, and UPR. The importance of CLCC1 is further underscored by its interaction with proteins localized to mitochondria-associated endoplasmic reticulum membranes (MAMs), where it participates …

Physiological And Morphological Plasticity In Response To Nitrogen Availability Of A Yeast Widely Distributed In The Open Ocean, Poppy Diver, Ben A. Ward, Michael Cunliffe

School of Biological and Marine Sciences

Yeasts are prevalent in the open ocean, yet we have limited understanding of their ecophysiological adaptations, including their response to nitrogen availability, which can have a major role in determining the ecological potential of other planktonic microbes. In this study, we characterized the nitrogen uptake capabilities and growth responses of marine-occurring yeasts. Yeast isolates from the North Atlantic Ocean were screened for growth on diverse nitrogen substrates, and across a concentration gradient of three environmentally relevant nitrogen substrates: nitrate, ammonium, and urea. Three strains grew with enriched nitrate while two did not, demonstrating that nitrate utilization is present but not …

Plastic Alternatives And Substitutes In The Packaging Sector – A Uk Consumer Perspective, Sohvi Nuojua, Sabine Pahl, Richard C. Thompson

School of Biological and Marine Sciences

Alternative and substitute materials to conventional plastic packaging offer a range of potential opportunities to help reduce the environmental impacts of single-use plastic. Policymakers and industry stakeholders are currently debating measures to address the plastic pollution crisis globally, but successful implementation of new policies or packaging technologies will require understanding of consumer perspectives and consumer acceptability. The present study aimed to examine consumer perceptions around plastic alternatives and substitutes by employing a life cycle approach. The Kano model of consumer satisfaction was used to investigate how UK consumers (n = 1177) responded to a variety of environmentally relevant attributes and …

Adapting Language Development Research Paradigms To Online Testing: Data From Preferential Looking, Word Learning And Vocabulary Assessment In Toddlers, Delphine K.L. Nguyen, Nadine Fitzpatrick, Caroline Floccia

School of Psychology

During the recent pandemic, it became necessary to adapt lab-based studies to online experiments. To investigate the impact of online testing on the quality of data, we focus on three paradigms widely used in infant research: a word recognition task using the Intermodal Preferential Looking Paradigm, a word learning task using the Switch task, and a language assessment tool (WinG) where children identify a target word amongst a set of picture cards. Our results for synchronous and asynchronous studies provide support for the robustness of online testing. In Experiment 1, robust word recognition was found in 24-month-old toddlers. In Experiment …

International Special Projects Internship--Mauritius, Jace Reese

Supply Chain Management Undergraduate Honors Theses

This thesis explains my international internship in Mauritius. During the internship, we surveyed Mauritian residents to help them battle food insecurity using the USDA's food security survey. Food security is very prevalent in our world, especially after COVID. Included are the results as well as what we learned from surveying the residents.

Navigating The Black Nuances: Analyzing And Understanding The Intersectional Perspectives Of Black Transgender Arkansans Utilizing Maslow's Hierarchy Of Needs, Kayla Alford

Graduate Theses and Dissertations

This thesis evaluates the current needs of the Black Transgender community in Northwest and Central Arkansas. The participants of this study were asked 40 questions based on each tier of Maslow’s Hierarchy of Needs. The participants of the study were three Transgender men, two Transgender women, and three non-binary individuals. Eight semi-structured interviews were completed utilizing narrative theory to expound on the personal experiences and duality of being Black and Transgender through a personal lens. The findings of this study were categorized into eight themes, which were basic needs, safety, love and belonging, esteem, self-realization, essence of being Transgender, lack …

Harnessing Eye And Face Movements: Bridging Technology And Human Interaction, Daniel Rubin

Master's Theses and Capstones

AbstractThe profound impact of non-verbal communication in the realms of psychology, virtual reality (VR), and automated systems; underscores, a critical inquiry: How can we effectively interpret and utilize non-verbal cues; for example, eye and head movements, to address current limitations in technology and ethics across various applications? This thesis explores the potential of eye and head movement techniques, as a transformative tool in enhancing diagnostic accuracy, user interaction, and ethical compliance in these fields. One significant contribution of my research is the identification and implementation methods of non-invasive diagnostic tools, in healthcare. Through, the advanced analysis of eye and head …