Digital Commons Network^™

Biosynthesis Of Silver Nanoparticles By Using Green Tea (Camellia Sinensis) Extracts, Hawazen H. Salih

Baghdad Science Journal

Due to its availability, affordability, effectiveness, and low cost, the green-based synthesis of silver nanoparticles by plants is gaining popularity. It is safe to handle and has a wide range of metabolites, including antioxidant and antibacterial activities. The production of AgNPs was established in this work utilizing aqueous and methanolic extracts of fresh Camellia sinensis leaves that reduced silver nitrate. This process enabled the creation of NPs, which were then characterized using a range of analytical techniques including ultraviolet-visible (UV-Vis) spectrophotometry, Fourier Transform Infrared spectroscopy (FTIR), Atomic Fluorescence Microscopy (AFM), X-ray scattering (XRD), and Zeta potential analyzer. The color of …

Total Phenolic, Flavonoids And Vitamin C Contents With Antioxidant Activity Of Urtica Dioica L. Leaves Growing In Zakho, Kurdistan Region-Iraq, Gharbia A. Omer, Lina Y. Mohammed

Baghdad Science Journal

The genus Urtica dioica L. (Urticaceae) is frequently grown in the Kurdistan region of Iraq and is used as a folk remedy by the locals to heal a variety of illnesses. The purpose of this study is to evaluate the total phenolic, flavonoid and vitamin C contents using spectrophotometric method with the determination of antioxidant activities for different solvents such as (aqueous, ethanol, ethyl acetate, chloroform and n-hexane) using different antioxidant methods namely (1,1-diphenyl-2-picrylhydrazyl, reducing power assay, total antioxidant capacity, nitric oxide scavenging, hydroxyl radical, β -carotene- Linoleic acid and iron chelating assays) and ascorbic acid as standard reference. Our …

Beyond The Bedroom Door: Investigating Representations Of Sex In Young Adult Literature, Amelia Gutche

English Undergraduate Honors Theses

This thesis examines representations of sex in young adult (YA) fiction, focusing on negative patterns, empowerment, and healthy relationships. Through analysis of seven YA novels and existing scholarship, three research questions are addressed: the evolution of sexual representations in the twenty-first century, patterns characterizing teenage sexual situations, and distinctions between healthy and unhealthy relationships. Findings reveal a shift toward more inclusive and empowering depictions, yet lingering conservative values and silences persist. YA literature often portrays sex as a source of fear and obsession, limiting adolescent power and perpetuating unrealistic ideals. Healthy relationships are characterized by support systems, mutual respect, and …

A New Approach To Patent Reform, Janet Freilich, Michael J. Meurer, Mark Schankerman, Florian Schuett

Faculty Scholarship

Scholars and policy makers have tried for years to solve the tenacious and harmful crisis of low quality, erroneously granted patents. Far from resolving the problem, these determined efforts have resulted in hundreds of conflicting policy proposals, failed Congressional bills, and no way to evaluate the policies’ value or impact or to decide between the overwhelming multiplicity of policies.

This Article provides not only new solutions, but a new approach for designing and assessing policies both in patent law and legal systems more generally. We introduce a formal economic model of the patent system that differs from existing scholarship because …

Ground-Breaking Stories In Contemporary Cinema: In A Market Full Of Remakes, What Form Does Cinematic Originality Take Today?, Elisa Fong-Hirschfelder

Student Scholar Symposium Abstracts and Posters

This work aims to analyze the evolution of both international and American cinema as an art form, specifically in relation to the abstract concept of originality, to determine what possible future trends in cinema may look like and the potential for the manifestation of “new waves” in cinema. Emerging during the Industrial Revolution, cinema has evolved as an entertainment medium from brief moving pictures presented as novelties to lengthy feature films. With its evolution arose trends in visual storytelling, including experimental, narrative, and remakes, whose own categories comprise the retelling of old stories, remakes of films in other languages, and …

The Effectiveness Of An Online Training Module For Pre-Service And In-Service Teachers: A Case Study, Areej Elsayary, Jenny Eppard, Laila Mohebi, Fatima Bailey, Hanada Taha Thomure

All Works

This study aims to understand the effectiveness of online training for pre-service and in-service teachers by exploring any differences between pre-service and in-service teachers’ satisfaction and learning following an online professional training video. Additionally, the study focused on evaluating any differences in satisfaction and learning of pre-service and in-service teachers based on age, experience, subject taught, and grade level, as well as nationality. An online 20-minute video session was shown to the participants and a survey question-naire, based on the Kirkpatrick Model, was used to explore their reactions and learning. The study employed Exploratory Factor Analysis (EFA) with independent sample …

Characterizing The Molecular And Cellular Changes Of Senescent Cells Induced By Diverse Stressors In 2d And 3d Microenvironments, Apoorva Chauhan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Aging is a risk factor for myriad diseases and is often associated with the accumulation of senescent cells. Cellular senescence, a process of irreversible cell cycle arrest, is associated with various changes in cellular morphology and function. While senescence will occur naturally in a time-dependent manner, it can be prematurely induced by various extrinsic and intrinsic factors. Most senescence studies model cell behavior in two-dimensional (2D) microenvironments; however, these models are not physiologically relevant. In this study, the effects of naturally occurring reactive oxygen species (ROS) hydrogen peroxide (H2O2) and commonly used chemotherapy drugs, doxorubicin and palbociclib, on cellular senescence …

Regulation Of Embryonic Eye Regrowth In Xenopus Laevis, Dylan Guerin

UNLV Theses, Dissertations, Professional Papers, and Capstones

Regrowth of lost organs and tissues is an amazing ability that some animals possess. For regrowth to be considered full, the organism must regrow the organ or tissue to a state that is structurally and functionally similar to that which was lost. The ability of an organism to regrow lost or damaged tissue varies among animals, both in the mechanisms utilized to achieve regrowth, and in what body parts can be regrown. Potentially even closely related species can vary wildly in regenerative ability. Therefore, regenerative research can look to other tissues and organisms for direction in elucidating the mechanisms through …

Mixed Methods Approach To Assess ‘Placental Opioid-Enhancing Factor’ Activity Within ‘Alternative’ Health Contexts Of Human Maternal Placentophagy, Jacob C. White

UNLV Theses, Dissertations, Professional Papers, and Capstones

Rats with elevated opioid levels experience an even greater increase in pain threshold after placenta or amniotic fluid consumption via placental opioid-enhancing factor (POEF) in the afterbirth. POEF only enhances opioid hypoalgesia; it cannot produce hypoalgesia alone. Although the POEF molecule remains unidentified and its efficacy in humans is unknown, it could be a safe, novel pain treatment. People who consume placenta as an alternative postpartum health practice are ideal for testing POEF bioactivity. Though rat models show that bioactive POEF is highly sensitive, some forms of the practice in humans may conserve POEF.

This project is the first attempt …

Cellular Mechanisms Of Embryonic Eye Regrowth In Xenopus Laevis, Randolph L. Grell

UNLV Theses, Dissertations, Professional Papers, and Capstones

The African Clawed Frog, Xenopus laevis, has been an indispensable model organism for over 100 years in the study of embryogenesis and development. In recent years, this vertebrate model has emerged as a robust tool for deciphering the cellular and molecular mechanisms underlying various modes of tissue, limb, and organ regeneration. In the context of eye repair, Xenopus offers a unique model, where the adult frog eye has limited regenerative capacity compared to its pre-metamorphic embryonic and tadpole forms, which exhibit a robust capacity for regrowth. Understanding the intricate molecular mechanisms that underlie this developmental shift in regrowth ability …

Adapting Language Development Research Paradigms To Online Testing: Data From Preferential Looking, Word Learning And Vocabulary Assessment In Toddlers, Delphine K.L. Nguyen, Nadine Fitzpatrick, Caroline Floccia

School of Psychology

During the recent pandemic, it became necessary to adapt lab-based studies to online experiments. To investigate the impact of online testing on the quality of data, we focus on three paradigms widely used in infant research: a word recognition task using the Intermodal Preferential Looking Paradigm, a word learning task using the Switch task, and a language assessment tool (WinG) where children identify a target word amongst a set of picture cards. Our results for synchronous and asynchronous studies provide support for the robustness of online testing. In Experiment 1, robust word recognition was found in 24-month-old toddlers. In Experiment …

Porcine Computational Modeling To Investigate Developmental Dysplasia Of The Hip, Chia-Yu Yu

Boise State University Theses and Dissertations

While it is well-established that early detection and initiation of treatment of developmental dysplasia of the hip is crucial to successful clinical outcome, research on mechanics of the hip joint during healthy and pathological hip development in infants has been limited. Quantification of mechanical behavior in both the healthy and dysplastic developing joints may provide insight into the causes of developmental dysplasia of the hip and facilitate innovation in treatment options. In this study, subject-specific three-dimensional finite element models of two pigs were developed: one healthy pig and one pig with induced dysplasia in the right hindlimb. The objectives of …

A Journey To The Center Of The Cell: The Characterization Of Novel Non-Canonical Mechanisms Of Notch Signaling, Tana Ranae Gazdik

Boise State University Theses and Dissertations

Cellular signaling pathways are the main method of communication between cells throughout the body. Of the many complex signaling pathways, the Notch signaling pathway is an ancient, highly conserved pathway critical to most animal life. This pathway is not only able to respond to juxtracrine signals from neighboring cells, but also acts as a microenvironment sensor, allowing cells to react to a variety of situations. Thus, understanding the mechanisms behind the regulation of Notch signaling is crucial to improving our basic understanding of Notch in cell biology and development. This dissertation introduces two previously undescribed non-canonical regulatory mechanisms of the …

Biological And Environmental Factors Associated With The Autumn Migration Timing Of North American Raptors, Nora R. Honkomp

Boise State University Theses and Dissertations

Migration is an energetically expensive and risky event in the life cycles of many organisms, and migration impacts survival and reproductive success through direct and carry-over effects. The timing of migration departure from the summer breeding grounds is important for determining the probability of survival and physical condition upon arrival at wintering sites. Many internal and external factors contribute to departure timing. It is important to study these factors across species, populations, and individuals to determine which traits and conditions are most important for shaping departure timing and its variability. Improving our understanding of the factors that affect organisms’ phenological …

Nesting In Urban Areas Affects American Kestrel Home Range Size And Adult Female Health, Jessica Michele Taylor

Boise State University Theses and Dissertations

Urbanization is happening at an unprecedented rate, and wildlife must adapt or face population declines. American Kestrels inhabit urban areas, however, whether human-dominated landscapes impact kestrel space-use, survival and reproductive success is largely unknown. We monitored American Kestrel nest boxes along a gradient of urbanization, measured using impervious surface area (ISA), and deployed GPS tags on breeding adults to examine the relationship between urbanization, home range size, and adult and nestling health. Male kestrel home ranges were 9.14 times larger than female home ranges, and home range size decreased as ISA increased for both sexes (β = -1.96, SE = …

On-Chip Active Pulse-Clamp Stimulation (Apcs) For Rapid Recovery, Charge-Balanced Neural Stimulation, F. N. U. Tala

Boise State University Theses and Dissertations

Neurostimulations are widely utilized to modulate brains and nervous systems functions for therapeutic purposes. Traditional neurostimulation involves applying a direct current delivered to the excitable tissues to elicit neural response. There is a growing demand for a robust, rapid stimulation system that ensures chronic safety through charge balancing in vivo. This dissertation is a compilation of previously published works, detailing various board-level stimulators, an innovative on-chip stimulation technique, and a distributed modelling method.

Chapter one introduces MEDUSA, a cost-effective, multi-functional neurostimulation system capable of achieving multi-channel, arbitrary stimulation for neuroscience research.

Chapter two delves into a scripted distributed model framework …

Patterns Of Non-Consumptive Public Land Users: How Do Birders Value Species And Make Foraging Decisions, Rebecca (Bekki) Ann Waskovich

Boise State University Theses and Dissertations

Non-consumptive wildlife-associated recreation has grown by over 1000% since 1970. While the number of consumptive users has remained largely unchanged. Behavioral ecology and foraging theory can help to explain birder behavior to ascertain recreationists’ values and motives while on the landscape. During the Christmas Bird Counts of December 2022, 68 participants from Boise, Bruneau, and Nampa, Idaho counts were surveyed. A subset of those participants (29) volunteered to be interviewed further. Rarity and native species were found to be a top value for birders with 127 unique species with low encounter rates across all sites appeared in the top ranked …

Vitamin D Regulates Covid-19 Associated Severity By Suppressing The Nlrp3 Inflammasome Pathway, Bariaa Khalil, Narjes Saheb Sharif-Askari, Shirin Hafezi, Fatemeh Saheb Sharif-Askari, Fatme Al Anouti, Qutayba Hamid, Rabih Halwani

All Works

Background The role of vitamin D3 (VitD3) in modulating innate and adaptive immunity has been reported in different disease contexts. Since the start of the coronavirus disease-2019 (COVID-19) pandemic, the role of VitD3 has been highlighted in many correlational and observational studies. However, the exact mechanisms of action are not well identified. One of the mechanisms via which VitD3 modulates innate immunity is by regulating the NLRP3-inflammasome pathway, being a main underlying cause of SARS-CoV-2-induced hyperinflammation. Aims and main methods Blood specimens of severe COVID-19 patients with or without VitD3 treatment were collected during their stay in the intensive care …

Utilizing Spatial Transcriptomics To Compare Gene Expression In Volumetric Muscle Loss Injury Recovery, Colton Gattis

Biomedical Engineering Undergraduate Honors Theses

Volumetric Muscle Loss (VML) injuries are known to disrupt the normal regenerative process via fibrosis leading to an extensive permanent loss of muscle function. The specific causation of this disruption remains to be defined; however, with new developments in transcriptomics, genetic trends can be identified across regions of tissue over time. This study follows VML injuries within the tibialis anterior of a mouse model for fifteen days after initial injury to attempt to identify expected transitions in healing. Genetic presence began to become more diversified as recovery progressed from four to fifteen days post injury with spatial clusters becoming globalized …

Photo-Carbon Monoxide Releasing Molecules For Antibacterial Benefits In Vascular Grafts, Beste Caner

Theses and Dissertations

Globally, the annual hemodialysis procedures surpass 1.5 million, emphasizing the vital role of reliable vascular access methods. However, common challenges like access infections and clot-induced blood flow reduction necessitate innovative solutions. This study delved into the potential therapeutic role of carbon monoxide (CO) and its effects on both endothelialization and non-pathogenic bacteria causing infections. The primary focus was evaluating the impact of loading different concentrations of carbon monoxide-releasing molecules (CORMs), specifically CORM diketone 4 (DK4), within 2D spin-coated films on cultured E. coli and endothelial cells. Initial assessments of CO release kinetics from DK4-loaded films demonstrated that the 10% condition …

Cervical Cancer Screening And Affordability Of Medical Care: A Cross-Sectional Study, Sarah M. Johnson

Capstone Experience: Master of Public Health

Objective: To determine if, among women aged 21-65, there is a positive association between avoiding healthcare due to cost and not being up to date on cervical cancer screening.

Methods: This cross-sectional study utilized the 2022 Behavioral Risk Factor Surveillance System dataset. A total of 123,275 women, aged 18-69 without a hysterectomy, were analyzed with bivariate and multivariate analyses. The outcome was length of time since last cervical cancer screening. The exposure was avoiding healthcare in the last 12 months due to cost.

Results: Women who avoided healthcare due to cost had higher odds of not being up to date …

Creating Cultural Competency Curriculum: How Diverse Are Your Jellybeans?, Noah Boggs Riley

Human Development and Family Sciences Undergraduate Honors Theses

As college enrollment continues to grow and diversity becomes more prominent, it is crucial to recognize the importance of nurturing cultural competence in campus communities. Cultural competence refers to the ability to build relationships with individuals from both similar and diverse backgrounds. In order for students to be successful in their future careers, they must develop knowledge and skills to effectively collaborate with people from different backgrounds. As college students actively engage in conversations about multiculturalism, cultural awareness, and the significance of appropriate accommodations, it is imperative that multicultural education plays a more significant role in college settings. This thesis …

Breaking Down The “Heritage Not Hate” Movement’S Origin, Usage, And Effect On Race Relations In The Post Civil War Era, Laith Kewan

History Undergraduate Honors Theses

When the Confederacy first formed, its governmental symbolism and ideology mirrored that of the northern United States. The two Constitutions were incredibly similar – minus the South’s adjustments to further enhance the rights of states and slaveowners – with the Confederate government installing a Legislative Branch, an Executive Branch, and a Judicial Branch. In addition to this Constitutional similarity, the Confederacy also created a flag that looked similar to the United States’ that Confederate troops had trouble differentiating the two in combat. Following a chaotic Battle of Bull Run in July of 1861, General Pierre Gustave Toutant-Beauregard pushed for the …

Dispersal Movement And Overwintering Ecology Of A Cryptic Migratory Forest Owl, Mitchell Lee Pruitt

Graduate Theses and Dissertations

Understanding species’ distributions and how a species uses its environment is a vital aspect of ecology and important for the development and implementation of conservation planning. In migratory species, with distinct breeding and nonbreeding ranges, understanding distributions is a complex endeavor. Nevertheless, evaluating movement behavior by linking seasonal distributions and identifying source areas is vital for understanding a species’ full annual cycle ecology. Understanding distributions is particularly important for predators, like birds of prey, that can exert top-down effects on community structure and ecosystem function through their influence on prey populations. Among raptors, owls are severely understudied in large part …

Regulation Of Piezo Channels By Membrane Lipids, Luis Octavio Romero Garcia

Theses and Dissertations (ETD)

In cellular physiology, the transformation of energy from mechanical cues into electrical and/or chemical signals is called mechanotransduction. This ability to sense and react to external and internal mechanical forces is essential for the survival of single cell to multicellular organisms. As such, it is no surprise that mechanotransduction appeared early in the evolutionary history of life on our planet. At the cellular level, mechanotransduction is mediated by proteins and/or protein complexes that respond to mechanical stimuli in different timescales, including but not limited to changes in membrane electric potential, Ca2+ signaling, and gene expression. Among such protein complexes, mechanosensitive …

Loss Of The Sac Components Slda Kinase Or Sldb Or In Vitro Adaptation To Triazole Produces Aneuploidy Associated With Triazole Heteroresistance In Aspergillus Fumigatus, Ashley Nywening

Theses and Dissertations (ETD)

The opportunistic pathogen Aspergillus fumigatus represents the chief causative agent of human and animal invasive filamentous fungal infections. Triazoles, the primary therapeutic options to combat invasive aspergillosis (IA), target the fungal biosynthesis of ergosterol, a vital component of the fungal cell membrane. Unfortunately, resistance to this class of medical therapeutic has arisen globally and now threatens the future usefulness of these compounds for antifungal treatment. Infection with A. fumigatus that has acquired triazole resistance increases an already high associated mortality rate and reduces the limited arsenal of therapeutic options to combat IA. Moreover, how this specific fungal pathogen obtains resistance …

Efficacy Of Communication Interventions For Amyotrophic Lateral Sclerosis, Gracie Rhea Rightnowar

Honors College Theses

The purpose of this literature review is to analyze the efficacy of various communication interventions for individuals with amyotrophic lateral sclerosis (ALS). The implications of disease presentation and progression are discussed. This research seeks to determine the role of a speech language pathologist in the treatment of an individual with this progressive neurological disease. Various interventions are considered. Methods of service consist primarily of compensatory strategies intended to prolong communication abilities beyond that which requires speech motor capabilities. This research seeks to better understand the associated factors with each treatment plan on the individual’s functionality and quality of life.

Use Of Topical Methylene Blue To Image Nuclear Morphometry With A Low-Cost Scanning Darkfield Microendoscope, Huayu Hou, Jennifer Carns, Richard A Schwarz, Ann M Gillenwater, Sharmila Anandasabapathy, Rebecca R Richards-Kortum

Faculty, Staff and Students Publications

SIGNIFICANCE: Fiber-optic microendoscopy is a promising approach to noninvasively visualize epithelial nuclear morphometry for early cancer and precancer detection. However, the broader clinical application of this approach is limited by a lack of topical contrast agents available for

AIM: The aim of this study was to evaluate the ability to image nuclear morphometry in vivo with a novel fiber-optic microendoscope used together with topical application of methylene blue (MB), a dye with FDA approval for use in chromoendoscopy in the gastrointestinal tract.

APPROACH: The low-cost, high-resolution microendoscope implements scanning darkfield imaging without complex optomechanical components by leveraging programmable illumination and …

Measuring Inclusive Leadership In Nonprofit Performing Arts Organizations, Thomas Abruzzo

Dissertations

Inclusive leadership is undoubtedly a practice to strive for, and few would argue against the value of leading inclusively. Yet, empirically, little is known about what constitutes effective inclusive leadership, especially in the context of nonprofit performing arts organizations. This sector is a particularly apt place to study and practice inclusive leadership because, in addition to the many benefits it provides, the nonprofit arts sector has problematic roots in terms of privileging a dominant social class by prioritizing certain art forms over others. For example, the popularity of the nonprofit form in the arts sector, when compared to for-profit or …

Lysophosphatidylcholine Acetyltransferase 2 (Lpcat2) Influences The Gene Expression Of The Lipopolysaccharide Receptor Complex In Infected Raw264.7 Macrophages, Depending On The E. Coli Lipopolysaccharide Serotype, Victory Ibigo Poloamina, Hanaa Alrammah, Wondwossen Abate, Neil D. Avent, Gyorgy Fejer, Simon K. Jackson

School of Biomedical Sciences

Escherichia coli (E. coli) is a frequent gram-negative bacterium that causes nosocomial infections, affecting more than 100 million patients annually worldwide. Bacterial lipopolysaccharide (LPS) from E. coli binds to toll-like receptor 4 (TLR4) and its co-receptor's cluster of differentiation protein 14 (CD14) and myeloid differentiation factor 2 (MD2), collectively known as the LPS receptor complex. LPCAT2 participates in lipid-raft assembly by phospholipid remodelling. Previous research has proven that LPCAT2 co-localises in lipid rafts with TLR4 and regulates macrophage inflammatory response. However, no published evidence exists of the influence of LPCAT2 on the gene expression of the LPS receptor complex induced …