Digital Commons Network^™

Endo/Exo, Delaney Rogers

Electronic Theses and Dissertations

The artist, Delaney Shae Rogers, discusses her Master of Fine Arts exhibition, Endo / Exo, held at the Tipton Gallery in downtown Johnson City, TN. The exhibition dates are from March 25th through April 5th, 2024, with a public reception held April 5th, 2024. The author provides insight into the concept behind the work in the exhibition and shares how the making process and specific materials impact the work. This body of work explores coping with grief, anxiety, and the state of the world through the process of making and communicating otherwise difficult topics through visually digestible symbolic language.

Developing A Suitability Model And Feasibility Report For The Tennessee Mesonet, Tristan Holmes

Electronic Theses and Dissertations

Mesoscale networks, also known as Mesonets, are advanced environmental monitoring systems that consist of multiple high-quality weather stations that collect meteorological data at frequent intervals (5 minutes or less). Tennessee currently lacks a Mesonet system, and this study identifies suitable and feasible locations for stations in all 95 counties. Layers needed to develop the suitability model included land cover, road centerlines, elevation, flood zones, building footprints, and hydrologic soil types. Geospatial analysis techniques were used to process and combine these layers to identify suitable areas. Once suitable areas were determined, a feasibility assessment that examined land ownership, accessibility, and cell …

Ìlànà Òrí-Òkè Àtiyanrìn: T(H)Reading Sands And Mountains, Akintayo Akintobi

Electronic Theses and Dissertations

The artist presents his Master of Fine Arts exhibition, entitled Ìlànà Òrí-òkè Àtiyanrìn: T(h)reading Sands and Mountains. The exhibit was mounted in Tipton Gallery in downtown Johnson City, TN, from February 1 to February 9, 2024. The exhibition consisted of 13 artworks, including mixed media paintings, fibers, sculptures, and installations. In this thesis, Akintobi discusses his life experiences growing up in Nigeria and traveling to the United States for his MFA, and how these experiences have affected his art over the past three years.

Through the exhibition, the artist delves into the intersection and variances of cultural perspectives, exploring …

Phase Ib/Ii Study Of Lacnotuzumab In Combination With Spartalizumab In Patients With Advanced Malignancies, Jibran Ahmed, Bettzy Stephen, Yali Yang, Evan Kwiatkowski, Chinenye Lynette Ejezie, Shubham Pant

Faculty, Staff and Student Publications

INTRODUCTION: Blocking the colony-stimulating factor 1 (CSF-1) signal on tumor-associated macrophages can lead to an upregulation of checkpoint molecules, such as programmed cell death ligand 1 (PD-L1), thus causing resistance to this blockade. Combining spartalizumab (PDR001), a high-affinity, ligand-blocking, humanized anti-PD-1 immunoglobulin G4 antibody, with lacnotuzumab (MCS110), a high-affinity, humanized monoclonal antibody directed against human CSF-1 can potentially overcome this resistance.

METHODS: This was a multicenter, phase Ib/II trial using a combination of spartalizumab with lacnotuzumab in patients with advanced cancers, including anti-PD-1/PD-L1 treatment-resistant melanoma, and anti-PD-1/PD-L1 treatment-naïve triple-negative breast cancer, pancreatic cancer, and endometrial cancer (ClinicalTrials.gov identifier: NCT02807844). The …

Disaster Plant Pathology: Smart Solutions For Threats To Global Plant Health From Natural And Human-Driven Disasters, Berea A. Etherton, Robin A. Choudhury, Ricardo I. Alcalá Briseño, Romaric A. Mouafo-Tchinda, Aaron I. Plex Sulá, Manoj Choudhury, Ashish Adhikari, Si Lin Lei, Nattapol Kraisitudomsook, Jacobo Robledo Buritica

School of Earth, Environmental, & Marine Sciences Faculty Publications

Disaster plant pathology addresses how natural and human-driven disasters impact plant diseases, and the requirements for smart management solutions. Local to global drivers of plant disease change in response to disasters, often creating environments more conducive to plant disease. Most disasters have indirect effects on plant health through factors such as disrupted supply chains and damaged infrastructure. There is also the potential for direct effects from disasters, such as pathogen or vector dispersal due to floods, hurricanes, and human migration driven by war. Pulse stressors such as hurricanes and war require rapid responses, while press stressors such as climate change …

A Precious Gift: A Reflection And Resource On Water Quality And Sustainability, Mark Potosnak, Andrew Panelli, Adrienne Kalmes, Antonio Quintanilla, Dr. George Nassos, Michael Terrien, Obl. Osb

College of Science and Health Faculty and Staff Works

This reflection, prepared by Illinois Catholics concerned with the intersection of faith, environmental stewardship, and social justice, explores the theological, moral, and practical dimensions of water quality and sustainability in the state. Rooted in Scripture, and Catholic liturgy and tradition, it affirms water as a sacred gift, essential for life and a universal human right. Drawing on Catholic social teaching and Pope Francis’ Encyclical Laudato Si’: On Care for Our Common Home, it examines pressing water challenges in Illinois, including contamination from coal ash, nitrates, PFAS, and lead, as well as infrastructure, affordability, and sustainability concerns. The document offers an …

Utilizing Electrical Geophysical Methods To Map Mycorrhizal Mycelium Networks Non-Invasively, Donald Pesonen

Graduate Dissertations and Theses

Mycorrhizal mycelium networks are a key component to forest health. These networks act as a transportation system for nutrients, are major players in carbon and nitrogen cycling, and can provide some level of drought resistance to the surrounding flora. Due to the location and size of these network’s filaments, studying mycelium non-invasively has been difficult. The alternative method of laboratory grown samples, lacks the important environmental factors that play into the growth and development of mycelium. Mycelium’s inherent conductivity and moisture retention allows for these networks to be a viable target for electrical geophysical equipment. CMD-Tiny, a small shallow depth …

An Actor's Approach To Contemporary Theatre, Ethan Harbin

Undergraduate Honors Theses

This paper is a composite of research and reflection in regards to Comemedia dell'arte as well as contemporary theatre. It is a personal exploration of the life and legacy of Aurand Harris. My personal application of the research is documented in this thesis.

Modeling Sex-Specific Changes In Myocardial Fibrosis, Grace Martin

Chemical Engineering Undergraduate Honors Theses

Heart disease the leading cause of death for both men and women in the United States. Cardiac fibrosis, or accumulation of extracellular matrix proteins in the heart, can occur after a heart attack and increase the risk for further complications. Current treatments for heart disease do not include extracellular matrix regulators, partly due to the complicated signaling network responsible for the production of these proteins. By using a computational model of the signaling network in cardia fibroblasts, the relationship between particular molecules and downstream extracellular matrix production can be examined.

Biological sex is an important factor for cardiac health and …

Books As Bridges: Utilizing Multicultural Literature To Foster Connection, Representation, And Inclusivity In Student Education, Elizabeth Vega

Curriculum and Instruction Undergraduate Honors Theses

Background: Linguistic and demographic diversity is growing in classrooms across the United States however teacher demographics remain overwhelmingly composed of monolingual white women. There is great need for a bridge between cultures that honors and empowers diverse experiences. Through personal and professional experiences, I have witnessed the power of crossing cultural bridges through literature. Purpose: This study investigates the role of multicultural literature as a powerful tool to bridge cultural divides, provide authentic representation for marginalized groups, and cultivate a sense of belonging among students from various backgrounds. Methodology: This study reviewed peer-reviewed sources to gather insights into the effectiveness …

Through Undertale To Interactive Storytelling: The Effect Of Game Design On Secondary Students’ Perceptions Of Creative Writing, Terrell Page Jr.

Curriculum and Instruction Undergraduate Honors Theses

Videogames have emerged as a globally influential storytelling medium, as evinced by the success of story-driven games like Undertale, The Legend of Zelda: Breath of the Wild, and The Last of Us II. This medium needs creative writers who can learn to think like game designers. But, recognizing that not all creative writers will pursue a career in game design, this project studied the impact of thinking like a game designer on the way creative writing students approach their craft. Drawing on a variety of videogames and genres, this project focused on the potential of world-building and player choice to …

Fungi In Cancer, Jessica Galloway-Peña, Iliyan D Iliev, Florencia Mcallister

Faculty, Staff and Student Publications

Both the gut and the tumour microbiome are now established as crucial regulators of cancer phenotypes and have been implicated in cancer initiation, progression and therapy response. Although the role of bacteria in these processes is beginning to be unravelled, the relevance of fungi is only just emerging. In this Viewpoint, we asked experts to discuss the current knowledge on the mycobiome–cancer connection and share their opinion on how to best solve open questions.

Use Of Advanced Diagnostics For Timely Identification Of Travel-Associated Leptospira Santarosai Infection In Four Adolescents Through Plasma Microbial Cell-Free Dna Sequencing With The Karius Test, Hai Nguyen-Tran, Guliz Erdem, P Marcelo Laufer, Lori Patterson, Asim A Ahmed, William A Bower, Renee Galloway, Sara Saporta-Keating

Faculty, Staff and Student Publications

Background: Leptospirosis is an important zoonotic infection worldwide. Diagnosis of leptospirosis is challenging given its nonspecific clinical symptoms that overlap with other acute febrile illnesses and limitations with conventional diagnostic testing. Alternative advanced diagnostics, such as microbial cell-free DNA (mcfDNA), are increasingly being used to aid in the diagnosis of infections and can be applied to pathogens with public health importance such as Leptospira , a nationally notifiable disease.

Methods: The Karius Test uses plasma mcfDNA sequencing to detect and quantify DNA-based pathogens. This test offered through the Karius lab detected 4 cases of Leptospira santarosai during a 5-month period …

Thinking From The Home: Emanuele Coccia On Domesticity And Happiness, Evan Edwards

Open Access Publishing Support Funded Articles

This article traces the idea of domesticity through the work of Emanuele Coccia to explain his conception of happiness. Coccia argues that it is only by taking domestic concerns seriously that philosophy can begin to theorize the possibility of happiness today, claiming that rather than beginning with the polis, “philosophy must think the city from the home, and the home from the kitchen.” The article begins by situating Coccia's work in the tradition of Giorgio Agamben's critical project and then explores the idea of the home from his 2016’s The Life of Plants through 2020’s Metamorphoses to understand the reason …

Impact Of Perinatal Escitalopram Exposure On Adolescent Behavior, Jessica Bezenah - Bottorff

Electronic Theses, Projects, and Dissertations

Escitalopram (EST), a selective serotonin reuptake inhibitor (SSRI), is an antidepressant frequently used during pregnancy, yet there is limited knowledge of its long-term effects on maternal use. Past studies suggest that maternal exposure may adversely affect the fetus, which may be due to the hyperserotonergic environment caused by the nature of SSRIs during early development. Modifications of the serotonergic system in offspring during certain critical periods of development may result in long-term behavioral and cognitive changes in adulthood. Further, recent human studies have demonstrated that prenatal exposure to SSRIs in humans may increase susceptibility to autism spectrum disorder (ASD) and …

The Disproportionate Impacts Of Certain Factors That Differentiate The Amount Of Mental Health Referrals Of School A Compared To School B, Jesus Barrientos

Electronic Theses, Projects, and Dissertations

This study explores the relationship between a variety of factors the school of attendance for two schools in the Inland Empire. This research project sought to assess if there are differing rates of exposure to parental substance use, geographical location, diagnosis of anxiety, diagnosis of depression, and exposure to traumatic events based on the high school of attendance. Secondary data was acquired from a school district in the Inland Empire. Fifty assessments from school A and fifty from school B were used; a total of 100 adolescent assessments were used. The adolescent assessment explores the location of living, questions regarding …

Interpreting Geochemical Sourcing In The Northwest Great Basin: The 26wa12962 Sample Study, Tyler Alexander Reinholt

Electronic Theses, Projects, and Dissertations

Located in Northwest Washoe County Nevada along the California and Nevada border, 26WA12962 is an upland spring site consisting of habitation debris and several thousand pieces of debitage on the surface. The purpose of this research project is to interpret energy dispersive x-ray fluorescence (EDXRF) results of 80 random samples of obsidian, and fine grain volcanics such as basalt and dacite from the excavations on 26WA12962 that were conducted in 2021. This thesis will investigate if there is a preference for a specific source, as well as assisting in gathering data within a lithic landscape. To accomplish this goal, I …

A Smart Hybrid Enhanced Recommendation And Personalization Algorithm Using Machine Learning, Aswin Kumar Nalluri

Electronic Theses, Projects, and Dissertations

In today’s age of streaming services, the effectiveness and precision of recommendation systems are crucial in improving user satisfaction. This project introduces the Smart Hybrid Enhanced Recommendation and Personalization Algorithm (SHERPA) a cutting-edge machine learning approach aimed at transforming how movie suggestions are made. By combining Term Frequency Inverse Document Frequency (TF-IDF) for content based filtering and Alternating Squares (ALS) with Weighted Regularization for filtering SHERPA offers a sophisticated method for delivering tailored recommendations.

The algorithm underwent evaluation using a dataset that included over 50 million ratings from 480,000 Netflix users encompassing 17,000 movie titles. The performance of SHERPA was …

“Barbie Is As Much About Fashion As She Is About Culture And Empowerment”: Feminism In Barbie The Movie And Its Postfeminist Marketing, Brooke Ashley Shepherd

Electronic Theses, Projects, and Dissertations

The Barbie movie has been celebrated by fans for its feminist narrative. Although the film garnered appreciation from fans across the world, my thesis illustrates that it ultimately serves as a vehicle to promote a product, leading to question its feminist narrative. This mixed method study, which combines feminist textual analysis and feminist political economy analysis, investigates feminism and postfeminism within the Barbie movie and the marketing for the movie. The feminist textual analysis identified both feminist and postfeminist ideologies that are present within the film. The feminist political economy analysis identified the marketing for the Barbie movie as postfeminist. …

Qualitative Assessment Of Human Embryonic- And Induced Pluripotent Stem Cell Derived Neural Stem Cells Under Cgmp Methods, Michelle Hernandez

Electronic Theses, Projects, and Dissertations

Neural stem cell therapies represent a promising tool for the development of regenerative medicine and are being tested in clinical trials for several neurological disorders. However, the clinical applicability of stem cell therapies is dependent on the implementation of current good manufacturing practices (cGMPs) to ensure the quality, safety, and consistency that stem cell products need to meet FDA regulatory requirements. As such, there is a need for a shift to xeno-free methodologies so experimental conditions are cGMP compliant. The purpose of this study is to test a GMP compatible production method to generate multipotent neural stem cells (NSCs) from …

Artificial Intelligence's Ability To Detect Online Predators, Olatilewa Osifeso

Electronic Theses, Projects, and Dissertations

Online child predators pose a danger to children who use the Internet. Children fall victim to online predators at an alarming rate, based on the data from the National Center of Missing and Exploited Children. When making online profiles and joining websites, you only need a name, an email and a password without identity verification. Studies have shown that online predators use a variety of methods and tools to manipulate and exploit children, such as blackmail, coercion, flattery, and deception. These issues have created an opportunity for skilled online predators to have fewer obstacles when it comes to contacting and …

Investigating The Potential Of Augmented Reality In Creating A Sense Of Place On College Campuses, Linda White

Electronic Theses, Projects, and Dissertations

This project examines how designing an augmented reality (AR) campus navigation app can improve college students' sense of place and connection with California State University, San Bernardino (CSUSB). To guide the design of the app, I engaged in qualitative research using a curated campus walk protocol that invited students to walk to their favorite place on campus and record their walk while narrating it.

My analysis reveals the larger patterns that students use to select favorite places and favorite routes to those places, as well as how space navigation may lead to the formation of a sense of connection with …

Deconstructing Standard English Ideology: Elements Of Equitable And Inclusive Language And Literacy Education For Our Times, Gricelda Carbajal

Electronic Theses, Projects, and Dissertations

ABSTRACT

This thesis argues for the deconstruction of the standard English ideology, which holds that standard English is inherently superior to other English varieties. It examines the ideology’s detrimental effects on those who speak and use nonstandard English varieties, mostly minorities and people of color, who are linguistically profiled and marginalized because of the ways they speak. The ideology can also generate intensified reactions to perceived grammar and usage errors in those who subscribe to its prescriptivist views, and can promote judgments and stereotypes which impede communication and connection between people. To help dismantle the standard English ideology, the author …

Where The Ancestors Sleep: Radiocarbon Dating Of Bioapatite From La Consentida, Oaxaca, Robert Mitchell

Electronic Theses, Projects, and Dissertations

This study aims to refine the chronology of the burial sequence at the Early Formative Period (2000–1000 BCE) site of La Consentida in Oaxaca, Mexico. Previously, the chronology of mortuary spaces at La Consentida was supported by nine radiocarbon dates (2020–1510 cal BCE) from secure contexts, including charcoal, carbonized material from pottery, and two human bone samples processed together using R_combine to establish a single direct date for human remains at the site. This thesis study dated bioapatite from nine sets of adult human remains found in the two known mortuary contexts at La Consentida and two carbon-rich sediment samples …

Effect Of Simulated Gastrointestinal Digestion On Antioxidant, And Anti-Inflammatory Activities Of Bioactive Peptides Generated In Sausages Fermented With Staphylococcus Simulans Qb7, Hongying Li, Hongbing Fan, Zihan Wang, Qiujin Zhu, Jianping Wu

Animal and Food Sciences Faculty Publications

Dry-fermented sausages are a good source of bioactive peptides, whose stability against gastrointestinal (GI) digestion determines their bioaccessibility. This study focused on evaluating the effect of peptide extracts from sausages fermented with Staphylococcus simulans QB7 during in vitro simulated GI digestion, including peptide profi les and antioxidant and anti-infl ammatory activities. Peptides present in sausages were degraded during digestion, with molecular weight reduced from > 12 kDa to < 1.5 kDa. Besides, the content of amino acids increased from 381.15 to 527.07 mg/g, especially tyrosine being found only after GI digestion. The anti-infl ammatory activities were increased after GI digestion, however, the changes in antioxidant activities were the opposite. A total number of 255, 252 and 386 peptide sequences were identified in undigested, peptic-digested and GI-digested samples, respectively. PeptideRanker, BIOPEP-UWM and admetSAR were used to further predict the functional properties and intestinal absorption of the identified peptide sequences from GI digestion. Finally, 18 peptides were discovered to possess either antioxidant or anti-infl ammatory capacities.

Investigation Of Geographic And Ontogenetic Venom Variation And Diversity Of Snake Venom Metalloproteinases In The Great Basin Rattlesnake (Crotalus Oreganus Lutosus), Eric Januszkiewicz

Dissertations

Snake venoms can show a large degree of phenotypic variation based on factors such as geographic location, environmental influences, and age which is likely beneficial for local adaptations to various ecological niches. Venom composition not only affects the ability of a snake to acquire prey but can also impact snakebite symptomology. This study, involving sixty-seven individual Great Basin Rattlesnake (Crotalus oreganus lutosus) venom samples collected from Idaho, Utah, California, and Arizona, showed that ontogenetic and geographic variables play a significant role and clearly drive the variation found within the venom of the Great Basin Rattlesnake. All six toxin families assessed …

Near-Surface Soil Property Change Over Time In Two Native Tallgrass Prairies In The Arkansas River Valley, Katie Jansson

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

One climate-change mitigation pathway is soil carbon (C) sequestration, which removes carbon dioxide from the atmosphere and stores C in various forms in the soil. Native prairie soils have long been known for their soil C sequestration abilities, but the full extent of their sequestration capacity is not completely understood. This study evaluated the effect of soil depth and soil map unit/prairie combination on changes in various soil properties over time from 2018 to 2022 in the top 20 cm of two native tallgrass prairie soils in the Arkansas River Valley in west-central Arkansas. Soil samples were collected from the …

Do You Know The Pangolin?: Analyzing Biodiversity Awareness And Attitudes, Ariel "Jazz" Holcomb

Honors Theses

Understanding the impact education has on environmental knowledge and values is critical for knowing how we can promote pro-environmental awareness and attitudes. Thus, this study investigated how environmental education level influences awareness and attitudes on environmental issues, specifically the Biodiversity Crisis. Through a survey primarily utilizing Likert scale statements, the researcher evaluated the differences in knowledge and care levels between classes taking an introductory environmental science course, one class of environmental science majors and one for non-majors. One focus point of the course is the world’s most trafficked mammal, the pangolin, so this species was used as a focus species …

Holiness And Faithfulness : Anglican Clergy In Kent And Some Factors As To Why They Stay In Post Serving Parishes And All The People Who Live In Them, Andrew J. Bawtree

ATS Dissertations

No abstract provided.

Becoming A Healthy Small United Methodist Church : A Tongan Pastor's Perspective, John Sione H. Tu'uta

ATS Dissertations

No abstract provided.