Digital Commons Network^™

Development Of A Nanoparticle-Based Nasal Vaccine Against Sars-Cov-2, Jorge Kalil, Roberta Liberato Pagni, Ana Iochabel Soares Moretti, Keity Souza Santos, Edécio Cunha-Neto, Verônica Porto Carreiro De Vasconcellos Coelho, Marco Antônio Stephano, Marcos Camargo Knirsch, Koiti Araki, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Ana Maria Moro

Vaccine Technology IX

Please click Additional Files below to see the full abstract

Authorizing Violence: Spatial Techniques Of Citizenship Politics In Northeast India, Samarth Vachhrajani

Masters of Environmental Design Theses

Authorizing Violence: Spatial Techniques of Citizenship Politics in Northeast India studies the spatial and legal instruments through which Hindu Nationalism and its political front, the Bhartiya Janata Party (BJP), operates in Northeast India. I document the means through which authoritarian power has been introduced into a democratic structure of governance. Emphasizing the role of architecture and spatial knowledge, I attend to how the violence of disenfranchisement and dispossession is legitimized under the force of law.

For this, Chapter 1, entitled 'Legislating Containment,' turns to the legal instrument of citizenship and studies the Goalpara detention center and multi-purpose criminal …

The Evolving Scope Of Ipr Estoppel As Applied To System And Product Prior Art, Michael Rueckheim, Richard Jung

Chicago-Kent Journal of Intellectual Property

No abstract provided.

The Effect Of A Lactobacillus Containing Gel On The Clitoral Microbiome Of The Mare, Fiona E. Herzog

LSU Master's Theses

The equine lower reproductive tract harbors bacterial populations that serve as a reservoir for potential pathogens. Dysbiosis of urogenital sites may play a role in reproductive disease of the mare, including endometritis. Metagenetic studies have evaluated microbiomes in the uterus, vagina and placenta, while the clitoral microbiome has yet to be described. In this study, the following hypotheses were tested; 1) the clitoris harbors a unique microbiome, 2) topical Lactobacillus genus complex (LGC) probiotic will alter this microbiome, 3) acceptable per cycle pregnancy rates (PCPR) following probiotic application will be achieved. Reproductively normal mares (n=14) were selected, and clitoral fossa …

Clark Memorandum: Spring 2024, J. Reuben Clark Law School, Byu Law School Alumni Association, J. Reuben Clark Law Society

The Clark Memorandum

• Facing Fear with Faith
• The Great Law(s) of Peace
• Grace in the Law School

Reassignment Of Some Caryospora Species (Apicomplexa: Eimeriidae) To Eumonospora (Apicomplexa: Sarcocystidae) And A Summary, Donald W. Duszynski

MANTER: Journal of Parasite Biodiversity

This review was crafted to clear up some of the current confusion regarding the correct taxonomic placement of those apicomplexan coccidians that produce unique monosporocystic octosporozoic (1 sporocyst with 8 sporozoites) oocysts during the sexual phase of their life history in vertebrate hosts. Currently, such oocysts have been placed in 1 of 4 genera, Avispora, Caryospora, Karyospora, or Eumonospora, 2 of which are no longer accepted or useful (Avispora and Karyospora). My review suggests that to present (2023) there are 62 valid Caryospora and 26 valid Eumonospora species. Caryospora species are recorded from a bird …

Il-2-Free Tumor-Infiltrating Lymphocyte Therapy With Pd-1 Blockade Demonstrates Potent Efficacy In Advanced Gynecologic Cancer, Jing Guo, Chunyan Wang, Ning Luo, Yuliang Wu, Wei Huang, Jihui Zhu, Weihui Shi, Jinye Ding, Yao Ge, Chunhong Liu, Zhen Lu, Robert C Bast, Guihai Ai, Weihong Yang, Rui Wang, Caixia Li, Rong Chen, Shupeng Liu, Huajun Jin, Binghui Zhao, Zhongping Cheng

Faculty, Staff and Student Publications

BACKGROUND: Tumor-infiltrating lymphocyte (TIL) therapy has been restricted by intensive lymphodepletion and high-dose intravenous interleukin-2 (IL-2) administration. To address these limitations, we conducted preclinical and clinical studies to evaluate the safety, antitumor activity, and pharmacokinetics of an innovative modified regimen in patients with advanced gynecologic cancer.

METHODS: Patient-derived xenografts (PDX) were established from a local recurrent cervical cancer patient. TILs were expanded ex vivo from minced tumors without feeder cells in the modified TIL therapy regimen. Patients underwent low-dose cyclophosphamide lymphodepletion followed by TIL infusion without intravenous IL-2. The primary endpoint was safety; the secondary endpoints included objective response rate, …

Structural Fiber Mesh Reinforcement Of A Polymeric Heart Valve: Improving Valve Durability And Leaflet Closure Effectiveness, Peter J. Choi, Hugo Zazueta, John A. Acevedo, Philip Park

Civil Engineering Faculty Publications

Objective: Bioprosthetic valves using either porcine or bovine pericardium have been widely used for transcatheter heart valve replacements. However, producing bioprosthetic valves is not a sustainable solution. Acquiring animal tissue is often not readily available and costly and requires time-consuming modifications. Moreover, its primary tissue failure requires reoperation after roughly 15 years. The suggested replacement of porcine and bovine leaflets with biocompatible polymers appears to be an attractive alternative to bioprosthetic valves. In this study, engineered fiber-reinforced polymers were developed, which are less degenerative and offer greater hemocompatibility in relation to mechanical valves.
Methods: Polydimethylsiloxane (PDMS) polymer reduces calcification significantly …

Animals In Prison: Is There Value In Inmate-Animal Rehabilitation Programs?, I. H. C.

Tredway Library Prize for First-Year Research

This paper demonstrates the benefits of animal rehabilitation programs in alleviating the mental harm of incarceration and improving outcomes for individuals upon their release. I.H.C. details the overwhelming mental health crises and conditions that inmates face in prison, arguing to redefine rehabilitation to center both practical preparations and on healing the underlying traumas and mental health concerns before release. His numerous examples drawn from prisons around the world thoroughly uphold the evidence that animal rehabilitation programs improve inmate wellbeing, decrease violent incidents in prison, enhance vocational and employment opportunities post-incarceration, and overall change inmates’ behavior – all benefits that ultimately …

Employing Digital Pcr For Enhanced Detection Of Perinatal Toxoplasma Gondii Infection: A Cross-Sectional Surveillance And Maternal-Infant Outcomes Study In El Salvador, Mary K. Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F. Torres-Romero, Hanson Cowan, Madeleine M. Meyer, Willber D. Castro-Godoy, Mufaro Kanyangarara Ph.D., Stella Coker Watson Self Ph.D., Ms, Berry A. Campbell, Melissa Nolan Ph.D., Mph

Faculty Publications

Toxoplasma gondii is a parasitic infection that can be transmitted in utero, resulting in fetal chorioretinitis and other long-term neurological outcomes. If diagnosed early, pregnancy-safe chemotherapeutics can prevent vertical transmission. Unfortunately, diagnosis of acute, primary infection among pregnant women remains neglected, particularly in low-and-middle-income countries. Clinically actionable diagnosis is complex due to the commonality of infection during childhood and early adulthood which spawn long-last antibody titers and historically unreliable direct molecular diagnostics. The current study employed a cross-sectional T. gondii perinatal surveillance study using digital PCR, a next generation molecular diagnostic platform, and a maternal-fetal outcomes survey to ascertain …

Signer-Independent Sign Language Recognition With Feature Disentanglement, İnci̇ Meli̇ha Baytaş, İpek Erdoğan

Turkish Journal of Electrical Engineering and Computer Sciences

Learning a robust and invariant representation of various unwanted factors in sign language recognition (SLR) applications is essential. One of the factors that might degrade the sign recognition performance is the lack of signer diversity in the training datasets, causing a dependence on the singer’s identity during representation learning. Consequently, capturing signer-specific features hinders the generalizability of SLR systems. This study proposes a feature disentanglement framework comprising a convolutional neural network (CNN) and a long short-term memory (LSTM) network based on adversarial training to learn a signer-independent sign language representation that might enhance the recognition of signs. We aim to …

Developing A Membrane-Proximal Cd33-Targeting Car T Cell, Ruby Freeman, Sanam Shahid, Abdul G Khan, Serena C Mathew, Sydney Souness, Erin R Burns, Jasmine S Um, Kento Tanaka, Winson Cai, Sarah Yoo, Andrew Dunbar, Young Park, Devin Mcavoy, Kinga K Hosszu, Ross L Levine, Jaap Jan Boelens, Ivo C Lorenz, Renier J Brentjens, Anthony F Daniyan

Faculty, Staff and Student Publications

BACKGROUND: CD33 is a tractable target in acute myeloid leukemia (AML) for chimeric antigen receptor (CAR) T cell therapy, but clinical success is lacking.

METHODS: We developed 3P14HLh28Z, a novel CD33-directed CD28/CD3Z-based CAR T cell derived from a high-affinity binder obtained through membrane-proximal fragment immunization in humanized mice.

RESULTS: We found that immunization exclusively with the membrane-proximal domain of CD33 is necessary for identification of membrane-proximal binders in humanized mice. Compared with clinically validated lintuzumab-based CAR T cells targeting distal CD33 epitopes, 3P14HLh28Z showed enhanced in vitro functionality as well as superior tumor control and increased overall survival in both …

‘Green Is The Color Of The Luxuriant Vegetation Of Our Motherland’: Marcus Garvey, Temporality, And Wilderness As A Repeating Phase, Colin Fisher

History: Faculty Scholarship

Like other nationalists of the early twentieth century, the Harlem-based Pan-Africanist Marcus Garvey invoked landscape to rally potential citizens across lines of difference and imagine national community. The centrality he and his organization, the Universal Negro Improvement Association (UNIA), gave to nature can be seen in the Pan-African flag, the green stripe of which symbolized the “luxuriant vegetation of our Motherland.” But unlike European and European American nationalists, Garvey understood time as cyclical rather than linear, which meant that he saw wilderness not as a national starting place to be preserved in national parks but rather as a repeating phase.Garvey’s …

Brain Science And Brain-Inspired Intelligence In Intelligent Era, Xu Zhang

Bulletin of Chinese Academy of Sciences (Chinese Version)

With intelligence technology as the core technology and intelligent computing power as the productive force, the intelligent era has once again pushed brain science to the forefront of world science and technology. Brain science is the science that studies the nature and rule of cognition and intelligence of human, animal, and machine. A comprehensive analysis of the structure and functional connection rule of the nervous system will eventually draw the functional connectivity map of the brain. In the past decade, neuroscience research has been committed to systematically analyzing the types of neurons and neural structural connections of the nervous system, …

A Potential Of Watercress Nasturtium Officinale Bioactive Compounds In Inhibiting Infectious Myonecrosis Virus (Imnv) By Targeting Rna-Dependent Rna Polymerase (Rdrp) Virus From Several Countries: In Silico Approach, Qurrota A’Yunin, Fatchiyah Fatchiyah, Maftuch Maftuch, Feri Eko Hermanto, Muhammad Hermawan Widyananda, Narendra Santika Hartana, Muhaimin Rifa’I, Yoga Dwi Jatmiko

Karbala International Journal of Modern Science

Infectious myonecrosis virus (IMNV) disease causes mass mortality and decreased shrimp production. The RdRp region projects to the interior, where it may function in transcription. The focus of this study was to determine the effect of amino acid polymorphisms from several countries on the structure of RdRp and identify the potential of watercress in inhibiting IMNV by targeting the RdRp protein of IMNV through an in silico approach. The results showed that the structure of the IMNV RdRp protein from Indonesia was similar to Mexico, and the protein structure from India_QDN was identical to India_QIL. Ligand binding affinity values showed …

Understanding Cadaver Dogs, Carlyn Sampson

Themis: Research Journal of Justice Studies and Forensic Science

The exploration of cadaver dogs as an accuracy and reliability tool in the field of forensic science. Due to limited research on cadaver dogs, this paper will illustrate the main factors that are crucial to making reliable and accurate scent detection dogs. It also highlights the olfactory system of dogs, which sets them apart from other mammals and enables them to detect scents with a high degree of accuracy. It will dive into the research on the genetics of canine olfaction, and the role of olfactory receptor genes in scent identification. It is demonstrated that different dog breeds are comparable …

Effects Of Fast And Slow-Wilting Soybean Genotypes On Fall Armyworm (Spodoptera Frugiperda) Growth And Development, Jessica Ayala, Alejandro Vasquez, Devi Balakrishnan, Evelyn Madrigal, Justin George, Rupesh R. Kariyat

School of Integrative Biological & Chemical Sciences Faculty Publications

Soybean (Glycine max) is the most important plant protein source, and Fall Armyworm (FAW, Spodoptera frugiperda) is considered a major pest. This study aimed to examine the impact of FAW feeding on soybean accessions that vary in their water use efficiency (WUE) traits, by examining FAW growth and life history parameters along with plant growth response to pest damage. Soybean accessions were grown in a greenhouse and exposed to FAW larval feeding for 48 h at three different soybean growth stages: V3, R3, and R6. The growth and development of the FAW and soybeans were monitored. Results showed …

24 Conference Program - Vaccine Technology Ix, Linda Lua, Charles Lutsch, Francesc Gòdia, Tara Tagmyer

Vaccine Technology IX

No abstract provided.

Effects Of Fast And Slow-Wilting Soybean Genotypes On Fall Armyworm (Spodoptera Frugiperda) Growth And Development, Jessica Ayala, Alejandro Vasquez, Devi Balakrishnan, Evelyn Madrigal, Justin George, Rupesh Kariyat

Entomology and Plant Pathology Faculty Publications and Presentations

Soybean (Glycine max) is the most important plant protein source, and Fall Armyworm (FAW, Spodoptera frugiperda) is considered a major pest. This study aimed to examine the impact of FAW feeding on soybean accessions that vary in their water use efficiency (WUE) traits, by examining FAW growth and life history parameters along with plant growth response to pest damage. Soybean accessions were grown in a greenhouse and exposed to FAW larval feeding for 48 h at three different soybean growth stages: V3, R3, and R6. The growth and development of the FAW and soybeans were monitored. Results showed that faster …

Police Dogs: A Useful Tool Or Expensive Legal Nightmare, Madeline Hoyt

Themis: Research Journal of Justice Studies and Forensic Science

This article critically evaluates the arguments for and against the continuing use of police dogs. Arguments against the continuing usage of police dogs include the high level of variability in success rates due to different traits of the dogs, differing training styles, and the various types of drugs that the dogs are trained to detect. Arguments against the continuance of police dogs also include the legal issues related to the use of police dogs; health implications, job-related injuries incurred by the dogs, and the expenses related to the purchasing, training, and care of the working dogs. The arguments in favor …

Effects Of Alternative Hermetic Bag Storage On Fermented And Dried Cocoa Bean (Theobroma Cacao L.), Kenneth Foster, Lina M. Suarez-Guzman, Diana C. Meza-Sepulveda, Dieudonne Baributsa, Carlos A. Zurita

Department of Agricultural Economics Faculty Publications

Cocoa beans, derived from the Cacao Tree (Theobroma cacao L.), are a cash crop among smallholder farmers in tropical regions. After harvest and processing, maintaining cocoa bean quality is critical to access lucrative markets. This paper examines the impact of hermetic storage on insect damage, mold, moisture content, and water activity of fermented and dried cocoa beans under farm conditions in collaboration with a farmer association of Belén de Umbría in Colombia. Three types of hermetic storage systems were assessed for a period of 12 months: Purdue Improved Crop Storage (PICS) bags, including both 2- and 3-layer variants, and Ecotact® …

179th University Of Notre Dame Commencement, University Of Notre Dame

Commencement Programs

• SCHEDULE OF EVENTS 3
• GRADUATE SCHOOL COMMENCEMENT CEREMONY 9
• DOCTORAL DEGREES 10
• MASTER DEGREES 23
• MENDOZA COLLEGE OF BUSINESS GRADUATE BUSINESS 38
• GRADUATE ARCHITECTURE 44
• LAW SCHOOL 45
• UNIVERSITY COMMENCEMENT CEREMONY 48
• COLLEGE OF ARTS AND LETTERS 51
• COLLEGE OF SCIENCE 59
• COLLEGE OF ENGINEERING 65
• MENDOZA COLLEGE OF BUSINESS 71
• SCHOOL OF ARCHITECTURE 77
• VALEDICTORIAN CANDIDATES 78
• EMERITI FACULTY 78
• HONOR SOCIETIES 78
• AWARDS AND PRIZES 86
• TASSELS 100

Commencement 2024

Commencement Programs

No abstract provided.

Oberlin’S Beaded Dakota Hymnal, Caleigh Lyons

Alison Scott Ricker Research Award

No abstract provided.

Recognizing Traps And Frightening Wolves: Foxes And Lions As A Representative Of Machiavellian Political Ideology In Shakespeare’S Comedies, Grace Powell

Undergraduate Theses and Capstone Projects

While William Shakespeare’s plays and sonnets have been the subject of literary discourse for centuries, one topic that has been less traversed is the connection between his Comedies and Niccolò Machiavelli’s political ideologies. This project will explore references of lions and foxes in Shakespeare’s Comedies and the leaders and monarchs within them to determine how beliefs about Machiavelli’s political ideology influenced Shakespeare’s literature and became symbols for leadership and power. This will be important for gaining historical context on Machiavellian political discourse and how it was represented in the contemporary dramatic literature of William Shakespeare. I closely examined Shakespeare’s Comedies …

Not Just A Walk In The Park: Environmental Injustice In New York City’S Green Spaces, Greta Laine Mclaughlin

Student Theses 2015-Present

This paper examines inequities in New York City’s green spaces, and it discusses the discrepancies in the quality and sizes of parks in lower- versus higher-income and white versus non-white areas. Although organizations herald the city’s parks as some of the best and most accessible in the country, marginalized residents face unsafe and insufficient surroundings. Chapter One considers the state of NYC’s green spaces. The chapter uses quantitative data collected by city agencies and non-profits to illustrate the disparities in the conditions of parks among various communities. By framing the issue using ecosystem services, the paper emphasizes the importance of …

Lyme Disease In The Northeast: The Unintended Consequence Of Suburban Development, Hayden Neubert

Student Theses 2015-Present

This paper addresses the role of suburban development in the suburbs of the Northeastern United States in increasing human Lyme disease infection. Over the past 50 years, Lyme disease has become the most common vector-borne disease in the United States. In 2021, the two states with the most Lyme disease cases were New York and New Jersey, with a collective 6,524 cases, with Connecticut still representing 541 total cases. It is not a coincidence that case numbers are concentrated in suburban areas with high forest fragmentation. Chapter 1 of this essay analyzes how human land development disrupts bioregulatory ecosystem actors …

The Multipurpose Dna Repair/Redox Protein Ape1 In Rodent And Human Lewy Body Disease, Kristin Marie Miner

Electronic Theses and Dissertations

Lewy body disorders are a family of neurodegenerative conditions characterized by proteostatic and redox disequilibrium, leading to deposition of the abundant protein α-synuclein in hallmark inclusions and oxidative damage to DNA. Sublethal oxidative DNA damage in neurons is repaired predominantly by the base excision repair pathway, which involves the coordinated activity of several enzymes, including apurinic/apyrimidinic endonuclease 1 (APE1). Despite emerging connections between α-synuclein, oxidative stress, and DNA damage/repair, along with evidence demonstrating the multifunctional nature of APE1, the link between APE1 and α-synuclein has not yet been explored.

Here, we conducted a broad investigation of APE1 in the context …

Hawaii’S Future Is Kānaka Maoli: Reconciling The Colonization Of Hawai’I To Promote A Greener Future, William Johnston

Student Theses 2015-Present

This paper will focus on the social and environmental degradation of the Kānaka Maoli people and the Hawaiian Islands and will show how Kānaka Maoli philosophy, culture, and knowledge will not only help combat climate change but how they are necessary for the continuation of life through and after this climate crisis. The destruction of our planet and the destruction of indigenous life have gone hand in hand in the United States, and throughout history, the decisions that have affected the environment affected Native Americans and vice versa. As the United States moves towards a greener and more sustainable way …

3-Hydroxyanthranilic Acid Delays Paralysis In Caenorhabditis Elegans Models Of Amyloid-Beta And Polyglutamine Proteotoxicity, Bradford T Hull, Kayla M Miller, Caroline Corban, Grant Backer, Susan Sheehan, Ron Korstanje, George L. Sutphin

Faculty Research 2024

Age is the primary risk factor for neurodegenerative diseases such as Alzheimer’s and Huntington’s disease. Alzheimer’s disease is the most common form of dementia and a leading cause of death in the elderly population of the United States. No effective treatments for these diseases currently exist. Identifying effective treatments for Alzheimer’s, Huntington’s, and other neurodegenerative diseases is a major current focus of national scientific resources, and there is a critical need for novel therapeutic strategies. Here, we investigate the potential for targeting the kynurenine pathway metabolite 3-hydroxyanthranilic acid (3HAA) using Caenorhabditis elegans expressing amyloid-beta or a polyglutamine peptide in body …