Digital Commons Network^™

Reimagining The Single-Author Seminar: Teaching Wheatley Peters, Milton, And The Master’S Discourse, Kate Ozment

ABO: Interactive Journal for Women in the Arts, 1640–1830

This article discusses a senior-level literature course that puts into dialogue Phillis Wheatley Peters and John Milton. Wheatley Peters’ poetry on tyranny and freedom during the American Revolution, especially “America,” is compared to Milton’s Tenure of Kings and Magistrates, Areopagitica, and Paradise Lost, which explore the same themes during the English Civil War. Students trace how Milton’s transformative but narrowed ideas of freedom for enfranchised subjects in England are powerfully reimagined by Wheatley Peters in double meanings of freedom for the colonies and enslaved subjects. Secondary sources allow students to engage in the canon-building of Milton as …

Fighting Erasure And Dispossession In The San Francisco Bay Area: Putting Archaeology To Work For The Muwekma Ohlone Tribe, Lee M. Panich, Monica V. Arellano, Michael Wilcox, Gustavo Flores

Faculty Publications

The Muwekma Ohlone Tribe has long been involved in the archaeology and stewardship of their ancestral homelands, both through their own cultural resource management (CRM) firm and though collaborations with academic and CRM archaeologists. In this article, we build on the past 40 years of archaeological collaborations in the southern San Francisco Bay region and offer examples of how archaeologists can support tribal heritage and environmental stewardship by using the traditional purview of material culture in combination with a broader array of evidence and concerns. As presented in our brief case studies, the Muwekma Ohlone Tribe and scholars are working …

Synesthetic Symbolism: Community Engagement With The Sacred At The Boudhanath Stupa, Madeleine E. Tevonian

Lawrence University Honors Projects

This paper is a discussion of the complex relationship between the Great Boudhanath Stupa in the Kathmandu Valley, and the diverse Buddhist community that surrounds it. I argue that liberative sense experience and movement-encoded cultural knowledge make the community of practitioners a part of the stupa—and thus necessary to any examination of it. My argument is contextualized by a background on stupas and etymology of several Sanskrit and Tibetan terms, and I utilize a framework of religious studies concepts of sacred space and pilgrimage as well as on-site anthropological fieldwork focusing on practitioners’ daily lives. I investigate how the stupa …

The Maternal Icon In Eleanor Sleath's The Orphan Of The Rhine, Esmeralda Orndorff, Joanne E. Myers

ABO: Interactive Journal for Women in the Arts, 1640–1830

In recent years, Eleanor Sleath’s long-neglected The Orphan of the Rhine has received attention as a valuable addition to the Gothic canon. In particular, critics have hailed the unconventionality of her worldly heroine Julie de Rubine. In this article, we resituate Julie’s exceptionalism in a specifically post-Reformation context, arguing that, in Julie, Sleath has created a powerful maternal icon whose mediating authority contests iconoclastic attacks on Marian devotion in seventeenth- and eighteenth-century England. Julie is, as critics have observed, the moral center of the text, and we show how that role is warranted specifically by her religiosity. Although partway through …

Reading Phillis Wheatley’S Catastrophist Poetics: Heroic Couplets And Environmental Justice, Katarina O'Briain

ABO: Interactive Journal for Women in the Arts, 1640–1830

This essay offers suggestions for reading Phillis Wheatley as an early poet of environmental justice by tracing the figure of catastrophe that runs throughout her works. The essay recounts teaching Phillis’s early poems in an upper-level undergraduate seminar on “Ecocriticism: Environmental Justice Literature” as well as in a graduate seminar called “Global Georgics: Land and Labour Across the Long Eighteenth Century.” Looking closely at moments where she describes “pestilential vapors,” or when “Heav’n quakes, earth trembles, and the shores resound,” I argue that Wheatley’s carefully ordered heroic couplet poems speak calamity more than regularity, catastrophe more than gradualism. This pedagogical …

Trpv1 Analgesics Disturb Core Body Temperature Via A Biased Allosteric Mechanism Involving Conformations Distinct From That For Nociception, Yi-Zhe Huang, Jing-Xian Ma, Yu-Jing Bian, Qin-Ru Bai, Yu-Hao Gao, Shu-Ke Di, Yun-Tao Lei, Hui Yang, Xiao-Na Yang, Chang-Yan Shao, Wen-Hui Wang, Peng Cao, Chang-Zhu Li, Michael X Zhu, Meng-Yang Sun, Ye Yu

Faculty, Staff and Student Publications

Efforts on developing transient receptor potential vanilloid 1 (TRPV1) drugs for pain management have been hampered by deleterious hypo- or hyperthermia caused by TRPV1 agonists/antagonists. Here, we compared the effects of four antagonists on TRPV1 polymodal gating and core body temperature (CBT) in Trpv1+/+, Trpv1-/-, and Trpv1T634A/T634A. Neither the effect on proton gating nor drug administration route, hair coverage, CBT rhythmic fluctuations, or inflammation had any influence on the differential actions of TRPV1 drugs on CBT. We identified the S4-S5 linker region exposed to the vanilloid pocket of TRPV1 to be critical for hyperthermia associated with certain TRPV1 antagonists. PSFL2874, …

Perturbations In Risk/Reward Decision Making And Frontal Cortical Catecholamine Regulation Induced By Mild Traumatic Brain Injury, Christopher P Knapp, Eleni Papadopoulos, Jessica A Loweth, Ramesh Raghupathi, Stan B Floresco, Barry D Waterhouse, Rachel L Navarra

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Mild traumatic brain injury (mTBI) disrupts cognitive processes that influence risk taking behavior. Little is known regarding the effects of repetitive mild injury (rmTBI) or whether these outcomes are sex specific. Risk/reward decision making is mediated by the prefrontal cortex (PFC), which is densely innervated by catecholaminergic fibers. Aberrant PFC catecholamine activity has been documented following TBI and may underlie TBI-induced risky behavior. The present study characterized the effects of rmTBI on risk/reward decision making behavior and catecholamine transmitter regulatory proteins within the PFC. Rats were exposed to sham, single (smTBI), or three closed-head controlled cortical impact (CH-CCI) injuries and …

Shea Position Statement On Pandemic Preparedness For Policymakers: Introduction And Overview, Robin L.P. Jump

Faculty Scholarship

Throughout history, pandemics and their aftereffects have spurred society to make substantial improvements in healthcare. After the Black Death in 14th century Europe, changes were made to elevate standards of care and nutrition that resulted in improved life expectancy.1 The 1918 influenza pandemic spurred a movement that emphasized public health surveillance and detection of future outbreaks and eventually led to the creation of the World Health Organization Global Influenza Surveillance Network.2 In the present, the COVID-19 pandemic exposed many of the pre-existing problems within the US healthcare system, which included (1) a lack of capacity to manage a large influx …

Klipper, Stuart, Sophia Maier Garcia

Bronx Jewish History Project

Stuart Klipper was born in 1941 and grew up in the Bronx, first living on Hoe Avenue and later on the Grand Concourse. His family background reflects Eastern European Jewish heritage, with his father’s side from Lithuania and his mother’s side from Galicia. Klipper’s childhood was shaped by the rich cultural life of the Bronx, frequent visits to the Bronx Zoo and the Botanical Garden, and an early interest in art and photography. He recalls a deep love for reading, art, and exploring New York City’s museums, which would later influence his career as a photographer.

Klipper attended P.S. 66 …

Blocking Oncostatin M Receptor Abrogates Stat3 Mediated Integrin Signaling And Overcomes Chemoresistance In Ovarian Cancer, Anjali Geethadevi, Zhiqiang Ku, Shirng-Wern Tsaih, Deepak Parashar, Ishaque P Kadamberi, Wei Xiong, Hui Deng, Jasmine George, Sudhir Kumar, Sonam Mittal, Ningyan Zhang, Sunila Pradeep, Zhiqiang An, Pradeep Chaluvally-Raghavan

The Brown Foundation: Institute of Molecular Medicine

Chemotherapy such as cisplatin is widely used to treat ovarian cancer either before or after surgical debulking. However, cancer relapse due to chemotherapy resistance is a major challenge in the treatment of ovarian cancer. The underlying mechanisms related to chemotherapy resistance remain largely unclear. Therefore, identification of effective therapeutic strategies is urgently needed to overcome therapy resistance. Transcriptome-based analysis, in vitro studies and functional assays identified that cisplatin-resistant ovarian cancer cells express high levels of OSMR compared to cisplatin sensitive cells. Furthermore, OSMR expression associated with a module of integrin family genes and predominantly linked with integrin αV (ITGAV) and …

Machines Of The Absurd: Leveraging Generative Ai For Creativity, Humor, And Playfulness, Tyler Sanders

College of Computing and Digital Media Dissertations

Machines of The Absurd is a collection of four projects exploring how generative AI can be leveraged for creativity, humor and playfulness.

1. neverOS — A node-based visual playground for interacting with large language models.

2. Other Calc — An iOS app with a calculator interface, where players can “calculate” text instead of numbers.

3. What Must Burn — An experiment where players type in text that can be dragged into a campfire to produce contextually appropriate sound effects.

4. Jazz vs Waffles — A turn-based comedy game, where players battle anything they type in.

Together, these projects make the …

Cover And Contents

Turkish Journal of Veterinary & Animal Sciences

No abstract provided.

Histomorphological Evaluation Of Osteoreplacement With Germanium-Doped Calcium Phosphate Ceramics For Model Bone Defects In Rabbits, Tetiana Todosiuk, Mykhailo Rublenko, Valeriy Chemerovskiy, Nataliia Ulianchych, Volodymyr Kolomiiets

Turkish Journal of Veterinary & Animal Sciences

To give calcium phosphate ceramics osteoinductive properties, they are doped with silicon, germanium, zinc, and magnesium ions. The aim of this study was to evaluate the effects of doped and undoped calcium phosphate ceramics on reparative osteogenesis in rabbits. Twenty-four California white rabbits, aged 3 months and weighing 2.5 kg each, were used for the study. The rabbits were divided equally into experimental (n=12) and control (n=12) groups. In the experimental group, defects were replaced with granules of germanium-doped hydroxyapatite ceramics (HA/β-TCP/l-Ge–700), while in the control group, defects were filled with granules of unalloyed ceramics (HA/β-TCP–700). Subsequently, clinical and histological …

Application Of Some Artificial Intelligence Optimization Methods To Determine The Freshness Of Eggs, Hasan Alp Şahi̇n, Hasan Önder

Turkish Journal of Veterinary & Animal Sciences

Egg quality, can be divided into two groups as internal and external, is evaluated using various methods whether breaking eggs. Image processing makes digital images usable for various purposes such as image compression, image editing, object recognition, face recognition, medical imaging, and many other areas such as the automotive industry. This study aimed to determine the freshness of eggs using different artificial intelligence optimization methods with image processing without breaking the eggs. Artificial neural networks (ANNs), artificial bee colony, particle swarm optimization, and genetic algorithms were compared using classification coefficients. As a result of the study, it was determined that …

Features Of Lying Behavior Of Gazella Marica Fawns In Semicaptive Conditions, Adi̇l Uztemur, Abdülkadi̇r Orman

Turkish Journal of Veterinary & Animal Sciences

The lying behavior of Gazella marica fawns was investigated in the gazelle breeding station established to prevent the extinction of this species, whose numbers are decreasing continuously in the wild. There are significant differences between the lying duration in the bedding sites of different kinds (plant-based site, soil-based, side of a stone or rock). Gazella marica fawns were lying on one side of the body 50.23 min on average in the plant-based bed sites, 36.06 min in the soil-based places, and 38.14 min in the stone/ rock area. Gazella marica fawns from semicaptive conditions lied on one body side longer …

Quantitative Proteomic Analysis Reveals Unique Hsp90 Cycle-Dependent Client Interactions, Erick I Rios, Davi Gonçalves, Kevin A Morano, Jill L Johnson

Faculty, Staff and Student Publications

Hsp90 is an abundant and essential molecular chaperone that mediates the folding and activation of client proteins in a nucleotide-dependent cycle. Hsp90 inhibition directly or indirectly impacts the function of 10-15% of all proteins due to degradation of client proteins or indirect downstream effects. Due to its role in chaperoning oncogenic proteins, Hsp90 is an important drug target. However, compounds that occupy the ATP-binding pocket and broadly inhibit function have not achieved widespread use due to negative effects. More selective inhibitors are needed; however, it is unclear how to achieve selective inhibition. We conducted a quantitative proteomic analysis of soluble …

Tl1a And Il-18 Synergy Promotes Gm-Csf-Dependent Thymic Granulopoiesis In Mice, Mario Ruiz Pérez, Kodi Ravichandran, Et Al.

2020-Current year OA Pubs

Acute systemic inflammation critically alters the function of the immune system, often promoting myelopoiesis at the expense of lymphopoiesis. In the thymus, systemic inflammation results in acute thymic atrophy and, consequently, impaired T-lymphopoiesis. The mechanism by which systemic inflammation impacts the thymus beyond suppressing T-cell development is still unclear. Here, we describe how the synergism between TL1A and IL-18 suppresses T-lymphopoiesis to promote thymic myelopoiesis. The protein levels of these two cytokines were elevated in the thymus during viral-induced thymus atrophy infection with murine cytomegalovirus (MCMV) or pneumonia virus of mice (PVM). In vivo administration of TL1A and IL-18 induced …

Evaluation Of Copanlisib In Combination With Eribulin In Triple-Negative Breast Cancer Patient-Derived Xenograft Models, Zhanfang Guo, Jingqin Luo, R Jay Mashl, Jeremy Hoog, Piyush Maiti, Nikki Fettig, Sherri R Davies, Rebecca Aft, Jason M Held, Ramaswamy Govindan, Li Ding, Shunqiang Li, Cornelius Von Morze, Kooresh I Shoghi, Cynthia X Ma, Et Al.

2020-Current year OA Pubs

UNLABELLED: The PI3K pathway regulates essential cellular functions and promotes chemotherapy resistance. Activation of PI3K pathway signaling is commonly observed in triple-negative breast cancer (TNBC). However previous studies that combined PI3K pathway inhibitors with taxane regimens have yielded inconsistent results. We therefore set out to examine whether the combination of copanlisib, a clinical grade pan-PI3K inhibitor, and eribulin, an antimitotic chemotherapy approved for taxane-resistant metastatic breast cancer, improves the antitumor effect in TNBC. A panel of eight TNBC patient-derived xenograft (PDX) models was tested for tumor growth response to copanlisib and eribulin, alone or in combination. Treatment-induced signaling changes were …

Oscillations In Neuronal Activity: A Neuron-Centered Spatiotemporal Model Of The Unfolded Protein Response In Prion Diseases, Elliot M. Miller, Tat Chung D. Chan, Carlos Montes-Matamoros, Omar Sharif, Laurent Pujo-Menjouet, Michael R. Lindstrom

School of Mathematical & Statistical Sciences Faculty Publications

Many neurodegenerative diseases (NDs) are characterized by the slow spatial spread of toxic protein species in the brain. The toxic proteins can induce neuronal stress, triggering the Unfolded Protein Response (UPR), which slows or stops protein translation and can indirectly reduce the toxic load. However, the UPR may also trigger processes leading to apoptotic cell death and the UPR is implicated in the progression of several NDs. In this paper, we develop a novel mathematical model to describe the spatiotemporal dynamics of the UPR mechanism for prion diseases. Our model is centered around a single neuron, with representative proteins P …

Barriers To And Facilitators Of Paediatric Medical Device Innovation: A Scoping Review Protocol, Lynn Kysh, Grzegorz Zapotoczny, Lisa Manzanete, Megan Carey, Payal Shah, Francesca Joseph, Haley Kempf, Abu Taher Sikder, Julia Finkel, Usha Thekkedath, Kara Toman, Chester J Koh, Kolaleh Eskandanian, Juan Espinoza

Faculty, Staff and Students Publications

INTRODUCTION: The development of paediatric medical devices continues to lag adult medical devices and contributes to issues of inequity, safety, quality and patient outcomes. New legislation and funding mechanisms have been introduced over the past two decades, but the gap remains. Clinical trials have been identified as a pain point, but components of effective clinical research infrastructure are poorly understood. As part of a multimodal research strategy, the Pediatric Device Consortia (PDC) will conduct a scoping review to better understand infrastructural barriers to and facilitators of paediatric medical device clinical research identified in the health sciences literature.

METHODS AND ANALYSIS: …

Sirt6 Protects Retinal Ganglion Cells And Optic Nerve From Degeneration During Aging And Glaucoma, Fan Xia, Shuizhen Shi, Erick Palacios, Wei Liu, Seth E Buscho, Joseph Li, Shixia Huang, Gianmarco Vizzeri, Xiaocheng Charlie Dong, Massoud Motamedi, Wenbo Zhang, Hua Liu

Faculty, Staff and Students Publications

Glaucoma is characterized by the progressive degeneration of retinal ganglion cells (RGCs) and their axons, and its risk increases with aging. Yet comprehensive insights into the complex mechanisms are largely unknown. Here, we found that anti-aging molecule Sirt6 was highly expressed in RGCs. Deleting Sirt6 globally or specifically in RGCs led to progressive RGC loss and optic nerve degeneration during aging, despite normal intraocular pressure (IOP), resembling a phenotype of normal-tension glaucoma. These detrimental effects were potentially mediated by accelerated RGC senescence through Caveolin-1 upregulation and by the induction of mitochondrial dysfunction. In mouse models of high-tension glaucoma, Sirt6 level …

Enhancing Default Mode Network Connectivity: Experimental Neuroscience And Computational Methods, Rachel Abbe

Undergraduate Research and Engagement Symposium

The default mode network (DMN) in the human brain is involved in a broad array of cognitive functions, including creative thinking. Transcranial Electrical Stimulation (TES) is a popular non-invasive brain stimulation. TES has three types: Transcranial Direct Current Stimulation (tDCS), Transcranial Alternating Current Stimulation (tACS), and Transcranial Random Noise Stimulation (tRNS). The mechanisms of each TES method still need to be better understood. This study proposes simulation of the DMN using HD-tDCS, alpha-HD-tACS, high-frequency HD-tRNS, and sham. We intend to reveal how the three TES methods impact DMN activity and connectivity using scalp electroencephalography (EEG). Co-Authored by: Kahiau Among, DJ …

Investigate The Role Of Ephrin-B2 And Epha7 In Frequency Map Formation In The Cochlear Nucleus, Joshua Morcos

Undergraduate Research and Engagement Symposium

Cochlea's spiral ganglion neurons (SGNs) transmit sound to the cochlear nucleus, forming a frequency map based on sound responses. Previous studies suggest Ephs and ephrins guide axons in sensory systems, leading us to investigate their role. Ephrin-B2 and EphA7 expression along the cochlear nucleus axis and in developing SGNs respectively implies their involvement in frequency mapping. Ephrin-B2 influences auditory nerve fiber trajectory. Absence of ephrin-B2 and EphA7 in mice reduces frequency band precision. Our findings suggest ephrin-B2 and EphA7 signals regulate frequency mapping in the auditory system.

Angelology: The Creation & The Fall In Neon Genesis Evangelion, Grace Trifunovich

Undergraduate Research and Engagement Symposium

This poster will walk through the angelology and comparisons Neon Genesis Evangelion has to the different creation and fall of humanity narratives of the book of Genesis. It will follow the basis of the world and lore behind the 1995 anime series Neon Genesis Evangelion and how it coincides with the biblically accurate representation of angels, as well as follows a post Eden world painted by the Genesis narrative.

The Effects Of A Low Or High Fat Diet That Determines The Outcome Of Diabetes, Tiara Guider

Undergraduate Research and Engagement Symposium

About 1 in 10 Americans have diabetes and about 90 –95% of those with diabetes have Type II diabetes (CDC). We wanted to look at the affects of diet, sex, and genes to determine if they play a significant role in Type II diabetes. We performed a glucose tolerance test injected the F34 LG,SM advanced intercross line. We found that determined that these factors play a role in having Type II diabetes.

The Religious Practices Of Hinduism In The Greater Chicago Area, Justyna Czopek, Iza Flores

Undergraduate Research and Engagement Symposium

This spring semester, as part of an engaged learning component of the course ‘Religions of Asia’, students visited a religious site related to the Indo-Asian religions studied throughout the course. My classmate and I visited the Hindu Temple of Greater Chicago in Lemont, Illinois. As part of our visit there, we photographed the temple buildings, observed architecture, and conducted interviews with three people. The interview covered questions about the history, the religious services, and demographics of the attendees among others. Through this project, we were able to compare and contrast beliefs of the religion that we learned in class to …

Monstrosity In Mary Shelley’S Frankenstein And Leigh Bardugo’S Six Of Crows, Jordyn Fortuna

Lux et Fides: A Journal for Undergraduate Christian Scholars

The main characters in Mary Shelley’s Frankenstein and Leigh Bardugo’s Six of Crows reveal the potential within everyone for Monstrosity. This disregard for humanity can stem from many things, but it can also be prevented through community and sympathy. Monstrosity is often misconstrued due to a false perception guided by a sighted bias. In reality, however, characters’ humanity can be shown to the reader through a greater insight into their traumas and intentions. This paper highlights the idea that reputation cannot be trusted, but instead must be further examined to reveal the Monster within.

Chronos Volume 13 Issue 1 - Full Issue

Chronos

No abstract provided.

Qinzong Emperor: An Insignificant Emperor?, Xinzhi Lin

Chronos

No abstract provided.

Normal Thymus Evaluation Using Radiographs And Computed Tomographic Images In Young And Adult Dogs, Yoenhee Park, Sang-Kwon Lee, Sooyoung Choi, Hojung Choi, Youngwon Lee, Kija Lee

The Thai Journal of Veterinary Medicine

The thymus generally presents as a sail-shaped soft-tissue opacity on thoracic radiographs in young, pre-pubescent dogs. After puberty, lymphatic tissue is replaced by adipose tissue and can usually no longer be identified on radiographs; however, thymic remnants have often been observed in adult dogs. The objective of this retrospective descriptive study was to investigate the incidence of thymic remnants using thoracic radiographs and to analyze the incidence in dogs by age, sex and breed. We analyzed the data from 1,464 dogs that underwent both thoracic ventrodorsal and right lateral radiography, of which 40 underwent both radiography and computed tomography (CT). …