Digital Commons Network^™

Elderly Mice With History Of Acetaminophen Intoxication Display Worsened Cognitive Impairment And Persistent Elevation Of Astrocyte And Microglia Burden, Celso S G Catumbela, Rodrigo Morales

Faculty, Staff and Student Publications

Acetaminophen (APAP) is a leading cause of acute liver failure. The effect of APAP metabolite's effects in the periphery are well characterized; however, associated consequences in the brain remain poorly understood. Animal studies on this subject are few and reveal that frequent APAP intake can trigger cerebral abnormalities that vary depending on the subject's age. Alarmingly, experimental efforts have yet to examine associated consequences in elderly hosts, who correspond to the highest risk of medication overload, impaired drug clearance, and cognitive deficits. Here, we interrogated the cerebral and peripheral pathology of elderly mice submitted to monthly episodes of APAP intoxication …

Knockdown Of Microrna390 Enhances Maize Brace Root Growth, Juan Meng, Weiya Li, Feiyan Qi, Tianxiao Yang, Na Li, Jiong Wan, Xiaoqi Li, Yajuan Jiang, Chenhui Wang, Meilian Huang, Yuanyuan Zhang, Yongqiang Chen, Sachin Teotia, Guiliang Tang, Zhanhui Zhang, Jihua Tang

Michigan Tech Publications

Brace root architecture is a critical determinant of maize's stalk anchorage and nutrition uptake, influencing root lodging resistance, stress tolerance, and plant growth. To identify the key microRNAs (miRNAs) in control of maize brace root growth, we performed small RNA sequencing using brace root samples at emergence and growth stages. We focused on the genetic modulation of brace root development in maize through manipulation of miR390 and its downstream regulated (). In the present study, miR167, miR166, miR172, and miR390 were identified to be involved in maize brace root growth in inbred line B73. Utilizing short tandem target mimic (STTM) …

Biodiversity Conservation In Western China With Scientific And Technological Support: Current Status, Challenges, And Suggestions, Fuwen Wei, Hang Sun, Jiaojun Zhu, Baoguo Li, Gexia Qiao, Shilong Chen, Jiang Zhu, Xiaoge Ping

Bulletin of Chinese Academy of Sciences (Chinese Version)

As a megadiverse country, China has made significant progress in biodiversity conservation in recent years. The western region is a critical area for biodiversity conservation in China, boasting rich species resources and a high proportion of endemic species. However, its ecosystems are fragile and vulnerable to the impacts of multiple factors like climate change and human activities. Scientific and technological support has played a vital supporting role in biodiversity conservation, providing comprehensive support from monitoring and assessment to restoration and decision-making through biodiversity surveys, scientific research, and the establishment of monitoring networks. Nevertheless, challenges remain, including gaps in taxa and …

Reconceiving Virtue: A Mengzian Adaptation Of Eudaimonic Virtue Ethics In Response To Contemporary Criticisms, Gina Elizabeth Lebkuecher

Dissertations

The primary question my dissertation aims to answer is: how might eudaimonic virtue ethics be reimagined to respond to contemporary criticisms from disability scholars, feminists, and empirical psychology? To answer this, I introduce the Eudaimonic View of Virtue, or EV, and propose a Mengzian adaptation of the EV (EV-M) in response to these criticisms. The EV captures the four core claims to which eudaimonic virtue ethical theories are committed: (i) virtues, in the sense of excellent character traits or dispositions, are the foundation of ethics or ethical action (i.e., aretaicism); (ii) virtue is at least partially constitutive of human well-being/flourishing …

Neurogenomics Of Competition And Parental Care In A Socially Polyandrous Shorebird, Tessa Mathur Patton

Master's Theses

Despite sharing largely similar genomes, females and males of the same species exhibit morphological, physiological, and behavioral differences. Sex-role reversal stems from a unique case of sexual selection in which females compete for mates and males conduct the majority of parental duties. We examined the extent to which aggression and parenting may be mediated by different neurogenomic mechanisms by comparing females versus males in the northern jacana (Jacana spinosa), a sex-role reversed shorebird. We hypothesized that sex differences in neural transcriptomic profiles explain sexual dimorphism in behavior. We conducted RNA-Seq in two brain regions within the social behavior network: the …

Erratum: Gut Microbiota Composition Is Associated With The Efficacy Of Delta-24-Rgdox In Malignant Gliomas, Natalie M Meléndez-Vázquez, Teresa T Nguyen, Xuejun Fan, Andrés R López-Rivas, Juan Fueyo, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and immunotherapy agents, there are no studies linking the gut microbiota with viroimmunotherapy efficacy. We hypothesize that gut bacterial signatures will be associated with oncolytic viral therapy efficacy. To test this hypothesis, we evaluated the changes in gut microbiota in two mouse cohorts: (1) GSC-005 glioblastoma-bearing mice treated orally with indoximod, an immunotherapeutic agent, or with Delta-24-RGDOX by intratumoral injection and …

The Osteological Neutral Pose Of The Neck Of An Apatosaurine Sauropod Based On Virtual And Physical Models, Colin Don Boisvert

Theses and Dissertations

An array of sauropod taxa coexisted in Late Jurassic North America. How so many giant genera coexisted without competing for food is puzzling considering their potential metabolic requirements. One aspect of this question is neck posture, which has been much contested, both in terms of the intrinsic curvature of the neck and the resultant elevation of the head. Neck curvature is characterized by the Osteological Neutral Pose (ONP), wherein the intervertebral joints are in an undeflected state. This pose is crucial to understanding neck posture. The articulated series of presacral vertebrae 2-19 of an exceptionally well-preserved apatosaurine, BYU 18531, are …

Sensory Asic3 Channel Exacerbates Psoriatic Inflammation Via A Neurogenic Pathway In Female Mice, Chen Huang, Pei-Yi Sun, Yiming Jiang, Yuandong Liu, Zhichao Liu, Shao-Ling Han, Bao-Shan Wang, Yong-Xin Huang, An-Ran Ren, Jian-Fei Lu, Qin Jiang, Ying Li, Michael X Zhu, Zhirong Yao, Yang Tian, Xin Qi, Wei-Guang Li, Tian-Le Xu

Faculty, Staff and Student Publications

Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerbates psoriatic inflammation through a sensory neurogenic pathway. Global or nociceptor-specific Asic3 knockout (KO) in female mice alleviates imiquimod-induced psoriatic acanthosis and type 17 inflammation to the same extent as nociceptor ablation. However, ASIC3 is dispensable for IL-23-induced psoriatic inflammation that bypasses the need for nociceptors. Mechanistically, ASIC3 activation induces the activity-dependent release of calcitonin gene-related peptide (CGRP) from sensory neurons to promote neurogenic inflammation. Botulinum neurotoxin A and CGRP antagonists prevent sensory neuron-mediated …

The Sound Of Silence: Listening For God In Cormac Mccarthy's The Road, Brittany Higgins Maloy

Theses and Dissertations

In the decimated and silent post-apocalyptic setting of Cormac McCarthy's The Road, the main characters spend a significant amount of time listening to silence, listening for signs of danger, but also listening for the voice of God. Many have discussed the hopeless nihilism juxtaposed with the heavy use of Christian iconography in the novel classifying it within one of these dichotomies or somewhere on the spectrum in between. This paper argues that the hopelessness and stark silence is required to reveal hope and the opportunity to hear God's voice. To demonstrate my argument, I define the characteristics of silence, stillness, …

Cytokine-Supplemented Maturation Medium Enhances Cytoplasmic And Nuclear Maturation In Bovine Oocytes, Renata Blocher, Ying Liu, Tayler Patrick, Irina A. Polejaeva

Animal, Dairy, and Veterinary Science Faculty Publications

Bovine in vitro oocyte maturation (IVM) is an easy way to obtain oocytes for subsequent assisted reproductive techniques but is inefficient compared to in vivo maturation. Supplementation of three cytokines, fibroblast growth factor 2 (FGF2), leukemia inhibitory factor (LIF), and insulin-like growth factor 1 (IGF1), or FLI, has increased oocyte maturation and embryo development in multiple species, but studies have not explored the oocyte differences caused by FLI IVM supplementation. This study aimed to assess important nuclear and cytoplasmic maturation events in high-quality oocytes. FLI-supplemented oocytes had a decreased GV (3.0% vs. 13.7%, p < 0.01) and increased telophase I incidence (34.6% vs. 17.6%, p < 0.05) after IVM, increased normal meiotic spindles (68.8% vs. 50.0%, p < 0.001), and an increased nuclear maturation rate (75.1% vs. 66.8%, p < 0.001). Moreover, in metaphase II oocytes, the percentage of FLI-treated oocytes with a diffuse mitochondrial distribution was higher (87.7% vs. 77.5%, p < 0.05) and with a cortical mitochondrial distribution was lower (11.6% vs. 17.4%, p < 0.05). Additionally, FLI-supplemented oocytes had more pattern I cortical granules (21.3% vs. 14.4%, p < 0.05). These data suggest that FLI supplementation in bovine in vitro maturation medium coordinates nuclear and cytoplasmic maturation to produce higher-quality oocytes.

Fifty Years Of Lucy, The Marvellous Ancestor, Chandrabhan P. Yadav, Surbhi Vatsa

Popular Media

Excerpt:

"The Institute of Human Origins at Arizona State University is celebrating this year as a ‘Year of Human Origins’ because 2024 marks the 50th anniversary of the discovery of ‘Lucy’. The discussions on human origins and Lucy provokes one to seriously think about human life and where we come from.... The momentousness of the discovery of Lucy, a cardinal juncture that pegged firmly our existence in the scientific idea of evolution, cannot and must not be undermined."

Immune Responses To Mycobacterium Tuberculosis Infection In The Liver Of Diabetic Mice, Ali Badaoui, Kayvan Sasaninia, Aishvaryaa Shree Mohan, Abrianna Beever, Nala Kachour, Anmol Raien, Afsal Kolloli, Ranjeet Kumar, Santhamani Ramasamy, Selvakumar Subbian, Vishwanath Venketaraman

Student Publications

Individuals with uncontrolled diabetes are highly susceptible to tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) infection. Novel treatments for TB are needed to address the increased antibiotic resistance and hepatoxicity. Previous studies showed that the administration of liposomal glutathione (L-GSH) can mitigate oxidative stress, bolster a granulomatous response, and diminish the M. tb burden in the lungs of M. tb-infected mice. Nonetheless, the impact of combining L-GSH with conventional TB treatment (RIF) on the cytokine levels and granuloma formation in the livers of diabetic mice remains unexplored. In this study, we evaluated hepatic cytokine profiles, GSH, and tissue pathologies …

Navigating Undergraduate Medical Education: The Impact Of Enhanced Mentorship Pairing At A New Medical School, Shawn Izadi

School of Medicine Publications

Introduction

Transitioning into medical school is challenging, particularly in the first year, with a notable support gap. This study aimed to evaluate a mentorship program at a new medical school.

Methods

Initiated in 2017 at the University of Texas Rio Grande Valley School of Medicine, the mentorship program had two iterations: initial random pairings and subsequent formative pairings based on matching criteria. A mixed-methods approach assessed its effectiveness in supporting first-year students.

Results

Of 109 first-year students, 76% completed a 6-month survey. Both classes primarily had male mentees with varied interests in primary or specialty care. No significant demographic differences …

Engaging Chemistry Educators Through Virtual Roundtables: How The Covid-19 Pandemic Led To A Community-Wide Initiative, M. Taylor Haynes, Justin M. Pratt, Matthew A. Cranswick, Kyle A. Grice, Chip Nataro, Sarah E. Shaner, Kari Stone, Meghan Porter, Jeffrey R. Raker

Chemistry Department Faculty Articles

Members of the Interactive Online Network of Inorganic Chemists (IONiC) report the development and sustained efforts to provide virtual professional development sessions: Supporting Learning with Interactive Teaching: a Hosted, Engaging Roundtable (SLiThEr). SLiThEr’s emerged from a community need at the start of the COVID-19 pandemic; since then, SLiThEr’s have become a standard event for the IONiC community. SLiThEr’s are real- time virtual community events, after which a recording of the SLiThEr is posted on the IONiC YouTube channel. In this paper, an overview of the structure, format, and emergence of SLiThEr’s is reported, followed by evaluation of SLiThEr offerings, a …

Invertebrate Diversity From Deep Wells Of The Southern Boundary Of The Edwards Aquifer Of Southcentral Texas, Kathryn E. Perez, Valentin Cantu, Vanessa Saenz, J. Randy Gibson, Patricia Duncan, Benjamin T. Hutchins

School of Integrative Biological & Chemical Sciences Faculty Publications

This study examined the invertebrate fauna from three deep wells located at the Uvalde National Fish Hatchery in south-central Texas. These wells provide a water source from geological strata of the southern boundary of the Edwards Aquifer ranging in age from Lower Cretaceous to Recent. Forty-seven collections, sampled on a continuous basis from November 2020 to January 2022, produced a total of 738 specimens comprising 15 different species. These collections reveal a diverse crustacean assemblage along with dominant numbers of the stygobiotic snail Balconorbis uvaldensis. This study provides a preliminary survey for future investigations of unidentified crustacean species as …

Oregon State Ranking Assessment For Lewis's Woodpecker (Melanerpes Lewis), Misty Nelson

Institute for Natural Resources Publications

Oregon State Ranking Assessment for Lewis's woodpecker (Melanerpes lewis) by the Oregon Biodiversity Information Center, following NatureServe 2024 methodology.

Uncovering The Dynamic Nature Of Fire Refugia Across Landscapes In Oregon's Western Cascades, Alec Scott Dyer

Dissertations and Theses

With increased fire activity, the presence of fire refugia is critical to support forest resiliency and mitigate large-scale vegetation conversion, however, the persistence of fire refugia within burn perimeters over time is uncertain. This study examines the dynamic nature of fire refugia by mapping the decline in forest cover over time, identifying spatiotemporal patch- and landscape-scale patterns and the biophysical drivers of delayed mortality following the 2020 Labor Day Fires occurring in Oregon’s western Cascades. After three years post-fire, delayed mortality accounted for an additional 8.5% of forest loss (total of 24,147 hectares in all five burns) compared to pre-fire …

Integration Of Ζ-Deficient Cars Into The Cd3Ζ Gene Conveys Potent Cytotoxicity In T And Nk Cells, Jonas Kath, Clemens Franke, Vanessa Drosdek, Weijie Du, Viktor Glaser, Carla Fuster-Garcia, Maik Stein, Tatiana Zittel, Sarah Schulenberg, Caroline E Porter, Lena Andersch, Annette Künkele, Joshua Alcaniz, Jens Hoffmann, Hinrich Abken, Mohamed Abou-El-Enein, Axel Pruß, Masataka Suzuki, Toni Cathomen, Renata Stripecke, Hans-Dieter Volk, Petra Reinke, Michael Schmueck-Henneresse, Dimitrios L Wagner

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR)-redirected immune cells hold significant therapeutic potential for oncology, autoimmune diseases, transplant medicine, and infections. All approved CAR-T therapies rely on personalized manufacturing using undirected viral gene transfer, which results in nonphysiological regulation of CAR-signaling and limits their accessibility due to logistical challenges, high costs and biosafety requirements. Random gene transfer modalities pose a risk of malignant transformation by insertional mutagenesis. Here, we propose a novel approach utilizing CRISPR-Cas gene editing to redirect T cells and natural killer (NK) cells with CARs. By transferring shorter, truncated CAR-transgenes lacking a main activation domain into the human CD3ζ (CD247) …

Around The Center, 1998 April, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the Pediatrics Development Center.

Around The Center, 1998 July, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the new equipment at the Radiology MR Institute.

Around The Center, 1997 March/April, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on a new strategic plan.

Around The Center, 1997 November/December, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the affiliation with Norwegian-American Hospital.

Evaluation Of An Autonomous Acoustic Surveying Technique For Grassland Bird Communities In Nebraska, Grace E. Schuster, Leroy J. Walston, Andrew R. Little

School of Natural Resources: Faculty Publications

Monitoring trends in wildlife communities is integral to making informed land management decisions and applying conservation strategies. Birds inhabit most niches in every environment and because of this they are widely accepted as an indicator species for environmental health. Traditionally, point counts are the common method to survey bird populations, however, passive acoustic monitoring approaches using autonomous recording units have been shown to be cost-effective alternatives to point count surveys. Advancements in automatic acoustic classification technologies, such as BirdNET, can aid in these efforts by quickly processing large volumes of acoustic recordings to identify bird species. While the utility of …

Robots, Markets, And The Value Of Deal Lawyers, Heather Hughes

Scholarly Articles in Law Reviews & Journals

Emerging forms of automation using artificial intelligence (AI) and distributed ledgers are raising transformative questions for the practice of law. Deal lawyers are well-situated to understand the convergence of various modes of automation and their implications for their clients and the markets they facilitate. This Article contends that digesting threats and leveraging opportunities associated with new technologies calls for granular, context-specific assessment. It presents one instance of automation in one predominant market—the market for asset-backed securities (ABS)—by comparing securitization to a blockchain-based analog, tokenization. It considers how lawyers support the ABS market and how automation of lawyers’ functions could intersect …

Character: The Flame Of Writing, Madison Kate Stagner

Masters Theses

The Keeper: A Ring’s Promiser follows three parallel plots; two reside in the present, the other in the past. The knowledge revealed in one increases the precariousness of the other. While in the very beginning, these three perspectives were intended to volley within one book, the course has evolved. Due to this becoming a series, the plots will intertwine slower than intended. The introduction of the others will be woven later than intended. In this first novel, the reader will follow the dynamic journey of a young Amara Knightfall. The soon-to-be queen, Elaraina Wastereon, will be tied into the plot …

Implementing 1.5 Millimeter Internal Diameter Columns And A Portable Capillary Column Instrument Into Monoclonal Antibody Analytical Workflows, Benjamin Libert

Theses and Dissertations

Using 1.5 mm inner diameter (i.d.) columns to bridge the gap between routinely used 2.1 mm i.d. columns and capillary bore columns allows for a sequential but significant increase in performance without the need for specialized equipment associated with very low dispersion liquid chromatography (LC) systems. These 1.5 mm i.d. columns balance an increase in sensitivity compared to 2.1 mm i.d. columns (theoretically doubling the time-domain peak area in mass sensitive detectors for the same mass load), while mitigating the efficiency losses due to extra-column dispersion effects that are commonly observed with 1.0 mm i.d. columns. Here, the use of …

Christotechtonics: Dildonic Prostheticity In Theological Formulation, Evan Taylor Marsolek

Dissertations

This dissertation asserts the following claim: Christ is a dildo. This project brings Paul B. Preciado into conversations with contemporary philosophies of religion and interrogates a hegemonic Christian theological political matrix. This project articulates a hermeneutic of christotechtonics, which studies appearance, formation, and utilization of Christ. This project is twofold. It begins with a transdisciplinary exploration that entangles queer and trans theories, religious studies, secular studies, and philosophy of religion to position reading queer and trans theories as forms of counter political theologies. The work then transitions into dildonic prostheticity in theological formulation. The 2019 Vatican document “Male and Female …

Effects Of Differing Radiation Methods On Charge Transport In Polymers, Zachary Gibson, Jr Dennison, Virginie Griseri

Presentations

The mitigation of deleterious arcing and sparking onboard spacecraft depends upon a thorough understanding of the electrical properties of the materials involved. This includes not only understanding steady-state parameters such as dark conductivity, but responses to the space environment as well. For example, radiation-induced conductivity drastically changes the conductivity of a material due to the presence of radiation. However, this change in conductivity diminishes away once the radiation is no longer present. There may also be permanent changes, or aging, in the material properties. The physical processes of aging can be complicated and are often difficult to model. Therefore, empirical …

Changes In Colonial Perspectives On Native Americans And Native-Christian Hybridity, Thomas Kelly Hassani

Masters Theses

The American West of the late nineteenth century is too often exhibited by scholars who study it from the point of view of the westward expansion of European settlers on to Native land. However, the nuance of this short period should be examined with careful consideration. With westward expansion came the proselytization of Christianity to the Native populations who retained their own religious ideology. Historians and anthropologists have studied extensively the viewpoints of Christians and practitioners of Native faiths on topics of faith, prayer, and spirituality. However, similar examinations have yet to examine the more accepting and permissive attitudes that …

Warhol, Drake, And Deepfakes: Monetizing The Right Of Publicity In The Generative Ai Era, Reid M. Koski

Georgia State University Law Review

The ability to easily recreate another’s face or voice and digitally superimpose it on one’s own has led to a surge in face and voice swapping using deepfakes and deep voices. This technology uses artificial intelligence to create digital replicas with hyperreal accuracy. These digital replicas challenge the underlying premise of the transformative use test that courts use to determine whether a right of publicity infringement merits First Amendment protection. This Note finds a win-win scenario where a stricter test combined with a likeness licensing repository may both allow for public figures to monetize their likeness and provide digital replica …