Digital Commons Network^™

Quaking Aspen In A High-Use Recreation Area: Challenges Of People, Ungulates, And Sodium On Landscape Resilience, Georgie Corkery, Anna B. Miller, Paul C. Rogers

Environment and Society Student Research

Quaking aspen (Populus tremuloides Michx.) landscapes are valued for their biodiversity, water retention, fire mitigation, aesthetics, and recreation opportunities. Across North America, some aspen populations are experiencing population declined as they face uninhibited ungulate browsing, drought, fire suppression, insects, disease, and inappropriate management. Increased human development and recreational use within aspen landscapes can serve as additive stressors, though there is a dearth of literature examining these elements. At a popular recreational area in Utah, USA, identifying the cause of apparent decline within a larger aspen community is complicated by development upstream and recreation-related activities. We sought to (1) assess …

Genes Related To Frontonasal Malformations Are Regulated By Mir-338-5p, Mir-653-5p, And Mir-374-5p In O9-1 Cells, Chihiro Iwaya, Sunny Yu, Junichi Iwata

Faculty, Staff and Student Publications

Frontonasal malformations are caused by a failure in the growth of the frontonasal prominence during development. Although genetic studies have identified genes that are crucial for frontonasal development, it remains largely unknown how these genes are regulated during this process. Here, we show that microRNAs, which are short non-coding RNAs capable of targeting their target mRNAs for degradation or silencing their expression, play a crucial role in the regulation of genes related to frontonasal development in mice. Using the Mouse Genome Informatics (MGI) database, we curated a total of 25 mouse genes related to frontonasal malformations, including frontonasal hypoplasia, frontonasal …

Promethia 2023-2024

Promethia

No abstract provided.

Association Analysis Of The Oprm1 Polymorphism Gene And Personality Traits Among A Cohort Of Professional Athletes., Remigiusz Recław, Agnieszka Boroń, Krzysztof Chmielowiec, Jolanta Chmielowiec, Katarzyna Prabucka, Milena Lachowicz, Łukasz Zadroga, Przemysław Guła, Maciej Brożyna, Anna Grzywacz

Baltic Journal of Health and Physical Activity

In sports research, genetic studies linked to the traits of the temperament, in addition to medical examinations and other physiological and biochemical tests, would enrich the scope of possibilities and successes that a competitor can accomplish. This could be beneficial for the protection of both mental and physical health. The study group comprised 391 male volunteers. Out of these, 222 sports subjects and 186 were non-addicted. The temperament and character questionnaire (TCI-R) was used to determine personality traits such as novelty seeking, harm avoidance, reward addiction and perseverance, as well as self-direction, cooperation and self-transcendence. Genotyping OPRM1 rs1799971 was carried …

Dinamika Hidrokimia Air Tanah Pada Akuifer Pasiran Pulau Yeben Raja Ampat, Papua Barat, Septian Vienastra, Erik Febriarta

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Kualitas air tanah pesisir di pulau kecil memiliki karakteristik yang dipengaruhi oleh faktor lingkungan dan luasan. Pulau Yeben merupakan pulau kecil dengan luas 1,3 km2 dengan prioritas kawasan pariwisata pesisir dan bahari di kepulauan Raja Ampat. Penelitian ini bertujuan untuk (1) menganalisis kadar parameter kualitas air tanah dan (2) menganalisis sampel air terhadap baku mutu air. Sampel air tanah yang diambil sejumlah 4 sampel dari lokasi kajian. Lokasi sampel air berada pada morfologi dataran pantai. Analisis setiap parameter fisik dan kimia masing-masing sampel air tanah dilakukan dengan perbandingan nilai standar baku mutu air minum Hasil penelitian disajikan dalam tabel perbandingan …

Faktor-Faktor Kesiapsiagaan Bencana Terintegrasi Pengetahuan Prekursor Gempa Bumi Pada Mahasiswa Pendidikan Ipa, Muhyiatul Fadilah, Enok Maryani, Riandi Riandi, Anna Permanasari

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Kesiapsiagaan merupakan kompetensi utama yang harus dimiliki oleh masyarakat rawan bencana, termasuk pada mahasiswa. Kesiapsiagaan dibangun oleh pengetahuan. Penelitian terdahulu menunjukkan level kesiapsiagaan mahasiswa sangat bervariasi, namun belum terdapat penjelasan tentang hubungan pengetahuan dan faktor-faktor lain yang memengaruhi kesiapsiagaan mahasiswa. Selain itu, pengukuran kesiapsiagaan belum mengkaji komponen penanda bencana atau prekursor. Penelitian ini dilakukan untuk mendeskripsikan faktor-faktor yang berhubungan dengan level kesiapsiagaan mahasiswa. Populasi penelitian adalah mahasiwa pendidikan IPA dan penentuan sampel penelitian dilakukan secara purposive, sehingga sebanyak 104 mahasiwa pendidikan IPA yang mengambil matakuliah IPBA ditetapkan sebagai sampel. Penelitian merupakan penelitian deksriptif. Pengumpulan data dilakukan melalui angket kesiapsiagaan TPPG …

Still Searching For (Education For) Sustainable Development – Reflections On The Need, Challenges, And Chances Of Transforming Education In The 21st Century, Lars Keller

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

Scientific evidence has been put forward over and over again in the past decades that, during the Anthropocene, human impact on the various spheres of the Earth has grown to an extent that actually threatens the overall resilience of the Earth system and thus the basis for the existence of future societies. New concepts to tackle the problems ahead and to regain control about positive future development are urgently needed. Education – or rather the transformation of education – and the possible role of education as a key instrument to reach the Sustainable Development Goals could play a prominent role …

The Discursive Representations Of Africanness And Blackness In Chinese Cyberspace : A Critical Discourse-Historical Analysis, Jiapei Gu

Lingnan Theses (MPhil & PhD)

Recent years have seen deepened Sino-African ties. However, unlike friendly rhetoric at the state level, racial issues at the individual level are becoming increasingly salient. This study aims to enrich our current understanding of racial issues in China by examining the digital discursive representations of Africanness and Blackness produced by Chinese Weibo users. It investigates three African/Black people-related racial occurrences in China from 2020 to 2021. Those include the release of the draft of the Permanent Residence Law for Foreigners in 2020, the Okonkwonwoye case, where Okonkwonwoye physically assaulted a nurse during quarantine in 2020, and the Abdulmatten murder case …

Genetic Diversity Of 1,845 Rhesus Macaques Improves Genetic Variation Interpretation And Identifies Disease Models, Jun Wang, Meng Wang, Ala Moshiri, R Alan Harris, Muthuswamy Raveendran, Tracy Nguyen, Soohyun Kim, Laura Young, Keqing Wang, Roger Wiseman, David H O'Connor, Zach Johnson, Melween Martinez, Michael J Montague, Ken Sayers, Martha Lyke, Eric Vallender, Tim Stout, Yumei Li, Sara M Thomasy, Jeffrey Rogers, Rui Chen

Faculty, Staff and Students Publications

Understanding and treating human diseases require valid animal models. Leveraging the genetic diversity in rhesus macaque populations across eight primate centers in the United States, we conduct targeted-sequencing on 1845 individuals for 374 genes linked to inherited human retinal and neurodevelopmental diseases. We identify over 47,000 single nucleotide variants, a substantial proportion of which are shared with human populations. By combining rhesus and human allele frequencies with established variant prediction methods, we develop a machine learning-based score that outperforms established methods in predicting missense variant pathogenicity. Remarkably, we find a marked number of loss-of-function variants and putative deleterious variants, which …

On The Intellectual Horizons Of Social Realism: A Response To Barton, Jim Hordern

School of Law, Humanities and Social Sciences

This paper comments on the arguments made in ‘knowledge without disciplines: a critique of social realism’s disciplinary fixation’, authored by Keith Barton. It is suggested that Barton has not fully grasped how social realism views disciplines and curricula and that this reflects a wider tendency amongst commentators to overlook some of the thinking underpinning social realism. A different, more generous interpretation of social realism is outlined in respect of disciplinarity, the constitution of knowledge, the relationship between disciplines and subjects and the socio-epistemic formation that make knowledgeability possible. Social realism is seen as having already made a substantive impact, with …

Dnaforge: A Design Tool For Nucleic Acid Wireframe Nanostructures, Antti Elonen, Leon Wimbes, Abdulmelik Mohammed, Pekka Orponen

Faculty Research, Scholarly, and Creative Activity

DNAforge is an online tool that provides a unified, user-friendly interface to several recent design methods for DNA and RNA wireframe nanostructures, with the possibility of integrating additional methods into the same framework. Currently, DNAforge supports three design methods for DNA nanostructures and two for RNA nanostructures. The tool enables the design, visualisation and sequence generation for highly complex wireframe nanostructures with a simple fully automated process. DNAforge is freely accessible at https://dnaforge.org/.

Executive Summary Of The American Radium Society Appropriate Use Criteria For Brain Metastases In Epidermal Growth Factor Receptor Mutated-Mutated And Alk-Fusion Non-Small Cell Lung Cancer, Manmeet Ahluwalia

All Publications

The American Radium Society (ARS) Central Nervous System (CNS) committee reviewed literature on epidermal growth factor receptor mutated (EGFRm) and ALK-fusion (ALK+) tyrosine kinase inhibitors (TKIs) for the treatment of brain metastases (BrMs) from non-small cell lung cancers (NSCLC) to generate appropriate use guidelines addressing use of TKIs in conjunction with or in lieu of radiotherapy (RT). The panel developed three key questions to guide systematic review: can radiotherapy be deferred in patients receiving EGFR or ALK TKIs at (1) diagnosis or (2) recurrence? Should TKI be administered concurrently with RT (3)? Two literature searches were performed (May 2019 and …

Resettled Reproduction: A History And Analysis Of Family Planning Opportunities Among Refugees In Tennessee., Nicholas Lee Rummell

Electronic Theses and Dissertations Archive

Refugee women face a myriad of barriers to health after resettlement, including access to family planning services. They often have little knowledge of available family planning or contraception options, or where to obtain them after resettlement. As a result, refugee women in Tennessee suffer from high rates of unintended pregnancies, stemming from limited access to family planning services, and unmet family planning needs after resettlement. This dissertation combines the disciplines of history, public health, and public administration/policy to better understand why refugee women in Tennessee have had limited access to family planning services. To achieve this, it was necessary to …

“Ganando Tiempo” Para La Universidad Woxsen … Y Para Todos Nosotros, James A. F. Stoner

Journal of Management for Global Sustainability

N/A

Tiam1-Mediated Maladaptive Plasticity Underlying Morphine Tolerance And Hyperalgesia, Changqun Yao, Xing Fang, Qin Ru, Wei Li, Jun Li, Zeinab Mehsein, Kimberley F Tolias, Lingyong Li

Faculty, Staff and Students Publications

Opioid pain medications, such as morphine, remain the mainstay for treating severe and chronic pain. Prolonged morphine use, however, triggers analgesic tolerance and hyperalgesia (OIH), which can last for a long period after morphine withdrawal. How morphine induces these detrimental side effects remains unclear. Here, we show that morphine tolerance and OIH are mediated by Tiam1-coordinated synaptic structural and functional plasticity in the spinal nociceptive network. Tiam1 is a Rac1 GTPase guanine nucleotide exchange factor that promotes excitatory synaptogenesis by modulating actin cytoskeletal dynamics. We found that prolonged morphine treatment activated Tiam1 in the spinal dorsal horn and Tiam1 ablation …

Transcriptional Precision In Photoreceptor Development And Diseases - Lessons From The Retinal Transcription Factor Crx, Yiqiao Zheng

Arts & Sciences Graduate Student Theses and Dissertations

Precise gene expression programs are foundational to organism development and homeostasis. Transcription factors play a central role in establishing and maintaining these programs. Large-scale transcriptomic studies have generated parts lists of transcription factors. However, these descriptive works rarely formulate a cohesive model of how these transcription factors work together to support a functional organism. Mutations that affect transcription factor functions can lead to a broad range of human diseases. Therefore, it is crucial to understand the principles that transcription factors achieve spatial, temporal, and quantitative precision in their regulated gene expression programs. I have investigated transcriptional regulation in rod and …

Game Changer: Exploring The Role Of Board Games In The Lives Of Autistic People, Gray Atherton, Liam Cross, Francesca Belshaw, Andrea Piovesan

School of Psychology

This mixed methods paper reports findings from three studies examining the overlap between autism and hobbyist board gaming. The first was a quantitative survey of over 1600 board gamers, showing that autistic individuals are overrepresented in this hobby compared to the general population and that autistic traits measured by the AQ are significantly elevated amongst board gamers. Study 1 also assessed gamers’ motivations and preferences and reported key differences as well as similarities between autistic and non-autistic gamers. The second was a qualitative study that reported the results of 13 interviews with autistic individuals who are hobbyist board gamers. Using …

Cell-Specific Single Viral Vector Crispr/Cas9 Editing And Genetically Encoded Tool Delivery In The Central And Peripheral Nervous Systems, Jamie C Moffa, India N Bland, Jessica R Tooley, Vani Kalyanaraman, Monique Heitmeier, Meaghan C Creed, Bryan A Copits

2020-Current year OA Pubs

CRISPR/Cas9 gene editing represents an exciting avenue to study genes of unknown function and can be combined with genetically encoded tools such as fluorescent proteins, channelrhodopsins, DREADDs, and various biosensors to more deeply probe the function of these genes in different cell types. However, current strategies to also manipulate or visualize edited cells are challenging due to the large size of Cas9 proteins and the limited packaging capacity of adeno-associated viruses (AAVs). To overcome these constraints, we developed an alternative gene editing strategy using a single AAV vector and mouse lines that express Cre-dependent Cas9 to achieve efficient cell-type specific …

Regional And Ethnic Inequality In Burkina Faso, Michael J. Kevane

Economics

This chapter summarizes data on regional and ethnic inequality in Burkina Faso. The Sahel and Est regions appear to be the worst-off, according to a variety of indicators. There is less data and research on ethnic inequality, but it is likely that the Peul and Gourma ethnic groups (residing predominantly in the Sahel and Est regions) are also worse off. There has been little systematic analysis of how government investment in public goods have affected regional and ethnic inequality. Some of the important drivers of inequality in Burkina Faso are likely similar to those identified for other African countries. These …

Conformational Alterations Of The Cell Surface Of Monomeric And Dimeric Β2m-Free Hla-I (Proto-Hla) May Enable Novel Immune Functions In Health And Disease, Mepur Ravindranath, Narendranath Ravindranath, Carly Amato-Menker, Fatiha El Hilali, Edward Filippone

Division of Nephrology Faculty Papers

Human leukocyte antigens (HLAs) are polymorphic glycoproteins expressed on the cell surface of nucleated cells and consist of two classes, HLA class I and HLA class II. In contrast, in mice, these molecules, known as H-2, are expressed on both nucleated cells and erythrocytes. HLA-I molecules (Face-1) are heterodimers consisting of a polypeptide heavy chain (HC) and a light chain, B2-microglobulin (B2m). The heterodimers bind to antigenic peptides and present them to the T-cell receptors of CD8+ cytotoxic T lymphocytes. The HCs can also independently emerge on the cell surface as B2m-free HC monomers without peptides (Face-2). Early investigators suggested …

Introduction To Strategies And Outcomes, Lisa A. Leitz, Socrates Mbamalu

Peace Studies Faculty Books and Book Chapters

"In this, Volume 48 of Research in Social Movements, Conflicts and Change, chapters contribute to scholarship on the strategies and outcomes of social movements, with only one (Corrigall-Brown, this volume) exploring the relationship between the two and others examining each aspect of social movement scholarship independently."

Impact Of Isotype On The Mechanism Of Action Of Agonist Anti-Ox40 Antibodies In Cancer: Implications For Therapeutic Combinations, Jane E Willoughby, Lang Dou, Sabyasachi Bhattacharya, Heather Jackson, Laura Seestaller-Wehr, David Kilian, Laura Bover, Kui S Voo, Kerry L Cox, Tom Murray, Mel John, Hong Shi, Paul Bojczuk, Junping Jing, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Tatyana Inzhelevskaya, Chris A Penfold, C Ian Mockridge, Vikki English, Sara J Brett, Roopa Srinivasan, Christopher Hopson, James Smothers, Axel Hoos, Elaine Paul, Stephen L Martin, Peter J Morley, Niranjan Yanamandra, Mark S Cragg

Faculty, Staff and Student Publications

BACKGROUND: OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-mouse (m) OX40 and anti-human (h) OX40 antibodies, including a clinically relevant monoclonal antibody (mAb) (GSK3174998) and evaluated how isotype can alter those mechanisms with the aim to develop improved antibodies for use in rational combination treatments for cancer.

METHODS: Anti-mOX40 and anti-hOX40 mAbs were evaluated in a number of in vivo models, including an OT-I adoptive transfer immunization model in hOX40 knock-in …

Context-Dependent T-Box Transcription Factor Family: From Biology To Targeted Therapy, Siwen Li, Xiangyuan Luo, Mengyu Sun, Yijun Wang, Zerui Zhang, Junqing Jiang, Dian Hu, Jiaqian Zhang, Zhangfan Wu, Yufei Wang, Wenjie Huang, Limin Xia

Faculty, Staff and Student Publications

T-BOX factors belong to an evolutionarily conserved family of transcription factors. T-BOX factors not only play key roles in growth and development but are also involved in immunity, cancer initiation, and progression. Moreover, the same T-BOX molecule exhibits different or even opposite effects in various developmental processes and tumor microenvironments. Understanding the multiple roles of context-dependent T-BOX factors in malignancies is vital for uncovering the potential of T-BOX-targeted cancer therapy. We summarize the physiological roles of T-BOX factors in different developmental processes and their pathological roles observed when their expression is dysregulated. We also discuss their regulatory roles in tumor …

Antitumor Effects Of Resveratrol Opposing Mechanisms Of Helicobacter Pylori In Gastric Cancer, Daniela Trautmann, Francesca Suazo, Keila Torres, Layla Simón

Faculty, Staff and Student Publications

Gastric cancer is an aggressive and multifactorial disease. Helicobacter pylori (H. pylori) is identified as a significant etiological factor in gastric cancer. Although only a fraction of patients infected with H. pylori progresses to gastric cancer, bacterial infection is critical in the pathology and development of this malignancy. The pathogenic mechanisms of this bacterium involve the disruption of the gastric epithelial barrier and the induction of chronic inflammation, oxidative stress, angiogenesis and metastasis. Adherence molecules, virulence (CagA and VacA) and colonization (urease) factors are important in its pathogenicity. On the other hand, resveratrol is a natural polyphenol with …

Protein Sumoylation Promotes Camp-Independent Epac1 Activation, Wenli Yang, Fang C Mei, Wei Lin, Mark A White, Li Li, Yue Li, Sheng Pan, Xiaodong Cheng

Faculty, Staff and Student Publications

Protein SUMOylation is a prevalent stress-response posttranslational modification crucial for maintaining cellular homeostasis. Herein, we report that protein SUMOylation modulates cellular signaling mediated by cAMP, an ancient and universal stress-response second messenger. We identify K561 as a primary SUMOylation site in exchange protein directly activated by cAMP (EPAC1) via site-specific mapping of SUMOylation using mass spectrometry. Sequence and site-directed mutagenesis analyses reveal that a functional SUMO-interacting motif in EPAC1 is required for the binding of SUMO-conjugating enzyme UBC9, formation of EPAC1 nuclear condensate, and EPAC1 cellular SUMOylation. Heat shock-induced SUMO modification of EPAC1 promotes Rap1/2 activation in a cAMP-independent manner. …

Optimizing Associative Memory In Autistic And Non-Autistic Adults: Retrieval Practice, Post-Retrieval Feedback, And Gesture, Brianna E. Cairney

LSU Doctoral Dissertations

Associative memory—or the ability to form a memory representation linking two previously unrelated concepts—is a critical aspect of learning. This work provides insight into strategies that can be used to support associative memory, their underlying mechanisms, and their effectiveness in autistic and non-autistic learners. Chapter 1 demonstrates that iconic gestures can be used as a tool to enhance associative memory by increasing word concreteness and imageability. This effect was eliminated when the iconic gestures were interspersed with ambiguous nonsense gestures, suggesting a boundary on these benefits that depends on listener expectations regarding gesture clarity. However, it remains unknown whether gestures …

Genetically Engineering Glycolysis In T Cells Increases Their Antitumor Function, Raphaëlle Toledano Zur, Orna Atar, Tilda Barliya, Shiran Hoogi, Ifat Abramovich, Eyal Gottlieb, Noga Ron-Harel, Cyrille J Cohen

Faculty, Staff and Student Publications

BACKGROUND: T cells play a central role in the antitumor response. However, they often face numerous hurdles in the tumor microenvironment, including the scarcity of available essential metabolites such as glucose and amino acids. Moreover, cancer cells can monopolize these resources to thrive and proliferate by upregulating metabolite transporters and maintaining a high metabolic rate, thereby outcompeting T cells.

METHODS: Herein, we sought to improve T-cell antitumor function in the tumor vicinity by enhancing their glycolytic capacity to better compete with tumor cells. To achieve this, we engineered human T cells to express a key glycolysis enzyme, phosphofructokinase, in conjunction …

Baseline Data Collections Of Lipopolysaccharide Content In 414 Herbal Extracts And Its Role In Innate Immune Activation, Vindy Tjendana Tjhin, Masataka Oda, Masashi Yamashita, Tomoko Iwaki, Yasuko Fujita, Koji Wakame, Hiroyuki Inagawa, Gen-Ichiro Soma

Faculty, Staff and Student Publications

Some herbal extracts contain relatively high amounts of lipopolysaccharide (LPS). Because orally administered LPS activates innate immunity without inducing inflammation, it plays a role as an active ingredient in herbal extracts. However, the LPS content in herbal extracts remains extensively unevaluated. This study aimed to create a database of LPS content in herbal extracts; therefore, the LPS content of 414 herbal extracts was measured and the macrophage activation potential was evaluated. The LPS content of these hot water extracts was determined using the kinetic-turbidimetric method. The LPS concentration ranged from a few ng/g to hundreds of μg/g (Standard Escherichia coli …

Influence Of Knot Strength On The Mechanical Performance Of A Biodegradable Gillnet, Louis Le Gué, Esther Savina, Mael Arhant, Peter Davies, Nicolas Dumergue, Benoit Vincent

Faculty, Staff and Student Publications

Ghost fishing is a global issue that can be addressed using fishing gear materials that do not persist in the marine environment. However, for these alternatives to be widely adopted, they must meet the same mechanical specifications as current commercial materials while degrading without any negative impact. The objective of this study was to compare a conventional gillnet made of polyamide 6 (PA6) with an alternative made of poly(butylene succinate-co-adipate-co-terephthalate) (PBSAT) at three different scales: monofilament, knot, and net. While the PBSAT monofilament's strength was half that of the conventional PA6 net, knot and net losses were even more significant. …

Examining The Regulation Of Traf4 In Extraembryonic Stem Cells And Tissues, Hannah Alexis Nelson-Lannom

Electronic Theses and Dissertations Archive

Mitogen-activated protein kinase kinase kinase 4 (MAP3K4) promotes fetal and placental growth by regulating growth-promoting pathways. Mice lacking MAP3K4 kinase activity exhibit placental insufficiency and fetal growth restriction. Upstream pathways activating MAP3K4 may represent key mechanisms to induce growth. We have previously shown that the MAP3K4 binding partner tumor necrosis factor receptor-associated factor 4 (TRAF4) promotes MAP3K4 activity in the embryo. However, the role of TRAF4 and its association with MAP3K4 in the placenta is unknown. Our analysis of single-cell RNA-Seq data showed that Traf4 is one of the most abundant Trafs in the mouse placenta and is coexpressed with …