Digital Commons Network^™

Targeting Astrogliosis In The Retrotrapezoid Nucleus: A Novel Approach To Ameliorate Respiratory Dysfunction And Alzheimer's Pathology In Mice, Zahid Iqbal, Ahmad El Hamamy, Ngoc Mai Le, Arya Ranjan, Yuxing Zhang, Li Qi, Bharti Manwani, Chunfeng Tan, Louise D Mccullough, Jun Li

Faculty, Staff and Student Publications

Alzheimer's disease (AD), a leading cause of dementia, is associated with significant respiratory dysfunctions. Our study explores the role of astrogliosis in the brainstem retrotrapezoid nucleus (RTN), a key breathing regulatory center, and its impact on breathing control and AD pathology in mice. Using Tg-2576 AD and wild-type mice, we investigated the effect of silencing the transforming growth factor-beta receptor II (TGFβR II) in the RTN. We performed behavioral tests, including the Barnes maze and novel object recognition test, along with whole-body plethysmography to assess breathing disorders. Our results showed that AD mice exhibited increased apneas and cognitive impairment, which …

In Silico Analysis Of The Rop29 Protein As A Vaccine Candidate Against Toxoplasma Gondii, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar, Abdolhossein Dalimi, Masoud Foroutan, John Horton, Javid Sadraei

Faculty, Staff and Student Publications

The progression of Toxoplasma gondii (T. gondii) invasion is aided by rhoptry proteins (ROPs), which are also crucial for the parasite's survival in host cells. In this study, in silico analysis was performed to examine the various aspects of the ROP29 protein, such as physicochemical properties, potential T- and B-cell epitopes, and other significant features. The research revealed that there were 55 possible sites for posttranslational modification in the ROP29 protein. The secondary structure of the ROP29 protein consists of a random coil, an alpha-helix, and an extended strand, which account for 49.69%, 36.81%, and 13.50%, respectively. Moreover, …

Macrophage Depletion Protects Against Cisplatin-Induced Ototoxicity And Nephrotoxicity, Cathy Yea Won Sung, Naoki Hayase, Peter S T Yuen, John Lee, Katharine Fernandez, Xuzhen Hu, Hui Cheng, Robert A Star, Mark E Warchol, Lisa L Cunningham

2020-Current year OA Pubs

Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney, are important drivers of both inflammatory and tissue repair responses. To investigate the roles of macrophages in cisplatin-induced toxicities, we used PLX3397, a U.S. Food and Drug Administration-approved inhibitor of the colony-stimulating factor 1 receptor, to eliminate tissue-resident macrophages. Mice treated with cisplatin alone had considerable hearing loss (ototoxicity) and kidney injury (nephrotoxicity). Macrophage ablation resulted in significantly reduced hearing loss and had greater outer hair cell survival. Macrophage ablation also protected against cisplatin-induced …

Trends Of Methicillin-Resistant Staphylococcus Aureus Infections Among Thai Pediatric Patients, Pintip Suchartlikitwong, Nopphon Wuthinantiwong, Watsamon Jantarabenjakul, Noppadol Wacharachaisurapol, Jiratchaya Sophonphan, Tanittha Chatsuwan, Thanyawee Puthanakit

Chulalongkorn Medical Journal

Background While reductions in methicillin-resistant Staphylococcus aureus (MRSA) infections have been reported, vancomycin prescription rates have remained high.

Objectives We aimed to update trends in pediatric prevalence and antibiotic susceptibilities of MRSA infections.

Methods We conducted a retrospective study in patients aged S. aureus infections during 2016-2022 at a Thai tertiary-care hospital. MRSA was defined when resistant to cefoxitin or oxacillin MIC of >4 µg/mL. Patients with MRSA infections and their first isolates were classified into HA-MRSA or CA-MRSA based on surveillance definitions. Antibiotic susceptibilities were tested using the VITEK 2XL automated system and disk diffusion. The annual prevalence of …

Patriots Or Rebels: Ethical Debate Behind The American Revolution, Nicolette Falvo

History Department Theses

This paper, "Patriots or Rebels: Ethical Debate Behind the American Revolution," critically examines the justification and historical significance of the American Revolution. It argues that the motivations behind the revolutionary war and the colonists' outrage against British policies were complex and multifaceted, prompting scrutiny of the legitimacy of their actions. Central to this analysis is the colonists' deliberate choice to establish a democratic republic, diverging from the English monarchy, and an evaluation of the contemporary state of American governance. Drawing on Gordon S. Wood's "The Radicalism of the American Revolution," which highlights its transformative impact on American society and political …

What The Cluck? Backyard Chickens And Maine's Mysterious Right To Food, Lucy Weaver

Maine Law Review

When Maine voters approved the nation’s first “right to food” constitutional amendment, many were concerned about the amendment’s potential to conflict with animal welfare, food safety, and other regulations currently in place at the state and local level. Born from a decade of advocacy, the amendment represents a new era for Maine’s food sovereignty movement. However, the boundaries of the amendment remain unclear, and Maine’s municipalities lack sufficient guidance as they attempt to navigate how this amendment applies to them. This Comment explores one example of the many challenges that may arise from the enactment of the right to food …

You Can Grow Your Own Way: Maine's Constitutional "Right To Food" Amendment, Kristin Hebert

Maine Law Review

Maine is the first state to constitutionalize a right to food. This is significant not only because no other states have enshrined such a right, but because this is Maine’s first foray into constitutionalizing any new individual rights. This raises a host of questions for courts to grapple with: What level of scrutiny should apply? What kinds of protections does this right afford? What are its limitations? This Comment offers a framework for courts to use when interpreting the right to food that is grounded in the legislative and voter intent. Given the amendment’s broad language, this comment argues that …

“Food Of Their Own Choosing”: Improving Access To Locally Grown, Sustainable, And Real Food, Alexia M. Kulwiec, Tom Starck

Maine Law Review

The State of Maine is leading the nation in efforts not only to promote production of locally and sustainably grown food, but the right of consumers to grow, produce, and consume the food of their choosing. This includes creation of a constitutional right to food, a right recognized in the global community but not throughout the United States. Many advocates in the United States emphasize the right to food as a human right, advocating for the same attention and protection as other human rights such as the right to life, liberty, freedom from slavery, and freedom from discrimination. The right …

Green Amendments And Ham: How Green Amendment Jurisprudence Can Inform Maine’S Right To Food, Sarah M. Everhart

Maine Law Review

Maine’s constitutional right to food is the first state constitutional right to food and the extent of the rights created by the amendment is largely unknown. The right to food, as enacted in Article I, Section 25 of the Maine Constitution, provides: Section 25. Right to food. All individuals have a natural, inherent and unalienable right to food, including the right to save and exchange seeds and the right to grow, raise, harvest, produce and consume the food of their own choosing for their own nourishment, sustenance, bodily health and well-being, as long as an individual does not commit trespassing, …

Realizing The Right To Food In Maine: Insights From International Law, Smita Narula

Maine Law Review

In November 2021, Maine made history as the first U.S. state to constitutionally recognize the right to food. Maine’s right to food amendment—which sought to address widespread food insecurity and corporate control of the food supply—proclaims food as a “natural, inherent and unalienable right,” and empowers Mainers to grow and consume food of their own choosing, affirming their right to food sovereignty. This Article makes three key contributions to scholarly examinations of this historic amendment. First, it situates the amendment within the broader landscape of domestic and global struggles for the right to food and food sovereignty. Second, the Article …

Initial Proof Of Concept For The Development And Commercialization Of Ellagic Acid Based Hemostats, Lisa Kemp

Defensive Publications Series

The hemostatic properties of ellagic acid and its derivatives have been known for decades, but there has been little commercialization of hemostatic agents, dressings or gauzes containing the material. We used the material and its derivatives in the preparation of various different hemostatic agents, dressings and gauzes, including combining with other known hemostatic materials, and tested these in-vitro. The use of ellagic acid or its derivatives produced superior hemostasis compared to similar devices produced without the material. These devices are worthy of further investigation and potential commercialization.

Vol.52 N.01 July 25th 2024, Voice Media Ventures

Black Voice News

No abstract provided.

Law, Language, And Authority: The Algorithmic Turn, Amanda Turnbull

PhD Dissertations

Law is formed by language and law utilizes language. Law is also like language in that it consists of social rules that aid in the structuring of society. From the time that we first put language into writing, we have been invested in the technologizing of language. There is a clear trajectory of our interest in having machines do things with language that we would otherwise do ourselves. This dissertation investigates how law’s relationship with language changes with the use of algorithmically driven technologies, and correspondingly, the consequences for the changing nature of authority since the use of language in …

Norms And Variance Fail To Predict Butterfly Effects On Social Dynamics By Idiosyncratic Individuals, Stephen F. Stringham, Lynn Rogers, Ann Bryant

Animal Sentience

Adaptations and adjustments to current environmental conditions are manifest in behavioral norms. Knowing norms facilitates population-level prediction, but doesn’t predict individual behavior where idiosyncrasies might trigger “butterfly effects." Knowledge of individual quirks is particularly important for risk assessment and management during close encounters between humans and potentially lethal wildlife, including bears (Ursus spp.). Innovative foraging techniques can alter population vigor and viability. Traits at the tails of a bell curve might hold the greatest potential for adapting to environmental change.

The Memory-Keeping Daughter: Exploring Object Stories And Family Legacies From America's Modern Wars, Susan R. Grayzel

History Faculty Publications

This essay demonstrates how wartime objects can have a special resonance in families as keepers of memory, and it especially explores the role of daughters of military participants in preserving the artifacts of their veteran fathers. Using several case studies from a recent public history project collecting objects and object stories in the American southwest, it argues that a focus on daughters as caretakers of family military history offers a new way to engage with descendants' histories by showing how the work of such women can contribute to our understanding of modern war and its legacies.

Leading With Joy: Lessons From The Literature, Jennifer A. Keach, Jenne M. Klotz, Galen J. Talis

Libraries

This article provides an introduction for library leaders at all levels to support equitable conditions for joy in the workplace, as well as for anyone who wants to develop their personal practice of joy through lessons discovered in popular, academic, and professional writing and multimedia. Joy has a place in contemporary libraries’ conversations about burnout, vocational awe, and care. The article begins with a guide to the annotated bibliography which explores five themes: defining joy, finding individual joy, work and organizational joy, empowering change with joy, and joy-adjacent emotions. The thematic guide may be read alone or used as an …

Issue 448: July 25-August 8, 2024, The Local Voice

The Local Voice

No abstract provided.

Effects Of Premortem Stress On Protein Expression, Steak Color, Oxidation, And Myofibrillar Fragmentation Index In The Longissimus Lumborum, Reganne K. Briggs, Jerrad F. Legako, Paul R. Broadway, Jeff A. Carroll, Nicole C. Burdick Sanchez, Nikole E. Ineck, Zachary K. Smith, Ranjith Ramanathan, Kara J. Thornton

Animal, Dairy, and Veterinary Science Faculty Publications

No abstract provided.

Wheat Response To Foliar-Applied Phosphorus Is Determined By Soil Phosphorus Buffering, Raj Malik, Craig Scanlan, Andrew Van Burgel, Balwinder Singh

Grain and Other Field Crops Research Articles

In no-till cropping systems, banding of phosphorus (P) fertiliser at seeding results in low use efficiency due to chemical reactions in soil. Foliar P has the potential to allow grain producers to respond tactically with P application after sowing when P supply from soil and fertiliser is not meeting crop demand. The objective of this study was to evaluate the effectiveness of foliar P on wheat grain yield, grain quality, biomass yield, P uptake and P use efficiency indices. Nine field experiments were conducted to investigate the response of wheat to foliar P. Three rates of P, 0, 2.5 and …

Effects Of Flipped Explicit Reading Instruction On College Efl Trainees’ Reading Comprehension Proficiency, Getu Dagne Yalew, Abiy Yigzaw Filate

Journal of Educational Technology Development and Exchange (JETDE)

The flipped classroom, a contemporary model, and explicit reading instruction, a widely recognized conventional approach, both offer unique benefits and have their own place in education. This study aimed to investigate the effects of Flipped Explicit Reading Comprehension Instruction (FERCI) on college EFL trainees’ Reading Comprehension Proficiency (RCP) and its impact on course achievement test scores. Conducted at Injibara College of Teachers Education in Ethiopia, the study involved 53 participants from October 7 to February 6, 2023, utilizing a quasi-experimental pre-test-post-test non-equivalent group design. The participants were assigned into experimental (N=28) and control (N=25) groups. The experimental group received the …

Analysis Of Global Tourism And Creative Economy Trends To Support Jakarta As A Global City, Banu Muhammad Haidlir, Budiman Mahmud Musthofa, Basuki Muhammad Mukhlish

Journal of Indonesian Tourism and Policy Studies

The city of Jakarta is currently faced with new challenges to become a global city because the status of the country's capital has been revoked. The transformation of Jakarta into a global city requires in-depth study by exploring global trends and looking for the city's potential so that Jakarta can become a globally competitive city. One of the areas that is the focus of this study is tourism and the creative economy. The aim of this study is to analyze global and national trends in tourism and the creative economy. Through library research and document study methods, the author discovered …

Bayesian Beta-Binomial Mixed Models For Longitudinal, Clustered, And Spatiotemporal Data, Chun-Che Wen

MUSC Theses and Dissertations

Overdispersed binomial data arise in many clinical and public health research studies. Examples include timeline followback data (TLFB), which are used in addiction research to monitor recent substance use. This dissertation proposes novel beta-binomial (BB) mixed models to address the challenges associated with overdispersed binomial data, including zero-inflation, heterogenous effects, and spatiotemporal correlation. Motivated by a 12-week randomized controlled trial evaluating the efficacy of varenicline tartrate for smoking cessation among adolescents, Aim 1 develops a Bayesian zero-inflated beta-binomial (ZIBB) model to analyze longitudinal and bounded TLFB data — namely, the number of abstinent days in the past week. Because treatment …

Good Order And Decolonizing: Blessings And Challenges, Kayko Driedger Hesslein

Consensus

No abstract provided.

T&T Clark Introduction To Spirit Christology, Héctor A. Acero Ferrer

Consensus

No abstract provided.

Csf1r Inhibition Depletes Brain Macrophages And Reduces Brain Virus Burden In Siv-Infected Macaques, Diana G. Bohannon, Laurent D. Zablocki-Thomas, Evan S. Leung, Jinbum K. Dupont, Julian B. Hattler, Jolanta Kowalewska, Miaoyun Zhao, Jiangtao Luo, Marco Salemi, Angela M. Amedee, Qingsheng Li, Marcelo J. Kuroda, Woong-Ki Kim

School of Graduate Studies Faculty Publications

Perivascular macrophages (PVMs) and, to a lesser degree, microglia are targets and reservoirs of HIV and simian immunodeficiency virus (SIV) in the brain. Previously, we demonstrated that colony-stimulating factor 1 receptor (CSF1R) in PVMs was upregulated and activated in chronically SIV-infected rhesus macaques with encephalitis, correlating with SIV infection of PVMs. Herein, we investigated the role of CSF1R in the brain during acute SIV infection using BLZ945, a brain-penetrant CSF1R kinase inhibitor. Apart from three uninfected historic controls, nine Indian rhesus macaques were infected acutely with SIVmac251 and divided into three groups (n = 3 each): an untreated control and …

Ultrasonic Cigarettes: Chemicals And Cytotoxicity Are Similar To Heated-Coil Pod-Style Electronic Cigarettes., Esther E. Omaiye, Wentai Luo, Kevin J. Mcwhirter, Prue Talbot

Civil and Environmental Engineering Faculty Publications and Presentations

Our purpose was to test the hypothesis that ultrasonic cigarettes (u-cigarettes), which operate at relatively low temperatures, produce aerosols that are less harmful than heated-coil pod-style electronic cigarettes (e-cigarettes). The major chemicals in SURGE u-cigarette fluids and aerosols were quantified, their cytotoxicity and cellular effects were assessed, and a Margin of Exposure risk assessment was performed on chemicals in SURGE fluids. Four SURGE u-cigarette flavor variants ("Blueberry Ice," "Watermelon Ice," "Green Mint," and "Polar Mint") were evaluated. Flavor chemicals were quantified in fluids and aerosols using gas chromatography/mass spectrometry. Cytotoxicity and cell dynamics were assessed using the MTT assay, live-cell …

Optimizing Lumpfish Rearing, Nicholas Gosling

UNH Today Archive

No abstract provided.

In Vivo Evaluation Of Fatty Acid Loaded Chitosan Membranes For Pain Relief And Biofilm Associated Infection Prevention, Yogita Manasa Dintakurthi

Electronic Theses and Dissertations Archive

Infections are the leading cause of burn related deaths worldwide. These infections not only complicate micro-environment of a burn wound, but further obscure the wound due to the formation of biofilms at the wound site. Local drug delivery (LDD) has been a highly researched solution due to its advantages in locally treating and preventing infection while avoiding systemic side effects. LDD systems also have advantages for complex wounds, like burns. Chitosan is a natural polymer that is often used in these systems due to its biodegradability, biocompatibility and versatility. Previous research has suggested that short chain unsaturated fatty acids, for …

Decoding Anotylus (Thomson 1859) Beetle Diversity: Dna And External Morphology Match In Área De Conservacion Guanacaste, Costa Rica, K. Dante Underwood, Robert Puschendorf, David T. Bilton, Daniel H. Janzen, Winnie Hallwachs, M. Alex Smith

School of Biological and Marine Sciences

Taxonomy underpins biological research because names are needed for comparative analysis, conservation status, and public communication. Despite this, many species remain undescribed and are therefore vulnerable and unprotected, particularly in the tropics. Neotropical Staphylinidae beetles (Coleoptera) are among the insect groups most likely to contain significant unknown and/or cryptic diversity. Here we used an integrative taxonomic framework to conduct a preliminary review of one particularly diverse genus of Staphylinidae (Anotylus) in Área de Conservaciόn Guanacaste, northwestern Costa Rica. We began by DNA barcoding novel collections and using Barcode Index Numbers (BINs) as an estimate of taxonomic diversity; we found 18 …

Synthesis Of Portions Of An Acinetobacter Baumannii Lipooligosaccharide (Los), Brandon Conrad

LSU Doctoral Dissertations

Glycoconjugate vaccines have become an effective strategy for protection against an array of globally persistent diseases resulting from pathogenic bacteria such as Haemophilus influenzae type b (Hib), Neisseria meningitidis, and Salmonella enterica serotype Typhi. Comprised of a carbohydrate (referred to as glycan) covalently inked to a carrier protein, these vaccines can initiate adaptive immunity by inducing B and T cell responses once in the lymphatic system. This is particularly relevant for infants two years of age and younger whose immune systems are not fully developed. A continuously emerging threat in clinical settings, Acinetobacter baumannii is a Gram-negative bacterium …