Digital Commons Network^™

The Dissemination And Implementation Of N95 Fit Testing Capacities For Nebraska Long-Term Care Facilities: A Mixed-Methods Analysis Using The Re-Aim Framework, Anthony Blake

Theses & Dissertations

Background: Ensuring the proper fit of N95 respirators used by healthcare workers in long-term care facilities (LTCF) is essential for their safety. The Nebraska Department of Health and Human Services launched a LTCF strike team project (STP) in the summer of 2022, focused on increasing the number of staff trained in infection control and building internal capacity for LTCFs to fit test their employees. This study describes the N95 fit-testing initiative for Nebraska LTCFs.

Methods: Staff from all 19 local health departments (LHD) received “train-the-trainer” training to prepare LTCF staff to perform qualitative fit testing. LTCF administrators were requested to …

Creativity, Vitality, Energy: A Profile Of Stephen Bird, Benjamin Scott Savard

UNH Today Archive

No abstract provided.

Power In Picturebooks: A Teacher's Critical Multicultural Analysis Of Illustrated Versions Of Little Red Riding Hood, Adrianna Catherine Galtieri

Theses and Dissertations

This study is a critical examination of the ways power is depicted in six illustrated versions of the "Little Red Riding Hood" story. Anchored in the notions that children's texts are neither ideologically neutral nor inherently benign, a kindergarten teacher analyzed "Little Red Riding Hood" tales for the ways the main character acts and/or is acted upon. Traditional versions of the story are often read as didactic tales that remind young readers to obey their parents in order to stay safe. However, the findings of this study suggest that reimagined versions of the classic tale can open important conversations about …

Developing Literacy Through Play, Molli Vanderjagt

Masters Projects

The loss of play in the classroom has had a significant impact on children’s foundational literacy skills. It has hindered children’s language development by reducing their verbal skills and language comprehension and decreasing vocabulary. Child development has not changed, and yet we continue to put more academic pressure on our youngest students. This project addresses the need for play in early education classrooms. It then provides research why play is important in developing foundational literacy skills, such as oral language and vocabulary, comprehension and recall and higher-level thinking, and possible classroom applications. The project concludes with a presentation for administrators, …

When The Tide Comes: A Critical Examination Of The Novel-Screenplay Hybrid With Example Chapters, Morgan F. Taylor Moore

Masters Theses

This thesis presents my research on the psychological realism genre, the stream of consciousness narrative technique, the usage of second person and the present tense, the biblical reasoning behind depicting the ordinary as extraordinary, the role of the demonic in domestic violence, the incorporation of screenplay styles, the scientific reasoning and personal findings of my project’s formatting, the examination of primary sources (novels) that have inspired my project, and finally, the research on ADHD, PTSD, and C-PTSD as the results of domestic abuse. Sample chapters of my project are included.

Body Length Determines Flow Refuging For Rainbow Trout (Oncorhynchus Mykiss) Behind Wing Dams, Terry R. Dial, Laura A. Collins, James C. Liao, Bret W. Tobalske

Environment and Society Faculty Publications

Complex hydrodynamics abound in natural streams, yet the selective pressures these impose upon different size classes of fish are not well understood. Attached vortices are produced by relatively large objects that block freestream flow, which fish routinely utilize for flow refuging. To test how flow refuging and the potential harvesting of energy (as seen in Kármán gaiting) varies across size classes in rainbow trout (Oncorhynchus mykiss; fingerling, 8 cm; parr, 14 cm; adult, 21 cm; n = 4 per size class), we used a water flume (4,100 L; freestream flow at 65 cm s^-1) and created …

An Examination Of “The Vine” Motif Through The Lens Of The Old Testament, The Books Of John And Revelation, And Peripheral Extrabiblical Sources, Ellsworth C. Huling Iv

Doctoral Dissertations and Projects

Motifs and themes are interchangeable, used in everyday speech, and common in scholarly literature. Some scholars view motifs and themes as the two most used forms of narrative repetition. “The vine” motif contains multiple meanings throughout the Old and New Testaments. Sometimes, “the vine” readers misunderstand motif-specific referents. Research on “the vine” motif can clarify those specific passages of Scripture that utilize this motif. The interpretation of Scripture is not easy to understand without a proper understanding of the vine motif. Throughout Scripture, especially in the Old Testament, Israel is “the vine.” In the Gospel of John, Jesus is “the …

A Qualitative Study Exploring Preservice Educators' Mindsets Regarding Training In Identifying Pre-Violence Indicator Patterns, Aaron Glenn Walp

Doctoral Dissertations and Projects

The purpose of this qualitative hermeneutical phenomenological study was to understand the mindsets of preservice educators regarding mandatory training in pre-violence indicator patterns at XYZ University. Pre-violence indicator patterns are defined as behaviors symptomatic of violent or aggressive behavior. The theory guiding this study was Dweck’s implicit theory of intelligence. The central research question was: What is the mindset of preservice educators regarding mandatory training in pre-violence indicator patterns? Qualitative hermeneutical phenomenological methods were used to study the beliefs of 12 preservice educators through a questionnaire, individual interviews, and a group discussion. The data were examined through line-by-line coding and …

Proximity Analysis Of Native Proteomes Reveals Phenotypic Modifiers In A Mouse Model Of Autism And Related Neurodevelopmental Conditions, Yudong Gao, Daichi Shonai, Matthew Trn, Jieqing Zhao, Erik J Soderblom, S Alexandra Garcia-Moreno, Charles A Gersbach, William C Wetsel, Geraldine Dawson, Dmitry Velmeshev, Yong-Hui Jiang, Laura G Sloofman, Joseph D Buxbaum, Scott H Soderling

Faculty, Staff and Students Publications

One of the main drivers of autism spectrum disorder is risk alleles within hundreds of genes, which may interact within shared but unknown protein complexes. Here we develop a scalable genome-editing-mediated approach to target 14 high-confidence autism risk genes within the mouse brain for proximity-based endogenous proteomics, achieving the identification of high-specificity spatial proteomes. The resulting native proximity proteomes are enriched for human genes dysregulated in the brain of autistic individuals, and reveal proximity interactions between proteins from high-confidence risk genes with those of lower-confidence that may provide new avenues to prioritize genetic risk. Importantly, the datasets are enriched for …

Epigenetic Reprogramming Driving Successful And Failed Repair In Acute Kidney Injury, Yoshiharu Muto, Eryn E Dixon, Yasuhiro Yoshimura, Nicolas Ledru, Yuhei Kirita, Haojia Wu, Benjamin D Humphreys

2020-Current year OA Pubs

Acute kidney injury (AKI) causes epithelial damage followed by subsequent repair. While successful repair restores kidney function, this process is often incomplete and can lead to chronic kidney disease (CKD) in a process called failed repair. To better understand the epigenetic reprogramming driving this AKI-to-CKD transition, we generated a single-nucleus multiomic atlas for the full mouse AKI time course, consisting of ~280,000 single-nucleus transcriptomes and epigenomes. We reveal cell-specific dynamic alterations in gene regulatory landscapes reflecting, especially, activation of proinflammatory pathways. We further generated single-nucleus multiomic data from four human AKI samples including validation by genome-wide identification of nuclear factor …

Tribal Water Rights: Private Law Alternatives To The Federal Trust Doctrine, Frances Williamson

San Diego Law Review

This Article discusses the federal promise of water, the judicial origins of the federal trust responsibility, and the impact of the Arizona v. Navajo Nation decision on tribal water rights. Most importantly, this Article proposes legal mechanisms for tribes and tribal advocates to use to depict and advance tribal water rights. Ideas from property law and contract law provide opportunities for exploration and hope to tribes seeking certainty in a time of water shortage.

Courts provide a forum for the vindication of the federal trust responsibility and the promise of water. Cases like Arizona v. Navajo Nation will continue to …

Mitochondrial Permeability Transition Dictates Mitochondrial Maturation Upon Switch In Cellular Identity Of Hematopoietic Precursors, Sandeep P Dumbali, Paulina D Horton, Travis I Moore, Pamela L Wenzel

Faculty, Staff and Student Publications

The mitochondrial permeability transition pore (mPTP) is a supramolecular channel that regulates exchange of solutes across cristae membranes, with executive roles in mitochondrial function and cell death. The contribution of the mPTP to normal physiology remains debated, although evidence implicates the mPTP in mitochondrial inner membrane remodeling in differentiating progenitor cells. Here, we demonstrate that strict control over mPTP conductance shapes metabolic machinery as cells transit toward hematopoietic identity. Cells undergoing the endothelial-to-hematopoietic transition (EHT) tightly control chief regulatory elements of the mPTP. During EHT, maturing arterial endothelium restricts mPTP activity just prior to hematopoietic commitment. After transition in cellular …

Biblical Choice Model: A St. Augustine-Inspired Approach To Behavioral Economics, Adebukola Adebayo

Doctoral Dissertations and Projects

Economics as defined by Lionel Robbins (1932), is a science which studies human behavior as a relationship between ends and scarce means which have alternative uses. While human behavior relates to how wants and desires are coordinated given decision-making mechanisms, social customs and political realities of society, the natural end of individual human actions should be eudaimonia (human flourishing). However, since sin has affected both our emotive and cultural plausibility structures, thereby leading to a distortion in our wants and desires and ability to desire the good, this has led to a generation that is self-ruling, self-creating and self-evaluating. The …

A Third Generation Long-Acting Dimeric Dolutegravir Prodrug Nanoformulation, Bhoomika Suresh Gowda

Theses & Dissertations

Dolutegravir (DTG) is an integrase strand transfer inhibitor (INSTI) widely used as a part of first-line combination antiretroviral therapy. DTG has a high barrier to resistance However, one therapeutic challenge centers on its life-long daily use. Sub-optimal adherence to daily oral pills underscore the need for long-acting formulations. To these ends, our research activities have focused on the development and translation of ultra-long-acting ART. Monomeric ester prodrugs provided initial success in extending the apparent half-life of DTG and other INSTIs. One is the DTG prodrug formulation called NM2DTG. NM2DTG’s significantly extended the parent drug’s apparent half-life [Nature Communications, 3226 (2022)]. …

Chemotherapy-Induced Modulation Of Tumor Antigen Presentation, Alaina C. Larson

Theses & Dissertations

Pancreatic cancer is a lethal malignancy, with a five-year overall survival rate of just 13%. Current treatment approaches thus require modification and attention has shifted towards improving immunotherapy efficacy. Select chemotherapy drugs possess inherent immunomodulatory activity and could be used to initiate immunotherapeutic success, thereby restoring anti-tumor immunity in pancreatic cancer. In this work, I evaluated the impact of the chemotherapy drug gemcitabine on tumor antigen presentation by human leukocyte antigen class I (HLA-I). Gemcitabine regulated HLA-I expression on multiple levels, increasing pancreatic cancer cells’ HLA-I mRNA transcripts, total protein and surface expression, as well as surface stability. Temperature-dependent assay …

Association Between Agrichemical Mixtures And Pediatric Health Outcomes: Evidence From A Nebraska Population-Based Surveillance, Jabeen Taiba

Theses & Dissertations

Human exposure to environmental contaminants is associated with various pediatric health outcomes. Agrichemicals are a significant environmental risk factor for childhood cancers and congenital anomalies, and reduced exposure could improve pediatric health outcomes. Previous studies in Nebraska have explored the association between single pollutants and pediatric cancers and birth defects. However, it is important to estimate the overall effect of the agrichemical mixture on these pediatric health outcomes. In addition to environmental risk factors, several social vulnerability factors also contribute to increased agrichemical exposure and show disparities in pediatric cancers and birth defects. The objectives of this dissertation are to …

Long-Term Neurodevelopmental Outcomes Post-Chronic Midazolam Exposure During Early Life, Nghi M. Nguyen

Theses & Dissertations

In recent decades, the rising number of neonates born in the Neonatal Intensive Care Unit (NICU) due to prematurity has raised concerns about their overall well-being and development. Premature neonates are at higher risk of health complications and often require invasive procedures. These invasive procedures often induce stress and agitation, prompting physicians and healthcare providers to provide sedation or general anesthesia to manage discomfort. Epidemiological studies of human patients have revealed a correlation between childhood exposure to general anesthetic and sedative agents and subsequent cognitive deficits. This association is also supported in animal models, which shows that exposure to anesthetics …

Understanding The Role Of Mastl In Colon Homeostasis And Colitis-Associated Cancer Development, Kristina Pravoverov

Theses & Dissertations

Colitis-associated cancer (CAC) is the most devastating complication of longstanding inflammatory bowel disease (IBD). Understanding the mechanisms underlying the switch from damage-repair to dysplasia in IBD is critical for identifying novel therapies to facilitate mucosal healing while mitigating CAC risk. Microtubule-associated serine-threonine kinase-like (MASTL), though crucial in cell growth and repair, is upregulated in sporadic colorectal cancer and CAC. This study sought to delineate the role of MASTL in colitis and CAC development.

First, we examined whether MASTL is associated with colitis and recovery. Review of publicly available data found significant elevation of MASTL and interleukin (IL)-22 in biopsies from …

Pharmacokinetics And Tissue Distribution Of A Lipid-Based Extended-Release Nano-Formulation Of Mo-Oh-Nap Tropolone To Enhance Pulmonary Delivery For The Treatment Of Pulmonary Metastatic Osteosarcoma, Wafaa N. Aldhafiri

Theses & Dissertations

Osteosarcoma is the most common primary bone tumor in children and adolescents. Metastasis is prevalent in 25% of patients, at diagnosis, with the lungs being the most common metastatic site. Pulmonary metastatic osteosarcoma is a significant therapeutic challenge with a 5-year survival rate of ≤30%. Patients with pulmonary metastatic disease at diagnosis receive the same standard of care as patients with local disease, which hasn’t changed over the past 30 years. The treatment and prevention of pulmonary metastatic osteosarcoma represents a significant critical and unmet need.

MO-OH-Nap tropolone is a novel small molecule with cytotoxic activity across multiple human osteosarcoma …

Delivery Of Small Molecule Using Polymeric Nanoparticles For The Treatment Of Alcoholic Liver Disease And Its Pharmacokinetics And Biodistribution In Mice, Jingyi Ma

Theses & Dissertations

Alcoholic liver disease is a challenging chronic disease worldwide. Alcohol abuse and subsequent inflammation, oxidative stress, and disordered lipid metabolism result in liver damage. This dissertation aims to develop a reliable therapeutic strategy for alcoholic liver disease treatment. We have employed polymeric nanoparticles as the delivery system to the liver and utilized PDE4B inhibitor as a novel approach for alcoholic liver disease treatment.

Chapter 1 is an overview of alcoholic liver disease, including the background, pathology, risk factors, and current treatment. In addition, the application of PDE4 inhibitors in alcoholic liver disease was discussed, suggesting a promising avenue for future …

Elucidating The First Protective Mutation From Inherited Alzheimer’S Disease - Apolipoprotein E3 Christchurch (Apoe3ch) And Insights Into Apoe Ligand-Receptor Interactions, Yun Chen

Arts & Sciences Graduate Student Theses and Dissertations

Alzheimer’s disease (AD) is the major cause of dementia. An inherited form of AD (dominant inherited AD) starts much earlier in life, often in the fourth and fifth decade. A recent case report described an individual who was resistant to dominantly inherited AD caused by a PSEN1-E280A mutation and was a homozygous carrier of the APOE3 Christchurch (APOE3ch) variant. A clear separation between amyloid and tau pathology occurred in this unique AD case. However, whether APOE3ch contributed to the protective effect remains unclear. In this thesis, we generated a humanized APOE3ch knock-in mouse and crossed it to an amyloid-β (Aβ) …

2024-08-09 Agenda Book, Morehead State University. Board Of Regents.

Morehead State Board of Regents Agenda Books and Meeting Minutes

Agenda booklet for the Board of Regents meeting of August 9, 2024, which includes the Board meeting minutes for June 14, 2024.

Kat2a And Kat2b Prevent Double-Stranded Rna Accumulation And Interferon Signaling To Maintain Intestinal Stem Cell Renewal, Mai-Uyen Nguyen, Angela Halstead, José B Sáenz, Et Al.

2020-Current year OA Pubs

Histone acetyltransferases

Questioning Reality: The Progressive Development Of Modern Physics, Joshua Lancman

STEM Month

Humanity has a tendency to divide time. The past is distinct from the present which is entirely separate from the future. In supposedly 20-20 vision history is neatly divided into different sections, distinct eras with sharp lines between them. What is present and in the future is always modern. What is past is something else with another name.

Yet time is not divided so neatly. We know this living through it: years and decades blend into one another in a non-uniform progression. To divide human history into separate eras is a necessary simplification, as it helps to ascribe order onto …

Keeping The Peace: From Bosnia To The Sahel, Jack Fitzgerald

Capstone Collection

This research has looked to analysis both the evolution and nature of geopolitical conflicts over the past 30 years, and the parallel advancement of long-term humanitarian operations during that period. Long-term United Nations peacekeeping operations have evolved since the end of the Cold-War to be much more political and military in nature. The term humanitarian diplomat is a direct by-product of that evolution. In the first generation of UN peacekeepers, humanitarian actors on the ground were not called on to be political negotiators. However, in the post-Cold War era the role of peacekeeping has shifted to one of peacebuilding within …

Estimation And Control Of Dynamic Mass-Moment Parameters For Spacecraft Attitude Simulator, Oleksii Padun, Ye Lu

Small Satellite Conference

Spacecraft attitude testbed has been a popular platform for the development, testing, and validation of real-time attitude determination, estimation, and control, algorithms. The focus of this paper is the development of a dynamic mass moment estimation algorithm and an automatic mass balancing control system with numerical validations. Two estimation layers are implemented: one for attitude estimation and another for mass-moment parameter estimation. Attitude estimation follows the existing literature of quaternion estimators with a nonlinear Kalman filter. Dynamic mass-moment parameter estimation is formulated as batch estimation with a nonlinear filter. The initialization process of the EKF parameter estimator is enhanced by …

High Mobility Group Box 1 (Hmgb1) Is A Potential Disease Biomarker In Cell And Mouse Models Of Duchenne Muscular Dystrophy, Rebecca A. Slick, Jessica Sutton, Margaret Haberman, Benjamin S. O'Briens, Jennifer A. Tinklenberg, Aashay Mardikar, Mariah J. Prom, Margaret Beatka, Melanie Gartz, Mark A. Vanden Avond, Emily Siebers, David L. Mack, J. Patrick Gonzalez, Allison D. Ebert, Kanneboyina Nagaraju, Michael W. Lawlor

Pharmacy Faculty Scholarship

Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder affecting 1:3500 male births and is associated with myofiber degeneration, regeneration, and inflammation. Glucocorticoid treatments have been the standard of care due to immunomodulatory/immunosuppressive properties but novel genetic approaches, including exon skipping and gene replacement therapy, are currently being developed. The identification of additional biomarkers to assess DMDrelated inflammatory responses and the potential efficacy of these therapeutic approaches are thus of critical importance. The current study uses RNA sequencing of skeletal muscle from two mdx mouse models to identify high mobility group box 1 (HMGB1) as a candidate biomarker potentially …

Revolutionizing Wild Silk Fibers: Ultrasound Enhances Structure, Properties, And Regenerability Of Protein Biomaterials In Ionic Liquids., Xincheng Zhuang, Haomiao Zhu, Fang Wang, Xiao Hu

College of Science & Mathematics Departmental Research

Ultrasound-assisted regulation of biomaterial properties has attracted increasing attention due to the unique reaction conditions induced by ultrasound cavitation. In this study, we explored the fabrication of wild tussah silk nanofiber membranes via ultrasound spray spinning from an ionic liquid system, characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray powder diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), atomic force microscopy (AFM), water contact angle, cytocompatibility tests, and enzymatic degradation studies. We investigated the effects of ultrasound propagation in an ionic liquid on the morphology, structure, thermal and mechanical properties, surface hydrophilicity, biocompatibility, and biodegradability …

Occupational Therapy’S Role In The Success And Positive Outcomes Of Youth Within The Foster System, Cassidy Solomon

Student Capstone Papers

This capstone paper will discuss the development of an occupational therapy program to support the needs of youth within the foster system and prepare this population to live independently. Background information including statistics, the need for occupational therapy, and the program specifics such as rationale, significance, and objective are discussed. The development of an occupational therapy program to aid in the success of children within the foster care system helps close a gap in research that will contribute to this population's success and positive outcomes. The purpose of this capstone was to develop a program for children in the foster …

Issue 449: August 8-22, 2024, The Local Voice

The Local Voice

No abstract provided.