Digital Commons Network^™

Shared And Distinct Cortical Morphometric Alterations In Five Neuropsychiatric Symptoms Of Parkinson’S Disease, Qianling Lu, Zhuang Zhu, Heng Zhang, Caiting Gan, Aidi Shan, Mengxi Gao, Huimin Sun, Xingyue Cao, Yongsheng Yuan, Joseph I Tracy, Qirui Zhang, Kezhong Zhang

Farber Institute for Neuroscience Faculty Papers

Neuropsychiatric symptoms (including anxiety, depression, apathy, impulse–compulsive behaviors and hallucinations) are among the most common non-motor features of Parkinson’s disease. Whether these symptoms should be considered as a direct consequence of the pathophysiologic mechanisms of Parkinson’s disease is controversial. Morphometric similarity network analysis and epicenter mapping approach were performed on T1-weighted images of 505 patients with Parkinson’s disease and 167 age- and sex-matched healthy participants from Parkinson’s Progression Markers Initiative database to reveal the commonalities and specificities of distinct neuropsychiatric symptoms. Abnormal cortical co-alteration pattern in patients with neuropsychiatric symptoms was in somatomotor, vision and frontoparietal regions, with epicenters in …

Ultrasonic Doppler As A Guide For Feline Peripheral Arterial Catheterization, Satoshi Haginoya, Elizabeth J. Thomovsky, Hsin-Yi Weng, Paula A. Johnson, Aimee C. Brooks

Purdue University Libraries Open Access Publishing Fund

Objectives

The study aimed to determine if an ultrasonic Doppler-guided technique (UDGT) leads to improved placement efficacy (time, success) of feline dorsal pedal arterial catheters vs the traditional palpation-guided technique (TPT).

Methods

A total of 26 adult, client-owned cats requiring sedation or general anesthesia for any reason, aged >12 months and weighing >3.0 kg, and with Doppler blood pressure measurements of at least 80 mmHg were enrolled. Each hindlimb was randomly assigned for dorsal pedal arterial catheterization using either the UDGT or TPT. With the UDGT, the location of the artery was identified by an audible sound using the Doppler. …

Virtual Reality Situation Judgment Test, Noah Gregory

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

Thermomechanical Analysis Of Biomass Plastic Composite (Bpc), Solomon Chijioke Madu, Victor Sunday Aigbodion, Ikechukwu Ike-Eze

Makara Journal of Technology

High-performance electrical insulation material can be manufactured using biomass plastic composite (BPC), which is a new type of composite material that is either made up of one or a combination of natural plant fibers/particulates, such as bamboo, cellulose fiber, rice husks, or hemp, and thermoplastic granules. In this study, the BPC composite material that was developed comprised polyethylene (PE), rice husk, and oyster shell. The results of the study showed a significant optimal improvement in the morphological, thermodynamic, and mechanical properties during the addition of 20% to 30% biomass particulates (i.e., rice husk and oyster shell). The thermogravimetric analysis, storage …

Analysis Of Bone Destruction Mechanism By Aggregatibacter Actinomycetemcomitans: A Systematic Review, Erik Idrus, Karenina Raihani Amalia Ardiman, Widya Lestari, Masita Mandasari, Sri Angky Soekanto

Journal of Dentistry Indonesia

Periodontitis is a disease marked by inflammation of the periodontium, caused by biofilms present in the oral cavity, and results in alveolar bone destruction. One of the main hallmarks of periodontitis is the presence of Aggregatibacter actinomycetecomitans, which is generally suppressed by antibiotic administration. The strategy to control A. actinomycetecomitans by small specific peptide inhibitors potentially halts the progression of alveolar bone damage while lowering the risk of antibiotic resistance. The detailed interaction mechanisms of A. actinomycetecomitans and bone cells are fundamental to discovering and constructing the specific inhibitor. Objective : To systematically review the mechanism of bone destruction by …

In Silico Modelling And Docking Simulation Of Egfr-Targeted Diphtheria Toxin Chimera With Various Targeting Moieties, Muhammad Afif Naufal Bmed, Benedictus Ansell Susanto Bmed, Talitha Dinda Gunawan Bmed, Azhar Ridha Lukman Bmed, Alifa Rahma Rizqina Bmed, Muhammad Misbahul Fuad Bmed

Indonesian Journal of Medical Chemistry and Bioinformatics

Introduction: Cancer is a major etiology of death worldwide due to high mortality and suboptimal medicine. However, an emerging field, targeted therapy enabled a more selective and effective therapeutic action. This article aims to analyze in-silico the hypothetical targeted therapy agent that is combinations of conjugate consisting of EGFR targeting moieties and diphtheria toxin (DT-390).

Method: Our novel peptide is a conjugate of a novel EGFR targeting peptide and DT-390, forming a chimera. The tertiary structure was predicted using AlphaFold 2.0. The best IDDT scoring and stereochemistry profiles were utilized. The HADDOCK2.4 webserver modelled the docking between our …

Meningkatkan Keterampilan Sosial-Emosional Siswa Sekolah Dasar Melalui Media Animasi Religi, Aisyahna Rizqita Nur Jannah, Surayanah Surayanah

Journal of Innovation and Teacher Professionalism

The use of religious animation media in education has become an intriguing topic, particularly in the context of enhancing the social-emotional skills of elementary school students. This article investi-gates the role and impact of using religious animation media in improving the social-emotional skills of elementary school-aged children. Through a meticulous literature review, this article elucidates the importance of social-emotional skills in the development of elementary school children, the role of animation media in child education, and the correlation between religion and social-emotional skills. The research method employed is a literature review, which involves searching, selecting, and analyzing relevant sources. The …

Thermokarst Landscape Exhibits Large Nitrous Oxide Emissions In Alaska’S Coastal Polygonal Tundra, Josh Hashemi, David A. Lipson, Kyle A. Arndt, Scott J. Davidson, Aram Kalhori, Kyle Lunneberg, Lona Van Delden, Walter C. Oechel, Donatella Zona

School of Geography, Earth and Environmental Sciences

Global atmospheric concentrations of nitrous oxide have been increasing over previous decades with emerging research suggesting the Arctic as a notable contributor. Thermokarst processes, increasing temperature, and changes in drainage can cause degradation of polygonal tundra landscape features resulting in elevated, well-drained, unvegetated soil surfaces that exhibit large nitrous oxide emissions. Here, we outline the magnitude and some of the dominant factors controlling variability in emissions for these thermokarst landscape features in the North Slope of Alaska. We measured strong nitrous oxide emissions during the growing season from unvegetated high centered polygons (median (mean) = 104.7 (187.7) µg N_{2 …}

Heat Hardening Improves Thermal Tolerance In Abalone, Without The Trade-Offs Associated With Chronic Heat Exposure, Manuela Truebano, Michael Collins, John Spicer, Robert Ellis, Ahmed Salama Ali Abbas

School of Biological and Marine Sciences

Marine animals are challenged by chronically raised temperatures alongside an increased frequency of discrete, severe warming events. Exposure to repeated heat shocks could result in heat hardening, where sub-lethal exposure to thermal stress temporarily enhances thermotolerance, and may be an important mechanism by which marine species will cope with future thermal challenges. However, we have relatively little understanding of the effects of heat hardening in comparison to chronic exposure to elevated temperatures. Therefore, we compared the effects of heat hardening from repeated exposure to acute heat shocks and chronic exposure to elevated temperatures on thermal tolerance in the European abalone, …

Stie: Single-Cell Level Deconvolution, Convolution, And Clustering In In Situ Capturing-Based Spatial Transcriptomics, Shijia Zhu, Naoto Kubota, Shidan Wang, Tao Wang, Guanghua Xiao, Yujin Hoshida

Faculty, Staff and Student Publications

In in situ capturing-based spatial transcriptomics, spots of the same size and printed at fixed locations cannot precisely capture the randomly-located single cells, therefore inherently failing to profile transcriptome at the single-cell level. To this end, we present STIE, an Expectation Maximization algorithm that aligns the spatial transcriptome to its matched histology image-based nuclear morphology and recovers missing cells from ~70% gap area, thereby achieving the real single-cell level and whole-slide scale deconvolution, convolution, and clustering for both low- and high-resolution spots. STIE characterizes cell-type-specific gene expression and demonstrates outperforming concordance with true cell-type-specific transcriptomic signatures than the other spot- …

Inhibition Of Ulk1/2 And Kras G12c Controls Tumor Growth In Preclinical Models Of Lung Cancer, Phaedra C Ghazi, Kayla T O'Toole, Sanjana Srinivas Boggaram, Michael T Scherzer, Mark R Silvis, Yun Zhang, Madhumita Bogdan, Bryan D Smith, Guillermina Lozano, Daniel L Flynn, Eric L Snyder, Conan G Kinsey, Martin Mcmahon

Faculty, Staff and Student Publications

Mutational activation of KRAS occurs commonly in lung carcinogenesis and, with the recent U.S. Food and Drug Administration approval of covalent inhibitors of KRASG12C such as sotorasib or adagrasib, KRAS oncoproteins are important pharmacological targets in non-small cell lung cancer (NSCLC). However, not all KRASG12C-driven NSCLCs respond to these inhibitors, and the emergence of drug resistance in those patients who do respond can be rapid and pleiotropic. Hence, based on a backbone of covalent inhibition of KRASG12C, efforts are underway to develop effective combination therapies. Here, we report that the inhibition of KRASG12C signaling increases autophagy in KRASG12C-expressing lung cancer …

Penggunaan Aplikasi Canva Pada Guru Sekolah Dasar Sebagai Upaya Menciptakan Media Pembelajaran Yang Kreatif, Alfin Dwicahyani, Arif Kiyat Bhaktiyana, Didi Suhendra, Krisantus Pius Usifa, Neni Wahyuningtyas

Journal of Innovation and Teacher Professionalism

Students will more easily remember and understand the lessons delivered by the teacher when they use interesting learning media such as broadcasts or displays produced from learning media. Canva is a graphic design tool that facilitates the creation of various artistic content online. Canva training materials as an innovation in creating creative learning media were chosen by researchers as a step to realizing quality education that is in line with this technological era. So, the aim of this training is as an effort to create creative and innovative learning media with the help of the Canva application for teachers at …

Global Perspective Of The Risks Of Falsified And Counterfeit Medicines: A Critical Review Of The Literature, Aonghus J. Feeney, Jeffery A. Goad, Gerard T. Flaherty

Pharmacy Faculty Articles and Research

Background

Methods

Longitudinal Imaging Of Injured Spinal Cord Myelin And White Matter With 3d Ultrashort Echo Time Magnetization Transfer (Ute-Mt) And Diffusion Mri, Qingbo Tang, Yajun Ma, Qun Cheng, Yuanshan Wu, Junyuan Chen, Jiang Du, Pengzhe Lu, Eric Y Chang

Faculty, Staff and Students Publications

Quantitative MRI techniques could be helpful to noninvasively and longitudinally monitor dynamic changes in spinal cord white matter following injury, but imaging and postprocessing techniques in small animals remain lacking. Unilateral C5 hemisection lesions were created in a rat model, and ultrashort echo time magnetization transfer (UTE-MT) and diffusion-weighted sequences were used for imaging following injury. Magnetization transfer ratio (MTR) measurements and preferential diffusion along the longitudinal axis of the spinal cord were calculated as fractional anisotropy or an apparent diffusion coefficient ratio over transverse directions. The area of myelinated white matter was obtained by thresholding the spinal cord using …

Persistent Mri Findings Unique To Blast And Repetitive Mild Tbi: Analysis Of The Cenc/Limbic Cohort Injury Characteristics, David F Tate, Benjamin S C Wade, Carmen S Velez, Erin D Bigler, Nicholas D Davenport, Emily L Dennis, Carrie Esopenko, Sidney R Hinds, Jacob Kean, Eamonn Kennedy, Kimbra Kenney, Andrew R Mayer, Mary R Newsome, Carissa L Philippi, Mary J Pugh, Randall S Scheibel, Brian A Taylor, Maya Troyanskaya, John K Werner, Gerald E York, William Walker, Elisabeth A Wilde

Faculty, Staff and Students Publications

Introduction: MRI represents one of the clinical tools at the forefront of research efforts aimed at identifying diagnostic and prognostic biomarkers following traumatic brain injury (TBI). Both volumetric and diffusion MRI findings in mild TBI (mTBI) are mixed, making the findings difficult to interpret. As such, additional research is needed to continue to elucidate the relationship between the clinical features of mTBI and quantitative MRI measurements.

Material and methods: Volumetric and diffusion imaging data in a sample of 976 veterans and service members from the Chronic Effects of Neurotrauma Consortium and now the Long-Term Impact of Military-Relevant Brain Injury Consortium …

The (Im)Possibility Of Anti-Systemic Politics: Uprisings, Exilic Spaces, And Alain Badiou, Jason C. Mueller

Emancipations: A Journal of Critical Social Analysis

The world-system is in crisis, and a flurry of uprisings challenge the mantra that 'there is no alternative' to capitalism. However, some questions remain. What will replace the global capitalist mode of production, and how will those aspiring to transform the system do so? These questions are of relevance to three separate but related domains of research: (1) the study of anti-systemic movements by world-systems analysts; (2) the study of exilic spaces by scholars using an anarchist perspective; and (3) the work of French Philosopher Alain Badiou. This article stages a discussion between these three areas, locating areas in each …

Vol. 23, No. 7 - Whole No. 74, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 23, No. 6 - Whole No. 73, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 23, No. 2 - Whole No. 69, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Joint Regional Conference, Prairie View A&M University

Sustainable Forestry and African American Land Joint Regional Conference

Prairie View A&M University (PVAMU) and the University of Arkansas at Pine Bluff (UAPB) are hosting the third annual Sustainable Forestry and African American Land Retention (SFLR) Joint Regional Conference from August 29 to August 30. Themed “Sustaining Forests and Saving Our Land,” the virtual conference will gather forestry and land management experts to offer critical insight into retaining land within family generations and growing generational wealth. The SFLR Program assists African American forest landowners with entry into forest management and addressing barriers to land retention.

Several notable conference speakers include PVAMU’s newly appointed President, Tomikia P. LeGrande, Ed.D., Dean …

Vol. 21, No. 11 - Whole No. 54, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 21, No. 8 - Whole No. 51, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 21, No. 7 - Whole No. 50, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 21, No. 6 - Whole No. 49, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 21, No. 4 - Whole No. 47, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Vol. 21, No. 2 - Whole No. 45, David Bratman

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Medical School Watercooler Newsletter - August 29, 2024, Lindsay Hughes

Watercooler Newsletter

This is the August 29, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• Medical students publish research study on match outcomes of neurosurgery residents
• Now accepting nominations for 2025 Medical Alumni Association Awards
• Alexeyev receives $1 million NSF grant to develop ‘designer' mitochondria
• Hall joins USA Health as emergency medicine physician
• New hospitalist volunteers her time and training here and abroad 

Creatures And Clans: The Symbolic Significance Of Animal Imagery In Jacob's Blessings And Beyond, Gregory S. Szarycz

Between the Species

This article delves into the symbolic significance of animals in the blessings of Jacob, particularly focusing on Genesis 49:1-28. It explores the nuanced portrayal of various animals and their characteristics, shedding light on the author’s keen observation of nature and its integration into the biblical narrative. Drawing on scholarly insights and biblical commentary, the article analyzes the use of animal metaphors to delineate the distinctive traits of each tribe as described in Jacob’s blessings. Through a comparative study of zoological characteristics and biblical symbolism, the article elucidates the deeper meanings embedded within these blessings and their relevance to understanding the …

Combination Therapy Of Ido1 Inhibition And Anti-Pd1 Mediates Anti-Tumor Immunity By Promoting Memory Immunity Development And Cytotoxicity Of Γδ T And Nk Cells Via Il-2 Signaling And By Overcoming Pro-Tumor Effects Of Tgf-Β Signaling, Hyuk Jee

Dartmouth College Master’s Theses

Cutaneous melanoma is the most aggressive form of skin cancer even though it takes only about 1% of all skin cancers. Even among all cutaneous melanomas, NRAS-mutant melanoma is more aggressive than any other, and about 10-25% of all cutaneous melanoma cases have mutations in NRAS. NRAS is a member of the RAS family of proto-oncogenic GTPase proteins, and it plays a key role in signal transduction pathways responsible for cellular survival, proliferation, and metabolism. Immunotherapy is the first line of defense against NRAS-mutant melanoma because, despite tremendous efforts made for decades, it has not been successful to develop small …

Development Of New Diffuse Large B Cell Lymphoma Mouse Models., Syed Hassan Mehdi, Ying-Zhi Xu, Leonard D. Shultz, Eunkyung Kim, Yong Gu Lee, Samantha Kendrick, Donghoon Yoon

Faculty Research 2024

Diffuse large B cell lymphoma (DLBCL) is the most diagnosed, aggressive non-Hodgkin lymphoma, with ~40% of patients experiencing refractory or relapsed disease. Given the low response rates to current therapy, alternative treatment strategies are necessary to improve patient outcomes. Here, we sought to develop an easily accessible new xenograft mouse model that better recapitulates the human disease for preclinical studies. We generated two Luciferase (Luc)-EGFP-expressing human DLBCL cell lines representing the different DLBCL cell-of-origin subtypes. After intravenous injection of these cells into humanized NSG mice, we monitored the tumor growth and evaluated the organ-specific engraftment/progression period. Our results showed that …