Digital Commons Network^™

An Exploration Of Antibiotic Resistance In Zoonotic Streptococcus Canis: From Susceptibility Testing To Genomic Profiling, Patricia Arceta, Robert Polkowski, Nina Francesca Soriano, Zeinab Helal, Guillermo Risatti

Honors Scholar Theses

Streptococcus canis, a zoonotic pathogen primarily associated with infections in companion animals, has recently been recognized as a cause of human infections. This study investigated the antibiotic resistance in S. canis, focusing on seven isolates obtained from previous cases submitted to the Connecticut Veterinary Medical Diagnostic Laboratory. Their identities were confirmed using phenotypic assays via the Omnilog PM System (Biolog Inc., Hayward, CA). Antibiotic susceptibility profiles were determined via the Kirby-Bauer Disk Diffusion Susceptibility Test, employing a panel of antibiotics commonly used against gram-positive bacteria as recommended by the Clinical & Laboratory Standards Institute (CLSI) for Veterinary Medicine. …

Regulatory Transposable Elements In The Encyclopedia Of Dna Elements, Alan Y Du, Jason D Chobirko, Xiaoyu Zhuo, Cédric Feschotte, Ting Wang

2020-Current year OA Pubs

Transposable elements (TEs) comprise ~50% of our genome, but knowledge of how TEs affect genome evolution remains incomplete. Leveraging ENCODE4 data, we provide the most comprehensive study to date of TE contributions to the regulatory genome. We find 236,181 (~25%) human candidate cis-regulatory elements (cCREs) are TE-derived, with over 90% lineage-specific since the human-mouse split, accounting for 8-36% of lineage-specific cCREs. Except for SINEs, cCRE-associated transcription factor (TF) motifs in TEs are derived from ancestral TE sequence more than expected by chance. We show that TEs may adopt similar regulatory activities of elements near their integration site. Since human-mouse divergence, …

Loss Of Periostin Function Impairs Ligament Fibroblast Activity And Facilitates Ros-Mediated Cellular Senescence, Muhammad Farooq Rai, Xin Duan, Mingming Yan, Robert H Brophy, Lei Cai

2020-Current year OA Pubs

Anterior cruciate ligament (ACL) injuries pose a significant challenge due to their limited healing potential, often resulting in premature arthritis. The factors and mechanisms contributing to this inadequate healing process remain elusive. During the acute phase of injury, ACL tissues express elevated periostin levels that decline over time. The functional significance of periostin in ligament biology remains understudied. In this study, we investigated the functional and mechanistic implications of periostin deficiency in ACL biology, utilizing ligament fibroblasts derived from patients and a murine model of ACL rupture. Our investigations unveiled that periostin knockdown compromised fibroblast growth characteristics, hindered the egress …

About Premedical Programs 2024-25, University Of Dayton

Pre-Health Resource Center Campus Communications

No abstract provided.

Reconstruction Of Sharia Law Enforcement In Islamic Banking By The Sharia Supervisory Board Using A Swot Analysis Approach, Mahipal Mahipal, Yudi Wahyudin

Indonesia Law Review

The implementation of sharia principles in Islamic banking management has not always benefited. A challenge lies in the fact that the Sharia Supervisory Board's (SSB) oversight of Islamic banking has not operated at peak efficiency. Developing plans and policies for SSB's rehabilitation in Islamic banking management is the goal of this study. The literature review method and SWOT analysis was used to conduct the research. The analysis's findings indicate that the most important factor influencing SSB's presence in an organization and the management structure of Islamic banking is the frequency with which organizational internal factors—weaknesses (1.00) and strengths (0.95) of …

Exploring Berberine As A Novel Therapeutic Agent Against Staphylococcus Aureus Infections: Targeting Inflammation And Antibiotic Resistance, Daniel Kopulos

NYMC Student Theses and Dissertations

Staphylococcus aureus is a versatile Gram-positive bacterium commonly found on human skin. While often harmless, it can cause various infections when the skin is compromised, ranging from minor issues to life-threatening conditions in immunocompromised individuals.

The bacterium’s ability to resist antibiotics, particularly methicillin, underscores its clinical challenge. Staphylococcus aureus can also acquire vancomycin resistance. It evades immune responses through multiple mechanisms, including capsule formation, interference with immune proteins like staphylococcal protein A, and secretion of toxins such as Panton-Valentine Leukocidin. Understanding these mechanisms is crucial for developing effective strategies against Staphylococcus aureus infections.

The immune response to Staphylococcus aureus infections …

Challenges And Future Perspective Of Gastroretentive Mucoadhesive Dosage Forms, Rayhan Akbar, Heri Setiawan, Baitha Palanggatan Maggadani, Raditya Iswandana, Kurnia Sari Setio Putri

Pharmaceutical Sciences and Research

Gastroretentive Mucoadhesive Dosage Form (GMDF) is one type of Gastroretentive Drug Delivery System (GRDDS) technology designed to exploit the adhesiveness of dosage forms in the gastric mucosa. This aims to increase drug residence time, enhance drug solubility and absorption, and ultimately improve drug bioavailability and therapeutic effect. Various studies have explored the use of different polymers to develop GMDF systems and dosage forms. However, despite extensive research in this field, there are still limited GMDF products approved by the US FDA and INA FDA. Therefore, this review addresses the challenges in developing GMDF, its current state, and potential future opportunities. …

Antioxidant And Anti-Inflammatory Activities Of Ethanol And Aqueous Extracts In The Amnouy Suksomjit’S Thai Folk Remedy, Wichida Larsomsri, Pannawat Chaiyawatthanananthn, Thanaporn Intarawan, Yupa Ngankogsoong, Katanchalee Houngiam

Asian Medical Journal and Alternative Medicine

Introduction: A Thai folk remedy is traditionally used to manage many diseases, such as diabetes mellitus, hyperlipidemia, and dementia, as they are related via oxidative stress and chronic inflammation pathways.

Objectives: This study investigates the antioxidant contents, and anti-oxidation and anti-inflammation properties of ethanol and aqueous extracts of Dr. Amnouy Suksomjitʼs Thai folk remedy (RM or the Remedy).

Methods: RM and its plant ingredients were extracted with ethanol maceration and water decoction. All extracts had their antioxidant compounds measured i.e. total phenolic contents (TPC) and total flavonoid contents (TFC), activity by DPPH, ABTS^+ and FRAP assays, and anti-inflammatory activity …

Unveiling The Botanical Riches: Enhancing Quality Control And Stability Assessment Of Sa-Tri-Lhung-Klod Remedy Extract Through Hplc Profiling And Anti-Inflammatory Potency Evaluation, Janjira Inprasit, Srisopa Ruangnoo, Arunporn Itharat, Sunita Makchuchit, Weerachai Pipatrattanaseree, Neal M. Davies

Asian Medical Journal and Alternative Medicine

Introduction: Sa-Tri-Lhung-Klod (ST) remedy is a Thai traditional medicine preparation, used for post-partum care including excreting amniotic fluid, reducing inflammation, and improving blood circulation. The standard quality values and the stability of ST have not been reported. Quality control and stability testing are necessary to determine and insure the standard quality of ST remedy.

Objectives: To evaluate the quality control of herbal components according to Thai Herbal Pharmacopoeia (THP). The stability of ST extracts was examined using high performance liquid chromatography (HPLC) and anti-inflammatory activity was measured.

Methods: The quality assessment of the ST and plant components was performed by …

The Potential For Automated Insect Classification Using Infrared Remote Sensing, Rachel Deahl

Theses

Insects play an important role within ecosystems, occupying almost all trophic levels and providing crucial services such as pollination and decomposition. In addition, they can directly and negatively impact humans as crop pests, parasites, and disease vectors. Thus, it is essential to understand the spatial and temporal dynamics of insect populations and communities. Various forms of remote sensing, such as LiDAR, have been used to capture data on insects but often are costly and require advanced expertise. The objective of this thesis is to evaluate a cost-effective methodology that balances information loss. This thesis aims to outline the discrimination required …

Leveraging The Science Of Early Life Predictability To Inform Policies Promoting Child Health, Laura M. Glynn, Sabrina R. Liu, Candice Taylor Lucas, Elysia Poggi Davis

Psychology Faculty Articles and Research

Addressing the tremendous burden of early-life adversity requires constructive dialogues between scientists and policy makers to improve population health. Whereas dialogues focused on several aspects of early-life adversity have been initiated, discussion of an underrecognized form of adversity that has been observed across multiple contexts and cultures is only now emerging. Here we provide evidence for “why unpredictability?”, including: 1. Evidence that exposures to unpredictability affect child neurodevelopment, with influences that persist into adulthood. 2. The existence of a translational non-human animal model of exposure to early life unpredictability that can be capitalized upon to causally probe neurobiological mechanisms. 3. …

Antibiotic-Resistant Gram-Negative Bacteria In A Local Wastewater Treatment Plant In North Georgia, Nou Moua, Lindsay Mccuen, Sarah White, Swapna Bhat, Margi Flood, Jeanelle Morgan

Georgia Journal of Science

Antibiotics are some of the most essential lifesaving drugs currently available to us against infectious diseases. Several pathogens are developing resistance to these drugs and many have become resistant to multiple antibiotics. Such multi-drug resistance is becoming a global issue and has been found in many environments including wastewater treatment plants (WWTPs). In this study, we sampled a local WWTP for antibiotic-resistant bacteria. This WWTP is in North Georgia and runs directly into Lake Lanier, which is the main source of drinking water for the Atlanta area as well as a popular spot for water recreation. We obtained treated and …

Ephemera As A Versatile Primary Resource: A Case Study Of The Nancy Tucker Postcard Collection, Dylan J. Mcdonald, Jennifer Olguin, Monika Glowacka-Musial

Journal of Western Archives

Ephemera are rich primary sources too often overlooked within archival materials and at collecting institutions. This case study argues that archivists and librarians should recognize ephemera, specifically postcards, as powerful historical documents worthy of scholarly investigation. By analyzing a sample set of digitized postcards held at the New Mexico State University Library, we show how scholars can use postcards to develop evidence-based arguments. Through the images, printed texts, and hand-written inscriptions found on these early 20th century postcards, we demonstrate how researchers can examine the pro-development messages found in southern New Mexico postcards.

Balancing Survival And Sustainability: Addressing Environmental Justice In The Democratic Republic Of Congo, Stephanie Nehema

Alfie Scholars Conferences

This presentation argues that addressing environmental justice in the Democratic Republic of Congo (DRC) requires dual focus on combating systemic corruption and global economic exploitation while promoting culturally sensitive and community-based solutions that balance immediate humanitarian needs with long-term sustainability. The presentation will explore the intricate relationship between environmental degradation and socio-economic challenges in the DRC,6 a nation rich in resources yet struggling with poverty and political instability. It will provide a historical overview of environmental injustice, tracing its roots to colonial exploitation and its perpetuation by contemporary global economic practices. The presentation will examine the detrimental effects of environmental …

Methodologies For Dry Fixation And Taxidermy Of Education-Oriented Scorpion Specimens, Victoria Tang

Euscorpius

Scorpions hold a renowned status as iconic creatures across numerous cultures in the world. Traditionally preserved as desiccated specimens for educational purposes, they have been exhibited in museums and pedagogic collections, serving as concrete epistemological conduits for public education on biodiversity. However, these specimens frequently lack meticulous organization, potentially misrepresenting the animals’ ethological characteristics. This brief article aims to offer paradigmatic guidance for taxidermy of scorpions, ensuring a more accurate depiction of their in vivo habitus, achievable through the use of readily obtainable tools and undemanding techniques.

Loss Of Tyrosine 211 Phosphorylation Of Proliferating Cell Nuclear Antigen (Pcna) Enhances Postnatal Mammary Gland Development, Yi-Chun Shen, You-Zhe Lin, Wan-Rong Wu, Pei-Le Lin, Chien-Ching Liao, Feng-Chi Chung, Chia-Yun Chen, Ching-Yu Weng, Shao-Chun Wang

BioMedicine

The intricately orchestrated progression of mammary tissue development involves the precise coordination of gland differentiation and cellular proliferation. Nevertheless, the understanding of the role and regulatory mechanisms governing the DNA replication machinery in mammary gland development remains limited. Given the essential role of DNA replication in the viability of living cells, any genetic disturbance to its replicative function, in any form, will impede organ development. This circumstance poses a technical challenge in elucidating the potential function of cell proliferation in mammary morphogenesis. PCNA is crucial in DNA replication, playing a pivotal role in the development of complete eukaryotic organisms. The …

Effect Of Inulin From Dahlia Tubers (Dahlia Variabilis) Extract On Insulitis Severity And Insulin Expression In Diabetic Rats, Ismawati Ismawati, Saryono Saryono, Mukhyarjon Mukhyarjon, Ilhami Romus, Veni Dayu Putri, Sri Yanti, Fitri Dyna, Nada Idzdihari Adesti

BioMedicine

Background: Dahlia (Dahlia variabilis), a widely cultivated ornamental plant in Indonesia, is known to contain 84.08% inulin in its tubers. Numerous studies have demonstrated the antidiabetic potential of inulin from various plant sources. However, most of the research is in the form of a mixture of inulin with other active substances, and no one has analyzed the effects of inulin derived from dahlia tubers. This study examines the effect of inulin from dahlia tuber extract on blood glucose levels, serum insulin expression, pancreatic tissue insulin expression, homeostatic model assessment of insulin resistance (HOMA-IR), and the extent of …

Effect Of Mucuna Pruriens Seed Extract On Depression-Like Behavior Derived From Mild Traumatic Brain Injury In Rats, Alfonso Mata-Bermudez, Ricardo Trejo-Chávez, Marina Martínez-Vargas, Adán Pérez-Arredondo, María De Los Ángeles Martínez-Cárdenas, Araceli Diaz-Ruiz, Camilo Rios, Héctor Alonso Romero-Sánchez, Agustino Martínez-Antonio, Luz Navarro

BioMedicine

Background: Traumatic brain injury (TBI) is a severe health problem for which there is no specific treatment, leading to neurological or neuropsychological consequences. One of the most described disorders, even after mild TBI (mTBI), is depression, related to mechanisms involving reactive oxygen species (ROS). The Mucuna pruriens (M. pruriens) plant has various antioxidant, neuroprotective, and anti-inflammatory properties.

Purpose: There is insufficient evidence of M. pruriens use for the treatment of neurobehavioral and depressive impairments induced by TBI and of the mechanisms underlying this effect, so we aimed to evaluate the ability of shortterm administration of M. pruriens extract …

Effect Of Alantolactones On Cardiac Parameters Of Animals Under Artificially Induced Oxidative Stress, Mishal Fatima, Hina Andaleeb, Tanzila Rehman, Ouz Gul, Shanza Azeezz, Huzaifa Rehman, Haq Nawaz

BioMedicine

Purpose: Phytochemicals have been found effective in reducing the oxidative stress and damage to cardiovascular and other tissues. In this study, the effects of alantolactone (AL) on cardiac parameters in rabbits exposed to artificially-induced oxidative stress were investigated. Method: The oxidative stress was induced in a group of White New Zealand rabbits by injecting 40% hydrogen peroxide solution (1 ml/kg body weight) thrice with an interval of 72 h. The hydrogen peroxide-treated animals were orally treated with AL extracted from the roots of Inula helenium (1 ml/kg repeated thrice after 72 h). Blood samples were taken before and after the …

Far-Right Ecological Extremism: The Synthesis Of Violence, Hate, And The Environment On /Pol/., Hannah Claire Dunleavy

Environmental Studies Senior Theses

American far-right ecologism incorporates the American far-right’s antidemocratic and exclusionary tendencies, fears of existential threats and conspiracies, apocalyptic fantasies, and commitment to racial hierarchies. There are many shades of far-right ecologisms – including authoritarian deep ecology, eco-fascism, and exclusionary eco-nationalism – but all threaten the United States’ democratic ideals, multiculturalism, and pluralistic society. This thesis examines the rise of far-right ecologism in the U.S. by analyzing posts from 4chan’s /pol/ board (2015–2020) with a mixed-methods that blends a literature review, quantitative analysis, and descriptive case study. From 2015 to 2019, far-right ecology posts increased by 410%, and violent rhetoric in …

Barriers And Facilitators To Administering Burn Pit Registry Exams In Vha Facilities, Patricia V Chen, Israel C Christie, Kyler M Godwin, Jaehwan Han, Nisha Jani, Anays Sotolongo, Asma Ali, Drew A Helmer

Faculty and Staff Publications

Introduction: The Veterans Health Administration (VHA) established the Airborne Hazards and Open Burn Pit Registry (AHOBPR) in 2014 to address exposure concerns for veterans who have served in military operations in Southwest Asia and Afghanistan. By 2021, over 236,086 veterans completed the online questionnaire and 60% requested an AHOBPR examination. Of those requesting an exam, only 12% had an exam recorded in their medical record. This article summarizes barriers and facilitators to delivering AHOBPR exams and shares lessons learned from facilities who have successfully implemented burn pit exams for veterans.

Materials and methods: We (I.C.C and J.H.) constructed a key …

Office Of Research, Economic Engagement And Outreach Update, August 30, 2024, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Bringing Imagination To Life: An Animated Tale Of "The Arabian Cinderella And The Secret Of The Woven Threads", Matthew Machazire

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

August 30, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Zebrafish (Danio Rerio) Behavioral Phenotypes Are Not Underscored By Different Gut Microbiomes, Paul A. Ayayee, Ryan Y. Wong

Biology Faculty Publications

Although bold and shy behavioral phenotypes in zebrafish (Danio rerio) have been selectively bred and maintained over multiple generations, it is unclear if they are underscored by different gut microbiota. Using the microbiota–gut–brain concept, we examined the relationship between gut microbiota and the behavioral phenotypes within this model animal system to assess possible gut microbe-mediated effects on host behavior. To this end, we amplified and sequenced 16S rRNA gene amplicons from the guts of bold and shy zebrafish individuals using the Illumina Miseq platform. We did not record any significant differences in within-group microbial diversity nor between-group community …

Female Fandom In The Digital Era: ‘Alternative Universe’ For Promoting Thai Boys Love Drama, Monika Sri Yuliarti

JURNAL KOMUNIKASI INDONESIA

Digital era has changed human’s life, including in the practice of fandom. It results in a much broader dissemination of fans-related products produced by the fans, such as alternative universe (AU) as part of fan fiction. In addition, nowadays, Thailand popular culture is rising, especially with the boys’ love drama series (Thai BL drama) which caught foreign viewers’ interest, including Indonesians. This study explores how AU can be considered as a tool for promoting Thai BL drama which goes to fandom actively involvement in the promotion of a foreign country's cultural product with taboo value. It is a qualitative content …

Development Of Transportation Training Modules For Adults With Disabilities To Support Community Mobility, Victoria Ann Owens

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Background: A person with Autism spectrum disorder (ASD) or Intellectual disability (ID) may encounter internal barriers to public transportation modes including executive functioning. These may include challenges in initiation, planning, topographical orientation, waiting, and selecting correct embarkment transfers trains and buses. Additionally, the whole person journey is negatively impacted by sensory overload from light, sounds, crowded spaces, and impaired regulation strategies.

Purpose: The purpose of this quality improvement project is to mitigate these challenges of internal barriers inhibiting transit needs within this population by developing and dispersing a transportation education video tool. These efforts aim to promote optimal transportation engagement …

Histone H3.3 Lysine 9 And 27 Control Repressive Chromatin At Cryptic Enhancers And Bivalent Promoters, Matteo Trovato, Daria Bunina, Umut Yildiz, Nadine Fernandez-Novel Marx, Michael Uckelmann, Vita Levina, Yekaterina Perez, Ana Janeva, Benjamin A Garcia, Chen Davidovich, Judith B Zaugg, Kyung-Min Noh

2020-Current year OA Pubs

Histone modifications are associated with distinct transcriptional states, but it is unclear whether they instruct gene expression. To investigate this, we mutate histone H3.3 K9 and K27 residues in mouse embryonic stem cells (mESCs). Here, we find that H3.3K9 is essential for controlling specific distal intergenic regions and for proper H3K27me3 deposition at promoters. The H3.3K9A mutation resulted in decreased H3K9me3 at regions encompassing endogenous retroviruses and induced a gain of H3K27ac and nascent transcription. These changes in the chromatin environment unleash cryptic enhancers, resulting in the activation of distinctive transcriptional programs and culminating in protein expression normally restricted to …

About Premedical Programs At Ud, 2024-25, Udayton

Pre-Health Resource Center Campus Communications

No abstract provided.

Effectiveness Of Digital Communication In Tackling Environmental Degradation In Owerri, Imo State, Nigeria, Bjc Anyanwu, Cynthia N. Jumbo, Oba Sunday Aikuirawo Anyi, Emeka Williams Etumnu, Alexander Chima Onyebuchi, Ezekiel S. Asemah

Library Philosophy and Practice (e-journal)

Environmental deterioration as a whole is dangerous because it is currently causing widespread health concerns. The technological determinism theory served as the basis for this study. A descriptive survey was used in the investigation. The Australian sample size calculator was used to select 385 participants from the 983,000 total population. The multistage sampling was applied. Data was collected via a questionnaire, and analysis was done using percentages. Results revealed that 53.6% of the respondents confirmed that digital communication is used to circulate information on the dangers of environmental degradation in Owerri, Imo State, but to a low extent. The results …